Fukamachi Haruka 深町はるか

… Alternative Names

深町はるかフカマチハルカ

FUKAMACHI Haruka 深町はるか

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Researcher Number	10433799
Other IDs	https://orcid.org/0000-0002-7178-6747
Affiliation (Current)	2025: 昭和大学, 歯学部, 助教
Affiliation (based on the past Project Information) *help	2017 – 2024: 昭和大学, 歯学部, 助教 2013 – 2015: 昭和大学, 歯学部, 助教 2010 – 2011: 昭和大学, 歯学部, 助教 2007 – 2008: Showa University, 歯学部, 助教 2007: 昭和大, 歯学部, 助手 2006: 昭和大学, 歯学部, 助手
Review Section/Research Field	Principal Investigator Morphological basic dentistry / Basic Section 57020:Oral pathobiological science-related Except Principal Investigator Morphological basic dentistry
Keywords	Principal Investigator クレブシエラ / 歯周病原細菌 / 齲蝕予防 / Sortase / RNA-seq / 環境適応 / ホスフォトランスフェラーゼシステム / クレブシエラ菌 / germ-freeマウス / gnotobioteマウス … More / 腸管免疫応答 / 腸管定着 / 肺炎球菌 / ヌクレアーゼ / 歯周病原性細菌 / Prevotella intermedia / 鉄獲得機構 / P. intermedia / S.mutans / デキストラン分解酵素 / Streptococcus mutans / Dextranase … More Except Principal Investigator 感染症 / 核酸 / 細菌 / Streptococcus oralis / csRNA / Streptococcus sanguinis / トランスポーター / リポ蛋白質 / LspA / Lgt / 抗食作用能 / 耐酸性 / Streptococcus mutans / リポタンパク質 Less

口腔・腸管に定着するクレブシエラ菌の環境適応と病原性発現との関連Principal Investigator
- Principal Investigator
  
  深町はるか
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Showa University
腸管粘液由来の糖利用競争力を介したクレブシエラ菌の腸内定着に及ぼす影響の解明Principal Investigator
- Principal Investigator
  
  深町はるか
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Showa University
Elucidation of the regulatory mechanisms for bacterial virulence with small RNAs.
- Principal Investigator
  
  Morisaki Hirobumi
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Showa University
Molecular analysis of nucleases from periodontal bacteria and the role in pneumococcal infectionPrincipal Investigator
- Principal Investigator
  
  Fukamachi Haruka
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Showa University
Characterization of heme acquisition system of periodontal bacteriaPrincipal Investigator
- Principal Investigator
  
  Fukamachi Haruka
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Showa University
リポ蛋白質合成酵素を標的とした新規齲蝕予防戦略の基礎研究
- Principal Investigator
  
  五十嵐武
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Showa University
Development of a new preventive strategy in dental caries : target to Sortase produced by cariogenic bacteriaPrincipal Investigator
- Principal Investigator
  
  FUKAMACHI Haruka
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Showa University
Sortaseを標的とした新しい病原細菌感染症予防法の開発に関する基礎研究Principal Investigator
- Principal Investigator
  
  深町はるか
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  Showa University

[Journal Article] The Klebsiella mannose phosphotransferase system promotes proliferation and the production of extracellular polymeric substances from mannose, facilitating adaptation to the host environment2024
- Author(s)
  Miki Suguru、Fukamachi Haruka、Itsumi Momoe、Fujiwara Nagatoshi、Takaki Takashi、Kurosawa Mie、Morisaki Hirobumi、Suzuki Noriyuki、Kuwata Hirotaka
- Journal Title
  
  Journal of Oral Biosciences
  
  Volume: 66 Issue: 1 Pages: 119-125
- DOI
  10.1016/j.job.2024.01.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K09861
[Journal Article] アテローム性動脈硬化病変部の細菌叢と口腔細菌叢のメタゲノム解析2021
- Author(s)
  三宅理子, 佐藤あや子, 清水茉利奈, 松井庄平, 深町はるか, 有本隆文, 桑田啓貴, 武藤光範, 木庭新治, 丸岡靖史
- Journal Title
  
