Kobayashi Taku 小林拓

Researcher Number	10424144
Other IDs	https://orcid.org/0000-0002-2073-4234
Affiliation (Current)	2025: 北里大学, 北里研究所病院, センター長
Affiliation (based on the past Project Information) *help	2022 – 2024: 北里大学, 北里研究所病院, センター長 2016 – 2019: 北里大学, 北里研究所病院, 副センター長 2015: 北里大学, 北里研究所病院, 特任准教授 2014: 北里大学, 北里研究所病院, 研究員 2013: 北里大学, 付置研究所, 研究員
Review Section/Research Field	Principal Investigator Gastroenterology / Basic Section 53010:Gastroenterology-related Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 52040:Radiological sciences-related / Gastroenterology
Keywords	Principal Investigator 炎症性腸疾患 / AI / 人工知能 / 潰瘍性大腸炎 / 病理学 / 組織学的寛解 / 糖尿病 / 糖質制限食 / 高脂肪 / 腸内細菌 … More / 粘膜免疫 / 低炭水化物 / 腸管免疫 / 食事 / 高脂肪食 / 腸内細菌叢 / 糖質制限 / FAIRE / 腸管マクロファージ / HDAC阻害剤 / クロマチン構造 / マクロファージ / エピゲノム … More Except Principal Investigator 炎症性腸疾患 / IBD / IL-10 / 腸管マクロファージ / 腸管恒常性 / 剪断波 / 腸管エコー / 糖質制限食 / 腸内細菌叢 / 高脂肪食 / NLRP-3 / IL-1R / NLRP3 Less

The Utility of Ultrasound Elastography in Predicting Treatment Outcomes for Ulcerative Colitis
- Principal Investigator
  
  佐上晋太郎
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  Kitasato University
Elucidation of IL-1/IL-1 receptor pathway in gut macrophages involved in the maintenance of intestinal homeostasis by the mucosal immune system
- Principal Investigator
  
  竹内修
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kitasato University
糖質制限食が腸内細菌と腸管免疫、腸炎に与える影響
- Principal Investigator
  
  黒沼智
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kitasato University
Exploring histologic risk factors for relapse in ulcerative colitis using artificial intelligencePrincipal Investigator
- Principal Investigator
  
  小林拓
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Kitasato University
Elucidation of gut microbiota-independent IL-10 production mechanism of intestinal macrophages
- Principal Investigator
  
  Takeuchi Osamu
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kitasato University
Impact of low-carbohydrate diet on the gut microbiota and mucosal immunityPrincipal Investigator
- Principal Investigator
  
  Kobayashi Taku
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kitasato University
Epigenetic regulation of macrophage function in inflammatory bowel diseasePrincipal Investigator
- Principal Investigator
  
  Kobayashi Taku
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kitasato University

All 2023 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] 特集デジタルパソロジー/サイトロジーとAIの進歩潰瘍性大腸炎におけるデジタルパソロジー･AIの有用性2023
- Author(s)
  芹澤奏、小林拓
- Journal Title
  
  医学のあゆみ
  
  Volume: 284 Issue: 3 Pages: 185-188
- DOI
  10.32118/ayu28403185
- ISSN
  0039-2359
- Year and Date
  2023-01-21
- Data Source
  KAKENHI-PROJECT-22K07992
[Journal Article] Phosphoinositide 3-Kinase P110δ-Signaling Is Critical for Microbiota-Activated IL-10 Production by B Cells that Regulate Intestinal Inflammation2019
- Author(s)
  Oka Akihiko、Mishima Yoshiyuki、Liu Bo、Herzog Jeremy W.、Steinbach Erin C.、Kobayashi Taku、Plevy Scott E.、Sartor R. Balfour
- Journal Title
  
  Cells
  
  Volume: 8 Issue: 10 Pages: 1121-1121
- DOI
  10.3390/cells8101121
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09382, KAKENHI-PROJECT-17K09393
[Journal Article] Individualized treatment based on CYP3A5 single-nucleotide polymorphisms with tacrolimus in ulcerative colitis2019
- Author(s)
  Okabayashi Shinji、Kobayashi Taku、Saito Eiko、Toyonaga Takahiko、Ozaki Ryo、Sagami Shintaro、Nakano Masaru、Tanaka Junichi、Yagisawa Keiji、Kuronuma Satoshi、Takeuchi Osamu、Hibi Toshifumi
- Journal Title
  
  Intestinal Research
  
  Volume: 17 Issue: 2 Pages: 218-226
- DOI
  10.5217/ir.2018.00117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09393, KAKENHI-PROJECT-19K08364
[Journal Article] A Simple 1-Day Colon Capsule Endoscopy Procedure Demonstrated to be a Highly Acceptable Monitoring Tool for Ulcerative Colitis2018
- Author(s)
  Okabayashi Shinji、Kobayashi Taku、Nakano Masaru、Toyonaga Takahiko、Ozaki Ryo、Carla Tablante Maria、Kuronuma Satoshi、Takeuchi Osamu、Hibi Toshifumi
- Journal Title
  
