MATSUNAGA Naoya 松永直哉

… Alternative Names

門田直哉

NAOYA Matsunaga 松永直哉(門田直哉)

門田直哉

松永直哉(門田直哉) マツナガナオヤ

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Researcher Number	10432915
Other IDs
Affiliation (Current)	2025: 九州大学, 薬学研究院, 教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 九州大学, 薬学研究院, 教授 2016 – 2020: 九州大学, 薬学研究院, 准教授 2017: 九州大学, 薬学研究院, 助教 2015: 九州大学, 薬学研究科(研究院), 准教授 2015: 九州大学, 大学院薬学研究院, 准教授 … More 2012 – 2015: 九州大学, 薬学研究科(研究院), 助教 2014: 九州大学, 大学院薬学研究院, 助教 2009 – 2011: Kyushu University, 大学院・薬学研究院, 助教 2008 – 2011: Kyushu University, 薬学研究院, 助教 Less
Review Section/Research Field	Principal Investigator Medical pharmacy / Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields / Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 59040:Nutrition science and health science-related Except Principal Investigator Applied pharmacology / Pain science / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 56060:Ophthalmology-related / Medical pharmacy
Keywords	Principal Investigator 体内時計 / マイクロ電流 / クロノマイクロカレントセラピー / 炎症 / 癌 / DDS / 時間治療 / 創薬 / グリア / 認知症 … More / マイクロ電流（カレント） / マイクロカレント癌免疫療法 / 腫瘍免疫 / PD-1 / クロノカレントセラピー / 乳癌幹細胞 / 操作 / TNBC / 難治性乳癌 / ハイスループットスクリーニング / 組織間コミュニケーションリズム / 分子時計 / 肝癌 / 慢性肝炎 / 低酸素応答性抗癌ベクター / 低酸素環境 / c, 医療薬剤学 / 医療薬剤学 … More Except Principal Investigator 分子時計 / 薬学 / 概日リズム / 神経障害痛 / 体内時計 / マクロファージ / 液性伝達時計 / 神経伝達時計 / 細胞伝達時計 / 細胞移植 / 増殖硝子体網膜症 / 細胞増殖 / 網膜 / 線維化 / 増殖性硝子体網膜症 / リポソーム / 形質転換 / 網膜剥離 / 糖尿病網膜症 / 網膜症 / 副腎皮質ホルモン / ケミカルバイオロジ― / 時間生物学 / 炎症 / ケミカルバイオロジー / 時間生物 / 幹細胞 / 恒常性 / 腎障害 / 神経障害性疼痛 / アストロサイト / 神経障害疼痛 / 生体リズム / 時計遺伝子 / がん性疼痛 / 医薬品開発 / 概日時計 / 創薬 / アポトーシス / 分化 / がん Less

細胞伝達時計の機能解析と創薬育薬を指向した基礎的研究
- Principal Investigator
  
  大戸茂弘
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  Kyushu University
慢性腎臓病時の学習記憶リズム障害機構を起点とした認知症の統合研究Principal Investigator
- Principal Investigator
  
  松永直哉
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
- Research Institution
  Kyushu University
Development of the regulation of tumor macrophages dynamics using microcurrent stimulationPrincipal Investigator
- Principal Investigator
  
  Matsunaga Naoya
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Kyushu University
ROCK inhibitor for treating intraocular fibrosis by modulating epithelial-to-mesenchymal transition.
- Principal Investigator
  
  Ishikawa Keijiro
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Kyushu University
Development of health promotion method using microcurrent stimulation to activate the body clockPrincipal Investigator
- Principal Investigator
  
  Naoya Matsunaga
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Kyushu University
Clarification of the mechanism underlying inflammation-based pathology from viewpoints of chrono-chemical biology
- Principal Investigator
  
  OHDO Shigehiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyushu University
Regulation of dynamics in breast cancer stem cells based on molecular clock.Principal Investigator
- Principal Investigator
  
  Matsunaga Naoya
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University
The underlying mechanism of glucocorticoid-regulated diurnal exacerbation of neuropathic pain hypersensitivity and its evaluation as a target of anti-allodynic drug
- Principal Investigator
  
  Koyanagi Satoru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pain science
- Research Institution
  Kyushu University
Role of molecular clock on the homeostatic communication between each organ in chronic kidney disease
- Principal Investigator
  
