Ohhashi Yumiko 大橋祐美子

… Alternative Names

OHHASHI Yumiko 大橋祐美子

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Researcher Number	10422669
Other IDs
Affiliation (Current)	2025: 東京科学大学, 総合研究院, 特任講師
Affiliation (based on the past Project Information) *help	2025: 東京科学大学, 総合研究院, 特任講師 2023 – 2024: 東京工業大学, 科学技術創成研究院, 特任講師 2020 – 2023: 神戸大学, 理学研究科, 特別研究員(RPD) 2013: 独立行政法人理化学研究所, 脳科学総合研究センター, 研究員 2011 – 2012: 独立行政法人理化学研究所, タンパク質構造疾患研究チーム, 研究員
Review Section/Research Field	Principal Investigator Basic Section 43030:Functional biochemistry-related / Basic Section 43020:Structural biochemistry-related / Biophysics / Science and Engineering Except Principal Investigator Basic Section 28040:Nanobioscience-related / Medium-sized Section 28:Nano/micro science and related fields / Basic Section 43040:Biophysics-related
Keywords	Principal Investigator 天然変性蛋白質 / アミロイド / Sup35 / アミロイド線維 / 液-液相分離 / 構造多形 / 揺らぎ / 核磁気共鳴法 / 低複雑性配列 / タンパク質 / 核磁気共鳴 / 部分構造 / amyloid … More Except Principal Investigator … More シミュレーション / 高速原子間力顕微鏡 / 構造機能相関 / 天然変性タンパク質 / アミロイド核生成 / エマルション / マイクロ水滴 / 細胞内液滴 / 核形成 / アミロイド線維 / 液液相分離 / ミスフォールディング / 準安定 / 中間体 / アミロイド / 蛋白質 Less

高速AFMを中心とした統合解析による天然変性タンパク質の動的ナノ構造-機能相関解明
- Principal Investigator
  
  紺野宏記
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 28040:Nanobioscience-related
- Research Institution
  Kanazawa University
液-液相分離による液滴からのアミロイド形成が抑制される細胞内機構Principal Investigator
- Principal Investigator
  
  大橋祐美子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Tokyo Institute of Technology
液液相分離中アミロイド生成の定量的解析法の確立
- Principal Investigator
  
  福山真央
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 28:Nano/micro science and related fields
- Research Institution
  Tohoku University
Deciphering the molecular mechanism of liquid-liquid phase separation from low-complexity sequences that vary by speciesPrincipal Investigator
- Principal Investigator
  
  Ohhashi Yumiko
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43020:Structural biochemistry-related
- Research Institution
  Tokyo Institute of Technology
  Kobe University
Exploring protein assembly mechanisms that induce amyloid nucleation
- Principal Investigator
  
  Chatani Eri
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  Kobe University
蛋白質の揺らぎとアミロイドの構造の関係Principal Investigator
- Principal Investigator
  
  大橋祐美子
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Science and Engineering
- Research Institution
  The Institute of Physical and Chemical Research
NMR study of the formation and dissolution mechanisms of Sup35 amyloid fibrils.Principal Investigator
- Principal Investigator
  
  OHHASHI Yumiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biophysics
- Research Institution
  The Institute of Physical and Chemical Research

All 2023 2022 2021 2020 2013 2012 2011

All Journal Article Presentation Book

[Book] 現代科学・増刊46「相分離生物学の全貌」2020
- Author(s)
  西奈美卓、大橋祐美子
- Total Pages
  395
- Publisher
  東京化学同人
- ISBN
  9784807913466
- Data Source
  KAKENHI-PROJECT-20K06525
[Journal Article] Detection of Fibril Nucleation in Micrometer-Sized Protein Condensates and Suppression of Sup35NM Fibril Nucleation by Liquid-Liquid Phase Separation2023
- Author(s)
  Fukuyama Mao、Nishinami Suguru、Maruyama Yoko、Ozawa Taiki、Tomita Shunsuke、Ohhashi Yumiko、Kasuya Motohiro、Gen Masao、Chatani Eri、Shiraki Kentaro、Hibara Akihide
- Journal Title
  
