Ishijima Yasushi 石嶋康史

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ISHIJIMA Yasushi 石嶋康史

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Researcher Number	10433640
Affiliation (Current)	2025: 鈴鹿医療科学大学, 薬学部, 准教授
Affiliation (based on the past Project Information) *help	2013 – 2017: 高崎健康福祉大学, 薬学部, 講師 2007 – 2012: 高崎健康福祉大学, 薬学部, 助教
Review Section/Research Field	Except Principal Investigator General medical chemistry
Keywords	Except Principal Investigator 遺伝子発現制御 / 転写因子 / マスト細胞 / 細胞分化 / トリプターゼ / 遺伝子発現 / プロテアーゼ / 赤血球 / 生体分子医学

Transcriptional regulation of mouse tryptase genes by GATA1 and GATA2 in mast cells.
- Principal Investigator
  
  Kinuko Ohneda
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Takasaki University of Health and Welfare
Roles of GATA transcription factors in the development and function of mast cells
- Principal Investigator
  
  OHNEDA Kinuko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Takasaki University of Health and Welfare
Roles of Gata1 in mature mast cells
- Principal Investigator
  
  OHNEDA Kinuko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Takasaki University of Health and Welfare
Analysis of gata1 deficiency in postnatal erythropoiesis
- Principal Investigator
  
  OHNEDA Kinuko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Takasaki University of Health and Welfare

All 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] GATA2 is critical for the maintenance of cellular identity in differentiated mast cells derived from mouse bone marrow.2015
- Author(s)
  Ohmori S, Moriguchi T, Noguchi Y, Ikeda M, Kobayashi K, Tomaru N, Ishijima Y, Ohneda O, Yamamoto M, Ohneda K.
- Journal Title
  
  Blood.
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24590359
[Journal Article] GATA2 is critical for the maintenance of cellular identity in differentiated mast cells derived from mouse bone marrow.2015
- Author(s)
  Ohmori S, Moriguchi T, Noguchi Y, Ikeda M, Kobayashi K, Tomaru N, Ishijima Y, Ohneda O, Yamamoto M, Ohneda K.
- Journal Title
  
  Blood
  
  Volume: 125 Issue: 21 Pages: 3306-3315
- DOI
  10.1182/blood-2014-11-612465
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860221, KAKENHI-PROJECT-15K08285, KAKENHI-PROJECT-15K19014
[Journal Article] Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese mice.2014
- Author(s)
  Ishijima Y, Ohmori S, Ohneda K.
- Journal Title
  
  FEBS Open Bio.
  
  Volume: 4 Pages: 18-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590359
[Journal Article] Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice.2014
- Author(s)
  Ohneda K, Moriguchi T, Ohmori S, Ishijima Y, Satoh H, Philipsen S, Yamamoto M.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 34 Issue: 10 Pages: 1812-1826
- DOI
  10.1128/mcb.01524-13
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590359, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24659142, KAKENHI-PUBLICLY-25118722, KAKENHI-PROJECT-25860221
[Journal Article] GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-γ12012
- Author(s)
  Ishijima Y, Ohmori S, Uenishi A, Ohneda K
- Journal Title
  
  Genes Cells
  
  Volume: 17 Pages: 285-301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590318
[Journal Article] The regulation of GATA factor expression is distinct between erythroid and mast cell lineages.2012
- Author(s)
  Ohmori S, Takai J, Ishijima Y, Suzuki M,　Moriguchi T, Philipsen S, Yamamoto M, Ohneda K.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 32 Issue: 23 Pages: 4742-4755
- DOI
  10.1128/mcb.00718-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590359, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24790957, KAKENHI-PUBLICLY-23118525
[Journal Article] GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-_Y12012
- Author(s)
  Ishijima Y, Ohmori S, Uenishi A, Ohneda K
- Journal Title
  
  Genes Cells
  
  Volume: 17 Pages: 285-301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590318
[Journal Article] Characterization of a functional ZBP-89 binding site that mediates Gata1 gene expression during hematopoietic development2009
- Author(s)
  Ohneda K, Ohmori S, Ishijima Y, Nakano M, Yamamoto M.
- Journal Title
  