  Ohdo Shigehiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyushu University
Exploration of analgesic target for tumor-induced neuropathic pain based on the molecular mechanism of circadian rhythm in allodynia
- Principal Investigator
  
  KOYANAGI Satoru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pain science
- Research Institution
  Kyushu University
Elucidation of the communication rhythm alteration mechanism between organizations at the time of the chronic hepatitis and development of the new anticancer medicinePrincipal Investigator
- Principal Investigator
  
  NAOYA Matsunaga
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University
Development of a new hypoxia targeting chrono-gene therapy in cancer.Principal Investigator
- Principal Investigator
  
  MATSUNAGA Naoya
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University
Discovery and development of antitumor drugs focused on the molecular clock of dedifferentiation and apoptosis during carcinogenesis
- Principal Investigator
  
  OHDO Shigehiro
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University
Molecular basis for the dosing-time dependent change in the intratumoral delivery of oxaliplatin by transferrin-targeting liposomesPrincipal Investigator
- Principal Investigator
  
  MATSUNAGA Naoya
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyushu University

All 2021 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008

All Journal Article Presentation Book Patent

[Book] Biological Clocks2017
- Author(s)
  Satoru Koyanagi, Naoki Kusunose, Naoya Matsunaga, Shigehiro Ohdo
- Publisher
  北海道大学出版会（本間研一、本間さと編）
- ISBN
  9784832903722
- Data Source
  KAKENHI-PROJECT-15H04765
[Journal Article] Optimizing the dosing schedule of l-asparaginase improves its anti-tumor activity in breast tumor-bearing mice.2018
- Author(s)
  Shiromizu S, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S.
- Journal Title
  
  J Pharmacol Sci.
  
  Volume: 136 Issue: 4 Pages: 228-233
- DOI
  10.1016/j.jphs.2018.01.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17K16972
[Journal Article] Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene2018
- Author(s)
  Katamune Chiharu、Koyanagi Satoru、Hashikawa Ken-ichi、Kusunose Naoki、Akamine Takahiro、Matsunaga Naoya、Ohdo Shigehiro
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 294 Issue: 2 Pages: 547-558
- DOI
  10.1074/jbc.ra118.004942
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17H06976
[Journal Article] Optimized dosing schedule based on circadian dynamics of mouse breast cancer stem cells improves the anti-tumor effects of aldehyde dehydrogenase2018
- Author(s)
  Naoya Matsunaga, Takashi Ogino, Yukinori Hara, Takahiro Tanaka, Satoru Koyanagi, Shigehiro Ohdo
- Journal Title
  
  Cancer research
  
  Volume: X
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08098
[Journal Article] Epithelial cell adhesion molecule expression in hepatic stem/progenitor cells is controlled by the molecular clock system2018
- Author(s)
  Kimura Hinako、Matsunaga Naoya、Kakimoto Keisuke、Watanabe Miyako、Tsuruta Akito、Kusunose Naoki、Shiromizu Shoya、Koyanagi Satoru、Ohdo Shigehiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 503 Issue: 2 Pages: 1063-1069
- DOI
  10.1016/j.bbrc.2018.06.117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262
[Journal Article] Circadian clock component PERIOD2 regulates diurnal expression of Na+/H+ exchanger regulatory factor-1 and its scaffolding function.2018
- Author(s)
  Tsurudome Y, Koyanagi S, Kanemitsu T, Katamune C, Oda M, Kanado Y, Kato M, Morita A, Tahara Y, Matsunaga N, Shibata S, Ohdo S.
- Journal Title
  
  Scientific Reports
  
  Volume: 8(1) Issue: 1 Pages: 9072-9072
- DOI
  10.1038/s41598-018-27280-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26220201, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17K19493, KAKENHI-PROJECT-18J11229
[Journal Article] Accumulation of sorbitol in the sciatic nerve modulates circadian properties of diabetes-induced neuropathic pain hypersensitivity in a diabetic mouse model2018
- Author(s)
  Akamine Takahiro、Kusunose Naoki、Matsunaga Naoya、Koyanagi Satoru、Ohdo Shigehiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 503 Issue: 1 Pages: 181-187
- DOI
  10.1016/j.bbrc.2018.05.209
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262, KAKENHI-PROJECT-17H06976
[Journal Article] Optimized dosing schedule based on circadian dynamics of mouse breast cancer stem cells improves the antitumor effects of aldehyde dehydrogenase inhibitor.2018
- Author(s)
  Matsunaga N, Ogino T, Hara Y, Tanaka T, Koyanagi S, Ohdo S.
- Journal Title
  
  Cancer Res.
  