  Analytical Chemistry
  
  Volume: 95 Issue: 26 Pages: 9855-9862
- DOI
  10.1021/acs.analchem.3c00766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19284, KAKENHI-PROJECT-20H03224
[Journal Article] Current Understanding of the Structure, Stability and Dynamic Properties of Amyloid Fibrils2021
- Author(s)
  Chatani Eri、Yuzu Keisuke、Ohhashi Yumiko、Goto Yuji
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 9 Pages: 4349-4349
- DOI
  10.3390/ijms22094349
- NAID
  120007038650
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-17H06352, KAKENHI-PROJECT-20J40038, KAKENHI-PROJECT-20K06525, KAKENHI-PROJECT-20K21396, KAKENHI-PROJECT-20H03224
[Journal Article] Short disordered protein segment regulates cross-species transmission of a yeast prion2020
- Author(s)
  Shida T, Kamatari YO, Yoda T, Yamaguchi Y, Feig M, Ohhashi Y, Sugita Y, Kuwata K, Tanaka M.
- Journal Title
  
  Nat Chem Biol
  
  Volume: 16 Issue: 7 Pages: 756-765
- DOI
  10.1038/s41589-020-0516-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06390, KAKENHI-PROJECT-20K06525, KAKENHI-PROJECT-19H03476, KAKENHI-PROJECT-20J40038, KAKENHI-PROJECT-19H03362, KAKENHI-PROJECT-20H04285
[Journal Article] Radically different amyloid conformations dictate the seeding specificity of a chimeric Sup35 prion2011
- Author(s)
  Foo CK, Ohhashi Y, Kelly MJ, Tanaka M, and Weissman JS
- Journal Title
  
