Tashima Yuko 田嶌優子

… Alternative Names

TASHIMA YUKO 田嶌優子

TASHIMA Yuko 田嶌優子

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Researcher Number	10423104
Other IDs
Affiliation (Current)	2025: 名古屋大学, 医学系研究科, 講師 2025: 名古屋大学, 糖鎖生命コア研究所, 講師
Affiliation (based on the past Project Information) *help	2024: 名古屋大学, 医学系研究科, 講師 2022: 名古屋大学, 医学系研究科, 講師 2016 – 2021: 名古屋大学, 医学系研究科, 助教 2014: 大阪大学, 微生物病研究所, 助教 2013: 独立行政法人国立循環器病研究センター, 研究所, 流動研究員
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Functional biochemistry / Hematology Except Principal Investigator Medium-sized Section 47:Pharmaceutical sciences and related fields / Hematology
Keywords	Principal Investigator 分子シャペロン / CADASIL変異 / 脳小血管病CADASIL / NOTCH3 / O型糖鎖 / 輸送 / 糖鎖 / ゴルジ装置 / 細胞内輸送 / GPIアンカー型タンパク質 … More / 糖脂質GPI / プラスミノーゲン栃木変異 / 肺塞栓 / 静脈血栓症 / 線溶 / プラスミノーゲン … More Except Principal Investigator グライコプロテオミクス / Notch シグナル / 質量分析 / 構造多様性 / O-グルコース糖鎖 / Notchシグナル / 糖転移酵素 / O-グルコース糖鎖修飾 / 糖鎖 / ライブイメージング / Bac-TRAP / トランスクリプトーム解析 / トランスジェニックマウス / 血管内皮細胞プロテインC受容体 / プロテイン C 受容体 / トランスクリプトーム / マウス / プロテインC受容体 / トロンボモジュリン / 遺伝子発現 / 血管内皮細胞 Less

構造異常NOTCH3がO型糖鎖を介した調節で適切に除去される仕組みの解明Principal Investigator
- Principal Investigator
  
  田嶌優子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Nagoya University
Significance of structural diversity of O-glucose glycans in Notch signaling
- Principal Investigator
  
  Takeuchi Hideyuki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  University of Shizuoka
  Nagoya University
Identification of factor proteins in the transport of GPI-anchored proteins to the cell surface from GolgiPrincipal Investigator
- Principal Investigator
  
  TASHIMA YUKO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Nagoya University
Production and analysis of Bac-TRAP mice that express fluorescent proteins driven by thrombomodulin or endothelial cell protein C receptor promoter
- Principal Investigator
  
  MIYATA TOSHIYUKI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  National Cardiovascular Center Research Institute
Generation and characterization of homozygous plasminogen-Tochigi mutant mice bearing reduced fibrinolytic activityPrincipal Investigator
- Principal Investigator
  
  TASHIMA Yuko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  Osaka University
  National Cardiovascular Center Research Institute

All 2022 2021 2020 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 新・血栓止血学, 2凝固反応, (2部ショック・敗血症と凝血・炎症系, 19.凝固系と補体系反応)2015
- Author(s)
  田嶌優子, 木下タロウ,一瀬白帝, 他
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-25860801
[Book] プリンシプル血液疾患の臨床, よくわかる血栓・止血異常の診療, (第1章　血栓止血異常症を理解するために, 凝固反応を理解する)2014
- Author(s)
  宮田敏行, 田嶌優子, 金倉譲, 他
- Total Pages
  297
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-25860801
[Book] シリーズ　プリンシプル血液疾患の臨床、４．　血栓・止血異常の診察、第１章　血栓止血異常症を理解するために、　 B. 凝固反応を理解する2014
- Author(s)
  宮田敏行　田嶌優子
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-25860801
[Book] よくわかる血栓・止血異常の診療2014
- Author(s)
  宮田敏行、田嶌優子
- Total Pages
  297
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-25670454
[Journal Article] Glycoproteomics of NOTCH1 EGF repeat fragments overexpressed with different glycosyltransferases in HEK293T cells reveals insights into O-GlcNAcylation of NOTCH12022
- Author(s)
  Tsukamoto Yohei、Ogawa Mitsutaka、Yogi Kentarou、Tashima Yuko、Takeuchi Hideyuki、Okajima Tetsuya
- Journal Title
  
