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WU Wenwen  呉 文文

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呉 文文  ウ ウェンウェン

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Researcher Number 10434408
Other IDs
Affiliation (Current) 2025: 聖マリアンナ医科大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help 2019: 聖マリアンナ医科大学, 医学研究科, 准教授
2016 – 2018: 聖マリアンナ医科大学, 医学研究科, 講師
2015: 聖マリアンナ医科大学, 医学(系)研究科(研究院), 講師
2014: 聖マリアンナ医科大学, 医学(系)研究科(研究院), 助教
2008 – 2013: St.Marianna University School of Medicine, 医学部, 助教
Review Section/Research Field
Principal Investigator
Pathological medical chemistry / General medical chemistry
Keywords
Principal Investigator
HERC2 / BRCA1 / BLM / Claspin / 複製フォーク / ユビキチン化 / 細胞周期 / MCM / RPA2 / グアニン4重鎖 … More / DNA複製ストレス応答 / RPA / RAP80 / BACH1 / DNA repair / BARD1 / PARPi / HKMTi / H3K9me2 / HP1 / CtIP / FANCJ / claspin / ATRIP / 細胞周期チェックポイント / MCM2 / ATRIP / BRCAI / DNA修復 / Chk1 / Mチェックポイント / G2 / DNA障害 / 乳癌 Less
  • Research Projects

    (4 results)
  • Research Products

    (40 results)
  • Co-Researchers

    (2 People)
  •  Study on the role for HERC2 in the response to replication stressPrincipal Investigator

    • Principal Investigator
      Wu Wenwen
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      St. Marianna University School of Medicine
  •  The Feature of BRCA1 function on DNA Damage Repair within higher-order chromatin structurePrincipal Investigator

    • Principal Investigator
      Wu Wenwen
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      St. Marianna University School of Medicine
  •  The role of BRCA1-HERC2 complex in DNA replication fork progression and stress responsePrincipal Investigator

    • Principal Investigator
      WU WENWEN
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      St. Marianna University School of Medicine
  •  A study on the molecular mechanisms of BRCA1-mediated cell cycle regulation from a comprehensive protein interaction analysis approachPrincipal Investigator

    • Principal Investigator
      WU Wenwen
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      St.Marianna University School of Medicine

All 2019 2018 2017 2016 2015 2013 2012 2011 2010 2009 2008 Other

All Journal Article Presentation

  • [Journal Article] HERC2 regulates RPA2 by mediating ATR-induced Ser33 phosphorylation and ubiquitin-dependent degradation.2019

    • Author(s)
      Lai Y, Zhu M, Wu W, Rokutanda N, Togashi Y, Liang W, Ohta T.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 14257-14257

    • DOI

      10.1038/s41598-019-50812-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08676, KAKENHI-PROJECT-17H03585
  • [Journal Article] HERC2 facilitates BLM and WRN helicase complex interaction with RPA to suppress G-quadruplex DNA.2018

    • Author(s)
      Wu W, Rokutanda N, Takeuchi J, Lai Y, Maruyama R, Togashi Y, Nishikawa H, Arai N, Miyoshi Y,Suzuki N, Saeki Y, Tanaka K, Ohta T.
    • Journal Title

      Cancer Res.

      Volume: 78 Issue: 22 Pages: 6371-6385

    • DOI

      10.1158/0008-5472.can-18-1877

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08676, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05498, KAKENHI-PROJECT-18H03993, KAKENHI-PROJECT-17H03585, KAKENHI-PROJECT-17K18336
  • [Journal Article] Fbxo22-mediated KDM4B degradation determines selective estrogen receptor modulator activity in breast cancer.2018

    • Author(s)
      Johmura Y, Maeda I, Suzuki N, Wu W, Goda A,Morita M, Yamaguchi K, Yamamoto M, Nagasawa S, Kojima Y, Tsugawa K, Inoue N, Miyoshi Y, Osako T Akiyama F, Maruyama R, Inoue JI, Fukukawa Y, Ohta T, Nkanishi M.
    • Journal Title

      J Clin Invest.

      Volume: 128 Issue: 12 Pages: 5603-5619

    • DOI

      10.1172/jci121679

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08676, KAKENHI-PROJECT-18K15235, KAKENHI-PLANNED-16H06575, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05026, KAKENHI-PROJECT-17H03575, KAKENHI-PROJECT-17H03585, KAKENHI-PROJECT-16H06148, KAKENHI-PROJECT-16K15238, KAKENHI-PROJECT-17K18336, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17H01398, KAKENHI-PROJECT-17K07214
  • [Journal Article] HP1 regulates the localization of FANCJ at sites of DNA double-strand breaks.2016

    • Author(s)
      Wu W, Togashi Y, Johmura Y, Miyoshi Y, Nobuoka S, Nakanishi M, Ohta T.
    • Journal Title

      Cancer Sci.