  J Mol Biol
  
  Volume: 408(1) Pages: 1-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23770193
[Presentation] A local structure of the intrinsically disordered region of Sup35 governs the temperature sensitivity of liquid-liquid phase separation.2023
- Author(s)
  Yumiko Ohhashi
- Organizer
  第46回日本分子生物学会
- Data Source
  KAKENHI-PROJECT-20K06525
[Presentation] アミロイド線維の生成場としての液滴の理解2023
- Author(s)
  茶谷絵理、大橋祐美子、福山真央
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] 酸化条件下におけるタウ液滴の凝集機構の解明2023
- Author(s)
  道上佑希、大橋裕美子、益井歩未、柚佳祐、山口圭一、河田康志、茶谷絵理
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] 酸化、還元条件下におけるタウ液滴の凝集機構の解明2023
- Author(s)
  道上佑希、大橋裕美子、益井歩未、柚佳祐、山口圭一、河田康志、茶谷絵理
- Organizer
  神戸大学研究基盤センター若手フロンティア研究会2023
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] タウ液滴の凝集に対する酸化還元状態の影響の解析2023
- Author(s)
  道上佑希、益井歩未、大橋祐美子、柚佳祐、山口圭一、後藤祐児、河田康志、茶谷絵理
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] タンパク質濃縮相からのアミロイド核生成解析に向けた濃縮相サイズ調節法2023
- Author(s)
  小澤大樹、川上純佳、佐藤安里、大橋祐美子、茶谷絵理、丸山洋子、白木賢太郎、火原彰秀、福山真央
- Organizer
  化学とマイクロ・ナノシステム学会第48回研究会
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] トランスサイレチン49-127断片のアミロイド線維形成反応における野生型と変異体の比較2023
- Author(s)
  中尾星哉、柚佳祐、松村美里、大橋祐美子、茶谷絵理
- Organizer
  第23回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] アルファシヌクレイン凝集の長時間測定に向けた水中マイクロ流体デバイスの観察2023
- Author(s)
  佐藤安里、小澤大樹、柚佳祐、大橋祐美子、茶谷絵理、福山真央
- Organizer
  令和5年度化学系学協会東北大会
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] 液-液相分離に高い温度感受性をもたらすSup35天然変性領域の局所構造2023
- Author(s)
  大橋祐美子、西奈美卓、白木賢太郎、茶谷絵理
- Organizer
  第46回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] 酵母プリオンタンパク質の液液相分離がアミロイド核生成に与える影響の評価2023
- Author(s)
  福山真央、西奈美卓、冨田峻介、大橋祐美子、小澤大樹, 玄大雄, 粕谷素洋、茶谷絵理、丸山洋子、白木賢太郎、火原彰秀
- Organizer
  化学とマイクロ・ナノシステム学会第48回研究会
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] Liquid-liquid phase separation and amyloid formation of Sup35 from four different yeast species2022
- Author(s)
  大橋祐美子、西奈美卓、白木賢太郎、茶谷絵理
- Organizer
  第60回日本生物物理学会年会
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] 液液相分離相からのアミロイド形成速度のサイズ依存2022
- Author(s)
  福山真央、西奈美卓、冨田峻介、大橋祐美子、粕谷素洋、茶谷絵理、丸山洋子、白木賢太郎、火原彰秀
- Organizer
  化学とマイクロ・ナノシステム学会第45回研究会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] Study on solvent conditions of prion protein droplet formation for amyloid nucleation analysis2022
- Author(s)
  Taiki Ozawa, Suguru Nishinami, Shunsuke Tomita, Yumiko Ohhashi, Motohiro Kasuya, Eri Chatani, Yoko Maruyama, Kentaro Shiraki, Akihide Hibara, and Mao Fukuyama
- Organizer
  令和4年度化学系学協会東北大会
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] Local conformation of intrinsically disordered regions of Sup35 produces temperature sensitivity of liquid-liquid phase separation2022
- Author(s)
  Yumiko Ohhashi, Suguru Nishinami, Kentaro Shiraki, and Eri Chatani
- Organizer
  Proteostasis & Disease Symposium 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] Local conformation of intrinsically disordered region of Sup35 produces temperature sensitivity of liquid-liquid phase separation.2022
- Author(s)
  Yumiko Ohhashi, Suguru Nishinami, Kentaro Shiraki, Eri Chatani
- Organizer
  Proteostasis & Disease SYMPOSIUM 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06525
[Presentation] Liquid-Liquid Phase Separation and Amyloid Formation of Sup35 from Three Different Yeast Species2022
- Author(s)
  大橋祐美子、西奈美卓、白木賢太郎、茶谷絵理
- Organizer
  第60回日本生物物理学会
- Data Source
  KAKENHI-PROJECT-20K06525
[Presentation] マイクロサイズプリオンタンパク質集合液滴中からのアミロイド核生成速度解析2022
- Author(s)
  福山真央、西奈美卓、冨田峻介、大橋祐美子、粕谷素洋、茶谷絵理、白木賢太郎、火原彰秀
- Organizer
  第82回分析化学討論会
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] Local structure of an intrinsically disordered region of Sup35 causes temperature sensitivity of liquid-liquid phase separation.2022
- Author(s)
  Yumiko Ohhashi
- Organizer
  Satellite seminar of Proteostasis & Disease SYMPOSIUM 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K06525
[Presentation] トランスサイレチン49-127断片のアミロイド線維化反応における塩の影響2022
- Author(s)
  中尾星哉、柚佳祐、松村美里、大橋祐美子、茶谷絵理
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] 天然変性領域の局所構造がSup35の液-液相分離の環境応答性を決定する2022
- Author(s)
  大橋祐美子、西奈美卓、白木賢太郎、茶谷絵理
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K06525
[Presentation] トランスサイレチン49-127断片のアミロイド線維化反応の特徴と変異効果2022
- Author(s)
  中尾星哉、柚佳祐、松村美里、大橋祐美子、茶谷絵理
- Organizer