  日本口腔科学会雑誌
  
  Volume: 70 Pages: 254-261
- NAID
  130008100564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11628
[Journal Article] Dysregulation of Intestinal Microbiota Elicited by Food Allergy Induces IgA-Mediated Oral Dysbiosis2019
- Author(s)
  Matsui Shohei、Kataoka Hideo、Tanaka Jun-Ichi、Kikuchi Mariko、Fukamachi Haruka、Morisaki Hirobumi、Matsushima Hitomi、Mishima Kenji、Hironaka Shoji、Takaki Takashi、Okahashi Nobuo、Maruoka Yasubumi、Kuwata Hirotaka
- Journal Title
  
  Infection and Immunity
  
  Volume: 88 Issue: 1
- DOI
  10.1128/iai.00741-19
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11628, KAKENHI-PROJECT-17K11958, KAKENHI-PROJECT-17H07108, KAKENHI-PROJECT-19K07423, KAKENHI-PROJECT-18K09558
[Journal Article] Streptococcus sanguinis non-coding csRNAs negatively regulate expression of type IV pilus retraction ATPase PilT and biofilm formation2018
- Author(s)
  Ota C, Morisaki H, Nakata M, Arimoto T, Fukamachi H, Kataoka H, Masuda Y, Suzuki N, Miyazaki T, Okahashi N, Kuwata H
- Journal Title
  
  Infect Immun
  
  Volume: 86 Issue: 3 Pages: 1-13
- DOI
  10.1128/iai.00894-17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11610, KAKENHI-PROJECT-17K11627, KAKENHI-PROJECT-17K11628, KAKENHI-PROJECT-17K11958, KAKENHI-PROJECT-17K19751, KAKENHI-PROJECT-15KK0306, KAKENHI-PROJECT-17H04369, KAKENHI-PROJECT-18K19643, KAKENHI-PROJECT-18K09558
[Journal Article] Microarray and gene co-expression analysis reveals that melatonin attenuates immune responses and modulates actin rearrangement in macrophages2017
- Author(s)
  Kadena Miki、Kumagai Yutaro、Vandenbon Alexis、Matsushima Hitomi、Fukamachi Haruka、Maruta Noboru、Kataoka Hideo、Arimoto Takafumi、Morisaki Hirobumi、Funatsu Takahiro、Kuwata Hirotaka
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 485 Issue: 2 Pages: 414-420
- DOI
  10.1016/j.bbrc.2017.02.063
- Data Source
  KAKENHI-PROJECT-17K11628
[Journal Article] Microarray analysis of macrophage response to infection with Streptococcus oralis reveals the immunosuppressive effect of hydrogen peroxide2017
- Author(s)
  H. Matsushima, Y. Kumagai, A. Vandenbon, H. Kataoka, M. Kadena, H. Fukamachi, T. Arimoto, H. Morisaki, N. Fujiwara, N. Okahashi, and H. Kuwata
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 485(2) Issue: 2 Pages: 461-467
- DOI
  10.1016/j.bbrc.2017.02.048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460543, KAKENHI-PROJECT-26463112, KAKENHI-PROJECT-16K08792, KAKENHI-PROJECT-17K11628, KAKENHI-PROJECT-17K11958
[Journal Article] Determination of reactive oxygen generated from natural medicines and their antibacterial activity2016
- Author(s)
  Tajima N, Takasaki M, Fukamachi H, Igarashi T, Nakajima Y, Arakawa H.
- Journal Title
  
  Journal of Pharmaceutical Analysis
  
  Volume: in press Issue: 4 Pages: 214-218
- DOI
  10.1016/j.jpha.2016.04.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25861750
[Journal Article] Effects of Hangeshashinto on Growth of Oral Microorganisms.2015
- Author(s)
  Fukamachi H, Matsumoto C, Omiya Y, Arimoto T, Morisaki H, Kataoka H, Kadena M, Funatsu T, Fukutake M, Kase Y, Kuwata H.
- Journal Title
  
