YAMANAKA Hajime 山中創

Researcher Number	10415573
Other IDs
Affiliation (based on the past Project Information) *help	2019: 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 特別研究員 2016 – 2019: 京都大学, 霊長類研究所, 特定研究員 2015: 国立研究開発法人理化学研究所, ライフサイエンス技術基盤研究センター, 特別研究員 2013 – 2014: 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, 特別研究員 2009 – 2012: The Institute of Physical and Chemical Research, 分子プローブ機能評価研究チーム, リサーチアソシエイト
Review Section/Research Field	Principal Investigator Psychiatric science / Applied pharmacology Except Principal Investigator Rehabilitation science/Welfare engineering / Rehabilitation science/Welfare engineering
Keywords	Principal Investigator うつ病 / 霊長類 / セロトニン1Bレセプター / 霊長類モデル / 薬物惹起性うつ病 / リポポリサッカライド / うつ病モデル / セロトニン / 脳機能イメージング / テストバッテリー … More / 薬物惹起性モデル / インターフェロン / セロトニントランスポーター / セロトニンレセプター / 活動量 / PETイメージング … More Except Principal Investigator 側坐核 / 脊髄損傷 / p11 / マカクサル / 精密把持 / セロトニン / 脳機能イメージング / PET / モチベーション / リハビリテーション / うつ病 / 神経ネットワーク / P11 / 精密把握 / 機能イメージング / 腹側線条体 / 脳機能再編 / 脳機能画像 / サル / 前脳基底核 / siRNA / 機能結合 / 腹測線条体 / 測坐核 / 機能回復 / Positron Emission Tomography / 拡散テンソル画像 / マイクロアレー / ポジトロンエミッショントモグラフィー / 脊髄損傷モデル / 5HT1B受容体 / motivation / ドーパミン / マカクザル / ポジトロンエミッショントモグラフィー(PET) Less

Verification of the "serotonin 1B receptor hypothesis" using a primate model of depressionPrincipal Investigator
- Principal Investigator
  
  Yamanaka Hajime
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Kyoto University
Elucidation of role of nucleus accumbens for neural circuit reorganization during motor function recovery
- Principal Investigator
  
  Onoe Hirotaka
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Kyoto University
  Institute of Physical and Chemical Research
Elucidation of the role of the nucleus accumbens in motor function recovery after spinal cord injury; neural and molecular basis relating to motivation and plasticity
- Principal Investigator
  
  Onoe Hirotaka
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  Institute of Physical and Chemical Research
Neuronal and biological bases of the motivation in rehabilitation
- Principal Investigator
  
  ONOE Hirotaka
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Rehabilitation science/Welfare engineering
- Research Institution
  The Institute of Physical and Chemical Research
Pathological mechanism for interferon-induced depressionPrincipal Investigator
- Principal Investigator
  
  YAMANAKA Hajime
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  The Institute of Physical and Chemical Research

All 2017 2014 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques.2014
- Author(s)
  Yamanaka H, Yokoyama C, Mizuma H, Kurai S, Finnema SJ, Halldin C, Doi H, Onoe H.
- Journal Title
  
  Transl Psychiatry
  
  Volume: 4 Issue: 1 Pages: e342-e342
- DOI
  10.1038/tp.2013.112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24300196
[Journal Article] An Alteration in the Lateral Geniculate Nucleus of Experimental Glaucoma Monkeys : In vivo Positron Emission Tomography Imaging of Glial Activation2012
- Author(s)
  Shimazawa M, Ito Y, Inokuchi Y, Yamanaka H, Nakanishi T, Hayashi T, Ji B, Higuchi M, Suhara T, Imamura K, Araie M, Watanabe Y, Onoe H, Hara H
- Journal Title
  
  PLoS One
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790529
[Journal Article] Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids2011
- Author(s)
  Takahashi K, Onoe K, Doi H, Nagata H, Yamagishi G, Hosoya T, Tamura Y, Wada Y, Yamanaka H, Yokoyama C, Mizuma H, Takashima T, Bergstrom M, Onoe H, Langstrom B, Watanabe Y
- Journal Title
  