  若手フロンティア研究会2022
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] Sup35天然変性領域の局所構造が液-液相分離の環境応答性を決定する2022
- Author(s)
  大橋祐美子、西奈美卓、白木賢太郎、茶谷絵理
- Organizer
  第22回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] Determination of amyloid nucleation rate in Sup35 droplet2021
- Author(s)
  Mao Fukuyama, Suguru Nishinami, Shunsuke Tomita, Motohiro Kasuya, Yumiko Ohhashi, Eri Chatani, Kentaro Shiraki, Akihide Hibara
- Organizer
  第二回分子夾雑化学国際会議
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] Sup35の液-液相分離におけるプリオンドメインの役割2021
- Author(s)
  大橋祐美子、西奈美卓、白木賢太郎、茶谷絵理
- Organizer
  第21回日本蛋白質科学会
- Data Source
  KAKENHI-PROJECT-20K06525
[Presentation] Sup35 の液- 液相分離におけるプリオンドメインの役割2021
- Author(s)
  大橋祐美子, 西奈美卓, 白木賢太郎, 茶谷絵理
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20H03224
[Presentation] Sup35の液-液相分離におけるプリオンドメインの役割2021
- Author(s)
  大橋祐美子、西奈美卓、白木賢太郎、茶谷絵理
- Organizer
  第21回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-20K06525
[Presentation] Molecular basis for diversification of amyloid conformation2020
- Author(s)
  Yumiko Ohhashi, Motomasa Tanaka
- Organizer
  第５８回日本生物物理学会
- Data Source
  KAKENHI-PROJECT-20K06525
[Presentation] 酵母プリオンSup35を用いたアミロイド構造多形形成メカニズムの解明2013
- Author(s)
  大橋祐美子
- Organizer
  第１３回日本蛋白質科学会
- Place of Presentation
  鳥取市　とりぎん文化会館
- Invited
- Data Source
  KAKENHI-PROJECT-23770193
[Presentation] 酵母プリオンSup35を用いたアミロイド構造多形形成メカニズムの解明2013
- Author(s)
  大橋祐美子
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取市とりぎん文化会館
- Year and Date
  2013-06-12
- Invited
- Data Source
  KAKENHI-PUBLICLY-23107734
[Presentation] 酵母プリオンSup35を用いたアミロイド構造多形形成メカニズムの解明2013
- Author(s)
  大橋祐美子、山口芳樹、鎌足雄司、花島慎弥、桑田一夫、田中元雅
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  鳥取市とりぎん文化会館
- Invited
- Data Source
  KAKENHI-PROJECT-23770193
[Presentation] Protein fluctuation in monomer determines prion strain conformations2012
- Author(s)
  大橋祐美子
- Organizer
  Asian Pacific Prion Symposium 2012
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2012-07-29
- Data Source
  KAKENHI-PUBLICLY-23107734
[Presentation] アミロイド構造の決定におけるタンパク質揺らぎの役割の解析2012
- Author(s)
  大橋祐美子、山口芳樹、鎌足雄司、花島慎弥、桑田一夫、田中元雅
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋大学東山キャンパス
- Data Source
  KAKENHI-PROJECT-23770193
[Presentation] Protein fluctuation in monomer determines prion strain conformations2012
- Author(s)
  Yumiko Ohhashi and Motomasa Tanaka
- Organizer
  Asian Pacific Prion Symposium 2012
- Place of Presentation
  Pacifico Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23770193
[Presentation] アミロイド構造の決定におけるタンパク質揺らぎの役割の解析2012
- Author(s)
  大橋祐美子
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋大学東山キャンパス
- Year and Date
  2012-09-22
- Data Source
  KAKENHI-PUBLICLY-23107734
[Presentation] Protein fluctuation in monomer determines prion strain conformations2012
- Author(s)
  大橋祐美子、田中元雅
- Organizer
  Asian Pacific Prion Symposium 2012
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-23770193
[Presentation] アミロイド構造の決定におけるタンパク質揺らぎの役割の解析2012
- Author(s)
  大橋祐美子、田中元雅
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋市・名古屋大学東山キャンパス
- Data Source
  KAKENHI-PROJECT-23770193
[Presentation] Role of protein fluctuation in determination of amyloid conformation.2011
- Author(s)
  大橋祐美子、田中元雅
- Organizer
  The International symposium on Nuclear Magnetic Resonance 2011
- Place of Presentation
  横浜、大さん橋ホール
- Data Source
  KAKENHI-PROJECT-23770193
[Presentation] Structural basis for the diversity of prion strain conformations2011
- Author(s)
  Yumiko Ohhashi and Motomasa Tanaka
- Organizer
  Asian Pacific Prion Symposium 2011
- Place of Presentation
  Hotel Marroad Karuizawa, Nagano, Japan
- Data Source
  KAKENHI-PROJECT-23770193
[Presentation] Role of protein fluctuation in determination of amyloid conformation2011
- Author(s)
  Yumiko Ohhashii and Motomasa Tanaka
- Organizer
  The ssInternational symposium on Nuclear Magnetic Resonance 2011
- Place of Presentation
  OSANBASHI Hall, Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-23770193
[Presentation] Role of protein fluctuation in determination of amyloid conformation2011
- Author(s)
  大橋祐美子、田中元雅
- Organizer
  The International symposium on Nuclear Magnetic Resonance 2011
- Place of Presentation
  大さん橋ホール(神奈川県)
- Year and Date
  2011-11-16
- Data Source
  KAKENHI-PUBLICLY-23107734