  Evidence-Based Complementary and Alternative Medicine
  
  Volume: 2015 Pages: 512947-512947
- DOI
  10.1155/2015/512947
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25861750
[Journal Article] Antibacterial Activities of Persimmon Extracts Relate with Their Hydrogen Peroxide Concentration2014
- Author(s)
  Arakawa H, Takasaki M, Tajima N, Fukamachi H, Igarashi T.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 37 Issue: 7 Pages: 1119-1123
- DOI
  10.1248/bpb.b13-00952
- NAID
  130004057433
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25861750
[Journal Article] Rothia dentocariosa induces TNF-alpha production in a TLR2-dependent manner.2014
- Author(s)
  Kataoka H, Taniguchi M, Fukamachi H, Arimoto T, Morisaki H, Kuwata H.
- Journal Title
  
  Pathog Dis.
  
  Volume: 71(1) Issue: 1 Pages: 65-8
- DOI
  10.1111/2049-632x.12115
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24570210, KAKENHI-PROJECT-25861750
[Journal Article] Identification and functional analysis of the gene cluster for fructan utilization in2013
- Author(s)
  Haruka Fuse, Haruka Fukamachi, Mitsuko Inoue, Takeshi Igarashi
- Journal Title
  
  Prevotella intermediaGene
  
  Volume: 515 Issue: 2 Pages: 291-297
- DOI
  10.1016/j.gene.2012.12.023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890210, KAKENHI-PROJECT-25861750
[Patent] L-システインの測定方法及び測定用試薬2008
- Inventor(s)
  中野善夫,吉田康夫,吉村満美子,深町はるか,西矢芳昭
- Industrial Property Rights Holder
  株式会社産学連携機構九州東洋紡績株式会社
- Filing Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19791350
[Patent] L-システインの測定方法及び測定用試薬2008
- Inventor(s)
  中野善夫, 吉田康夫, 吉村満美子, 深町はるか, 西矢芳昭
- Industrial Property Rights Holder
  株式会社産学連携機構九州東洋紡績株式会社
- Filing Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19791350
[Presentation] ヒト口腔細菌叢移植マウスの急性肺障害誘導による誤嚥性肺炎マウスモデルの作製2023
- Author(s)
  林真奈美，森美菜，逸見百江，黒澤実愛，深町はるか，森崎弘史，桑田啓貴
- Organizer
  第９６回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-21K09861
[Presentation] Klebsiellaの腸内定着に及ぼすマンノースホスホトランスフェラーゼシステムの影響2023
- Author(s)
  三木優, 深町はるか, 逸見百江, 森崎弘史, 黒澤実愛, 桑田啓貴
- Organizer
  第34回日本生体防御学会学術総会
- Data Source
  KAKENHI-PROJECT-21K09861
[Presentation] 口腔粘膜好中球の分化誘導における常在細菌叢の役割2023
- Author(s)
  森美菜，林真奈美，中村夏野，逸見百江，黒澤実愛，深町はるか，森崎弘史，桑田啓貴
- Organizer
  第９６回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-21K09861
[Presentation] Klebsiellaのマンノースホスホトランスフェラーゼシステムは腸管定着関連因子である2023
- Author(s)
  三木優, 深町はるか, 逸見百江, 森崎弘史, 黒澤実愛, 桑田啓貴
- Organizer
  第65回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-21K09861
[Presentation] Klebsiella pneumoniaeの腸管定着におけるマンノースホスホトランスフェラーゼシステムの役割の解明2023
- Author(s)
  三木優, 深町はるか, 逸見百江, 森崎弘史, 黒澤実愛, 鈴木規元, 桑田啓貴
- Organizer
  第392回昭和大学学士会例会
- Data Source
  KAKENHI-PROJECT-21K09861
[Presentation] HOMA（ヒト口腔細菌定着）マウスモデルを用いた口腔常在菌による肺炎増悪誘導の解析2022
- Author(s)
  林真奈美、逸見百江、森美菜、深町はるか、桑田啓貴
- Organizer
  第９５回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17K11628
[Presentation] 常在細菌は口腔内の免疫細胞の分化に重要な役割を果たしている2022
- Author(s)
  森美菜、Natasa Trtic、逸見百江、中村夏野、林真奈美、深町はるか、桑田啓貴
- Organizer
  第９５回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17K11628
[Presentation] HOMA(ヒト口腔細菌定着)マウスモデルを用いた口腔常在菌による肺炎増悪誘導の解析2022
- Author(s)
  林真奈美、逸見百江、森美菜、深町はるか、桑田啓貴
- Organizer
  第９５回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-21K09861
[Presentation] Regulation of type IV pilus retraction ATPase pilT by small noncoding RNAs in Streptococcus sanguinis2017