  Volume: 78(13) Issue: 13 Pages: 3698-3708
- DOI
  10.1158/0008-5472.can-17-4034
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262
[Journal Article] Dysfunction of the circadian transcriptional factor CLOCK in mice resists chemical carcinogen-induced tumorigenesis2017
- Author(s)
  Hashikawa KI, Katamune C, Kusunose N, Matsunaga N, Koyanagi S, Ohdo S
- Journal Title
  
  Scientific reports
  
  Volume: 7 Issue: 1 Pages: 9995-9995
- DOI
  10.1038/s41598-017-10599-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636
[Journal Article] Periodic variation in bile acids controls circadian changes in uric acid via regulation of xanthine oxidase by the orphan nuclear receptor PPARα.2017
- Author(s)
  Kanemitsu T, Tsurudome Y, Kusunose N, Oda M, Matsunaga N, Koyanagi S, Ohdo S
- Journal Title
  
  The Journal of biological chemistry
  
  Volume: 292 Issue: 52 Pages: 21397-21406
- DOI
  10.1074/jbc.m117.791285
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16972, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-17H06262
[Journal Article] Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction.2016
- Author(s)
  Hamamura K, Matsunaga N, Ikeda E, Kondo H, Ikeyama H, Tokushige K, Itcho K, Furuichi Y, Yoshida Y, Matsuda M, Yasuda K, Doi A, Yokota Y, Amamoto T, Aramaki H, Irino Y, Koyanagi S, Ohdo S.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 291 Issue: 10 Pages: 4913-4927
- DOI
  10.1074/jbc.m115.696930
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H06795, KAKENHI-PROJECT-25253038
[Journal Article] Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression.2016
- Author(s)
  Okazaki F, Matsunaga N, Okazaki H, Azuma H, Hamamura K, Tsuruta A, Tsurudome Y, Ogino T, Hara Y, Suzuki T, Hyodo K, Ishihara H, Kikuchi H, To H, Aramaki H, Koyanagi S, Ohdo S
- Journal Title
  
  The Journal of biological chemistry
  
  Volume: 291 Issue: 13 Pages: 7017-7028
- DOI
  10.1074/jbc.m115.713412
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K19167, KAKENHI-PROJECT-15H06795, KAKENHI-PROJECT-26860097, KAKENHI-PROJECT-25253038
[Journal Article] Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia.2016
- Author(s)
  S. Koyanagi, N. Kusunose, M. Taniguchi, T. Akamine, Y. Kanado, Y. Ozono, T. Masuda, Y. Kohro, N. Matsunaga, M. Tsuda, M. Salter, K. Inoue, and S. Ohdo.
- Journal Title
  
  Nat. Commun.
  
  Volume: 7 Issue: 1 Pages: 13102-13102
- DOI
  10.1038/ncomms13102
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-25117013, KAKENHI-PROJECT-15H02522, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-15H04765, KAKENHI-PROJECT-16K18885
[Journal Article] Different roles of negative and positive components of the circadian clock in oncogene-induced neoplastic transformation.2016
- Author(s)
  Katamune C, Koyanagi S, Shiromizu S, Matsunaga N, Shimba S, Shibata S, Ohdo S.
- Journal Title
  
  J Biol Chem.
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25253038
[Journal Article] Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease.2016
- Author(s)
  Matsunaga N, Ikeda E, Kakimoto K, Watanabe M, Shindo N, Tsuruta A, Ikeyama H, Hamamura K, Higashi K, Yamashita T, Kondo H, Yoshida Y, Matsuda M, Ogino T, Tokushige K, Itcho K, Furuichi Y, Nakao T, Yasuda K, Doi A, Amamoto T, Aramaki H, Tsuda M, Inoue K, Ojida A, Koyanagi S, Ohdo S
- Journal Title
  
