TSUKAMOTO HIROTAKE 塚本博丈

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Tsukamoto Hirotake 塚本博丈

塚本博丈

粟井博丈(塚本博丈) アワイヒロタケ

AWAI Hirotake 粟井博丈

TSUKAMOTO Hirotake 塚本博丈

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Researcher Number	10433020
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定准教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 京都大学, 医学研究科, 特定准教授 2018 – 2020: 熊本大学, 大学院生命科学研究部(医), 講師 2017: 熊本大学, 大学院生命科学研究部, 講師 2016: 熊本大学, 大学院生命科学研究部(医), 助教 2015: 熊本大学, その他の研究科, 助教 … More 2013 – 2014: 熊本大学, 大学院生命科学研究部, 助教 2011 – 2013: 熊本大学, 生命科学研究部, 助教 2010 – 2012: 熊本大学, 大学院・生命科学研究部, 助教 Less
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor immunology / Sections That Are Subject to Joint Review: Basic Section45050:Physical anthropology-related , Basic Section45060:Applied anthropology-related / Basic Section 45060:Applied anthropology-related / Basic Section 45050:Physical anthropology-related / Tumor therapeutics Except Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Tumor therapeutics / Tumor immunology
Keywords	Principal Investigator がん免疫療法 / 免疫老化 / T細胞 / マクロファージ / 炎症 / IL-6 / がん / 免疫抑制 / PD-1 / 免疫関連有害事象 … More / PD-1阻害療法 / 老化 / irAE実験モデル / 有害事象 / PD-1阻害 / 個体老化 / 自己炎症応答 / Th１細胞 / 細胞老化 / 免疫応答 / 加齢 / Th1分化 / 可溶性IL-6受容体 / CD4陽性T細胞 / 癌免疫療法 / 抗腫瘍免疫 / sIL-6R / 抗腫瘍免疫応答 / 免疫療法 / CD4 T細胞 / Th1 / CD4+ T細胞 / MDSC / 免疫制御 / ミエロイド系抑制性細胞 / CD4^+T細胞 … More Except Principal Investigator がん免疫療法 / 腫瘍免疫 / クリニカルバイオリソース / 関節炎 / B細胞 / 免疫関連有害事象 / 免疫チェックポイント阻害薬 / 長鎖癌抗原ペプチド / 癌抗原ワクチン / 癌抗原 / 免疫抑制解除療法 / 長鎖がん抗原ペプチド / がん抗原ワクチン / ＨＬＡ / IL-6 シグナル / 免疫抑制 / 細胞傷害性Ｔ細胞 / 腫瘍関連抗原ペプチド / 免疫抑制解除 / 免疫抑制的腫瘍微小環境 / IL-6シグナル / ヘルパーT細胞 / 細胞傷害性T細胞 / 抗原ペプチド / 腫瘍関連抗原 / 拒絶反応回避 / Ｔ細胞 / iPS細胞 / T 細胞 / がん抗原 / 樹状細胞 / iPS 細胞 Less

Clarification of macrophage subsets contributing to adverse events and immunosuppressive effects in cancer immunotherapyPrincipal Investigator
- Principal Investigator
  
  塚本博丈
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 45050:Physical anthropology-related
  Basic Section 45060:Applied anthropology-related
  Sections That Are Subject to Joint Review: Basic Section45050:Physical anthropology-related , Basic Section45060:Applied anthropology-related
- Research Institution
  Kyoto University
development of therapeutic strategy for immune related adverse events by immune checkpoint inhivitor by focusing on B lymphocyte
- Principal Investigator
  
  村上孝作
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Kyoto University
Development of irAE management strategy based on immuno-senescence, and novel cancer immunotherapy balancing augmented anti-tumor immunity and decreased risk of adverse eventsPrincipal Investigator
- Principal Investigator
  
  Tsukamoto Hirotake
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kyoto University
Development of novel cancer immunotherapeutic approach based on age-associated inflammatory responsePrincipal Investigator
- Principal Investigator
  
  Tsukamoto Hirotake
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kumamoto University
Development of cancer immunotherapy using tumor-associated antigen-derived long peptides and liberation from immune suppression mediated trough IL-6 signaling
- Principal Investigator
  
  Nishimura Yasuharu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kumamoto University
The detrimental effect of soluble IL-6 receptor on CD4 T cell-mediated anti-tumor immune responsesPrincipal Investigator
- Principal Investigator
  
  Tsukamoto Hirotake
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Kumamoto University
Analysis of functional defects in tumor-specific CD4+ T cells in aged animalsPrincipal Investigator
- Principal Investigator
  
  AWAI Hirotake (TSUKAMOTO Hirotake)
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor immunology
- Research Institution
  Kumamoto University
Development of cellular cancer immunotherapy by using humaniPS-cell-derived dendritic cells and ideal cancer-associated antigens
- Principal Investigator
  
  NISHIMURA Yasuharu
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor immunology
- Research Institution
  Kumamoto University
Analysis of Myeloid-derived suppressor cell-induced functional defects of CD4+T cells in tumor-bearing animalsPrincipal Investigator
- Principal Investigator
  
  AWAI Hirotake
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor immunology
- Research Institution
  Kumamoto University

[Book] 医学のあゆみ：PD-(L)1阻害療法に伴う有害事象に関わる免疫応答機序2023
- Author(s)
  塚本博丈
- Total Pages
  2
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-21H02788
[Book] 医学のあゆみ　「PD-(L)1阻害療法に伴う有害事象に関わる免疫応答機序」2023
- Author(s)
  塚本博丈
- Total Pages
  2
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-21H02788
[Book] 臨床免疫・アレルギー科：免疫チェックポイント分子によるがん免疫制御、耐性、副反応2023
- Author(s)
  塚本博丈
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-21H02788
[Book] 実験医学増刊「新・腫瘍免疫学：がん免疫におけるマクロファージの役割」2020
- Author(s)
  菰原義弘, 塚本博丈
- Total Pages
  6
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-18K07325
[Book] Precision Medicine がん治療における個別化医療の潮流2020
- Author(s)
  塚本博丈
- Total Pages
  8
- Publisher
  北隆館
- Data Source
  KAKENHI-PROJECT-18K07325
[Book] 「がん免疫におけるマクロファージの役割」実験医学増刊2019
- Author(s)
  菰原義弘、塚本博丈
- Total Pages
  9
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-18K07325
[Book] IL-6とPD-1/PD-L1シグナルの併用阻害による免疫抑制効果の相互制御の遮断2019
- Author(s)
  塚本博丈、押海裕之
- Total Pages
  6
- Publisher
  臨床免疫・アレルギー科　科学評論社
- Data Source
  KAKENHI-PROJECT-18K07325
[Book] 標準免疫学第3版第2編第5章 G. ＭＨＣの構造と機能2018
- Author(s)
  塚本博丈、西村泰治
- Total Pages
  7
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-15H04311
[Book] アンチ・エイジング医学「免疫老化とがん免疫」2017
- Author(s)
  塚本博丈
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-26430165
[Book] 臨床免疫・アレルギー科「IL-6と老年における免疫応答の低下」2016
- Author(s)
  塚本博丈
- Total Pages
  7
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-26430165
[Book] 臨床免疫・アレルギー科2016
- Author(s)
  塚本博丈
- Total Pages
  8
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-26430165
[Book] 臨床免疫・アレルギー科「Myeloid-derived suppressor cells (MDSC)によるTh1細胞の抑制機序」2014
- Author(s)
  塚本博丈
- Total Pages
  8
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-26430165
[Book] Myeloid-derived suppressor cells (MDSC)によるTh1細胞の抑制機序2014
- Author(s)
  塚本　博丈
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-24700994
[Book] 「Myeloid-derived suppressor cells (MDSC)によるTh1細胞の抑制機序」臨床免疫・アレルギー科(61)2014
- Author(s)
  塚本博丈
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-24700994
[Book] 「腫瘍免疫の最前線:T細胞を介した抗腫瘍免疫応答」実験医学9月増刊(31)2013
- Author(s)
  塚本博丈, 西村泰治
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24700994
[Book] 腫瘍免疫の最前線：　T細胞を介した抗腫瘍免疫応答2013
- Author(s)
  塚本　博丈, 西村　泰治
- Total Pages
  8
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-24700994
[Book] 炎症・免疫分野とノーベル賞,炎症と免疫2010
- Author(s)
  塚本博丈, 西村泰治
- Publisher
  先端医学社
- Data Source
  KAKENHI-PROJECT-22700897
[Journal Article] Age-associated reduction of sinus macrophages in human mesenteric lymph nodes2024
- Author(s)
  Kanemitsu Kosuke、Yamada Rin、Pan Cheng、Tsukamoto Hirotake、Yano Hiromu、Shiota Takuya、Fujiwara Yukio、Miyamoto Yuji、Mikami Yoshiki、Baba Hideo、Komohara Yoshihiro
- Journal Title
  