- Author(s)
  Chiaki Ota, Hirobumi Morisaki, Takafumi Arimoto, Haruka Fukamachi, Hideo Kataoka, Yoshiko Masuda, Noriyuki Suzuki, Takashi Miyazaki,Hirotaka Kuwata
- Organizer
  第65回国際歯科研究学会日本部会総会・学術大会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11627
[Presentation] Streptococcus sanguinisのノンコーディングcsRNAはⅣ型線毛pilT遺伝子の発現を負に制御し、バイオフィルム形成を抑制する2017
- Author(s)
  大田　千明、森崎　弘史、有本　隆文、深町　はるか、片岡　嗣雄、増田　宜子、鈴木　規元、宮﨑　隆、桑田　啓貴
- Organizer
  第59回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-17K11627
[Presentation] Streptococcus sanguinis のノンコーディング csRNA は IV 型線毛 pilT 遺伝子の発現を負に制御し，バイオフィルム形成を抑制する2017
- Author(s)
  大田千明，森崎弘史，有本隆文，深町はるか，片岡嗣雄，鈴木規元，増田宜子，宮崎隆，桑田啓貴
- Organizer
  第59回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-17K11628
[Presentation] Prevotella melaninogenicaのDextranase遺伝子の同定とその解析2009
- Author(s)
  深町はるか, 高橋真和, 五十嵐武
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-03-12
- Data Source
  KAKENHI-PROJECT-19791350
[Presentation] Prevotella melaninogenicaのDextranase遺伝子の同定とその解析2009
- Author(s)
  深町はるか,高橋真和,五十嵐武
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19791350
[Presentation] prevotella intermediaのフルクタン分解酵素の活性部位の解析2009
- Author(s)
  布施晴香, 深町はるか, 井上美津子, 五十嵐武
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-03-12
- Data Source
  KAKENHI-PROJECT-19791350
[Presentation] Prevotella intermediaのフルクタン分解酵素の活性部位の検索2009
- Author(s)
  布施晴香,深町はるか,井上美津子,五十嵐武
- Organizer
  第82回日本細菌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19791350
[Presentation] Streptococcus mutansのTrehalose-6-リン酸分解酵素の解析2008
- Author(s)
  深町はるか,森崎弘史,栗原華絵子,有本隆文,五十嵐武
- Organizer
  第49回歯科基礎医学会学術大会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19791350
[Presentation] Prevotella intermediaのフルクタン分解酵素の解析2008
- Author(s)
  布施晴香,深町はるか,井上美津子,五十嵐武
- Organizer
  第50回歯科基礎医学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19791350
[Presentation] Prevotella intermediaのシステイン分解酵素の解析2008
- Author(s)
  矢野智也, 深町はるか, 山本松男, 五十嵐武
- Organizer
  第50回歯科基礎医学会学術大会
- Place of Presentation
  TOC有明コンベンションホール
- Year and Date
  2008-09-24
- Data Source
  KAKENHI-PROJECT-19791350
[Presentation] Prevotella intermediaのフルクタン分解酵素の解析2008
- Author(s)
  布施晴香, 深町はるか, 井上美津子, 五十嵐武
- Organizer
  第50回歯科基礎医学会学術大会
- Place of Presentation
  TOC有明コンベンションホール
- Year and Date
  2008-09-24
- Data Source
  KAKENHI-PROJECT-19791350
[Presentation] Prevotella intermediaのシステイン分解酵素の解析2008
- Author(s)
  矢野智也,深町はるか,山本松男,五十嵐武
- Organizer
  第50回歯科基礎医学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19791350
[Presentation] Streptococcus mutansのリポタンパク質修飾酵素prolipoprotein diacylglyceryl transferaseの機能解析2007
- Author(s)
  有本隆文,深町はるか,森崎弘史,栗原華絵子,櫨場八裕,五十嵐武
- Organizer
  第49回歯科基礎医学会学術大会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-19791350
[Presentation] Streptococcus mutansのTrehalose-6-酸分解酵素の解析2007
- Author(s)
  深町はるか・森崎弘史・栗原華絵子・有本隆文・高橋真和・五十嵐武
- Organizer
  第49回歯科基礎医学会
- Place of Presentation
  北海道大学
- Data Source
  KAKENHI-PROJECT-19791350
[Presentation] Prevotella intermedia extracellular nucleases contribute to degradation of neutrophil extracellular traps
- Author(s)
  Haruka Fukamachi, Midori Doke, Hirobumi Morisaki, Takafumi Arimoto, Hideo Kataoka, and Hirotaka Kuwata
- Organizer
  Japanese Association for Dental Research
- Place of Presentation
  大阪市
- Year and Date
  2014-12-04 – 2014-12-05
- Data Source
  KAKENHI-PROJECT-25861750