  Glycobiology
  
  Volume: N/A Issue: 7 Pages: 616-628
- DOI
  10.1093/glycob/cwac015
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22490, KAKENHI-PROJECT-19K16073, KAKENHI-PROJECT-19H03176, KAKENHI-PROJECT-20F20410, KAKENHI-PROJECT-19KK0195, KAKENHI-PROJECT-19H03416, KAKENHI-PROJECT-23K24077
[Journal Article] Secretory expression of mammalian NOTCH tandem epidermal growth factor-like repeats based on increased O-glycosylation2022
- Author(s)
  Zhang Ailing、Tsukamoto Yohei、Takeuchi Hideyuki、Nishiwaki Kimitoshi、Tashima Yuko、Okajima Tetsuya
- Journal Title
  
  Analytical Biochemistry
  
  Volume: 656 Pages: 114881-114881
- DOI
  10.1016/j.ab.2022.114881
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19KK0195, KAKENHI-PROJECT-19H03416, KAKENHI-PROJECT-23K24077
[Journal Article] Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and L-fringe in Pancreatic Cancers2021
- Author(s)
  Barua Rashu、Mizuno Kazuyuki、Tashima Yuko、Ogawa Mitsutaka、Takeuchi Hideyuki、Taguchi Ayumu、Okajima Tetsuya
- Journal Title
  
  Molecules
  
  Volume: 26 Issue: 4 Pages: 882-882
- DOI
  10.3390/molecules26040882
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K16073, KAKENHI-PROJECT-19H03416, KAKENHI-PROJECT-20F20410, KAKENHI-PROJECT-19K22490, KAKENHI-PROJECT-19H03176, KAKENHI-PROJECT-19KK0195
[Journal Article] N-Glycans on EGF domain-specific O-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization2020
- Author(s)
  Alam Sayad Md. Didarul、Tsukamoto Yohei、Ogawa Mitsutaka、Senoo Yuya、Ikeda Kazutaka、Tashima Yuko、Takeuchi Hideyuki、Okajima Tetsuya
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 25 Pages: 8560-8574
- DOI
  10.1074/jbc.ra119.012280
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22490, KAKENHI-PROJECT-19K16073, KAKENHI-PROJECT-19KK0195, KAKENHI-PROJECT-19H03416, KAKENHI-PROJECT-19H03176
[Journal Article] Contribution of extracellular O-GlcNAc to the stability of folded epidermal growth factor-like domains and Notch1 trafficking2020
- Author(s)
  Ogawa M, Tashima Y, Sakaguchi Y, Takeuchi H and Okajima T
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 526 Issue: 1 Pages: 184-190
- DOI
  10.1016/j.bbrc.2020.03.066
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22490, KAKENHI-PROJECT-19K16073, KAKENHI-PROJECT-19KK0195, KAKENHI-PROJECT-19H03176, KAKENHI-PROJECT-19H03416
[Journal Article] Congenital diseases caused by defective O-glycosylation of Notch receptors2018
- Author(s)
  Yuko Tashima, Tetsuya Okajima
- Journal Title
  
  Nagoya Journal of Medical Science
  
  Volume: 80 Issue: 3 Pages: 299-307
- DOI
  10.18999/nagjms.80.3.299
- NAID
  120006502463
- ISSN
  2186-3326
- URL
  https://nagoya.repo.nii.ac.jp/records/26320
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K14696
[Journal Article] プラスミノーゲン栃木変異は血漿プラスミン活性を低下させるが、血栓症モデル実験では症状を悪化させない2018
- Author(s)
  田嶌優子
- Journal Title
  