  PET study with[^<11> C] vorozole. Neuroreport
  
  Volume: 22 Pages: 326-330
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790529
[Journal Article] Involvement of endoplasmic reticulum stress on neuronal cell death in the lateral geniculate nucleus in the monkey glaucoma model2011
- Author(s)
  Ito Y, Shimazawa M, Inokuchi Y, Yamanaka H, Tsuruma K, Imamura K, Onoe H, Watanabe Y, Aihara M, Araie M, Hara H
- Journal Title
  
  Eur J Neurosci
  
  Volume: 33 Pages: 843-855
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790529
[Journal Article] Developmental changes in P-glycoprotein function in the blood-brain barrier of nonhuman primates : PET study with R-^<11> C-verapamil and 11C-oseltamivir2011
- Author(s)
  Takashima T, Yokoyama C, Mizuma H, Yamanaka H, Wada Y, Onoe K, Nagata H, Tazawa S, Doi H, Takahashi K, Morita M, Kanai M, Shibasaki M, Kusuhara H, Sugiyama Y, Onoe H, Watanabe Y
- Journal Title
  
  J Nucl
  
  Volume: 52 Pages: 950-957
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790529
[Journal Article] Mapping of serotonin transporters by positron emission tomography with[^<11> C] DASB in conscious common marmosets : comparison with rhesus monkeys2010
- Author(s)
  Yokoyama C, Yamanaka H, Onoe K, Kawasaki A, Nagata H, Shirakami K, Doi H, Onoe H
- Journal Title
  