1. Morisaki Hirobumi (30317581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. 五十嵐武 (10159585)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 片岡嗣雄 (60451390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 桑田啓貴 (60380523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. NAKATA Masanobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. FUSE Haruka

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 藤原永年

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Fukamachi Haruka 深町 はるか

深町 はるか フカマチ ハルカ

FUKAMACHI Haruka 深町 はるか

Research Projects

Research Products

Co-Researchers

口腔・腸管に定着するクレブシエラ菌の環境適応と病原性発現との関連Principal Investigator

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腸管粘液由来の糖利用競争力を介したクレブシエラ菌の腸内定着に及ぼす影響の解明Principal Investigator

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Elucidation of the regulatory mechanisms for bacterial virulence with small RNAs.

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Molecular analysis of nucleases from periodontal bacteria and the role in pneumococcal infectionPrincipal Investigator

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Characterization of heme acquisition system of periodontal bacteriaPrincipal Investigator

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リポ蛋白質合成酵素を標的とした新規齲蝕予防戦略の基礎研究

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Development of a new preventive strategy in dental caries : target to Sortase produced by cariogenic bacteriaPrincipal Investigator

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Sortaseを標的とした新しい病原細菌感染症予防法の開発に関する基礎研究Principal Investigator

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[Journal Article] The Klebsiella mannose phosphotransferase system promotes proliferation and the production of extracellular polymeric substances from mannose, facilitating adaptation to the host environment2024

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[Journal Article] アテローム性動脈硬化病変部の細菌叢と口腔細菌叢のメタゲノム解析2021

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NAID

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[Journal Article] Dysregulation of Intestinal Microbiota Elicited by Food Allergy Induces IgA-Mediated Oral Dysbiosis2019

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[Journal Article] Streptococcus sanguinis non-coding csRNAs negatively regulate expression of type IV pilus retraction ATPase PilT and biofilm formation2018

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[Journal Article] Microarray and gene co-expression analysis reveals that melatonin attenuates immune responses and modulates actin rearrangement in macrophages2017

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[Journal Article] Microarray analysis of macrophage response to infection with Streptococcus oralis reveals the immunosuppressive effect of hydrogen peroxide2017

Fukamachi Haruka 深町はるか

深町はるかフカマチハルカ

FUKAMACHI Haruka 深町はるか

[Presentation] ヒト口腔細菌叢移植マウスの急性肺障害誘導による誤嚥性肺炎マウスモデルの作製2023