OHKUBO Nobutaka 大久保信孝

Researcher Number	10432791
Other IDs
Affiliation (Current)	2025: 愛媛大学, 医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2007 – 2010: Ehime University, 大学院・医学系研究科, 講師 2008: Ehime University, 大学院医学系研究科, 講師
Review Section/Research Field	Principal Investigator General physiology / Nerve anatomy/Neuropathology Except Principal Investigator General internal medicine (including Psychosomatic medicine)
Keywords	Principal Investigator アポリポ蛋白E / 角膜 / がん / 血管内皮細胞増殖因子(VEGF) / 血管新生 / 細胞間相互作用 / 形態形成 / 細胞運動 / To11様受容体 / ミクログリア細胞 … More / Toll様受容体 / ミクログリア / 炎症性サイトカイン / 自然免疫 / 老化性痴呆疾患 … More Except Principal Investigator アンチエイジング / 血液レオロジー / 紅参由来サポニン / 赤血球 / 酸化ストレス / 老年医学 Less

Functional analysis of apolipoprotein E as a new regulator for angiogenesisPrincipal Investigator
- Principal Investigator
  
  OHKUBO Nobutaka
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Ehime University
Elucidating mechanism of protection of saponins from Ginseng Panax against oxidative stress.
- Principal Investigator
  
  SUZUKI Yoji
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General internal medicine (including Psychosomatic medicine)
- Research Institution
  Ehime University
Signaling pathway for Apolipoprotein E inhibition of innate immunePrincipal Investigator
- Principal Investigator
  
  OHKUBO Nobutaka
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Nerve anatomy/Neuropathology
- Research Institution
  Ehime University

All 2011 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A.2011
- Author(s)
  Christensen DJ, Ohkubo N, Oddo J, Van Kanegan MJ, Neil J, Li F, Colton CA, Vitek MP.
- Journal Title
  
  Journal of immunology
  
  Volume: 186 Pages: 2535-2542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790203
[Journal Article] Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A.2011
- Author(s)
  Christensen DJ, Ohkubo N, Oddo J, Van Kanegan MJ, Neil J, Li F, Cotton CA, Vitek MP.
- Journal Title
  
  J Immunol. 186
  
  Pages: 2535-2542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590701
[Journal Article] Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A.2011
- Author(s)
  Christensen DJ, Ohkubo N, Oddo J, Van Kanegan MJ, Neil J, Li F, Colton CA, Vitek MP.
- Journal Title
  
  Journal of immunology 186(4)
  
  Pages: 2535-2542
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790203
[Journal Article] Essential role of p38 MAPK in caspase-independent, iPLA(2)-dependent cell death under hypoxia/low glucose conditions.2009
- Author(s)
  Aoto, M., Shinzawa, K., Suzuki, Y., Ohkubo, N., Mitsuda, N., Tsujimoto Y
- Journal Title
  
  FEBS Letter 583
  
  Pages: 1611-1618
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790203
[Journal Article] Protective effect of ginsenosides Rg (2) and Rh (1) on oxidation-induced impairment of erythrocyte membrane properties.2008
- Author(s)
  Samukawa K, Suzuki Y, Ohkubo N, Aoto M, Sakanaka M, Mitsuda N
- Journal Title
  
  Biorheology 45
  
  Pages: 689-700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590701
[Journal Article] Protective effect of gins des Rg2 and Rhl onoxidationinduced impriiunalt of ervthrocvle membrane properties.2008
- Author(s)
  Samukawa K, Suzuki Y, Ohkubo N, Aoto M. Sakanaka M and Mitsuda N
- Journal Title
  
  Biorheology 45
  
  Pages: 689-700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700326
[Journal Article] Protective effect of ginsenosides Rg2 and Rh1on oxidation-induced impairment of erythrocyte membrane properties2008
- Author(s)
  Samukawa K, Suzuki Y, Ohkubo N, Aoto M, Sakanaka M and Mitsuda N
- Journal Title
  
  Biorheology 45(6)
  
  Pages: 689-700
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700326
[Journal Article] Reelin signals surival through Src-family kinases that inactivate BAD activity.2007
- Author(s)
  Ohkubo N, et. al.
- Journal Title
  
  Joumal of Neurochemistry 103・2
  
  Pages: 820-830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700326
[Journal Article] Reelin signals survival through Src-family kinases that inactivate BAD activity2007
- Author(s)
  Ohkubo N, Vitek MP,Morishima A, Suzuki Y, Miki T, Maeda, N and Mitsuda N
- Journal Title
  
  J Neurochem. 103(2)
  
  Pages: 820-830
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700326
[Journal Article] Participation of caspase-3-like protease in oxidation-induced impairment of erythrocyte membrane properties2007
- Author(s)
  Suzuki Y, Ohkubo N, Aoto M, Maeda N, Cicha I, Miki T and Mitsuda N
- Journal Title
  
