Deguchi Atsuko 出口敦子

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DEGUCHI Atsuko 出口敦子

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Researcher Number	10422932
Other IDs
Affiliation (Current)	2025: 東京女子医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2023 – 2024: 東京女子医科大学, 医学部, 教授 2021 – 2022: 東京女子医科大学, 医学部, 准教授 2020: 東京女子医科大学, 医学部, 講師 2012 – 2019: 東京女子医科大学, 医学部, 助教 2006 – 2009: 京都大学, 医学研究科, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology / Tumor biology / Experimental pathology Except Principal Investigator Experimental pathology / Biological Sciences
Keywords	Principal Investigator 肝転移 / がん微小環境 / S100A8 / 微小環境 / 大腸がん / 自然免疫 / 転移 / 自然炎症 / 大腸癌 / 癌 … More / キナーゼ / LKB1 / シグナル伝達 / 肝細胞癌 / 腫瘍 … More Except Principal Investigator LKB1 / Microarray / Mouse / Kinase / Hepatocellular carcinoma / マイクロアレイ / マウス / キナーゼ / 肝臓癌 / 増殖因子 / ケモカイン / 癌 / がん / 転移 / TLR / 内因性リガンド / 炎症 / ADAM12 / CCR2 / がん転移 / 自然免疫 / ephrinA1 / CCL2 / S100A8 / SAA3 / TLR4 Less

Single-cell transcriptome analysis of hetatic premetastatic niche formationPrincipal Investigator
- Principal Investigator
  
  出口敦子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokyo Women's Medical University
Premetastatic niche formation maintains metastatic stem cell phenotypePrincipal Investigator
- Principal Investigator
  
  出口敦子
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokyo Women's Medical University
Liver tropism by premetastatic niche formation and tumor-niche crosstalkPrincipal Investigator
- Principal Investigator
  
  DEGUCHI ATSUKO
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tokyo Women's Medical University
Premetastatic niche enhances liver metastasisPrincipal Investigator
- Principal Investigator
  
  DEGUCHI ATSUKO
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Tokyo Women's Medical University
Toll-like receptor-mediated hepatic premetastatic microenvironmentPrincipal Investigator
- Principal Investigator
  
  DEGUCHI Atsuko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Tokyo Women's Medical University
Endogenous TLR4 ligands in tumor metastasis.
- Principal Investigator
  
  MARU Yoshiro
- Project Period (FY)
  2009 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Women's Medical University
The mechanisms of hepatocarcinogenesis by loss of LKB1Principal Investigator
- Principal Investigator
  
  DEGUCHI Atsuko
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyoto University
The mechanisms of preneoplastic nodule formation in the liver by loss of LKB1
- Principal Investigator
  
  MIYOSHI Hiroyuki
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Kyoto University

[Book] Cancer Metastasis and Cancer Stem Cell/Niche2016
- Author(s)
  Takeshi Tomita, Atsuko Deguchi, Yoshiro Maru
- Total Pages
  145
- Publisher
  Bentham Science Publisher
- Data Source
  KAKENHI-PROJECT-15K06842
[Journal Article] Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway2023
- Author(s)
  Deguchi A, Watanabe-Takahashi M, Mishima T, Omori T, Ohto U, Arashiki N, Nakamura F, Nishikawa K, Maru Y.
- Journal Title
  
  Cancer Gene Ther
  
  Volume: - Issue: 7 Pages: 1-12
- DOI
  10.1038/s41417-023-00604-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07157, KAKENHI-PROJECT-19H03506, KAKENHI-PROJECT-21K19207, KAKENHI-PROJECT-23K23820
[Journal Article] Inflammation and premetastasis niche formation.2022
- Author(s)
  Deguchi A, Maru Y.
- Journal Title
  
  Inflamm Regen
  
  Volume: 42 Issue: 1 Pages: 22-22
- DOI
  10.1186/s41232-022-00208-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07157, KAKENHI-PROJECT-19H03506
[Journal Article] S100A8 may govern hyper-inflammation in severe COVID-19.2021
- Author(s)
  Deguchi A, Yamamoto T, Shibata N, Maru Y.
- Journal Title
  
  FASEB J.
  