  日本血栓止血学会誌
  
  Volume: 29(4) Pages: 398-404
- NAID
  130007431886
- Data Source
  KAKENHI-PROJECT-16K14696
[Journal Article] Congenital diseases caused by defective O-glycosylation of Notch receptors2018
- Author(s)
  Tashima T, Okajima T
- Journal Title
  
  Nagoya Journal of Medical Science
  
  Volume: 80(3)
- NAID
  120006502463
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K14696
[Journal Article] Plasminogen Tochigi mice exhibit phenotypes similar to wild-type mice under experimental thrombotic conditions2017
- Author(s)
  Tashima Yuko、Banno Fumiaki、Kita Toshiyuki、Matsuda Yasuyuki、Yanamoto Hiroji、Miyata Toshiyuki
- Journal Title
  
  PLOS ONE
  
  Volume: 12 Issue: 7 Pages: e0180981-e0180981
- DOI
  10.1371/journal.pone.0180981
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09834, KAKENHI-PROJECT-16K09835, KAKENHI-PROJECT-16K14696, KAKENHI-PROJECT-16K19045
[Journal Article] Influence of ADAMTS13 deficiency on venous thrombosis in mice2015
- Author(s)
  Tashima Y, Banno F, Akiyama M, Miyata T
- Journal Title
  