  Journal of Clinical and Experimental Hematopathology
  
  Volume: 64 Issue: 2 Pages: 79-85
- DOI
  10.3960/jslrt.24001
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06466, KAKENHI-PROJECT-21H02788
[Journal Article] Combined phospholipids adjuvant augments anti-tumor immune responses through activated tumor-associated dendritic cells.2023
- Author(s)
  Shui Y., Hu X., Hirano H., Tsukamoto H., Guo W. Z., Hasumi K., Ijima F., Fujino M., and Li X. K.
- Journal Title
  
  Neoplasia
  
  Volume: 39 Pages: 100893-100893
- DOI
  10.1016/j.neo.2023.100893
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02788, KAKENHI-PROJECT-21K15586
[Journal Article] Predictive value of CXCL10 for the occurrence of immune‐related adverse events in patient with renal cell carcinoma2023
- Author(s)
  Miura Yuji、Motoshima Takanobu、Anami Toshiki、Yano Hiromu、Mito Remi、Pan Cheng、Urakami Shinji、Kinowaki Keiichi、Tsukamoto Hirotake、Kurahashi Ryoma、Murakami Yoji、Yatsuda Junji、Fujiwara Yukio、Kamba Tomomi、Komohara Yoshihiro
- Journal Title
  
  Microbiology and Immunology
  
  Volume: Online ahead of print. Issue: 7 Pages: 345-354
- DOI
  10.1111/1348-0421.13067
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09560, KAKENHI-PROJECT-23K06362, KAKENHI-PROJECT-20K07669, KAKENHI-PROJECT-20K16450, KAKENHI-PROJECT-21H02788
[Journal Article] Association of Clostridium butyricum Therapy Using the Live Bacterial Product CBM588 with the Survival of Patients with Lung Cancer Receiving Chemoimmunotherapy Combinations2023
- Author(s)
  Tomiya Y, Sakata S, Imamura K, Iyama S, Jodai T, et al.
- Journal Title
  
  Cancers
  
  Volume: 16 Issue: 1 Pages: 47-47
- DOI
  10.3390/cancers16010047
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K16449, KAKENHI-PROJECT-22KK0277, KAKENHI-PROJECT-22K08256, KAKENHI-PROJECT-21K08494, KAKENHI-PROJECT-18K15928, KAKENHI-PROJECT-21H02788, KAKENHI-PROJECT-23K24139
[Journal Article] Involvement of protumor macrophages in breast cancer progression and characterization of macrophage phenotypes2023
- Author(s)
  Komohara Y.#, Kurotaki D.#, Tsukamoto H.#, Miyasato Y., Yano H., Pan C., Yamamoto Y., and Fujiwara Y. (#Contributed equally)
- Journal Title
  
  Cancer Sci.
  
  Volume: - Issue: 6 Pages: 2220-2229
- DOI
  10.1111/cas.15751
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02788, KAKENHI-PROJECT-23K06362, KAKENHI-PROJECT-20H03459
[Journal Article] E3 ubiquitin ligase Riplet is expressed in T cells and suppresses T cell-mediated anti-tumor immune responses.2022
- Author(s)
  Iwamoto A., Tsukamoto H., Nakayama H., and Oshiumi H.
- Journal Title
  
  J. Immunol.
  
  Volume: 208 Issue: 8 Pages: 2067-2076
- DOI
  10.4049/jimmunol.2100096
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02788
[Journal Article] Aging-associated and CD4 T-cell-dependent ectopic CXCL13 activation predisposes to anti?PD-1 therapy-induced adverse events2022
- Author(s)
  Tsukamoto Hirotake、Komohara Yoshihiro、Tomita Yusuke、Miura Yuji、Motoshima Takanobu、Imamura Kosuke、Kimura Toshiki、Ikeda Tokunori、Fujiwara Yukio、Yano Hiromu、Kamba Tomomi、Sakagami Takuro、Oshiumi Hiroyuki
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 29
- DOI
  10.1073/pnas.2205378119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K08541, KAKENHI-PROJECT-21H02788, KAKENHI-PROJECT-20K09560
[Journal Article] Stromal reprogramming through dual PDGFRα/β blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors.2022
- Author(s)
  T. Akiyama, T. Yasuda, T. Uchihara, N. Yasuda-Yoshihara, BJY. Tan, A. Yonemura, T. Semba, J. Yamasaki, Y. Komohara, K. Ohnishi, F. Wei, L. Fu, J. Zhang, F. Kitamura, K. Yamashita, K. Eto, S. Iwagami, H. Tsukamoto, T. Umemoto, M. Masuda, O. Nagano, Y. Satou, H. Saya, P. Tan, H. Baba, T. Ishimoto
- Journal Title
  
  Cancer Res.
  
  Volume: 83 Issue: 5 Pages: 753-770
- DOI
  10.1158/0008-5472.can-22-1890
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07370, KAKENHI-PROJECT-22K20836, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-20H03531, KAKENHI-PROJECT-21H02788, KAKENHI-PROJECT-20K07690, KAKENHI-PROJECT-21K19416, KAKENHI-PROJECT-21K19535, KAKENHI-PROJECT-23K08051, KAKENHI-PROJECT-21KK0153, KAKENHI-PROJECT-23K27463
[Journal Article] Circulating extracellular vesicle microRNAs associated with adverse reactions, proinflammatory cytokine, and antibody production after COVID-19 vaccination.2022
- Author(s)
  Miyashita Y, Yoshida T, Takagi Y, Tsukamoto H, Takashima K, Kouwaki T, Makino K, Fukushima S, Nakamura K, Oshiumi H.
- Journal Title
  
  NPJ Vaccines
  
  Volume: 7 Issue: 1 Pages: 16-16
- DOI
  10.1038/s41541-022-00439-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03480, KAKENHI-PROJECT-21H02788, KAKENHI-PROJECT-21K08351, KAKENHI-PUBLICLY-22H05603, KAKENHI-PROJECT-20K08259, KAKENHI-PROJECT-21K20841
[Journal Article] TICAM-1/TRIF associates with Act1 and suppresses IL-17 receptor-mediated inflammatory responses2021
- Author(s)
  Miyashita Y, Kouwaki T, Tsukamoto H, Okamoto M, Nakamura K, Oshiumi H.
- Journal Title
  