  Synapse
  
  Volume: 64 Pages: 594-601
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790529
[Presentation] A sucrose preference test modified for evaluation of depression-like behavior in macaque monkeys2017
- Author(s)
  Hajime Yamanaka, Nami Hosaka, Masahiko Takada, Hirotaka Onoe
- Organizer
  Society for Neuroscience 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10231
[Presentation] マカクザルにおけるうつ様行動評価のためのスクロース嗜好性テストの改良2017
- Author(s)
  Hajime Yamanaka1, Nami Hosaka, Masahiko Takada, Hirotaka Onoe
- Organizer
  日本神経科学大会
- Data Source
  KAKENHI-PROJECT-16K10231
[Presentation] ケタミンの抗うつ作用メカニズムに側坐核と腹側淡蒼球のセロトニン１Bレセプターが関与する可能性―マカクザルを用いたPET研究―2014
- Author(s)
  山中創, 横山ちひろ, 水間広, 大野正裕, 武田千穂, 森智子, Sjoerd J Finnema, Christer Halldin, 土居久志, 尾上浩隆
- Organizer
  第９回日本分子イメージング学会
- Place of Presentation
  千里ライフサイエンスセンター, 大阪
- Year and Date
  2014-05-22
- Data Source
  KAKENHI-PROJECT-24300196
[Presentation] Ketamine Act As an Antidepressant : Involvement of Nucleus Accumbens and Ventral Pallidum 5-HT1B Receptors2014
- Author(s)
  Hajime Yamanaka, Chihiro Yokoyama, Hisashi Doi, Christer Halldin, Hirotaka Onoe
- Organizer
  第３７回日本神経科学大会
- Place of Presentation
  パシフィコ横浜, 横浜
- Year and Date
  2014-09-12
- Data Source
  KAKENHI-PROJECT-24300196
[Presentation] Ketamine acts on 5-HT1B receptors in the nucleus accumbens and ventral pallidum: a possible role for its antidepressant action2014
- Author(s)
  Hajime Yamanaka, Chihiro Yokoyama, Hiroshi Mizuma, Hisashi Doi, Sjoerd J Finnema, Christer Halldin, Hirotaka Onoe
- Organizer
  Neuroscience 2014
- Place of Presentation
  the Walter E. Washington Convention Center, Washington DC, USA
- Year and Date
  2014-11-18
- Data Source
  KAKENHI-PROJECT-24300196
[Presentation] Increase in 5-HT1B receptors in nucleus accumbens and ventral pallidum by ketamine as its possible mechanism of antidepressant action: PET study with rhesus monkeys2014
- Author(s)
  Hirotaka Onoe, Hajime Yamanaka, Chihiro Yokoyama, Hiroshi Mizuma, S. J. Finnema, Hisashi Doi, C. Halldin,
- Organizer
  EANM Congress 2014
- Place of Presentation
  The Swedish Exhibition & Congress Centre, Gothenburg, Sweden
- Year and Date
  2014-10-20
- Data Source
  KAKENHI-PROJECT-24300196
[Presentation] 麻酔薬の[^<11> C] DASB結合能に対する影響:マカクザルを用いた検討2012
- Author(s)
  山中創、大野正裕、森智子、武田千穂、平尾有日子、安藤亜美、横山ちひろ、土居久志、尾上浩隆
- Organizer
  日本分子イメージング学会
- Place of Presentation
  浜松
- Year and Date
  2012-05-25
- Data Source
  KAKENHI-PROJECT-21790529
[Presentation] 無麻酔下アカゲザルのセロトニン1Bレセプターイメージング-[^<11>C]AZ10419369を用いたPET研究-2011
- Author(s)
  山中創、横山ちひろ、大野正裕、武田千穂、平尾有日子、倉井佐知、土居久志、尾上浩隆
- Organizer
  第6回日本分子イメージング学会総会・学術集会
- Place of Presentation
  神戸(神戸コンベンションセンター)
- Year and Date
  2011-05-26
- Data Source
  KAKENHI-PROJECT-21300205
[Presentation] 無麻酔下アカゲザルのセロトニン1Bレセプターイメージング-[^<11>C]AZ10419369を用いたPET研究-2011
- Author(s)
  山中創、横山ちひろ、大野正裕、武田千穂、平尾有日子、倉井佐知、土居久志、尾上浩隆
- Organizer
  第6回日本分子イメージング学会総会・学術集会
- Place of Presentation
  神戸(神戸国際会議場)
- Year and Date
  2011-05-26
- Data Source
  KAKENHI-PROJECT-21790529
[Presentation] 無麻酔下アカゲザルのセロトニン1Bレセプターイメージング-[^<11> C] AZ10419369を用いたPET研究-2011
- Author(s)
  山中創、横山ちひろ、大野正裕、武田千穂、平尾有日子、倉井佐知、土居久志、尾上浩隆
- Organizer
  日本分子イメージング学会
- Place of Presentation
  神戸
- Year and Date
  2011-05-26
- Data Source
  KAKENHI-PROJECT-21790529
[Presentation] 小動物におけるモノアミントランスポーターPETイメージング2010
- Author(s)
  山中創
- Organizer
  分子イメージング研究シンポジウム2010
- Place of Presentation
  東京
- Year and Date
  2010-01-22
- Data Source
  KAKENHI-PROJECT-21790529
[Presentation] PETを用いた緑内障早期診断法の確立2010
- Author(s)
  嶋澤雅光、井口勇太、伊藤保志、山中創、林拓也、季斌、樋口真人、須原哲也、今村一之、新家眞、渡辺恭良、尾上浩隆、原英彰
- Organizer
  日本分子イメージング学会
- Place of Presentation
  大津
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-21790529
[Presentation] Influence of propofol anesthesia on regional functional state of brain serotonin transporter2010
- Author(s)
  Yamanaka, H., Onoe, K., Yokoyama, C., Onoe, H.
- Organizer
  PET study with[^<11> C] DASB in macaque monkeys. World Molecular Imaging Congress
- Place of Presentation
  Kyoto
- Year and Date
  2010-09-09
- Data Source
  KAKENHI-PROJECT-21790529
[Presentation] プロポフォール麻酔は[^<11> C] DASBのセロトニントランスポーターへの結合を上昇させる:マカクザルを用いたPET研究2010
- Author(s)
  山中創、尾上嘉代、横山ちひろ、尾上浩隆
- Organizer
  日本神経科学大会
- Place of Presentation
  神戸
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-21790529
[Presentation] 小動物用PETを用いたマカクサルおよびマーモセット脳における[^<11> C] DASB結合能2009
- Author(s)
  山中創、横山ちひろ、長田浩子、土居久志、尾上嘉代、渡辺恭良、尾上浩隆
- Organizer
  日本分子イメージング学会
- Place of Presentation
  東京
- Year and Date
  2009-05-14
- Data Source
  KAKENHI-PROJECT-21790529
[Presentation] C^^<11>-Labeled cetrozole : a better PET tracer for aromatase2009
- Author(s)
  Takahashi, K., Hosoya, T., Onoe, K., Doi, H., Nagata, H., Hiramatsu, T., Li, X. L., Wada, Y., Takashima, T., Katayama, Y., Yamanaka, H., Suzuki, M., Onoe, H., Watanabe, Y.
- Organizer
  World Molecular Imaging Congress
- Place of Presentation
  Montreal
- Year and Date
  2009-09-24
- Data Source
  KAKENHI-PROJECT-21790529
[Presentation] 無麻酔下コモンマーモセットの[^<11> C] DASBによるPETイメージング:アカゲザルとの比較2009
- Author(s)
  横山ちひろ、山中創、尾上嘉代、川崎章弘、長田浩子、白神恵子、土居久志、和田康弘、渡辺恭良、尾上浩隆
- Organizer
  日本神経科学大会
- Place of Presentation
  名古屋
- Year and Date
  2009-09-18
- Data Source
  KAKENHI-PROJECT-21790529