  EBioMedicine
  
  Volume: 13 Pages: 262-273
- DOI
  10.1016/j.ebiom.2016.10.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-25117013, KAKENHI-PROJECT-16H02636, KAKENHI-PROJECT-15H06795
[Journal Article] Modulation of peroxisome proliferator-activated receptor-α activity by bile acids causes circadian changes in the intestinal expression of Octn1/Slc22a4 in mice.2015
- Author(s)
  Wada E, Koyanagi S, Kusunose N, Akamine T, Masui H, Hashimoto H, Matsunaga N, Ohdo S.
- Journal Title
  
  Mol Pharmacol
  
  Volume: 87 Issue: 2 Pages: 314-322
- DOI
  10.1124/mol.114.094979
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24390149, KAKENHI-PUBLICLY-25136716, KAKENHI-PROJECT-25253038, KAKENHI-PROJECT-25670079, KAKENHI-PROJECT-26670317, KAKENHI-PROJECT-26861456
[Journal Article] 24-Hour Rhythm of Aquaporin-3 Function in the Epidermis Is RegUlated by Molecular Clocks2014
- Author(s)
  Naoya Matsunaga, Kazufumi Itcho, Kengo Hamamura, Eriko Ikeda, Hisako Ikeyama, Yoko Furuichi, Miyako Watanabe, Satoru Koyanagi, Shigehiro Ohdo
- Journal Title
  
  Joumal of lnvestigative Dermatology
  
  Volume: (印刷中) Issue: 6 Pages: 1636-1644
- DOI
  10.1038/jid.2014.13
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J04175, KAKENHI-PUBLICLY-25136716, KAKENHI-PROJECT-25253038, KAKENHI-PROJECT-25670079
[Journal Article] Bile acid-regulated peroxisome proliferator-activated receptor-α (PPARα) activity underlies circadian expression of intestinal peptide absorption transporter PepT1/Slc15a1.2014
- Author(s)
  Okamura A, Koyanagi S, Dilxiat A, Kusunose N, Chen JJ, Matsunaga N, Shibata S, Ohdo S.
- Journal Title
  
  J Biol Chem.
  
  Volume: 289(36) Issue: 36 Pages: 25296-25305
- DOI
  10.1074/jbc.m114.577023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-25136716, KAKENHI-PROJECT-25253038, KAKENHI-PROJECT-25670079, KAKENHI-PROJECT-26220201, KAKENHI-PROJECT-26670317, KAKENHI-PROJECT-26861456
[Journal Article] Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma2014
- Author(s)
  Okazaki, H., Matsunaga, N., Fujioka, T., Okazaki, F., Akagawa, Y., Tsurudome, Y., Ono, M,. Kuwano, M., Koyanagi, S., and Ohdo, S.
- Journal Title
  
  Cancer Res.
  
  Volume: 74 Issue: 2 Pages: 543-551
- DOI
  10.1158/0008-5472.can-12-3241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24650646, KAKENHI-PUBLICLY-25136716, KAKENHI-PROJECT-25253038, KAKENHI-PROJECT-25670079
[Journal Article] Renal circadian clock regulates the dosing-time dependency of cisplatin-induced nephrotoxicity in mice.2014
- Author(s)
  Oda M, Koyanagi S, Tsurudome Y, Kanemitsu T, Matsunaga N, Ohdo S.
- Journal Title
  
  Mol Pharmacol
  
  Volume: 85 Issue: 5 Pages: 715-722
- DOI
  10.1124/mol.113.089805
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390149, KAKENHI-PUBLICLY-25136716, KAKENHI-PROJECT-25253038, KAKENHI-PROJECT-25670079, KAKENHI-PROJECT-26670317
[Journal Article] Stress-regulated transcription factor ATF4 promotes neoplastic transformation by suppressing expression of the INK4a/ARF cell senescence factors2012
- Author(s)
  Horiguchi M, Koyanagi S, Okamoto A, Suzuki SO, Matsunaga N, Ohdo S.
- Journal Title
  
  Cancer Res
  
  Volume: 72(2) Pages: 395-401
- Data Source
  KAKENHI-PROJECT-21390047
[Journal Article] Influence of CLOCK on cytotoxicity induced by diethylnitrosamine in mouse primary hepatocytes.2011
- Author(s)
  Matsunaga N, et al.
- Journal Title
  