  Life Sci Alliance
  
  Volume: 5 Issue: 2 Pages: e202101181-e202101181
- DOI
  10.26508/lsa.202101181
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03480, KAKENHI-PROJECT-21H02788
[Journal Article] Immunotherapy with 4-1BBL-Expressing iPS Cell-Derived Myeloid Lines Amplifies Antigen-Specific T Cell Infiltration in Advanced Melanoma2021
- Author(s)
  Kuriyama H, Fukushima S, Kimura T, Kanemaru H, Miyashita A, Okada E, Kubo Y, Nakahara S, Tokuzumi A, Nishimura Y, Kajihara I, Makino K, Aoi J, Masuguchi S, Tsukamoto H, Inozume T, Zhang R, Nakatsura T, Uemura Y, Senju S, Ihn H.
- Journal Title
  
  Int J Mol Sci .
  
  Volume: 22(4) Issue: 4 Pages: 1958-1958
- DOI
  10.3390/ijms22041958
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09186, KAKENHI-PROJECT-18K07325, KAKENHI-PROJECT-18K08301, KAKENHI-PROJECT-20K17353, KAKENHI-PROJECT-20K22850
[Journal Article] miR-451a levels rather than human papillomavirus vaccine administration is associated with the severity of murine experimental autoimmune encephalomyelitis.2021
- Author(s)
  Nakashima M., Ishikawa K., Fugiwara A., Shu K., Fukushima Y., Okamoto M., Tsukamoto H., Kouwaki T. and Oshiumi H.
- Journal Title
  
  Sci. Rep
  
  Volume: 11 Issue: 1 Pages: 9369-9369
- DOI
  10.1038/s41598-021-88842-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02788
[Journal Article] Improved safety of induced pluripotent stem cell-derived antigen presenting cell-based cancer immunotherapy.2021
- Author(s)
  ashima H., Zhang R., Kobayashi T., Hagiya Y., Tsukamoto H., Liu T., Iwama T., Nakatsuka R., Mishima Y., Okada S., Senju S., Takasu N., Kaneko S., Idiris A., Ohdan H., Nakatsura T., Uemura Y.
- Journal Title
  
  Mol. Ther. Methods Clin. Dev.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07325
[Journal Article] β-glucan from Aureobasidium pullulans augments the anti-tumor immune responses through activated tumor-associated dendritic cells.2021
- Author(s)
  Shui Y., Hu X., Hirano H., Kusano K., Tsukamoto H., Li M., Hasumi K., Guo W.Z. and Li X.K.
- Journal Title
  
  Int. Immunopharmacol.
  
  Volume: 101 Pages: 108265-108265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02788
[Journal Article] The role of macrophages in anti-tumor immune responses: pathological significance and potential as therapeutic targets.2021
- Author(s)
  Tsukamoto H., Komohara Y. and Oshiumi H
- Journal Title
  
  Human Cell
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07325
[Journal Article] The role of macrophages in anti-tumor immune responses: pathological significance and potential as therapeutic targets2021
- Author(s)
  Tsukamoto H., Komohara Y. and Oshiumi H.
- Journal Title
  
  Human Cell
  
  Volume: 34 Issue: 4 Pages: 1031-1039
- DOI
  10.1007/s13577-021-00514-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02788
[Journal Article] Aging-Associated Extracellular Vesicles Contain Immune Regulatory microRNAs Alleviating Hyperinflammatory State and Immune Dysfunction in the Elderly2020
- Author(s)
  Hirotake Tsukamoto, Takahisa Kouwaki, Hiroyuki Oshiumi
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 9 Pages: 101520-101520
- DOI
  10.1016/j.isci.2020.101520
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03480, KAKENHI-PROJECT-18K07325
[Journal Article] HTLV-1 induces T cell malignancy and inflammation by viral antisense factor-mediated modulation of the cytokine signaling2020
- Author(s)
  Higuchi Yusuke、Yasunaga Jun-ichirou、Mitagami Yu、Tsukamoto Hirotake、Nakashima Kazutaka、Ohshima Koichi、Matsuoka Masao
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 24 Pages: 13740-13749
- DOI
  10.1073/pnas.1922884117
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K22904, KAKENHI-PROJECT-19H03689, KAKENHI-PROJECT-18K07325, KAKENHI-PROJECT-20H03514
[Journal Article] Generation of GM-CSF-producing antigen-presenting cells that induce a cytotoxic T cell-mediated antitumor response.2020
- Author(s)
  Mashima H, Zhang R, Kobayashi T, Hagiya Y, Tsukamoto H, Liu T, Iwama T, Yamamoto M, Lin C, Nakatsuka R, Mishima Y, Watanabe N, Yamada T, Senju S, Kaneko S, Idiris A, Nakatsura T, Ohdan H, Uemura Y.
- Journal Title
  
  Oncoimmunology
  
  Volume: 9(1) Issue: 1 Pages: 1814620-1814620
- DOI
  10.1080/2162402x.2020.1814620
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09186, KAKENHI-PROJECT-20K16439, KAKENHI-PROJECT-18K07325
[Journal Article] Induced pluripotent stem cell‐derived myeloid cells expressing OX40 ligand amplify antigen‐specific T cells in advanced melanoma2020
- Author(s)
  Kimura Toshihiro、Fukushima Satoshi、Okada Etsuko、Miyashita Azusa、Tsukamoto Hirotake、Uemura Yasushi、Senju Satoru、Ihn Hironobu
- Journal Title
  
  Pigment Cell & Melanoma Research
  
  Volume: - Issue: 5 Pages: 744-755
- DOI
  10.1111/pcmr.12887
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16345, KAKENHI-PROJECT-19K21328, KAKENHI-PROJECT-20K09186, KAKENHI-PROJECT-20K22850, KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-18K07325, KAKENHI-PROJECT-18K08301
[Journal Article] Cancer therapy with MHC-deficient and interferon β-producing myeloid cells derived from allogeneic embryonic stem cells.2019
- Author(s)
  Satoshi Umemoto, Miwa Haruta, Masataka Sakisaka, Tokunori Ikeda, Hirotake Tsukamoto, Yoshihiro Komohara, Motohiro Takeya, Yasuharu Nishimura, Satoru Senju.
- Journal Title
  
  Cancer Science
  
  Volume: 110 Pages: 3027-3037
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07325
[Journal Article] Nivolumab‐induced colitis in a patient with malignant melanoma: A case report and immunological analysis2019
- Author(s)
  Miyashita Azusa、Fukushima Satoshi、Tsukamoto Hirotake、Itai Hisae、Miyamoto Hideaki、Nakahara Satoshi、Kubo Yosuke、Kimura Toshihiro、Kuriyama Haruka、Ihn Hironobu
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 0000 Issue: 9 Pages: 0000-0000
- DOI
  10.1111/1346-8138.14857
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07325, KAKENHI-PROJECT-18K08301, KAKENHI-PROJECT-17K16345
[Journal Article] Combined Blockade of IL6 and PD-1/PD-L1 Signaling Abrogates Mutual Regulation of Their Immunosuppressive Effects in the Tumor Microenvironment2018
- Author(s)
  Tsukamoto Hirotake、Fujieda Koji、Miyashita Azusa、Fukushima Satoshi、Ikeda Tokunori、Kubo Yosuke、Senju Satoru、Ihn Hironobu、Nishimura Yasuharu、Oshiumi Hiroyuki
- Journal Title
  