1. Chatani Eri (00432493)

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
2. 福山真央 (40754429)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 粕谷素洋 (00582040)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 白木賢太郎 (90334797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. 冨田峻介 (50726817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 紺野宏記 (80419267)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. FLECHSIG HOLGER (00758964)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 後藤祐児

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 鎌足雄司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ohhashi Yumiko 大橋 祐美子

OHHASHI Yumiko 大橋 祐美子

Research Projects

Research Products

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高速AFMを中心とした統合解析による天然変性タンパク質の動的ナノ構造-機能相関解明

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液-液相分離による液滴からのアミロイド形成が抑制される細胞内機構Principal Investigator

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液液相分離中アミロイド生成の定量的解析法の確立

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Deciphering the molecular mechanism of liquid-liquid phase separation from low-complexity sequences that vary by speciesPrincipal Investigator

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Exploring protein assembly mechanisms that induce amyloid nucleation

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蛋白質の揺らぎとアミロイドの構造の関係Principal Investigator

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NMR study of the formation and dissolution mechanisms of Sup35 amyloid fibrils.Principal Investigator

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[Book] 現代科学・増刊46「相分離生物学の全貌」2020

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[Journal Article] Detection of Fibril Nucleation in Micrometer-Sized Protein Condensates and Suppression of Sup35NM Fibril Nucleation by Liquid-Liquid Phase Separation2023

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[Journal Article] Current Understanding of the Structure, Stability and Dynamic Properties of Amyloid Fibrils2021

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NAID

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[Journal Article] Short disordered protein segment regulates cross-species transmission of a yeast prion2020

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[Journal Article] Radically different amyloid conformations dictate the seeding specificity of a chimeric Sup35 prion2011

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[Presentation] A local structure of the intrinsically disordered region of Sup35 governs the temperature sensitivity of liquid-liquid phase separation.2023

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[Presentation] アミロイド線維の生成場としての液滴の理解2023

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Ohhashi Yumiko 大橋祐美子

OHHASHI Yumiko 大橋祐美子