  Toxicology
  
  Volume: 280(3) Pages: 144-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390047
[Journal Article] Influence of CLOCK on cytotoxicity induced by diethylnitrosamine in mouse primary hepatocytes2011
- Author(s)
  Matsunaga N, Kohno Y, Kakimoto K, Hayashi A, Koyanagi S, Ohdo S.
- Journal Title
  
  Toxicology
  
  Volume: 280(3) Pages: 144-151
- Data Source
  KAKENHI-PROJECT-21390047
[Journal Article] Molecular basis of chronopharmaceutics2011
- Author(s)
  Ohdo S, Koyanagi S, Matsunaga N, Hamdan A.
- Journal Title
  
  J Pharm Sci
  
  Volume: 100(9) Pages: 3560-3576
- Data Source
  KAKENHI-PROJECT-21390047
[Journal Article] Circadian rhythm of transferrin receptor 1 gene expression controlled by c-Myc in colon cancer-bearing mice2010
- Author(s)
  Okazaki F, Matsunaga N, Okazaki H, Utoguchi N, Suzuki R, Maruyama K, Koyanagi S, Ohdo S.
- Journal Title
  
  Cancer Res
  
  Volume: 70(15) Pages: 6238-6246
- Data Source
  KAKENHI-PROJECT-21390047
[Journal Article] Hypoxia-response plasmid vector producing bcl-2 shRNA enhances the apoptotic cell death of mouse rectum carcinoma2010
- Author(s)
  Fujioka T, Matsunaga N, Okazaki H, Koyanagi S, Ohdo S.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 113(4) Pages: 353-361
- NAID
  10027746067
- Data Source
  KAKENHI-PROJECT-21390047
[Journal Article] Glucocorticoid-dependent expression of O(6)-methylguanine-DNA methyltransferase gene modulates dacarbazine-induced hepatotoxicity in mice2010
- Author(s)
  Horiguchi M, Kim J, Matsunaga N, Kaji H, Egawa T, Makino K, Koyanagi S, Ohdo S.
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 333(3) Pages: 782-787
- Data Source
  KAKENHI-PROJECT-21390047
[Journal Article] Hypoxia-response plasmid vector producing bcl-2 shRNA enhances the apoptotic cell death of mouse rectum carcinoma.2010
- Author(s)
  Fujioka T, Matsunaga N
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 113 Pages: 353-61
- NAID
  10027746067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790158
[Journal Article] Chronopharmacological strategies : Intraand inter-individual variability of molecular clock2010
- Author(s)
  Ohdo S, Koyanagi S, Matsunaga N.
- Journal Title
  
  Adv Drug Deliv Rev
  
  Volume: 62(9-10) Pages: 885-897
- Data Source
  KAKENHI-PROJECT-21390047
[Journal Article] Hypoxia-response plasmid vector producing bcl-2 shRNA enhances the a poptotic cell death of mouse rectum carcinoma2010
- Author(s)
  Fujioka T, Matsunaga N, et al
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 113 Pages: 353-61
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790158
[Journal Article] Clock gene mutation modulates the cellular sensitivity to genotoxic stress through altering the expression of N-methylpurine DNA glycosylase gene2009
- Author(s)
  Kim J, Matsunaga N, Koyanagi S, Ohdo S.
- Journal Title
  