  Cancer Research
  
  Volume: 78 Issue: 17 Pages: 5011-5022
- DOI
  10.1158/0008-5472.can-18-0118
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07325, KAKENHI-PROJECT-18K08301, KAKENHI-PROJECT-17K16345, KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-16K10165
[Journal Article] Activation of TLR3 and its adaptor TICAM-1 increases miR-21 levels in extracellular vesicles released from human cells2018
- Author(s)
  Fukushima Yoshimi、Okamoto Masaaki、Ishikawa Kana、Kouwaki Takahisa、Tsukamoto Hirotake、Oshiumi Hiroyuki
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: In Press Issue: 3 Pages: 744-750
- DOI
  10.1016/j.bbrc.2018.04.146
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-18K07325
[Journal Article] Extracellular vesicles deliver host and virus RNA and regulate innate immune response.2017
- Author(s)
  Kouwaki T., Okamoto M., Tsukamoto H., Fukushima Y. and Oshiumi H.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 18 Issue: 3 Pages: 666-666
- DOI
  10.3390/ijms18030666
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430165, KAKENHI-PROJECT-15K08517
[Journal Article] Soluble IL-6R expressed by myeloid cells reduces tumor-specific Th1 differentation and drives tumor progression2017
- Author(s)
  Tsukamoto H, Fujieda K, Hirayama M, Ikeda T, Yuno A, Matsumura K, Fukuma D, Araki K, Mizuta H, Nakayama H, Senju S, Nishimura Y
- Journal Title
  
  Cancer Research
  
  Volume: 14 Issue: 9 Pages: 2279-2291
- DOI
  10.1158/0008-5472.can-16-2446
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K19493, KAKENHI-PROJECT-16K07093, KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-15H04311, KAKENHI-PROJECT-17H04272, KAKENHI-PROJECT-15K11296, KAKENHI-PROJECT-16H06276
[Journal Article] Immune-suppressive effects of interleukin-6 on T-cell-mediated anti-tumor immunity2017
- Author(s)
  Tsukamoto Hirotake、Fujieda Koji、Senju Satoru、Ikeda Tokunori、Oshiumi Hiroyuki、Nishimura Yasuharu
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 3 Pages: 523-530
- DOI
  10.1111/cas.13433
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-15H04311, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-18K07325
[Journal Article] Soluble IL-6R expressed by myeloid cells Th1 differentiation and drives tumor progression.2017
- Author(s)
  Tsukamoto H., Fujieda K., Hirayama M., Ikeda T., Yuno A., Matsumura K., Fukuma D, Araki K., Hiroshi M., Nakayama H., Senju S. and Nishimura Y.
- Journal Title
  
  Cancer Research
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430165
[Journal Article] An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs2016
- Author(s)
  M. Hirayama, Y. Tomita, A. Yuno, H. Tsukamoto, S. Sejju, Y. Imamura, M. A. Sayem, A. Irie, Y. Yoshitake, D. Fukuma, M. Shinohara, A. Hamada, H. Jono, E. Yuba, K. Kono, K. Yoshida, T. Tsunoda, H. Nakayama, Y. Nishimura
- Journal Title
  
  OncoImmunology
  
  Volume: 5 Issue: 6 Pages: e1123368-e1123368
- DOI
  10.1080/2162402x.2015.1123368
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26242049, KAKENHI-PROJECT-15H03024, KAKENHI-PROJECT-25461918, KAKENHI-PLANNED-16H06498, KAKENHI-PROJECT-15H04311, KAKENHI-PROJECT-16H07082, KAKENHI-PROJECT-26460972, KAKENHI-PROJECT-16K11725
[Journal Article] Identification of Glypican-3-derived long peptides activating both CD8+ and CD4+ T-cells; prolonged overall survival in cancer patients with Th cell response.2016
- Author(s)
  2.Sayem M., Tomita Y., Yuno A., Hirayama M., Irie A., Tsukamoto H., Senju S., Yuba E., Yoshikawa T., Kono K., Nakatsura T., and Nishimura Y.
- Journal Title
  
  Oncoimmunology
  
  Volume: 5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430165
[Journal Article] An oncofetal antigen, IMP-3-derived long peptides induce immune responses of both helper T cells and CTLs.2016
- Author(s)
  Hirayama M., Tomita Y., Yuno A., Tsukamoto H., Senju S., Imamura Y., Sayem M., Irie A., Yoshitake Y., Fukuma D., Shinohara M., Hamada A., Jono H., Yuba E., Kono K., Yoshida K., Tsunoda T., Nakayama H., and Nishimura Y.
- Journal Title
  
  Oncoimmunology
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430165
[Journal Article] Identification of glypican-3-derived long peptides activating both CD8 and CD4 T cells; prolonged overall survival in cancer patients with Th cell response2016
- Author(s)
  Sayem, M. A. Tomita, Y. Yuno, A. Hirayama, M. Irie, A. Tsukamoto, H. Senju, S. Yuba, E. Yoshikawa, T. Kono, K. Nakatsura, T. Nishimura, Y.
- Journal Title
  
  Oncoimmunology
  
  Volume: 5 Issue: 1 Pages: e1062209-e1062209
- DOI
  10.1080/2162402x.2015.1062209
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460972, KAKENHI-PROJECT-26242049, KAKENHI-PROJECT-15H03024, KAKENHI-PROJECT-15H04311, KAKENHI-PLANNED-16H06498
[Journal Article] IL-6-mediated environmental conditioning of defective Th1 differentiation dampens anti-tumor immune responses in old age.2015
- Author(s)
  Tsukamoto, H., Senju, S., Matsumura, K., Swain, S.L., and Nishimura, Y.
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 6702-6702
- DOI
  10.1038/ncomms7702
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04311, KAKENHI-PROJECT-26430165
[Journal Article] CXCL10 and CCL2 mRNA expression in monocytes is inversely correlated with the HLA-DR lower fraction of monocytes in patients with renal cell carcinoma.2015
- Author(s)
  4.Motoshima T., Komohara Y., Horlad H., Tsukamoto H., Fujita M., Saito Y., Tanoue K., Kasejima Y., Sugiyama Y., Kawano Y., Nishimura Y., Takeya M., Eto M.
- Journal Title
  
  Oncol Lett
  
  Volume: ２ Pages: 4132-4132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26430165
[Journal Article] CXCL10 and CCL2 mRNA expression in monocytes is inversely correlated with the HLA-DR lower fraction of monocytes in patients with renal cell carcinoma.2015
- Author(s)
  Motoshima T., Komohara Y., Horlad H., Tsukamoto H., Fujita M., Saito Y., Tanoue K., Kasejima Y., Sugiyama Y., Kawano Y., Nishimura Y., Takeya M., Eto M.
- Journal Title
  
  Oncology letters
  
  Volume: In Press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430165
[Journal Article] LY6K-specific CD4+ T-cell immunity in patients with malignant tumor: Identification of LY6K long peptide encompassing both CD4+ and CD8+ T-cell epitopes.2014
- Author(s)
  Tomita Y., Yuno A., Tsukamoto H., Senju S., Kuroda Y., Hirayama M. Irie A., Yatsuda J., Hamada A., Jono H., Yoshida K., Tsunoda T., Daigo Y., Kohrogi H., Yoshitake Y., Nakamura Y., Shinohara M., and Nishimura Y.
- Journal Title
  