  Volume: 35 Issue: 9
- DOI
  10.1096/fj.202101013
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K07157, KAKENHI-PROJECT-19H03506, KAKENHI-PROJECT-18K07245
[Journal Article] Lung Tumor Cell Recruitment Assay2019
- Author(s)
  Tomita T, Ieguchi K, Deguchi A, Takita M, Tsukahara F, Hiratsuka S, Maru Y.
- Journal Title
  
  J Vis Exp
  
  Volume: 144 Issue: 144
- DOI
  10.3791/53172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07245
[Journal Article] がん転移と自然免疫2018
- Author(s)
  出口　敦子、丸　義朗
- Journal Title
  
  医学のあゆみ
  
  Volume: 265 Pages: 1271-1275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07245
[Journal Article] Dickkopf-1 helps metastasis by immune evasion2017
- Author(s)
  Atsuko Deguchi, Yoshiro Maru
- Journal Title
  
  Translational Cancer Research
  
  Volume: 6 Issue: S9 Pages: S1422-S1424
- DOI
  10.21037/tcr.2017.10.43
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K06842
[Journal Article] Histone deacetylase inhibitor panobinostat induces calcineurin degradation in multiple myeloma2016
- Author(s)
  Imai Y, Ohta E, Takeda S, Sunamura S, Ishibashi M, Tamura H, Wang Y, Deguchi A, Tanaka J, Maru Y, and Motoji,T.
- Journal Title
  
  JCI Insight
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K06842
[Journal Article] Eritoran inhibits S100A8-mediated TLR4/MD-2 activation and tumor growth by changing the immune microenvironment.2016
- Author(s)
  Deguchi A, Tomita T, Ohto U, Takemura K, Kitao A, Akashi-Takamura, S, Miyake K, and Maru Y.
- Journal Title
  
  Oncogene
  
  Volume: 35 Issue: 11 Pages: 1445-1456
- DOI
  10.1038/onc.2015.211
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06842, KAKENHI-PROJECT-26440063, KAKENHI-PROJECT-15K14471, KAKENHI-PLANNED-25104002, KAKENHI-PROJECT-15H04357, KAKENHI-PROJECT-26711002, KAKENHI-PROJECT-15K09491
[Journal Article] Curcumin targets in inflammation and cancer.2015
- Author(s)
  Deguchi, A.
- Journal Title
  
  Endocrine Metabolic and Immune Disorders-Drug Targets
  
  Volume: 2
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24501321
[Journal Article] がんの転移前ニッチ2015
- Author(s)
  出口敦子、丸義朗
- Journal Title
  
  実験医学増刊　がん微小環境と標的治療
  
  Volume: 33 Pages: 155-159
- Data Source
  KAKENHI-PROJECT-24501321
[Journal Article] ADAM12-cleaved ephrin-A1 contributes to lung metastasis2014
- Author(s)
  Ieguchi K, Tomita T, Omori T, Komatsu A, Deguchi A, Masuda J, Duffy S, Coulthard M, Boyd A, Maru Y
- Journal Title
  
  Oncogene
  
  Volume: 33(17) Pages: 2179-2190
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] ADAM12-cleaved ephrin-A1 contributes to lung metastasis.2014
- Author(s)
  Ieguchi K, Tomita T, Omori T, Komatsu A, Deguchi A, Masuda J, Duffy SL, Coulthard MG, Boyd A, Maru Y.
- Journal Title
  
  Oncogene
  
  Volume: 未定 Issue: 17 Pages: 2179-90
- DOI
  10.1038/onc.2013.180
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23590347, KAKENHI-PROJECT-24501321, KAKENHI-PUBLICLY-25122716, KAKENHI-PROJECT-25860797, KAKENHI-PROJECT-25870760, KAKENHI-PROJECT-26640079
[Journal Article] Ephrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 42013
- Author(s)
  Ieguchi K, Omori T, Komatsu A, Tomita T, Deguchi A, Maru Y
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 440(4) Pages: 623-629
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Serum Amyroid A3 binds MD-2 to activates p38 and NF-kB pathway in a MyD88-dependent manner2013
- Author(s)
  Deguchi A, Tomita T, Omori T, Komatsu A, Ohto U, Takahashi S, Tanimura N, Akashi-Takamura S, Miyake K, Maru Y
- Journal Title
  
  J Immunol. 2013
  
  Volume: 191, 4, 2013 Pages: 1856-1864
- Data Source
  KAKENHI-PLANNED-21117008
[Journal Article] Ephrin-A1 expression induced by S100A8 is mediated by the toll-like receptor 42013
- Author(s)
  Ieguchi K, Omori T, Komatsu A, Tomita T, Deguchi A, Maru Y
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 440(4) Issue: 4 Pages: 623-629
- DOI
  10.1016/j.bbrc.2013.09.119
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008, KAKENHI-PROJECT-23590347, KAKENHI-PROJECT-24501321, KAKENHI-PUBLICLY-25122716, KAKENHI-PROJECT-25870760
[Journal Article] Serum Amyroid A3 binds MD-2 to activates p38 and NF-kB pathway in a MyD88-dependent manner2013
- Author(s)
  Deguchi A, Tomita T, Omori T, Komatsu A, Ohto U, Takahashi S, Tanimura N, Akashi-Takamura S, Miyake K, Maru Y
- Journal Title
  