  J Biol Chem. 284
  
  Pages: 30187-30199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590318
[Journal Article] Characterization of a functional ZBP-89 binding site that mediates Gata1 gene expression during hematopoietic development2009
- Author(s)
  Ohneda K, Ohmori S, Ishijima Y, Nakano M, Yamamoto M
- Journal Title
  
  J Biol Chem
  
  Volume: 284 Pages: 30187-30199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21590318
[Presentation] CRISPR/Cas9法によるGata2-136K領域を欠失した3T3-L1細胞の作製とその解析2017
- Author(s)
  石嶋康史, 大井田晃莉,　大森慎也, 大根田絹子
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K08285
[Presentation] マウス骨髄由来マスト細胞におけるGATA因子によるCebpa転写抑制機序の解析2017
- Author(s)
  島武志, 大森慎也, 石嶋康史, 大根田絹子
- Organizer
  平成29年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-15K08285
[Presentation] マウス皮下組織由来脂肪前駆細胞の分化過程における転写因子GATA2の機能解析2017
- Author(s)
  和田圭祐, 大森慎也, 丸山恭平, 石嶋康史, 大根田絹子
- Organizer
  平成29年度日本生化学会関東支部例会
- Data Source
  KAKENHI-PROJECT-15K08285
[Presentation] BMMCsにおいてCebpaはGATA因子とPU.1の相互作用によって制御される2017
- Author(s)
  大森慎也, 島武志,　養田真理, 石嶋康史, 大根田絹子
- Organizer
  2017年度生命科学系学会合同年次大会
- Data Source
  KAKENHI-PROJECT-15K08285
[Presentation] マウス骨髄由来マストにおけるGATA2、PU.1、RUNX1によるCebpa抑制メカニズムの解析2016
- Author(s)
  大森慎也, 掛野晶,　石嶋康史, 大根田絹子
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15K08285
[Presentation] 3T3-L1細胞の脂肪細胞分化においてGlucocorticoid受容体の活性化がGATA2の発現抑制をもたらす2016
- Author(s)
  石嶋康史, 大森慎也, 采女愛, 青木佑介, 小堀美樹, 大根田絹子
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際会議場（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15K08285
[Presentation] マスト細胞におけるGATA2のCebpa転写抑制メカニズムの解析－CRISPR/Cas9法によるCebpa+37K領域の機能的貢献の解析2016
- Author(s)
  掛野晶, 大森慎也, 石嶋康史, 大根田絹子
- Organizer
  平成28年度日本生化学会関東支部例会
- Place of Presentation
  自治医科大学　医学部　教育研究棟(栃木県下野市）
- Year and Date
  2016-06-11
- Data Source
  KAKENHI-PROJECT-15K08285
[Presentation] マスト細胞分化過程におけるGATA2を介したCebpa遺伝子の発現抑制メカニズムの解析2015
- Author(s)
  大森慎也, 石嶋康史, 大根田絹子
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K08285
[Presentation] 脂肪細胞分化におけるGATA因子の発現抑制機構の解析2015
- Author(s)
  石嶋康史, 大森慎也, 青木佑介, 采女愛, 丹野志保, 前川悠理, 大根田絹子
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K08285
[Presentation] マスト細胞におけるGATA2によるCebpa遺伝子の発現抑制機構の解析2014
- Author(s)
  小林浩太,　大森慎也,　石嶋康史,　森口尚,　山本雅之,　大根田絹子
- Organizer
  平成26年度日本生化学会関東支部例会
- Place of Presentation
  水戸
- Year and Date
  2014-06-14
- Data Source
  KAKENHI-PROJECT-24590359
[Presentation] GATA2欠失マスト細胞の分化転換能の解析2014
- Author(s)
  野口由紀,　大森慎也,　石嶋康史,　森口尚,　山本雅之,　大根田絹子
- Organizer
  平成26年度日本生化学会関東支部例会
- Place of Presentation
  水戸
- Year and Date
  2014-06-14
- Data Source
  KAKENHI-PROJECT-24590359
[Presentation] 脂肪細胞分化におけるGATA転写因子の機能解析2014
- Author(s)
  高木美紀,　石嶋康史,　大森慎也,　池田翔冴,　前川悠理,　大根田絹子
- Organizer
  平成26年度日本生化学会関東支部例会
- Place of Presentation
  水戸
- Year and Date
  2014-06-14
- Data Source
  KAKENHI-PROJECT-24590359
[Presentation] GATA2はマスト細胞の分化形質の維持に必須である2013
- Author(s)
  大森慎也,　石嶋康史,　森口尚,　山本雅之,　大根田絹子
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24590359
[Presentation] マスト細胞の欠失により脂肪組織に脂肪前駆細胞が蓄積する2013
- Author(s)
  石嶋康史,　大森慎也,　大根田絹子
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590359
[Presentation] 遺伝子の発現抑制が骨髄マスト細胞の分化形質の維持に必須である2013
- Author(s)
  大森慎也,　石嶋康史,　野口由紀,　森口尚,　山本雅之,　大根田絹子
- Organizer
  第36回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590359
[Presentation] GATA2 is essential for the maintenance of cellular identity in differentiated mast cells derived from mouse bone marrow.2012
- Author(s)
  大根田絹子、大森慎也、石嶋康史、森口尚、山本雅之
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24590359
[Presentation] GATA1 is dispensable for maturation of mast cells derived from mouse bone marrow.2012
- Author(s)
  大森慎也、石嶋康史、森口尚、山本雅之、大根田絹子
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場・マリンメッセ福岡
- Data Source