  Oncoimmunology
  
  Volume: 3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430165
[Journal Article] Identification of CDCA1 long peptides bearing both CD4+ and CD8+ T-cell epitopes : CDCA1-specific CD4+ T-cell immunity in cancer patients2014
- Author(s)
  Tomita Y., Yuno A., Tsukamoto H., Senju S., Yoshimura S., Osawa R., Kuroda Y., Hirayama M., Hamada A., Jono H., Irie A., Tsunoda T., Kohrogi H., Yoshitake Y., Nakamura Y., Shinohara M., and Nishimura Y.
- Journal Title
  
  Int. J . Cancer
  
  Volume: 134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700994
[Journal Article] LY6K-specific CD4+ T-cell immunity in patients with malignant tumor: Identification of LY6K long peptide encompassing both CD4+ and CD8+ T-cell epitopes.2014
- Author(s)
  Tomita Y., Yuno A., Tsukamoto H., Senju S., Kuroda Y., Hirayama M. Irie A., Yatsuda J., Hamada A., Jono H., Yoshida K., Tsunoda T., Daigo Y., Kohrogi H., Yoshitake Y., Nakamura Y., Shinohara M., and Nishimura Y.
- Journal Title
  
  Oncoimmunology
  
  Volume: In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700994
[Journal Article] LY6K-specific CD4^+ T-cell immunity in patients with malignant tumor : Identification of LY6K long peptide encompassing both CD4^+ and CD8^+ T-cell epitopes2014
- Author(s)
  Tomita Y., Yuno A., Tsukamoto H., Senju S., Kuroda Y., Hirayama M. Irie A., Yatsuda J., Hamada A., Jono H., Yoshida K., Tsunoda T., Daigo Y., Kohrogi H., Yoshitake Y., Nakamura Y., Shinohara M., and Nishimura Y.
- Journal Title
  
  Oncoimmunology
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700994
[Journal Article] Identification of CDCA1 long peptides bearing both CD4+ and CD8+ T-cell epitopes: CDCA1-specific CD4+ T-cell immunity in cancer patients.2014
- Author(s)
  Tomita Y., Yuno A., Tsukamoto H., Senju S., Yoshimura S., Osawa R., Kuroda Y., Hirayama M., Hamada A., Jono H., Irie A., Tsunoda T., Kohrogi H., Yoshitake Y., Nakamura Y., Shinohara M., and Nishimura Y.
- Journal Title
  
  Int. J. Cancer
  
  Volume: 134 Pages: 352-366
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700994
[Journal Article] Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.2014
- Author(s)
  13.Suppression of Th1-mediated autoimmunity by embryonic stem cell-derived dendritic cells.da, T., Hirata, S., Takamatsu, K., Haruta, M., Tsukamoto, H., Ito, T., Uchino, M., Ando, Y., Nagafuchi, S., Nishimura, Y., Senju, S.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 12 Pages: e115198-e115198
- DOI
  10.1371/journal.pone.0115198
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24300334, KAKENHI-PROJECT-25461499, KAKENHI-PROJECT-25670461, KAKENHI-PROJECT-25870540, KAKENHI-PROJECT-26430165
[Journal Article] Identification of CDCA1 long peptides bearing both CD4+ and CD8+ T-cell epitopes: CDCA1-specific CD4+ T-cell immunity in cancer patients.2014
- Author(s)
  Tomita Y., Yuno A., Tsukamoto H., Senju S., Yoshimura S., Osawa R., Kuroda Y., Hirayama M., Hamada A., Jono H., Irie A., Tsunoda T., Kohrogi H., Yoshitake Y., Nakamura Y., Shinohara M., and Nishimura Y.
- Journal Title
  
  International Journal of Cancer
  
  Volume: 134 Pages: 352-366
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26430165
[Journal Article] Establishment of HLA-DR4 transgenic mice for the identification of CD4+ T cell epitopes of tumor-associated antigens.2013
- Author(s)
  Yatsuda J, Irie A, Harada K, Michibata Y, Tsukamoto H, Senju S, Tomita Y, Yuno A, Hirayama M, Abu Sayem M, Takeda N, Shibuya I, Sogo S, Fujiki F, Sugiyama H, Eto M, Nishimura Y.
- Journal Title
  
  PLoS One
  
  Volume: 8 Issue: 12 Pages: e84908-e84908
- DOI
  10.1371/journal.pone.0084908
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22133001, KAKENHI-PLANNED-22133005, KAKENHI-PROJECT-23510243, KAKENHI-PROJECT-24700991, KAKENHI-PROJECT-24700994
[Journal Article] Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells2013
- Author(s)
  Horlad, H., Fujiwara, Y., Takemura, K., Ohnishi, K., Ikeda, T., Tsukamoto, H., Mizuta, H., Nishimura, Y., Takeya, M., Komohara, Y.
- Journal Title
  
  Mol. Nutr. Food Res.
  
  Volume: 57 Pages: 1046-1054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700994
[Journal Article] Establishment of HLA-DR4 transgenic mice for the identification of CD4+ T cell epitopes of tumor-associated antigens2013
- Author(s)
  Yatsuda J., Irie A., Harada K., Michibata Y., Tsukamoto H., Senju S., Tomita Y., Yuno A., Hirayama M., Abu Sayem M., Takeda N., Shibuya I., Sogo S., Fujiki F., Sugiyama H., Eto M. and Nishimura Y.
- Journal Title
  
  PLoS One
  
  Volume: 8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700994
[Journal Article] Myeloid-derived suppressor cells attenuate Th1 development through IL-6 during tumor progression.2013
- Author(s)
  Tsukamoto, H., Nishikata, R., Senju, S. and Nishimura, Y.
- Journal Title
  
  Cancer. Immunol. Res.
  
  Volume: 1 Issue: 1 Pages: 64-76
- DOI
  10.1158/2326-6066.cir-13-0030
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22133005, KAKENHI-PROJECT-24300334, KAKENHI-PROJECT-24700994
[Journal Article] Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells2013
- Author(s)
  Horlad Hasita, Fujiwara Yukio, Takemura Kenichi, Ohnishi Koji, Ikeda Tsuyoshi, Tsukamoto Hirotake, Mizuta Hiroshi, Nishimura Yasuharu, Takeya Motohiro, Komohara Yoshihiro
- Journal Title
  
  Mol. Nutri. Food Res
  
  Volume: 57 (6) Issue: 6 Pages: 1-9
- DOI
  10.1002/mnfr.201200610
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590010, KAKENHI-PROJECT-23659204, KAKENHI-PROJECT-23790407, KAKENHI-PROJECT-23790747, KAKENHI-PROJECT-24700994, KAKENHI-PROJECT-24790353, KAKENHI-PROJECT-25293089, KAKENHI-PROJECT-25460460, KAKENHI-PROJECT-25860501
[Journal Article] Myeloid-derived suppressor cells attenuate Th1 development through IL-6 production to promote tumor progression.2013
- Author(s)
  Tsukamoto, H., Nishikata, R., Senju, S., and Nishimura, Y.
- Journal Title
  
  Cancer Immunology Research
  
  Volume: In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700994
[Journal Article] Promiscuous CDCA1 long peptides induce CD4+ T cell and CTLs: CDCA1-specific CD4+ T cell immunity augmented by CTL-epitope vaccination in cancer patients.2013
- Author(s)
  Tomita, Y., Yuno, A., Tsukamoto, H., Senju, S., Yoshimura, S., Osawa, R., et al.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: submitted
- Data Source
  KAKENHI-PROJECT-24700994
[Journal Article] Myeloid-derived suppressor cells attenuate TH1 development through IL-6 production to promote tumor progression2013
- Author(s)
  Tsukamoto, H., Nishikata, R., Senju, S., and Nishimura, Y.
- Journal Title
  
  Cancer. Immunol. Res.
  