  Thromb Haemost
  
  Volume: 印刷中 Issue: 07 Pages: 206-207
- DOI
  10.1160/th14-08-0656
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670454, KAKENHI-PROJECT-25860801, KAKENHI-PROJECT-25461465
[Presentation] 細胞外 O-GlcNAc 修飾は EGF ドメインの安定性と Notch1 のトラフィッキングに寄与する2020
- Author(s)
  小川光貴、田嶌優子、坂口大和、竹内英之、岡島徹也
- Organizer
  第 93 回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19KK0195
[Presentation] Plasminogen Tochigi mice show reduced fibirinolytic activity but exhibit phenotypes similar to wild-type mice under experimental conditions2018
- Author(s)
  田嶌優子
- Organizer
  第40回日本血栓止血学会学術集会　奨励賞受賞講演
- Invited
- Data Source
  KAKENHI-PROJECT-16K14696
[Presentation] GPIアンカー型タンパク質の小胞体からの輸送に働くp24タンパク質複合体のサブユニット構成の解析2016
- Author(s)
  田嶌優子、木下タロウ
- Organizer
  第35回日本糖質学会年会
- Place of Presentation
  高知市文化プラザ　かるぽーと (高知県高知市)
- Year and Date
  2016-09-01
- Data Source
  KAKENHI-PROJECT-16K14696
[Presentation] 日本人に高頻度に見られるプラスミノーゲン栃木変異をもつ遺伝子改変マウスの血栓傾向の解析2014
- Author(s)
  田嶌優子, 坂野史明, 喜多俊行, 松田泰幸, 柳本広二, 宮田敏行
- Organizer
  第19回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター(大阪府豊中市)
- Year and Date
  2014-08-08
- Data Source
  KAKENHI-PROJECT-25860801
[Presentation] Generation and characterization of homozygous plasminogen-Tochigi mutant mice bearing reduced fibrinolytic activity2014
- Author(s)
  Yuko Tashima, Fumiaki Banno, Toshiyuki Kita, Yasuyuki Matsuda, Hiroji Yanamoto, Toshiyuki Miyata
- Organizer
  Gordon Research Seminar, Plasminogen Activation & Extracellular Proteolysis
- Place of Presentation
  Four Points Sheraton / Holiday Inn Express (USA, California, Ventura)
- Data Source
  KAKENHI-PROJECT-25860801
[Presentation] Generation and characterization of homozygous plasminogen-Tochigi mutant mice bearing reduced fibrinolytic activity2014
- Author(s)
  Yuko Tashima, Fumiaki Banno, Toshiyuki Kita, Yasuyuki Matsuda, Hiroji Yanamoto, Toshiyuki Miyata
- Organizer
  Gordon Research Conferences, Plasminogen Activation & Extracellular Proteolysis
- Place of Presentation
  Four Points Sheraton / Holiday Inn Express (USA, California, Ventura)
- Data Source
  KAKENHI-PROJECT-25860801
[Presentation] Exacerbated venous thromboembolism in mice with the protein S Tokushima mutation2013
- Author(s)
  Fumiaki Banno, Toshiyuki Kita, Hiroji Yanamoto, Yuko Tashima, Koichi Kokame, Toshiyuki Miyata
- Organizer
  XXIV Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-25670454
[Presentation] Generation of protein S-Tokushima mutant mice to provide an in vivo evaluation system for thrombosis in Japanese2013
- Author(s)
  Fumiaki Banno, Toshiyuki Kita, Hiroji Yanamoto, Yuko Tashima, Koichi Kokame, Toshiyuki Miyata
- Organizer
  第35回日本血栓止血学会学術集会
- Place of Presentation
  山形市
- Data Source
  KAKENHI-PROJECT-25670454
[Presentation] マウスプラスミノーゲン栃木変異は血漿プラスミン活性を低下させるが血栓塞栓症の原因にはならない2013
- Author(s)
  田嶌優子, 坂野史明, 喜多俊行, 松田泰幸, 柳本広二, 宮田敏行
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-25670454
[Presentation] Generation and characterization of homozygous plasminogen-Tochigi mutant mice bearing reduced fibrinolytic activity2013
- Author(s)
  Yuko Tashima, Fumiaki Banno, Toshiyuki Kita, Yasuyuki Matsuda, Hiroji Yanamoto, Toshiyuki Miyata
- Organizer
  XXIV Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Amsterdam RAI Exhibition and Convention Centre (The Netherlands, Amsterdam)
- Data Source
  KAKENHI-PROJECT-25860801
[Presentation] Generation and characterization of homozygous plasminogen-Tochigi mutant mice bearing reduced fibrinolytic activity2013
- Author(s)
  Yuko Tashima, Fumiaki Banno, Toshiyuki Kita, Yasuyuki Matsuda, Hiroji Yanamoto, Toshiyuki Miyata
- Organizer
  XXIV Congress of the International Society on Thrombosis and Haemostasis
- Place of Presentation
  Amsterdam, Netherlands
- Data Source
  KAKENHI-PROJECT-25670454
[Presentation] ADAMTS13遺伝子欠損マウスの静脈血栓塞栓症状の解析
- Author(s)
  田嶌優子, 坂野史明, 宮田敏行
- Organizer
  第36回日本血栓止血学会学術集会
- Place of Presentation
  大阪国際交流センター(大阪府大阪市)
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-25860801
[Presentation] Analysis of mice carrying northeast Asian-specific genetic mutations in thrombosis
- Author(s)
  Fumiaki Banno, Yuko Tashima, Toshiyuki Kita, Yasuyuki Matsuda, Hiroji Yanamoto, Koichi Kokame, Toshiyuki Miyata
- Organizer
  The 18th International Vascular Biology Meeting
- Place of Presentation
  都メッセ、京都府、京都市
- Year and Date
  2014-04-14 – 2014-04-17
- Data Source
  KAKENHI-PROJECT-25670454
[Presentation] マウスプラスミノーゲン栃木変異は血漿プラスミン活性を低下させるが血栓塞栓症の原因にはならない
- Author(s)
  Yuko Tashima, Fumiaki Banno, Toshiyuki Kita, Yasuyuki Matsuda, Hiroji Yanamoto, Toshiyuki Miyata
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜 (神奈川県横浜市)
- Data Source
  KAKENHI-PROJECT-25860801
[Presentation] ADAMTS13遺伝子欠損マウスの静脈血栓塞栓症状の解析
- Author(s)
  田嶌優子、坂野史明、小亀浩市、宮田敏行
- Organizer
  第36回日本血栓止血学会学術集会
- Place of Presentation
  大阪国際交流センター、大阪府、大阪市
- Year and Date
  2014-05-29 – 2014-05-31
- Data Source
  KAKENHI-PROJECT-25670454
[Presentation] 日本人に高頻度に見られるプラスミノーゲン栃木変異をもつ遺伝子改変マウスの血栓傾向の解析
- Author(s)
  田嶌優子、坂野史明、喜多俊行、松田泰幸、柳本広二、宮田敏行
- Organizer
  第19回日本病態プロテアーゼ学会学術集会
- Place of Presentation
  千里ライフサイエンスセンター、大阪府、豊中市
- Year and Date
  2014-08-08 – 2014-08-09
- Data Source
  KAKENHI-PROJECT-25670454