  J Immunol
  
  Volume: 191(4) Issue: 4 Pages: 1856-1864
- DOI
  10.4049/jimmunol.1201996
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21117008, KAKENHI-PROJECT-23590347, KAKENHI-PROJECT-23590564, KAKENHI-PROJECT-24501321, KAKENHI-PUBLICLY-25115504, KAKENHI-PUBLICLY-25121709, KAKENHI-PROJECT-25650029
[Journal Article] Hepatocellular carcinoma development by conditional b-catenin activation in Lkb1 (+/-) mice.2009
- Author(s)
  Hiroyuki Miyoshi, Atsuko Deguchi, Yasushi Kojima, Masayuki Nakau, Masahiro Aoki, Makoto M. Taketo.
- Journal Title
  
  Cancer Sci. 100
  
  Pages: 2046-2053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790304
[Journal Article] Activation of protein kinase G increases the expression of p21 CIP1, p27KIP1 and histidine triad protein through Sp1.2008
- Author(s)
  Cen B, Deguchi A, Weinstein IB.
- Journal Title
  
  Cancer Res 68
  
  Pages: 5355-5362
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790304
[Journal Article] LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylating at Tht109 in the p21-binding domain.
- Author(s)
  Atsuko Deguchi, Hiroyuki Miyoshi, Yasushi Kojima, Katsuya Okawa, Masahiro Aoki, Makoto M. Taketo.
- Journal Title
  