  Biorheology 148(7)
  
  Pages: 3383-3390
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700326
[Journal Article] Androgen-mediated immune function is altered by the apolipoprotein E gene2007
- Author(s)
  Brown CM, Xu Q, Ohkubo N, Vitek MP and ColtonCA
- Journal Title
  
  Endocrinology 44(3)
  
  Pages: 179-190
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19700326
[Presentation] 血液保存における赤血球レオロジー機能障害と紅蔘由来サポニンの効果2010
- Author(s)
  鈴木洋司、大久保信孝、寒川慶一、青戸守、満田憲昭
- Organizer
  第33回日本バイオレオロジー学会
- Data Source
  KAKENHI-PROJECT-21790203
[Presentation] 満田憲昭紅蔘由来サポニンの血液保存時の機能障害に対する保護効果2010
- Author(s)
  河野広貴、鈴木洋司、大久保信孝、寒川慶一、青戸守
- Organizer
  第62回日本生理学会中国四国地方会
- Data Source
  KAKENHI-PROJECT-21790203
[Presentation] 紅蔘由来サポニンの血液保存時の機能障害に対する保護効果2010
- Author(s)
  河野広貴、鈴木洋司、大久保信孝, 寒川慶一、青戸守、満田憲昭
- Organizer
  第62回日本生理学会中国四国地方会
- Place of Presentation
  島根大学出雲キャンパス,出雲市
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21790203
[Presentation] 血液保存における赤血球レオロジー機能障害と紅蔘由来サポニンの効果2010
- Author(s)
  鈴木洋司、大久保信孝、寒川慶一、青戸守、満田憲昭
- Organizer
  第33回日本バイオレオロジー学会年会
- Place of Presentation
  理化学研究所(和光),和光市
- Year and Date
  2010-06-04
- Data Source
  KAKENHI-PROJECT-21790203
[Presentation] アポリポ蛋白E由来ペプチドによる炎症制御メカニズムの解析2009
- Author(s)
  大久保信孝
- Organizer
  第30回免疫・感染・炎症研究会
- Place of Presentation
  愛媛(松山)
- Year and Date
  2009-01-30
- Data Source
  KAKENHI-PROJECT-19700326
[Presentation] Reelin inhibits P19 embryonal cell death during neuronal differentiation.2009
- Author(s)
  大久保信孝、鈴木洋司、満田憲昭
- Organizer
  第36回国際生理学会
- Year and Date
  2009-08-01
- Data Source
  KAKENHI-PROJECT-21790203
[Presentation] Reelin inhibits P19 embryonal cell death during neuronal differentiation.2009
- Author(s)
  Ohkubo, N., Suzuki, Y., Mitsuda, N.
- Organizer
  第36回国際生理学会大会
- Place of Presentation
  京都
- Year and Date
  2009-08-01
- Data Source
  KAKENHI-PROJECT-21790203
[Presentation] アポリポ蛋白E由来ペプチドによる炎症制御メカニズムの解析2009
- Author(s)
  大久保信孝
- Organizer
  第30回免疫・感染・炎症研究会
- Data Source
  KAKENHI-PROJECT-21790203
[Presentation] Essential role of p38 MAPK in caspase-independent, iPLA2-dependent cell death under hypoxia/low glucose conditions2009
- Author(s)
  青戸守、大久保信孝、鈴木洋司、満田憲昭、新沢康英、辻本賀英
- Organizer
  第36回国際生理学会
- Data Source
  KAKENHI-PROJECT-21790203
[Presentation] Effect of ginsenosides on rheological function of erythrocytes against oxidative stress.2009
- Author(s)
  鈴木洋司、大久保信孝、寒川慶一、阪中雅広、満田憲昭
- Organizer
  第36回国際生理学会
- Year and Date
  2009-08-01
- Data Source
  KAKENHI-PROJECT-21790203
[Presentation] 低酸素/低グルコース刺激によって誘導される非アポトーシス型細胞死の解析2009
- Author(s)
  青戸守、大久保信孝、鈴木洋司、満田憲昭、新沢康英、辻本賀
- Organizer
  第61回日本生理学会中国四国地方会
- Data Source
  KAKENHI-PROJECT-21790203
[Presentation] Essential role of p38 MAPK in caspase-independent, iPLA2-dependent cell death under hypoxia/low glucose conditions2008
- Author(s)
  青戸守、新沢康英、鈴木洋司、大久保信孝、満田憲昭、辻本賀英
- Organizer
  第60回日本生理学会中四国大会
- Place of Presentation
  愛媛(松山)
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-19700326
[Presentation] STAT3コンディショナルノックアウトマウスにおける貧血の解析2008
- Author(s)
  大久保信孝、鈴木洋司、青戸守、青野賢治、満田憲昭
- Organizer
  第60回日本生理学会中四国大会
- Place of Presentation
  愛媛(松山)
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-19700326
[Presentation] Signaling cascade for apoE-peptide-mediated inbibition of inflammation2008
- Author(s)
  Ohkubo N, et. al.
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  東京(新宿)
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19700326
[Presentation] Essential role of p38 MAPK in caspaseindependent, iPLA2dependent cell death under hvnoxia/low glucose conditions2008
- Author(s)
  青戸守、新沢康英、鈴木洋司、大久保信孝、満田憲昭、辻本賀英
- Organizer
  第60回日本生理学会中四国大会
- Place of Presentation
  愛媛(松山)
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-19700326
[Presentation]2008
- Author(s)
  鈴木洋司、大久保信孝、寒川慶一、前田信治、満田憲昭
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  東京(新宿)
- Year and Date
  2008-03-27
- Data Source
  KAKENHI-PROJECT-19700326
[Presentation] 酸化ストレスによる赤血球膜の酸化障害とGingsen由来サポニンの保護効果2008
- Author(s)
  鈴木洋司、大久保信孝、青戸守、満田憲昭
- Organizer
  第60回日本生理学会中四国大会
- Place of Presentation
  愛媛(松山)
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-19700326
[Presentation] アポリポ蛋白E由来ペプチドによる炎症抑制シグナル伝達の解析2008
- Author(s)
  大久保信孝、鈴木洋司、満田憲昭
- Organizer
  第85回日本生理学会大会
- Place of Presentation
  東京(新宿)
- Year and Date
  2008-03-26
- Data Source
  KAKENHI-PROJECT-19700326
[Presentation] 赤血球の酸化障害に対するGinseng由来サポニン分画の保護効果2007
- Author(s)
  鈴木洋司、大久保信孝、寒川慶一、前田信治、満田憲昭
- Organizer
  第59回日本生理学会大会
- Place of Presentation
  徳島(徳島)
- Year and Date
  2007-11-10
- Data Source
  KAKENHI-PROJECT-19700326
[Presentation] アンドロゲンによる炎症抑制作用はアポリポ蛋白Eの遺伝子型により変化する2007
- Author(s)
  大久保信孝、鈴木洋司、満田憲昭
- Organizer
  第59回日本生理学会大会
- Place of Presentation
  徳島(徳島)
- Year and Date
  2007-11-10
- Data Source
  KAKENHI-PROJECT-19700326