  Volume: 1 Pages: 64-76
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700994
[Journal Article] Identification of promiscuous KIF20A long peptides bearing both CD4+ and CD8+ T-cell epitopes : KIF20A-specific CD4+ T-cell immunity in patients with malignant tumor2013
- Author(s)
  Tomita Y., Yuno A., Tsukamoto H., Senju S., Kuroda Y., Hirayama M., Irie A., Kawahara K., Yatsuda J., Hamada A., Jono H., Yoshida K., Tsunoda T., Kohrogi H., Yoshitake Y., Nakamura Y., Shinohara M., and Nishimura Y.
- Journal Title
  
  Clin. Cancer Res.
  
  Volume: 15 Pages: 4508-4520
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700994
[Journal Article] Identification of promiscuous KIF20A long peptides bearing both CD4+ and CD8+ T-cell epitopes: KIF20A-specific CD4+ T-cell immunity in patients with malignant tumor.2013
- Author(s)
  Tomita, Y.*, Yuno, A.*, Tsukamoto, H., Senju, S., Kuroda, Y., Hirayama, M., Irie, A., Kawahara, K., Yatsuda, J., Hamada, A., Jono, H., Yoshida, K., Tsunoda, T., Kohrogi, H., Yoshitake, Y., Nakamura, Y., Shinohara, M. and Nishimura, Y. (*equal contribution)
- Journal Title
  
  Clin. Cancer Res
  
  Volume: 19 Issue: 16 Pages: 4508-4520
- DOI
  10.1158/1078-0432.ccr-13-0197
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22133005, KAKENHI-PROJECT-23510243, KAKENHI-PROJECT-24700994
[Journal Article] Promiscuous LY6K long peptide induces CD4+ T cells and CTLs: LY6K-specific CD4+ T cell immunity augmented by CTL-epitope vaccination in cancer patients.2013
- Author(s)
  Tomita, Y., Yuno, A., Tsukamoto, H., Senju, S., Kuroda, Y., Hirayama, M. et al.
- Journal Title
  
  J. Clin. Oncl.
  
  Volume: submitted
- Data Source
  KAKENHI-PROJECT-24700994
[Journal Article] Identification of promiscuous KIF20A long peptides bearing both CD4+ and CD8+ T-cell epitopes: KIF20A-specific CD4+ T-cell immunity in patients with malignant tumor.2013
- Author(s)
  Tomita, Y., Yuno, A., Tsukamoto, H., Senju, S., Kuroda, Y., Hirayama, M., et al.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: submitted
- Data Source
  KAKENHI-PROJECT-24700994
[Journal Article] Corosolic acid impairs tumor development and lung metastasis by inhibiting the immunosuppressive activity of myeloid-derived suppressor cells.2013
- Author(s)
  Horlad, H., Fujiwara, Y., Takemura, K., Ohnishi, K., Ikeda, T., Tsukamoto, H., Mizuta, H.,Nishimura, Y., Takeya, M., Komohara, Y.
- Journal Title
  
  Mol. Nutr. Food Res.
  
  Volume: In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700994
[Journal Article] Bim dictates naive CD4 T cell lifesp an and the development of age-associated func tional defects2010
- Author(s)
  Tsukamoto, H., Huston, G. E., Dibble, J., Duso, D. K. and Swain, S.
- Journal Title
  
  J. Immunol
  
  Volume: 185 Pages: 4535-4544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700897
[Journal Article] Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects2010
- Author(s)
  Hirotake Tsukamoto
- Journal Title
  