  J. Biol. Chem. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790304
[Patent] S100A8-INHIBITING PEPTIDE AND DISEASE THERAPEUTIC AGENT CONTAINING SAME2022
- Inventor(s)
  丸義朗、出口敦子、髙橋美帆、西川喜代孝、大戸梅治
- Industrial Property Rights Holder
  東京女子医科大学、同志社
- Industrial Property Rights Type
  特許
- Filing Date
  2022
- Overseas
- Data Source
  KAKENHI-PROJECT-21K07157
[Patent] S100A8阻害ペプチドとこれを含む疾患治療薬2021
- Inventor(s)
  丸義朗、出口敦子、髙橋美帆、西川喜代孝、大戸梅治
- Industrial Property Rights Holder
  学校法人東京女子医科大学、学校法人同志社
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-18K07245
[Patent] S100A8阻害ペプチドとこれを含む疾患治療薬2021
- Inventor(s)
  丸義朗、出口敦子、髙橋美帆、西川喜代孝、大戸梅治
- Industrial Property Rights Holder
  学校法人東京女子医科大学、学校法人同志社
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-21K07157
[Patent] S100A8阻害ペプチドとこれを含む疾患治療薬2020
- Inventor(s)
  丸義朗、出口敦子、髙橋美帆、西川喜代孝、大戸梅治
- Industrial Property Rights Holder
  東京女子医科大学、同志社
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-096367
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-18K07245
[Presentation] Inhibition of TLR4 pathway by novel multivalent S100A8 inhibitory peptides attenuates tumor progression and metastasis.2023
- Author(s)
  Atsuko Deguchi, Miho Watanabe-Takahashi, Taishi Mishima, Tsutomu Omori, Umeharu Ohto, Nobuto Arashiki, Fumio Nakamura, Kiyotaka Nishikawa, and Yoshiro Maru.
- Organizer
  The 82nd Annual Meeting of the Japan Cancer Association.
- Data Source
  KAKENHI-PROJECT-21K07157
[Presentation] S100A8を標的とした新規がん微小環境改善薬の開発2022
- Author(s)
  出口敦子、西川喜代孝、丸義朗
- Organizer
  日本医療研究開発機構革新的医療技術創出拠点令和3年度成果報告会
- Data Source
  KAKENHI-PROJECT-21K07157
[Presentation] S100A8を標的とした新規がん微小環境改善薬の開発2022
- Author(s)
  出口敦子、西川喜代孝、丸義朗
- Organizer
  日本医療研究開発機構革新的医療技術創出拠点令和3年度成果報告会
- Data Source
  KAKENHI-PROJECT-18K07245
[Presentation] 転移前肝ニッチ形成因子による肝転移促進の分子機序2021
- Author(s)
  出口敦子
- Organizer
  アステラス病態代謝研究会第51回研究報告会
- Data Source
  KAKENHI-PROJECT-18K07245
[Presentation] 転移前肝ニッチ形成因子による肝転移促進の分子機序2021
- Author(s)
  出口敦子
- Organizer
  アステラス病態代謝研究会第51回研究報告会
- Data Source
  KAKENHI-PROJECT-21K07157
[Presentation] 喫煙による転移前微小環境形成の促進と血清アミロイドA3の意義2021
- Author(s)
  出口敦子、丸義朗
- Organizer
  喫煙科学研究財団第35回令和2年度助成研究発表会
- Data Source
  KAKENHI-PROJECT-21K07157
[Presentation] 喫煙による転移前微小環境形成の促進と血清アミロイドA3の意義2021
- Author(s)
  出口敦子、丸義朗
- Organizer
  喫煙科学研究財団第35回令和2年度助成研究発表会
- Data Source
  KAKENHI-PROJECT-18K07245
[Presentation] 転移前微小環境形成による転移促進2021
- Author(s)
  丸義朗、出口敦子
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07157
[Presentation] 転移前微小環境形成による転移促進2021
- Author(s)
  丸義朗、出口敦子
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07245
[Presentation] 転移前ニッチ形成を標的とした新規がん治療への展開2018
- Author(s)
  出口敦子、丸義朗
- Organizer
  第357回東京女子医科大学学会例会
- Invited
- Data Source
  KAKENHI-PROJECT-15K06842
[Presentation] 胃がん進展におけるToll様受容体内因性リガンドの作用2017
- Author(s)
  出口敦子、大島浩子、大島正伸、丸義朗
- Organizer
  金沢大学がん進展制御研究所共同利用・共同研究拠点シンポジウム
- Data Source
  KAKENHI-PROJECT-15K06842
[Presentation] 胃がん増悪化におけるToll様受容体内因性リガンドの関与2017
- Author(s)
  出口敦子、大島浩子、大島正伸、丸義朗
- Organizer
  金沢大学がん進展制御研究所共同利用・共同研究拠点シンポジウム
- Place of Presentation
  金沢東急ホテル(石川県金沢市)
- Year and Date
  2017-02-14
- Data Source
  KAKENHI-PROJECT-15K06842
[Presentation] 大腸癌肝転移に伴う転移前微小環境の形成2014
- Author(s)
  出口敦子
- Organizer
  第349回東京女子医科大学学会例会
- Place of Presentation
  東京女子医科大学
- Data Source
  KAKENHI-PROJECT-24501321
[Presentation] Synthetic peptide of SAA3 activates TLR4 signaling2012
- Author(s)
  Atsuko Deguchi, Yoshiro Maru
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌, 札幌
- Data Source
  KAKENHI-PROJECT-24501321
[Presentation] Gene expression profiles of hepatocellular carcinoma in Lkb1 (+/-) mice.2007
- Author(s)
  Deguchi A, Miyoshi H, Kojima Y, Taketo MM.
- Organizer
  International Symposium 2007
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20790304
[Presentation] Gene expression profile s of hepatocellular carcinoma in Lkb1 (+/-) mice.2006
- Author(s)
  Deguchi A, Miyoshi H, Kojima Y, Taketo MM
- Organizer
  21st Century COE Colloquium Animal models for Cancer Research
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-20790304
[Presentation] Involvement of endogenous TLR4 ligands in premetastatic microenvironment
- Author(s)
  Atsuko Deguchi, Takeshi Tomita, and Yoshiro Maru
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24501321

1. MARU Yoshiro (00251447)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
2. NAKAMURA Sachie (60313087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. TSUKAHARA Fujiko (40119996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TOMITA Takeshi (20302242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. IEGUCHI Katsuaki (90586348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. TAKITA Morichika (80533455)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. MIYOSHI Hiroyuki (30362479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Deguchi Atsuko 出口 敦子

DEGUCHI Atsuko 出口 敦子

Research Projects

Research Products

Co-Researchers

Single-cell transcriptome analysis of hetatic premetastatic niche formationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Premetastatic niche formation maintains metastatic stem cell phenotypePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Liver tropism by premetastatic niche formation and tumor-niche crosstalkPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Premetastatic niche enhances liver metastasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Toll-like receptor-mediated hepatic premetastatic microenvironmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Endogenous TLR4 ligands in tumor metastasis.

Principal Investigator

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Research Category

Review Section

Research Institution

The mechanisms of hepatocarcinogenesis by loss of LKB1Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanisms of preneoplastic nodule formation in the liver by loss of LKB1

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Cancer Metastasis and Cancer Stem Cell/Niche2016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inflammation and premetastasis niche formation.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] S100A8 may govern hyper-inflammation in severe COVID-19.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lung Tumor Cell Recruitment Assay2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] がん転移と自然免疫2018

Author(s)

Deguchi Atsuko 出口敦子

DEGUCHI Atsuko 出口敦子