  KAKENHI-PROJECT-24590359
[Presentation] The roles of mast cells in diet-induced obesity in mice2011
- Author(s)
  Ishijima Y, et al.
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-21590318
[Presentation] GATA転写因子はPLC-γ1の発現調節を介してマスト細胞の脱顆粒に関与する2010
- Author(s)
  石嶋康史, 他
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-21590318
[Presentation] GATA transcription factors are involved in degranulation by enhancing the expression of phospholipase Cγ1 in RBL-2H3 cells2010
- Author(s)
  Ishijima Y, Uenishi A, Ohmori S, Ohneda K
- Organizer
  5^<th> International Symposium on GATA factors
- Place of Presentation
  東北大学艮陵会館(仙台)
- Data Source
  KAKENHI-PROJECT-21590318
[Presentation] GATA1は骨髄マスト細胞(BMMCs)の増殖と生存に必要である2010
- Author(s)
  植栗幸洋、大森慎也、石嶋康史、平林優奈、森口尚、Sjaak Philipsen、山本雅之、大根田絹子
- Organizer
  BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同年会)
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-21590318
[Presentation] GATA transcription factors are involved in degranulation by enhancing the expression of phospholipase C-γ1 in RBL-2H3 cells2010
- Author(s)
  Ishijima Y, et al.
- Organizer
  5^<th> International Symposium on GATA factors
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-21590318
[Presentation] Autonomous and network regulation of GATA factors in mast cells2010
- Author(s)
  Ohmori S, Ishijima Y, Ohneda K
- Organizer
  5^<th> International Symposium on GATA factors
- Place of Presentation
  東北大学艮陵会館(仙台)
- Data Source
  KAKENHI-PROJECT-21590318
[Presentation] GATA1 is required for survival and proliferation of committed mast cells derived from adult mouse bone marrow.2010
- Author(s)
  Ohneda K, Ohmori S, Yasushi Ishijima Y, Ueguri Y, Hirabayashi Y, Moriguchi T, Philipsen S, Yamamoto M
- Organizer
  5^<th> International Symposium on GATA factors
- Place of Presentation
  東北大学艮陵会館(仙台)
- Data Source
  KAKENHI-PROJECT-21590318
[Presentation] GATA転写因子はPLC-γ1の発現調節を介してマスト細胞の脱顆粒に関与する2010
- Author(s)
  石嶋康史, 上西綾乃, 大森慎也, 大根田絹子
- Organizer
  BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同年会)
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-21590318
[Presentation] GATA transcription factors are involved in degranulation of RBL-2H3 cells2009
- Author(s)
  石嶋康史, 他
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-21590318
[Presentation] マスト細胞におけるGATA 転写因子の自立的およびネットワーク発現機構BMB20082008
- Author(s)
  大森慎也、石嶋康史、大根田絹子
- Organizer
  日本生化学会・日本分子生物学会合同年会
- Place of Presentation
  神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-19590286
[Presentation] Characterization of a functional ZBP-89 biniding site that mediates gata1 gene expression during hematopoietic development2008
- Author(s)
  Ohneda K, Nakano M, Ishijima Y, Yamamoto M.
- Organizer
  16^<th> Hemoglobin Switching meeting
- Place of Presentation
  Monterey, California
- Data Source
  KAKENHI-PROJECT-19590286
[Presentation] マスト細胞におけるGATA転写因子の自立的およびネットワーク発現機構2008
- Author(s)
  大森慎也, 石嶋康史, 大根田絹子
- Organizer
  BMB2008 (日本生化学会・日本分子生物学会合同年会)
- Place of Presentation
  兵庫県神戸市神戸ポートアイランド
- Data Source
  KAKENHI-PROJECT-19590286
[Presentation] 3T3-L1細胞の脂肪細胞分化におけるGATA因子の機能解析
- Author(s)
  石嶋康史,　大森慎也,　池田翔冴,　高木美紀,　前川悠理,　大根田絹子
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24590359
[Presentation] Delta doubleGATAマウスにおけるマスト細胞の性状解析
- Author(s)
  戸野倉知佳、石嶋康史、大森慎也、大根田絹子
- Organizer
  平成24年度日本生化学会関東支部例会
- Place of Presentation
  群馬大学
- Data Source
  KAKENHI-PROJECT-24590359
[Presentation] 骨髄マスト細胞(BMMCs)の増殖と生存にGATA1は必須ではない
- Author(s)
  中島可絵、大森慎也、石嶋康史、大根田絹子
- Organizer
  平成24年度日本生化学会関東支部例会
- Place of Presentation
  群馬大学
- Data Source
  KAKENHI-PROJECT-24590359
[Presentation] GATA2がCebpaの転写を抑制することが骨髄マスト細胞の分化形質維持に必要である,
- Author(s)
  大森慎也,　登丸菜月,　石嶋康史,　森口尚,　山本雅之,　大根田絹子
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-24590359