  Journal of Immunology
  
  Volume: 185 Pages: 4535-4544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700897
[Patent] PD-1阻害薬又はPD-L1阻害薬によるがん免疫療法における治療応答性の向上薬2023
- Inventor(s)
  塚本博丈
- Industrial Property Rights Holder
  塚本博丈
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-073380
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-21H02788
[Presentation] Development of preclinical models for immune checkpoint inhibitor induced arthritis2024
- Author(s)
  Kosaku Murakami, Yunhong Hotta, Akiko Yoshida, Hirotake Tsukamoto, Mirei Shirakashi, Tsuneyasu Yoshida, Akio Morinobu
- Organizer
  Annual European Congress of Rheumatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K08541
[Presentation] 老齢マウスモデルの知見から、がん免疫療法に伴うirAE病態の理解を目指して2023
- Author(s)
  塚本博丈
- Organizer
  第43回　阿蘇シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21H02788
[Presentation] 老齢マウスモデルの知見からirAE病態の理解を目指して2023
- Author(s)
  塚本博丈
- Organizer
  第39回　日本皮膚悪性腫瘍学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02788
[Presentation] がん免疫療法における有害事象の発症機序　老齢実験動物を用いた知見から2023
- Author(s)
  塚本博丈
- Organizer
  第96回　日本内分泌学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02788
[Presentation] 老齢マウスモデルの知見から　がん免疫療法に伴うirAE病態の理解を目指して2023
- Author(s)
  塚本博丈
- Organizer
  第27回　日本がん免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02788
[Presentation] がん免疫療法における有害事象の発症機序　~老齢実験動物を用いた知見から2022
- Author(s)
  塚本博丈
- Organizer
  第26回　日本がん免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02788
[Presentation] Aging-associated and CD4 T cell-dependent ectopic CXCL13 activation predisposes to anti-PD-1 therapy-induced adverse events2022
- Author(s)
  Hirotake Tsukamoto
- Organizer
  第51回　日本免疫学会学術総会
- Data Source
  KAKENHI-PROJECT-21H02788
[Presentation] Targeting of age-associated increase in IL-6 improves the responsiveness to cancer immunotherapies in old age2019
- Author(s)
  Hirotake Tsukamoto
- Organizer
  第78回　日本癌学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07325
[Presentation] Exosomal miR192 regulates inflammatory response induced by Influenza whole vaccine2019
- Author(s)
  Hirotake Tsukamoto, Takahisa Kouwaki, Kana Ishikawa, and Hiroyuki Oshiumi
- Organizer
  第48回　日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07325
[Presentation] Combined blockade of IL-6 and PD-1/PD-L1 signaling abrogates mutual regulation of their immunosuppressive effects in the tumor microenvironment2018
- Author(s)
  Hirotake Tsukamoto, Azusa Miyashita, Satoshi Fukushima, Yasuharu Nishimura, Hiroyuki Oshiumi.
- Organizer
  第47回　日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07325
[Presentation] Combined blockade of IL-6 and PD-1/PD-L1 signals breaks mutual regulation of their immunosuppressive effects2018
- Author(s)
  Hirotake Tsukamoto
- Organizer
  第77回　日本癌学会
- Invited
- Data Source
  KAKENHI-PROJECT-18K07325
[Presentation] 免疫抑制因子としての IL-6シクグナルを標的とした抗腫瘍免疫応答予測と、IL-6/PD-L1 阻害併用療法の有効性の検討2017
- Author(s)
  4.塚本博丈、藤枝浩司、福島聡、池田徳典、宮下梓、久保陽介、千住覚、尹浩信、押海裕之、西村泰治
- Organizer
  第21回日本がん免疫学会総会
- Data Source
  KAKENHI-PROJECT-15H04311
[Presentation] A possible Th1 cell-activating combination cancer immunotherapy using active immunization and IL-6 signaling blockade2017
- Author(s)
  2.Tsukamoto H, Tsuruta M, Hirayama M, Senju S, Nakayama H and Nishimura Y
- Organizer
  The 36th Sapporo International Cancer Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04311
[Presentation] SASP factor IL-6-mediated dysfunction of CD4 T cells diminishes anti-tumor immunity in old age2016
- Author(s)
  塚本博丈
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-11-08
- Invited
- Data Source
  KAKENHI-PROJECT-26430165
[Presentation] Immune-suppressive role of IL-6/sIL-6R signaling in CD4 T cell-mediated anti-tumor immunity2016
- Author(s)
  塚本博丈
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-26430165
[Presentation] HLA 拘束性 T 細胞を活性化するがん抗原ペプチドワクチンの開発2016
- Author(s)
  西村泰治、平山真敏、Mohammad Abu Sayem、湯野晃、冨田雄介、今村悠哉、千住覚、塚本 (粟井) 博丈、入江厚、河野健司、吉武義泰、中村祐輔、中面哲也、篠原正徳、中山秀樹
- Organizer
  シンポジウム３ [基礎] MHCを視点とした免疫異常・感染症治療戦略の新展開、第25回日本組織適合性学会大会
- Place of Presentation
  北海道大学学術交流会館（北海道札幌市）
- Year and Date
  2016-10-22
- Invited
- Data Source
  KAKENHI-PROJECT-15H04311
[Presentation] IL-6/可溶性IL-6受容体を介したT細胞抗腫瘍免疫応答の抑制機構2016
- Author(s)
  塚本博丈
- Organizer
  日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-10-06
- Invited
- Data Source
  KAKENHI-PROJECT-26430165
[Presentation] Multifaceted dysfunction of CD4 T cells during aging process and their impact on antitumor immunity2015
- Author(s)
  Hirotake Tsukamoto, Satoru Senju, Keiko Matsumura, Susan Swain, Yasuharu Nishimura
- Organizer
  日本癌学会学術総会
- Place of Presentation
  名古屋コングレスセンター
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-26430165
[Presentation] 癌胎児性抗原IMP-3由来のCTLとTh1細胞の誘導活性を併せ持つ、多様なHLAクラスII拘束性の長鎖癌抗原ペプチドの同定2015
- Author(s)
  平山真敏、冨田雄介、湯野晃、Mohammad Abu Sayem、千住覚、入江厚、塚本博丈、中根未季、弓場英司、河野健司、吉田浩二、中村祐輔、中山秀樹、西村泰治
- Organizer
  第24回日本組織適合性学会大会
- Place of Presentation
  ホテルレイクビュー水戸（水戸市
- Year and Date
  2015-09-10
- Data Source
  KAKENHI-PROJECT-15H04311
[Presentation] CTLとTh1細胞の誘導活性を併せ持つ癌胎児性抗原IMP-3由来のロングペプチドの同定2015
- Author(s)
  平山真敏、冨田雄介、湯野晃、Abu Sayem Mohammad、塚本博丈、千住覚、福間大喜、弓場英司、河野健司、吉田浩二、中村祐輔、中山秀樹、西村泰治
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15H04311
[Presentation] sIL-6R-mediated defective Th1 differentiation dampens anti-tumor immune responses in tumor-bearing mice.2015
- Author(s)
  Hirotake Tsukamoto, Satoru Senju, Yasuharu Nishimura
- Organizer
  免疫学会学術総会
- Place of Presentation
  札幌コンベンションセンター
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26430165
[Presentation] Identification of oncofetal antigen (IMP-3)-derived long peptides encompassing both CTL epitopes and multiple HLA class II-restricted Th cell epitopes2015
- Author(s)
  Hirayama, M., Tomita, Y., Yuno, A., Sayem M.A., Nakane, M., Tsukamoto, H., Irie, A., Senju, S., Yoshitake, Y., Fukuma, D., Shinohara, M., Yuba, E., Kono, K., Yoshida, K., Nakamura, Y., Nakayama, H., Nishimura, Y.
- Organizer
  International Conference of Cancer Immunotherapy and Macrophages 2015
- Place of Presentation
  Ito Hall, Ito International Research Center, The University of Tokyo, Tokyo
- Year and Date
  2015-07-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04311
[Presentation] IL-6-mediated c-Maf induction attenuates Th1 differentiation and anti-tumor immune responses in old age.2015
- Author(s)
  Hirotake Tsukamoto, Satoru Senju, Keiko Matsumura, Susan L Swain, Yasuharu Nishimura
- Organizer
  日本がん免疫学会総会・マクロファージ分子細胞生物学国際シンポジウム
- Place of Presentation
  東京大学　伊藤国際学術センター　伊藤謝恩ホール
- Year and Date
  2015-07-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430165
[Presentation] Age-associated increase of IL-6 dampens anti-tumor immune responses through attenuating Th1 differentiation of tumor-specific CD4 T cells2014
- Author(s)
  Tsukamoto, H., Senju, S., S.L. Swain and Nishimura, Y.
- Organizer
  アメリカ免疫学会
- Place of Presentation
  米国, Pittsburgh
- Data Source
  KAKENHI-PROJECT-24700994
[Presentation] 担癌個体で増加する可溶性IL-6Rは、腫瘍特異的Th1細胞分化の抑制を介して腫瘍増大に寄与する2013
- Author(s)
  Tsukamoto, H., Senju, S., and Nishimura, Y
- Organizer
  第17回日本がん免疫学会
- Place of Presentation
  山口、ANAクラウンプラザホテル宇部
- Data Source
  KAKENHI-PROJECT-24700994
[Presentation] 担癌個体で増加する可溶性IL-6Rは、腫瘍特異的Th1細胞の分化抑制を介して腫瘍増大に寄与する2013
- Author(s)
  塚本　博丈、千住　覚、西村　泰治
- Organizer
  日本がん免疫学会
- Place of Presentation
  山口県宇部市　ANAクラウンプラザホテル
- Data Source
  KAKENHI-PROJECT-24700994
[Presentation] 担癌個体で増加する可溶性IL-6Rは、腫瘍特異的TH1細胞の分化抑制を介して腫瘍を増大させる2013
- Author(s)
  Tsukamoto H, Matsumura K, Senju S and Nishimura Y
- Organizer
  日本免疫学会
- Place of Presentation
  千葉市　幕張メッセ
- Data Source
  KAKENHI-PROJECT-24700994
[Presentation] Soluble IL-6 receptor diminishes the differentiation of tumor-specific TH1 cells to exacerbate tumor progression2013
- Author(s)
  Tsukamoto, H., Senju, S., and Nishimura, Y.
- Organizer
  第42回日本免疫学会
- Place of Presentation
  千葉、幕張メッセ
- Data Source
  KAKENHI-PROJECT-24700994
[Presentation] Myeloid-derived suppressor cells attenuate Th1 development through IL-6 production to promote tumor progression2013
- Author(s)
  Tsukamoto H, Senju S and Nishimura Y
- Organizer
  International Congress of Immunology
- Place of Presentation
  イタリア　ミラノ
- Data Source
  KAKENHI-PROJECT-24700994
[Presentation] MDSC attenuate TH1 development of tumor-specific effector CD4 T cells through IL-6 production2012
- Author(s)
  Tsukamoto, H., Senju, S., and Nishimura, Y.
- Organizer
  第41回日本免疫学会
- Place of Presentation
  兵庫、神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24700994
[Presentation] Gr-1+ MDSC attenuate development of tumor-specific Th1 cells through IL-6 production to promote tumor progression2012
- Author(s)
  Tsukamoto, H., Senju, S., and Nishimura, Y.
- Organizer
  第16回日本がん免疫学会
- Place of Presentation
  北海道、北海道大学学術交流会館
- Data Source
  KAKENHI-PROJECT-24700994
[Presentation] Gr-1+ MDSC attenuate development of tumor-specific Th1 cells through IL-6 production to promote tumor progression.2012
- Author(s)
  Tsukamoto, H.
- Organizer
  第１６回　日本がん免疫学会総会
- Place of Presentation
  北海道大学学術交流会館
- Data Source
  KAKENHI-PROJECT-24700994
[Presentation] MDSC attenuate Th1 development of tumor-specific effector CD4+ T cells through IL-62012
- Author(s)
  Tsukamoto, H.
- Organizer
  第１4回　日本免疫学会総会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-24700994
[Presentation] タイトル: Gr-1^+MDSCは腫瘍特異的CD4^+T細胞の機能不全を誘導する2011
- Author(s)
  塚本博丈、千住覚、西村泰治
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  千葉、幕張メッセ
- Year and Date
  2011-12-02
- Data Source
  KAKENHI-PROJECT-22700897
[Presentation] Gr-1+MDSCは腫瘍特異的CD4+T細胞の機能不全を誘導する2011
- Author(s)
  塚本(粟井)博丈
- Organizer
  日本免疫学会総会・学術集会
- Place of Presentation
  千葉県幕張メッセ
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22700897
[Presentation] Bim dictates the development of age-associateds functional defects in naive CD4 T cells by regulating thier lifespan.2010
- Author(s)
  粟井(塚本)博丈
- Organizer
  第14回国際免疫学会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2010-08-26
- Data Source
  KAKENHI-PROJECT-22700897
[Presentation] Title : Bim dictates the development of age-associated functional defects in naive CD4 T cells by regulating their lifespan2010
- Author(s)
  Tsukamoto, H., Huston, G. E., Dibble, J., Duso, D. K. and Swain, S.
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe(International Exhibition Hall), Japan
- Year and Date
  2010-08-25
- Data Source
  KAKENHI-PROJECT-22700897
[Presentation] 老齢個体で増加するIL-6は、CD4+T細胞を介した抗腫瘍免疫応答を抑制する
- Author(s)
  塚本　博丈、　千住　覚、　松村　桂子、 Susan L. Swain、　西村　泰治
- Organizer
  第18回日本がん免疫学会総会
- Place of Presentation
  ひめぎんホール（愛媛県松山市）
- Year and Date
  2014-07-30 – 2014-08-01
- Data Source
  KAKENHI-PROJECT-26430165
[Presentation] IL-6-mediated environmental conditioning of defective Th1 differentiation dampens anti-tumour immune responses in old age.
- Author(s)
  Hirotake Tsukamoto, Satoru Senju, Susan L. Swain, Yasuharu Nishimura
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都国際会議場（京都市）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26430165