1. ONOE Hirotaka (80214196)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
2. NISHIMURA Yukio (20390693)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. TAHARA Tsuyoshi (20419708)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. ISA Tadashi (20212805)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
5. HAYASHI Takuya (50372115)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KAKUMOTO Kyoko (00442583)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. KOJIMA Toshio (00311340)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 水間広 (00382200)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YAMANAKA Hajime 山中 創

Research Projects

Research Products

Co-Researchers

Verification of the "serotonin 1B receptor hypothesis" using a primate model of depressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of role of nucleus accumbens for neural circuit reorganization during motor function recovery

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the role of the nucleus accumbens in motor function recovery after spinal cord injury; neural and molecular basis relating to motivation and plasticity

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neuronal and biological bases of the motivation in rehabilitation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Pathological mechanism for interferon-induced depressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A possible mechanism of the nucleus accumbens and ventral pallidum 5-HT1B receptors underlying the antidepressant action of ketamine: a PET study with macaques.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] An Alteration in the Lateral Geniculate Nucleus of Experimental Glaucoma Monkeys : In vivo Positron Emission Tomography Imaging of Glial Activation2012

Author(s)

Journal Title

Data Source

[Journal Article] Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids2011

Author(s)

Journal Title

Data Source

[Journal Article] Involvement of endoplasmic reticulum stress on neuronal cell death in the lateral geniculate nucleus in the monkey glaucoma model2011

Author(s)

Journal Title

Data Source

[Journal Article] Developmental changes in P-glycoprotein function in the blood-brain barrier of nonhuman primates : PET study with R-^<11> C-verapamil and 11C-oseltamivir2011

Author(s)

Journal Title

Data Source

[Journal Article] Mapping of serotonin transporters by positron emission tomography with[^<11> C] DASB in conscious common marmosets : comparison with rhesus monkeys2010

Author(s)

Journal Title

Data Source

[Presentation] A sucrose preference test modified for evaluation of depression-like behavior in macaque monkeys2017

Author(s)

Organizer

Data Source

[Presentation] マカクザルにおけるうつ様行動評価のためのスクロース嗜好性テストの改良2017

Author(s)

Organizer

Data Source

[Presentation] ケタミンの抗うつ作用メカニズムに側坐核と腹側淡蒼球のセロトニン１Bレセプターが関与する可能性―マカクザルを用いたPET研究―2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Ketamine Act As an Antidepressant : Involvement of Nucleus Accumbens and Ventral Pallidum 5-HT1B Receptors2014

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Ketamine acts on 5-HT1B receptors in the nucleus accumbens and ventral pallidum: a possible role for its antidepressant action2014

YAMANAKA Hajime 山中創