  Biochem Pharmacol
  
  Volume: 78(8) Pages: 1075-1082
- Data Source
  KAKENHI-PROJECT-21390047
[Patent] METHOD FOR DOSING TRANSFERRIN RECEPTOR-TARGETING LIPOSOMES OPTIMIZING DOSAGE TIMING2009
- Inventor(s)
  代表発明者大戸、松永
- Industrial Property Rights Holder
  国立大学法人九州大学総長
- Acquisition Date
  2009-10-14
- Overseas
- Data Source
  KAKENHI-PROJECT-20790137
[Patent] METHOD FOR DOSING TRANSFERRIN RECEPTOR-TARGETING LIPOSOMES OPTIMIZING DOSAGE TIMING2009
- Inventor(s)
  代表発明者大戸、松永
- Industrial Property Rights Holder
  国立大学法人九州大学総長
- Filing Date
  2009-09-22
- Overseas
- Data Source
  KAKENHI-PROJECT-20790137
[Patent] METHOD FOR DOSING TRANSFERRIN RECEPTOR-TARGETING LIPOSOMES OPTIMIZING DOSAGE TIMING2009
- Inventor(s)
  大戸(代表)、松永
- Industrial Property Rights Holder
  九州大学
- Filing Date
  2009-09-22
- Data Source
  KAKENHI-PROJECT-20790137
[Patent]2009
- Inventor(s)
  大戸(代表)、松永
- Industrial Property Rights Holder
  九州大学
- Filing Date
  2009-10-14
- Data Source
  KAKENHI-PROJECT-20790137
[Presentation] Effects of Liposome-encapsulated Ripasudil on Proliferative Vitreoretinopathy2021
- Author(s)
  Rui Ji1, Keijiro Ishikawa1, Kenichiro Mori1, Naoya Matsunaga2, Iori Wada1, Takahito Nakama1, Shintaro Nakao1, Shigehiro Ohdo2, Koh-Hei Sonoda1
- Organizer
  第125回　日本眼科学会総会
- Data Source
  KAKENHI-PROJECT-20K09828
[Presentation] Effects of Liposome-encapsulated Ripasudil on Proliferative Vitreoretinopathy2021
- Author(s)
  Rui ji, Ishikawa K, Mori K, Naoya Matsunaga, Wada I, Nakama T, Nakao S, Shigehiro Ohdo, Sonoda KH;
- Organizer
  The 14th Joint Meeting of Japan-China-Korea Ophthalmologists, Fukuoka,Japan,
- Data Source
  KAKENHI-PROJECT-20K09828
[Presentation] 神経障害性疼痛の概日リズム制御機構を基盤とした病態解明と創薬への応用2018
- Author(s)
  楠瀬直喜、小柳悟、松永直哉、大戸茂弘
- Organizer
  日本薬学会138回年会（シンポジウム講演）
- Invited
- Data Source
  KAKENHI-PROJECT-15H04765
[Presentation] 神経障害性疼痛の概日リズム制御機構と治療・創薬研究への応用2017
- Author(s)
  楠瀬直喜、小柳悟、松永直哉、大戸茂弘
- Organizer
  医療薬学フォーラム2017（シンポジウム講演）
- Invited
- Data Source
  KAKENHI-PROJECT-15H04765
[Presentation] 転写因子に着目した難治性乳がんの新規治療法の検討2016
- Author(s)
  荻野敬史、松永直哉、原幸稔、渡邊美弥子、田仲孝広、吉種光、深田吉孝、小柳悟、大戸茂弘
- Organizer
  136回　日本薬学会
- Place of Presentation
  横浜
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-15K08098
[Presentation] Molecular basis for circadian regulation of the intensity of cancer-derived pain in tumor-bearing mice2015
- Author(s)
  谷口真理恵、小柳悟、楠瀬直喜、赤嶺孝祐、松永直哉、大戸茂弘
- Organizer
  第9回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  千葉（千葉大学）
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-15H04765
[Presentation] Circadian oscillation in the intestinal expression of Octn1/Slc22a4 underlies the dosing time-dependent changes in the absorption of pregabalin and its analgesic effects on diabetic neuropathy2015
- Author(s)
  赤嶺孝祐、和田恵里香、楠瀬直喜、橋本華、谷口真理恵、松永直哉、小柳悟、大戸茂弘
- Organizer
  第9回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  千葉（千葉大学）
- Year and Date
  2015-11-07
- Data Source
  KAKENHI-PROJECT-15H04765
[Presentation] Chronopharmacological study of pregabalin for diabetic peripheral neuropathic pain2015
- Author(s)
  赤嶺孝祐、和田恵里香、楠瀬直喜、橋本華、谷口真理恵、松永直哉、小柳悟、大戸茂弘
- Organizer
  第22回日本時間生物学会学術大会
- Place of Presentation
  東京（東京大学）
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-15H04765
[Presentation] 神経障害性疼痛の概日リズム形成メカニズムと鎮痛標的分子の探索2014
- Author(s)
  小柳悟、楠瀬直喜、松永直哉、大戸茂弘
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市（熊本大学）
- Data Source
  KAKENHI-PROJECT-24390149
[Presentation] Chronopharmacological aspects of transporters2013
- Author(s)
  大戸茂弘、小柳悟、松永直哉
- Organizer
  日本薬物動態学会　第28回年会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-25253038
[Presentation] 神経障害性疼痛の概日リズム制御に関わるグルココルチコイド標的遺伝子の探索2013
- Author(s)
  楠瀬直喜、小柳悟、松永直哉、大戸茂弘