1. MIYATA TOSHIYUKI (90183970)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
2. BANNO Fumiaki (00373514)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. MARUYAMA Keiko (30712624)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Takeuchi Hideyuki (80361608)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
5. LO PEIWEN (20822406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 浦田悠輔 (90897357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 大橋憲太郎 (50332953)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 小川光貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tashima Yuko 田嶌 優子

TASHIMA YUKO 田嶌 優子

TASHIMA Yuko 田嶌 優子

Research Projects

Research Products

Co-Researchers

構造異常NOTCH3がO型糖鎖を介した調節で適切に除去される仕組みの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Significance of structural diversity of O-glucose glycans in Notch signaling

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of factor proteins in the transport of GPI-anchored proteins to the cell surface from GolgiPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Production and analysis of Bac-TRAP mice that express fluorescent proteins driven by thrombomodulin or endothelial cell protein C receptor promoter

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation and characterization of homozygous plasminogen-Tochigi mutant mice bearing reduced fibrinolytic activityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 新・血栓止血学, 2凝固反応, (2部ショック・敗血症と凝血・炎症系, 19.凝固系と補体系反応)2015

Author(s)

Publisher

Data Source

[Book] プリンシプル血液疾患の臨床, よくわかる血栓・止血異常の診療, (第1章 血栓止血異常症を理解するために, 凝固反応を理解する)2014

Author(s)

Total Pages

Publisher

Data Source

[Book] シリーズ プリンシプル血液疾患の臨床、 ４． 血栓・止血異常の診察、 第１章 血栓止血異常症を理解するために、 B. 凝固反応を理解する2014

Author(s)

Publisher

Data Source

[Book] よくわかる血栓・止血異常の診療2014

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Glycoproteomics of NOTCH1 EGF repeat fragments overexpressed with different glycosyltransferases in HEK293T cells reveals insights into O-GlcNAcylation of NOTCH12022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Secretory expression of mammalian NOTCH tandem epidermal growth factor-like repeats based on increased O-glycosylation2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and L-fringe in Pancreatic Cancers2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] N-Glycans on EGF domain-specific O-GlcNAc transferase (EOGT) facilitate EOGT maturation and peripheral endoplasmic reticulum localization2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Contribution of extracellular O-GlcNAc to the stability of folded epidermal growth factor-like domains and Notch1 trafficking2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Congenital diseases caused by defective O-glycosylation of Notch receptors2018

Tashima Yuko 田嶌優子

TASHIMA YUKO 田嶌優子

TASHIMA Yuko 田嶌優子

[Book] プリンシプル血液疾患の臨床, よくわかる血栓・止血異常の診療, (第1章　血栓止血異常症を理解するために, 凝固反応を理解する)2014

[Book] シリーズ　プリンシプル血液疾患の臨床、４．　血栓・止血異常の診察、第１章　血栓止血異常症を理解するために、　 B. 凝固反応を理解する2014

[Presentation] GPIアンカー型タンパク質の小胞体からの輸送に働くp24タンパク質複合体のサブユニット構成の解析2016