  Inflammatory Bowel Diseases
  
  Volume: 印刷中 Issue: 11 Pages: 2404-2412
- DOI
  10.1093/ibd/izy125
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09393
[Journal Article] Th17 plasticity and its relevance to inflammatory bowel disease2018
- Author(s)
  Ueno A, Jeffery L, Kobayashi T, Hibi T, Ghosh S, Jijon H
- Journal Title
  
  J Autoimmun
  
  Volume: 87 Pages: 38-49
- DOI
  10.1016/j.jaut.2017.12.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09324, KAKENHI-PROJECT-17K09393
[Journal Article] 連載「免疫病動物モデルの特長と限界」炎症性腸疾患動物モデル2018
- Author(s)
  小林拓
- Journal Title
  
  炎症と免疫
  
  Volume: 26 Pages: 162-166
- Data Source
  KAKENHI-PROJECT-16K09324
[Journal Article] Ⅱ:炎症性腸疾患と腸内細菌(3)食事の欧米化と腸内細菌の変化2017
- Author(s)
  小林拓
- Journal Title
  
  INTESTINE
  
  Volume: 21 Pages: 310-314
- Data Source
  KAKENHI-PROJECT-16K09324
[Journal Article] Lipocalin 2 prevents intestinal inflammation by enhancing phagocytic bacterial clearance in macrophages2016
- Author(s)
  Toyonaga T, Matsuura M, Mori K, Honzawa Y, Minami N, Yamada S, Kobayashi T, Hibi T, Nakase H
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 35104-35104
- DOI
  10.1038/srep35014
- NAID
  120006318859
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460967, KAKENHI-PROJECT-26461224, KAKENHI-PROJECT-16K09324, KAKENHI-PROJECT-16K15469, KAKENHI-PROJECT-16K19150
[Journal Article] First trough level of infliximab at week 2 predicts future outcomes of induction therapy in ulcerative colitis - results from a multicenter prospective randomized controlled trial and its post-hoc analysis.2016
- Author(s)
  Kobayashi T, Suzuki Y, Motoya S, Hirai F, Ogata H, Ito H, Sato N, Osaki K, Watanabe M, Hibi T
- Journal Title
  
  J Gastroenterol
  
  Volume: 51(3) Issue: 3 Pages: 241-51
- DOI
  10.1007/s00535-015-1102-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460960
[Journal Article] Involvement of herbal medicine as a cause of mesenteric phlebosclerosis: results from a large-scale nationwide survey2016
- Author(s)
  Shimizu S, Kobayashi T, Tomioka H, Ohtsu K, Matsui T, Hibi T. .
- Journal Title
  
  J Gastroenterol
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460960
[Journal Article] Ulcerative colitis: Which makes patients happier, surgery or anti-TNF?2014
- Author(s)
  Kobayashi T and Hibi T
- Journal Title
  
  Nat Rev Gastroenterol Hepatol
  
  Volume: 11 Issue: 5 Pages: 272-273
- DOI
  10.1038/nrgastro.2014.28
- Data Source
  KAKENHI-PROJECT-25460960
[Journal Article] Innate PI3K p110δ regu lates Th1/Th17 development and microbiota-dependent colitis.2014
- Author(s)
  Steinbach EC, Kobayashi T, Russo SM, Sheikh SZ, Gipson G, Kennedy S, Uno JK, Mishima Y, Borst LB, Liu B, Herfarth H, Ting J, Sartor RB, Plevy SE
- Journal Title
  
  J Immunol
  
  Volume: 192 Issue: 8 Pages: 3958-3968
- DOI
  10.4049/jimmunol.1301533
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460960
[Journal Article] Modified bowel preparation regimen for use in second-generation colon capsule endoscopy in patients with ulcerative colitis2014
- Author(s)
  Usui S, Hosoe N, Matsuoka K, Kobayashi T, Nakano M, Naganuma M, Ishibashi Y, Kimura K, Yoneno K, Kashiwagi K, Hisamatsu T, Inoue N, Serizawa H, Hibi T, Ogata H, Kanai T.
- Journal Title
  
  Digestive Endoscopy
  
  Volume: 26(5) Issue: 5 Pages: 665-72
- DOI
  10.1111/den.12269
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249046, KAKENHI-PROJECT-25460960
[Journal Article] NFIL3-Deficient Mice Develop Microbiota-Dependent, IL-12/23-Driven Spontaneous Colitis.2014
- Author(s)
  Kobayashi, T., Steinbach, E.C., Russo, S.M., Matsuoka, K., Nochi, T., Maharshak, N., Borst, L.B., Hostager, B., Garcia-Martinez, J.V., Rothman, P.B., Kashiwada, M., Sheikh, S.Z., Murray, P.J. and Plevy, S.E.
- Journal Title
  