1. NISHIMURA Yasuharu (10156119)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. Ikeda Tokunori (00613530)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
3. Nakayama Hideki (70381001)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
4. Araki Kimi (90211705)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Senju Satoru (50274709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
6. Eto Masatoshi (90315078)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 入江厚 (30250343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
8. 河野健司 (90215187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
9. 冨田雄介 (90648619)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 村上孝作 (70599927)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 菰原義弘 (40449921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 三浦裕司 (10453698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. Fujieda Koji

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 冨田章裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 弓場英司

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 押海裕之

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
17. 平山令明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 西村康治

# of Collaborated Projects: 0 results

# of Collaborated Products: 25 results
19. 植村靖史

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. 張エイ

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. 樋口悠介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 倉橋竜磨

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 神波大己

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 元島崇信

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 矢津田旬二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 坂田晋也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. 宮下梓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 池田剛

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
29. 大西紘二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TSUKAMOTO HIROTAKE 塚本 博丈

Tsukamoto Hirotake 塚本 博丈

塚本博丈

粟井 博丈(塚本博丈) アワイ ヒロタケ

AWAI Hirotake 粟井 博丈

TSUKAMOTO Hirotake 塚本 博丈

Research Projects

Research Products

Co-Researchers

Clarification of macrophage subsets contributing to adverse events and immunosuppressive effects in cancer immunotherapyPrincipal Investigator

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development of therapeutic strategy for immune related adverse events by immune checkpoint inhivitor by focusing on B lymphocyte

Principal Investigator

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Development of irAE management strategy based on immuno-senescence, and novel cancer immunotherapy balancing augmented anti-tumor immunity and decreased risk of adverse eventsPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

Development of novel cancer immunotherapeutic approach based on age-associated inflammatory responsePrincipal Investigator

Principal Investigator

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Research Institution

Development of cancer immunotherapy using tumor-associated antigen-derived long peptides and liberation from immune suppression mediated trough IL-6 signaling

Principal Investigator

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The detrimental effect of soluble IL-6 receptor on CD4 T cell-mediated anti-tumor immune responsesPrincipal Investigator

Principal Investigator

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Analysis of functional defects in tumor-specific CD4+ T cells in aged animalsPrincipal Investigator

Principal Investigator

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Development of cellular cancer immunotherapy by using humaniPS-cell-derived dendritic cells and ideal cancer-associated antigens

Principal Investigator

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Analysis of Myeloid-derived suppressor cell-induced functional defects of CD4+T cells in tumor-bearing animalsPrincipal Investigator

Principal Investigator

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Research Institution

[Book] 医学のあゆみ：PD-(L)1阻害療法に伴う有害事象に関わる免疫応答機序2023

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Data Source

[Book] 医学のあゆみ 「PD-(L)1阻害療法に伴う有害事象に関わる免疫応答機序」2023

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[Book] 臨床免疫・アレルギー科：免疫チェックポイント分子によるがん免疫制御、耐性、副反応2023

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[Book] 実験医学増刊「新・腫瘍免疫学： がん免疫におけるマクロファージの役割」2020

Author(s)

TSUKAMOTO HIROTAKE 塚本博丈

Tsukamoto Hirotake 塚本博丈

粟井博丈(塚本博丈) アワイヒロタケ

AWAI Hirotake 粟井博丈

TSUKAMOTO Hirotake 塚本博丈

[Book] 医学のあゆみ　「PD-(L)1阻害療法に伴う有害事象に関わる免疫応答機序」2023

[Book] 実験医学増刊「新・腫瘍免疫学：がん免疫におけるマクロファージの役割」2020

[Book] 「がん免疫におけるマクロファージの役割」実験医学増刊2019

[Book] 標準免疫学第3版第2編第5章 G. ＭＨＣの構造と機能2018

[Book] アンチ・エイジング医学「免疫老化とがん免疫」2017

[Book] 臨床免疫・アレルギー科「IL-6と老年における免疫応答の低下」2016

[Book] 臨床免疫・アレルギー科「Myeloid-derived suppressor cells (MDSC)によるTh1細胞の抑制機序」2014

[Book] 腫瘍免疫の最前線：　T細胞を介した抗腫瘍免疫応答2013