- Organizer
  第20回日本時間生物学会学術大会
- Place of Presentation
  大阪市（近畿大学）
- Data Source
  KAKENHI-PROJECT-24390149
[Presentation] がん細胞の薬剤感受性の概日リズム制御メカニズムと投薬のタイミング.2013
- Author(s)
  大戸茂弘、小柳悟、松永直哉
- Organizer
  第86回日本生化学会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PROJECT-25253038
[Presentation] 時間薬理による副作用低減.シンポジウム「副作用低減のための新しい薬理学的アプローチ」(オーガナイザー:植田真一郎、大石了三)2011
- Author(s)
  大戸茂弘、小柳悟、松永直哉
- Organizer
  第84回日本薬理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] 分子時計を基盤にした時間治療.シンポジウム「生命現象を担う生体分子に着目した創薬と臨床応用」(オーガナイザー:荒牧弘範、前仲勝実)2011
- Author(s)
  大戸茂弘、小柳悟、松永直哉
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] 時間薬物送達システム2011
- Author(s)
  松永直哉、小柳悟、大戸茂弘
- Organizer
  第18回日本時間生物学会学術大会
- Place of Presentation
  名古屋
- Year and Date
  2011-11-25
- Data Source
  KAKENHI-PROJECT-22790158
[Presentation] 時間薬理学とは.シンポジウム「時間薬理学と時間栄養学による新しい治療戦略の開拓」(オーガナイザー:柴田重信、大戸茂弘)2010
- Author(s)
  大戸茂弘、小柳悟、松永直哉
- Organizer
  第83回日本薬理学会年会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] 癌の時間治療と今後の展望.シンポジウム「体内時計を利用した創薬から治療戦略まで」(オーガナイザー:柴田重信、守屋孝洋)2010
- Author(s)
  大戸茂弘、小柳悟、松永直哉
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] 体内時計の分子機構を基盤にした薬物投与設計.シンポジウム1「薬物療法を支える基礎研究と臨床研究の糸口、進め方と成果の活用」(オーガナイザー:家入一郎、大戸茂弘)2010
- Author(s)
  小柳悟、松永直哉、大戸茂弘
- Organizer
  医療薬学フォーラム2010第18回クリニカルファーマシーシンポジウム
- Place of Presentation
  広島
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] 創薬・育薬を指向した時間薬剤学的研究2010
- Author(s)
  大戸茂弘、小柳悟、松永直哉
- Organizer
  第47回薬剤学懇談会研究討論会「新技術・新素材が切り拓く薬剤開発」岐阜県飛騨高山
- Place of Presentation
  高山グリーンホテル、天領閣
- Year and Date
  2010-06-24
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] マウス結腸がん細胞の増殖に及ぼす低酸素感受性shRNA発現ベクターの影響2009
- Author(s)
  藤岡孝志、松永直哉、小柳悟、大戸茂弘
- Organizer
  第16回日本時間生物学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-22790158
[Presentation] 抗がん剤の時間薬理.シンポジウム4「PK/PD解析から見た抗がん剤の効果・副作用」(オーガナイザー:鈴木洋史、桂敏也)2009
- Author(s)
  大戸茂弘、松永直哉、小柳悟
- Organizer
  医療薬学フォーラム2009第17回クリニカルファーマシーシンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] Molecular clock mechanisms of drug metabolism.2009
- Author(s)
  Ohdo S, Matsunaga N, Koyanagi S.
- Organizer
  Symposium"Functional genomics"16th International Conference on Cytochrome P450
- Place of Presentation
  Japan(Okinawa)
- Data Source
  KAKENHI-PROJECT-21390047
[Presentation] マウス結腸がん細胞の増殖に及ぼす低酸素感受性b⊂1-2shRNA発現ベクターの影響2009
- Author(s)
  藤岡孝志,松永直哉,小柳悟,大戸茂弘
- Organizer
  次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22790158
[Presentation] 1Transferrin receptor標的リポソーム製剤の至適投薬タイミングの検討2008
- Author(s)
  岡崎史泰、松永直哉、丸山一雄、小柳悟、大戸茂弘
- Organizer
  第2回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-20790137
[Presentation] マウス結腸がん細胞の増殖に及ぼす低酸素感受性shRNA発現ベクターの影響2008
- Author(s)
  藤岡孝志,松永直哉,小柳悟,大戸茂弘
- Organizer
  第23回日本薬物動態学会年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-22790158
[Presentation] ヒト膠芽細胞腫の増殖に及ぼす低酸素感受性NK4発現ベクターの影響2008
- Author(s)
  松永直哉、吉富秀亮、藤岡孝志、小柳悟、大戸茂弘
- Organizer
  第2回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22790158
[Presentation] マウス結腸がん細胞の増殖に及ぼす低酸素感受性shRNA発現ベクターの影響2008
- Author(s)
  藤岡孝志、松永直哉、小柳悟、大戸茂弘
- Organizer
  第2回次世代を担う若手医療薬科学シンポジウム
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22790158
[Presentation] Dosing-time dependent antitumor effects of Transferrin-Liposome Oxaliplatin (Tf-Lip-LOHP) in tumor bearing mice LRD20082008
- Author(s)
  Shigehiro Ohdo, Fumiyasu Okazaki, Kazuo Maruyama, Naoya Matsunaga, Satoru Koyanagi
- Organizer
  11th liposome research days conference
- Place of Presentation
  YOKOHAMA
- Data Source
  KAKENHI-PROJECT-20790137
[Presentation] トランスフェリン標的リポソーム製剤の至適投薬タイミングの検討2008
- Author(s)
  岡崎史泰, 松永直哉, 丸山一雄, 小柳悟, 大戸茂弘
- Organizer
  日本薬剤学会第23年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-20790137