  Journal of Immunology
  
  Volume: 192 Issue: 4 Pages: 1918-1927
- DOI
  10.4049/jimmunol.1301819
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590088, KAKENHI-PROJECT-25460960
[Journal Article] 潰瘍性大腸炎とクローン病は何がどう違うのか（１）免疫学的違いは？2014
- Author(s)
  小林拓
- Journal Title
  
  Medicina
  
  Volume: 51 Pages: 1004-1007
- Data Source
  KAKENHI-PROJECT-25460960
[Presentation] クローン病疾患管理はどこまで進化できるのか～デジタル技術を利用した個別化医療の可能性～2023
- Author(s)
  小林拓
- Organizer
  第19回日本消化管学会
- Invited
- Data Source
  KAKENHI-PROJECT-22K07992
[Presentation] NUDT15 variance increases DNA-incorporated thiopurine metabolites and lymphocyte apoptosis in patients with Inflammatory Bowel Disease2020
- Author(s)
  Hiroki Kiyohara, Takahiko Toyonaga, Satoshi Kuronuma, Aito Ueno, Shinji Okabayashi, Ryo Ozaki, Osamu Takeuchi, Sally A. Coulthard, Christopher P,F. Redfern, Hideki Terai, Yoichi Tanaka, Masaru Nakano, Toshifumi Hibi, Taku Kobayashi
- Organizer
  Congress of European Crohns and Colitis Organisation (ECCO)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09393
[Presentation] 高脂肪食がマウスの腸炎及び腸内細菌叢に与える影響に関する検討2020
- Author(s)
  宇田川文, 小林拓, 黒沼智, 竹内修, 日比則孝, 小林朋, 林芳, 和田安代, 日比紀文
- Organizer
  第23回日本病態栄養学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17K09393
[Presentation] 高脂肪低炭水化物食がマウスの腸管及び腸内細菌叢に与える影響2018
- Author(s)
  根本華歩、小林拓、上野明紀、黒沼智、竹内修、和田安代、日比紀文
- Organizer
  第21回日本病態栄養学会
- Data Source
  KAKENHI-PROJECT-16K09324
[Presentation] 潰瘍性大腸炎患者のタクロリムスTDM用ソフトウェアの作成とその有用性2017
- Author(s)
  熊埜御堂沙英、田中潤、篠崎公一、小林拓、竹内修、黒沼智、佐上晋太郎、岡林慎二、渡辺由紀、石橋とよみ、中野雅、豊永貴彦、尾崎良、日比紀文、斎藤太寿、小林義和、齋藤雅俊
- Organizer
  第34回日本TDM学会・学術大会
- Data Source
  KAKENHI-PROJECT-17K09393
[Presentation] 腸管マクロファージにおけるIL-10産生機序の解明2017
- Author(s)
  竹内修、小林拓、豊永貴彦、黒沼智、Maria Carla、岡林慎二、佐上晋太郎、上野明紀、日比紀文
- Organizer
  第54回消化器免疫学会
- Data Source
  KAKENHI-PROJECT-17K09393
[Presentation] マウスへの高脂肪低炭水化物食給餌による大腸炎と腸内細菌への影響2016
- Author(s)
  黒沼智、小林拓、他
- Organizer
  日本消化器免疫学会
- Place of Presentation
  ホテルニューオータニ大阪（大阪）
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-16K09324
[Presentation] 24.First trough level of infliximab at week 2 predicts future outcomes of induction therapy in ulcerative colitis-A post-hoc analysis of a multicenter prospective randomized controlled trial2015
- Author(s)
  Kobayashi T
- Organizer
  ACG Annual scientific Meeting
- Place of Presentation
  Honolulu (USA)
- Year and Date
  2015-10-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460960
[Presentation] 臨床免疫学的アプローチから見た炎症性腸疾患感受性遺伝子2015
- Author(s)
  小林拓
- Organizer
  第43回日本臨床免疫学会総会ワークショップ３
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-10-21
- Invited
- Data Source
  KAKENHI-PROJECT-25460960
[Presentation] Usefulness of fecal S100A12 in defining mucosal healing in ulcerative colitis2015
- Author(s)
  Kobayashi T
- Organizer
  3rd Asian Organization of Crohn's and Colitis
- Place of Presentation
  Beijing (China)
- Year and Date
  2015-06-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460960
[Presentation] 炎症性腸疾患感受性遺伝子NFIL3欠損マウスは自然免疫異常を介し腸炎を自然発症する2014
- Author(s)
  小林拓
- Organizer
  第51回消化器免疫学会総会
- Place of Presentation
  京都大学医学部芝蘭会館（京都市）
- Year and Date
  2014-07-11
- Data Source
  KAKENHI-PROJECT-25460960
[Presentation] 炎症性腸疾患感受性遺伝子NFIL3の機能とその欠損マウスにおける腸炎の発症機序解明2014
- Author(s)
  小林拓
- Organizer
  第42回日本臨床免疫学会総会
- Place of Presentation
  京王プラザホテル（東京都新宿区）
- Year and Date
  2014-09-25
- Data Source
  KAKENHI-PROJECT-25460960
[Presentation] Genetically Driven Chromatin Organization Identifies Regulatory SNPs Associated with Crohn's Disease2014
- Author(s)
  Matthew Weiser, Chelsea Raulerson, Adam Robinson, Gregory Gipson, Tomohisa Sujino, Osamu Takeuchi, Taku Kobayashi, Hans H. Herfarth, Ryan B. Sartor, Dermot P. McGovern, Jason D. Lieb, Terrence S. Furey, Shehzad Z. Sheikh
- Organizer
  DDW2014
- Place of Presentation
  Chicago, USA
- Data Source
  KAKENHI-PROJECT-25460960
[Presentation] IBD粘膜固有層単核細胞分離技術を応用したエピゲノム、代謝研究とその人種差検討
- Author(s)
  小林拓
- Organizer
  「難治性炎症性腸管障害に関する調査研究」平成27年度第１回総会
- Place of Presentation
  味の素㈱本社ビル（東京都中央区）
- Year and Date
  2015-01-22 – 2015-01-23
- Data Source
  KAKENHI-PROJECT-25460960
[Presentation] IBD粘膜固有層単核細胞分離技術を応用したエピゲノム、代謝研究とその人種差検討
- Author(s)
  小林拓
- Organizer
  「難治性炎症性腸管障害に関する調査研究」平成26年度第2回総会
- Place of Presentation
  味の素㈱本社ビル（東京都中央区）
- Year and Date
  2014-07-23 – 2014-07-24
- Data Source
  KAKENHI-PROJECT-25460960