1. SUZUKI Yoji (20226567)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
2. MITSUDA Noriaki (10314329)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

OHKUBO Nobutaka 大久保 信孝

Research Projects

Research Products

Co-Researchers

Functional analysis of apolipoprotein E as a new regulator for angiogenesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidating mechanism of protection of saponins from Ginseng Panax against oxidative stress.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Signaling pathway for Apolipoprotein E inhibition of innate immunePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A.2011

Author(s)

Journal Title

Data Source

[Journal Article] Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A.2011

Author(s)

Journal Title

Data Source

[Journal Article] Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A.2011

Author(s)

Journal Title

Data Source

[Journal Article] Essential role of p38 MAPK in caspase-independent, iPLA(2)-dependent cell death under hypoxia/low glucose conditions.2009

Author(s)

Journal Title

Data Source

[Journal Article] Protective effect of ginsenosides Rg (2) and Rh (1) on oxidation-induced impairment of erythrocyte membrane properties.2008

Author(s)

Journal Title

Data Source

[Journal Article] Protective effect of gins des Rg2 and Rhl onoxidationinduced impriiunalt of ervthrocvle membrane properties.2008

Author(s)

Journal Title

Data Source

[Journal Article] Protective effect of ginsenosides Rg2 and Rh1on oxidation-induced impairment of erythrocyte membrane properties2008

Author(s)

Journal Title

Data Source

[Journal Article] Reelin signals surival through Src-family kinases that inactivate BAD activity.2007

Author(s)

Journal Title

Data Source

[Journal Article] Reelin signals survival through Src-family kinases that inactivate BAD activity2007

Author(s)

Journal Title

Data Source

[Journal Article] Participation of caspase-3-like protease in oxidation-induced impairment of erythrocyte membrane properties2007

Author(s)

Journal Title

Data Source

[Journal Article] Androgen-mediated immune function is altered by the apolipoprotein E gene2007

Author(s)

Journal Title

Data Source

[Presentation] 血液保存における赤血球レオロジー機能障害と紅蔘由来サポニンの効果2010

Author(s)

Organizer

Data Source

[Presentation] 満田憲昭紅蔘由来サポニンの血液保存時の機能障害に対する保護効果2010

Author(s)

Organizer

Data Source

[Presentation] 紅蔘由来サポニンの血液保存時の機能障害に対する保護効果2010

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

OHKUBO Nobutaka 大久保信孝