1. OHNEDA Kinuko (50323291)

# of Collaborated Projects: 4 results

# of Collaborated Products: 37 results
2. OHMORI Shinya (10509194)

# of Collaborated Projects: 4 results

# of Collaborated Products: 37 results

Ishijima Yasushi 石嶋 康史

ISHIJIMA Yasushi 石嶋 康史

Research Projects

Research Products

Co-Researchers

Transcriptional regulation of mouse tryptase genes by GATA1 and GATA2 in mast cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of GATA transcription factors in the development and function of mast cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of Gata1 in mature mast cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of gata1 deficiency in postnatal erythropoiesis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] GATA2 is critical for the maintenance of cellular identity in differentiated mast cells derived from mouse bone marrow.2015

Author(s)

Journal Title

Data Source

[Journal Article] GATA2 is critical for the maintenance of cellular identity in differentiated mast cells derived from mouse bone marrow.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mast cell deficiency results in the accumulation of preadipocytes in adipose tissue in both obese and non-obese mice.2014

Author(s)

Journal Title

Data Source

[Journal Article] Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-γ12012

Author(s)

Journal Title

Data Source

[Journal Article] The regulation of GATA factor expression is distinct between erythroid and mast cell lineages.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-_Y12012

Author(s)

Journal Title

Data Source

[Journal Article] Characterization of a functional ZBP-89 binding site that mediates Gata1 gene expression during hematopoietic development2009

Author(s)

Journal Title

Data Source

[Journal Article] Characterization of a functional ZBP-89 binding site that mediates Gata1 gene expression during hematopoietic development2009

Author(s)

Journal Title

Data Source

[Presentation] CRISPR/Cas9法によるGata2-136K領域を欠失した3T3-L1細胞の作製とその解析2017

Author(s)

Organizer

Data Source

[Presentation] マウス骨髄由来マスト細胞におけるGATA因子によるCebpa転写抑制機序の解析2017

Author(s)

Organizer

Data Source

[Presentation] マウス皮下組織由来脂肪前駆細胞の分化過程における転写因子GATA2の機能解析2017

Author(s)

Organizer

Data Source

Ishijima Yasushi 石嶋康史

ISHIJIMA Yasushi 石嶋康史