1. KOYANAGI Satoru (60330932)

# of Collaborated Projects: 6 results

# of Collaborated Products: 31 results
2. OHDO Shigehiro (00223884)

# of Collaborated Projects: 4 results

# of Collaborated Products: 22 results
3. TSUDA Makoto (40373394)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. Ishikawa Keijiro (00795304)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. 武田篤信 (40560313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 中尾新太郎 (50583027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. 村上祐介 (50634995)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MASUDA Takahiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 楠瀬直喜

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
10. 桑野信彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 濱村賢吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 岡崎裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 田原優

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 柴田重信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 井上和秀

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

MATSUNAGA Naoya 松永 直哉

門田直哉

NAOYA Matsunaga 松永 直哉(門田直哉)

門田 直哉

松永 直哉(門田直哉) マツナガ ナオヤ

Research Projects

Research Products

Co-Researchers

細胞伝達時計の機能解析と創薬育薬を指向した基礎的研究

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慢性腎臓病時の学習記憶リズム障害機構を起点とした認知症の統合研究Principal Investigator

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Development of the regulation of tumor macrophages dynamics using microcurrent stimulationPrincipal Investigator

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ROCK inhibitor for treating intraocular fibrosis by modulating epithelial-to-mesenchymal transition.

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Development of health promotion method using microcurrent stimulation to activate the body clockPrincipal Investigator

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Clarification of the mechanism underlying inflammation-based pathology from viewpoints of chrono-chemical biology

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Regulation of dynamics in breast cancer stem cells based on molecular clock.Principal Investigator

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The underlying mechanism of glucocorticoid-regulated diurnal exacerbation of neuropathic pain hypersensitivity and its evaluation as a target of anti-allodynic drug

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Role of molecular clock on the homeostatic communication between each organ in chronic kidney disease

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Exploration of analgesic target for tumor-induced neuropathic pain based on the molecular mechanism of circadian rhythm in allodynia

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Elucidation of the communication rhythm alteration mechanism between organizations at the time of the chronic hepatitis and development of the new anticancer medicinePrincipal Investigator

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Development of a new hypoxia targeting chrono-gene therapy in cancer.Principal Investigator

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MATSUNAGA Naoya 松永直哉

NAOYA Matsunaga 松永直哉(門田直哉)

門田直哉

松永直哉(門田直哉) マツナガナオヤ