1. Takeuchi Osamu (00249997)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
2. 山田悟 (10286487)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. NAKANO Masaru (50265807)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ASAI Tomohiro (00381731)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 黒沼智 (90748055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 山本陽一朗 (00573247)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 前田一郎 (30350664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 佐上晋太郎 (10837371)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TOYONAGA Takahiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. HONZAWA Yusuke

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. MINAMI Naoki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. YAMADA Satoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 松浦稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 金井隆典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 日比紀文

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 緒方晴彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 柏田正樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 三島義之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kobayashi Taku 小林 拓

Research Projects

Research Products

Co-Researchers

The Utility of Ultrasound Elastography in Predicting Treatment Outcomes for Ulcerative Colitis

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of IL-1/IL-1 receptor pathway in gut macrophages involved in the maintenance of intestinal homeostasis by the mucosal immune system

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

糖質制限食が腸内細菌と腸管免疫、腸炎に与える影響

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploring histologic risk factors for relapse in ulcerative colitis using artificial intelligencePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of gut microbiota-independent IL-10 production mechanism of intestinal macrophages

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Impact of low-carbohydrate diet on the gut microbiota and mucosal immunityPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Epigenetic regulation of macrophage function in inflammatory bowel diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 特集 デジタルパソロジー/サイトロジーとAIの進歩 潰瘍性大腸炎におけるデジタルパソロジー･AIの有用性2023

Author(s)

Journal Title

DOI

ISSN

Year and Date

Data Source

[Journal Article] Phosphoinositide 3-Kinase P110δ-Signaling Is Critical for Microbiota-Activated IL-10 Production by B Cells that Regulate Intestinal Inflammation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Individualized treatment based on CYP3A5 single-nucleotide polymorphisms with tacrolimus in ulcerative colitis2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Simple 1-Day Colon Capsule Endoscopy Procedure Demonstrated to be a Highly Acceptable Monitoring Tool for Ulcerative Colitis2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Th17 plasticity and its relevance to inflammatory bowel disease2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 連載「免疫病動物モデルの特長と限界」炎症性腸疾患動物モデル2018

Author(s)

Journal Title

Data Source

[Journal Article] Ⅱ:炎症性腸疾患と腸内細菌(3)食事の欧米化と腸内細菌の変化2017

Author(s)

Journal Title

Kobayashi Taku 小林拓

[Journal Article] 特集デジタルパソロジー/サイトロジーとAIの進歩潰瘍性大腸炎におけるデジタルパソロジー･AIの有用性2023

[Presentation] クローン病疾患管理はどこまで進化できるのか～デジタル技術を利用した個別化医療の可能性～2023