      Volume: 107 Issue: 10 Pages: 1406-1415

    • DOI

      10.1111/cas.13008

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-24112005, KAKENHI-PROJECT-16H06148, KAKENHI-PROJECT-26460402, KAKENHI-PROJECT-16K15238, KAKENHI-PROJECT-16K15712, KAKENHI-PROJECT-16K15239, KAKENHI-PROJECT-26290042, KAKENHI-PROJECT-26250027
  • [Journal Article] Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage.2015

    • Author(s)
      Wu W, Nishikawa H, Fukuda T, Vittal V, Asano M, Miyoshi Y, Klevit RE, Ohta T
    • Journal Title

      Cancer Res

      Volume: 75 Issue: 7 Pages: 1311-1321

    • DOI

      10.1158/0008-5472.can-14-2796

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460402, KAKENHI-PLANNED-24112005, KAKENHI-PROJECT-26670730, KAKENHI-PROJECT-25290031, KAKENHI-PROJECT-26290042
  • [Journal Article] Class I HDAC inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage2015

    • Author(s)
      Fukuda T,Wu W, Okada M,Maeda I, Kojima Y, Hayami R, Miyoshi Y, Tsugawa K, Ohta T
    • Journal Title

      Cancer Science

      Volume: 106 Issue: 8 Pages: 1050-1056

    • DOI

      10.1111/cas.12717

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460402, KAKENHI-PLANNED-24112005, KAKENHI-PUBLICLY-26102741, KAKENHI-PROJECT-26670730, KAKENHI-PROJECT-26290042
  • [Journal Article] Liganded ERα stimulates the E3 ubiquitin ligase activity of UBE3C to facilitate cell proliferation2015

    • Author(s)
      Okada M, Ohtake F, Nishikawa H, Wu W, Saeki Y, Takana K, Ohta T
    • Journal Title

      Molecular Endocrinology

      Volume: 29 Issue: 11 Pages: 1646-1657

    • DOI

      10.1210/me.2015-1125

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460402, KAKENHI-PLANNED-24112005, KAKENHI-PLANNED-24112008, KAKENHI-PUBLICLY-26102741, KAKENHI-PROJECT-26670730, KAKENHI-PROJECT-26290042, KAKENHI-PROJECT-26000014
  • [Journal Article] MED12 exon 2 mutations in phyllodes tumors of the breast2015

    • Author(s)
      Nagasawa S, Maeda I, Fukuda T, Wu W, Hayami R, Kojima Y, Tsugawa KI, Ohta T
    • Journal Title

      Cancer Med

      Volume: Epub ahead of print Issue: 7 Pages: 1-5

    • DOI

      10.1002/cam4.462

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460402, KAKENHI-PLANNED-24112005, KAKENHI-PROJECT-26670730, KAKENHI-PROJECT-26290042
  • [Journal Article] The BARD1/HP1 interaction: another clue about heterochromatin involvement in homologous recombination2015

    • Author(s)
      Fukuda T, Tsuruga T, Kuroda T, Takeuchi J, Wu W, Ohta T
    • Journal Title

      Molecular & Cellular Oncology

      Volume: aEpub ahead of print Issue: 2 Pages: 1-3

    • DOI

      10.1080/23723556.2015.1030535

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460402, KAKENHI-PLANNED-24112005, KAKENHI-PROJECT-26670730, KAKENHI-PROJECT-26290042
  • [Journal Article] Aberrant DNA methylation status of DNA repair genes in breast cancer treated with neoadjuvant chemotherapy2013

    • Author(s)
      Watanabe Y, Maeda I, Oikawa R, Wu W, Tsuchiya K, Miyoshi Y, Itoh F, Tsugawa K, Ohta T
    • Journal Title

      Genes to Cells

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590348
  • [Journal Article] Aberrant DNA methylation status of DNA repair genes in breast cancer treated with neoadjuvant chemotherapy2013

    • Author(s)
      Watanabe Y, Maeda I, Oikawa R, Wu W, Tsuchiya K, Miyoshi Y, Itoh F, Tsugawa K, Ohta T
    • Journal Title

      Genes to Cells

      Volume: 18(12) Issue: 12 Pages: 1120-1130

    • DOI

      10.1111/gtc.12100

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23300358, KAKENHI-PROJECT-23590348, KAKENHI-PLANNED-24112005
  • [Journal Article] HERC2 Interacts with Claspin and regulates DNA origin firing and replication fork progression2011

    • Author(s)
      Izawa N, Wu W, Sato K, Nishikawa H, Kato A, Boku N, Itoh F, Ohta T
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 5621-5625

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590348
  • [Journal Article] The BRCA1 ubiquitin ligase and homologous recombination repair2011

    • Author(s)
      Ohta T, Sato K, Wu W
    • Journal Title

      FEBS Lett

      Volume: 585 Pages: 2836-2844

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590348
  • [Journal Article] phosphorylated NPM1 to sites of DNA damage through RNF8-dependent ubiquitin conjugates.2010

    • Author(s)
      Koike A, Nishikawa H, Wu W, Okada Y, Venkitaraman AR, Ohta T
    • Journal Title

      Cancer Res. 70

      Pages: 6746-56

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590318
  • [Journal Article] is an E3 ligase that targets BRCA1 for degradation.2010

    • Author(s)
      Wu W, Sato K, Koike A, Nishikawa H, Koizumi H, Venkitaraman AR, Ohta T
    • Journal Title

      Cancer Res. 70

      Pages: 6384-92

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590318
  • [Journal Article] Prediction of breast cancer sensitivity to neoadjuvant chemotherapy based on status of DNA damage repair proteins.2010

    • Author(s)
      Asakawa H, Koizumi H, Koike A, Takahashi M, Wu W, Hirotaka Iwase, Fukuda M, Ohta T
    • Journal Title

      Breast Cancer Research. 12:R17

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590318
  • [Journal Article] HERC2 is an E3 ligase that targets BRCA1 for degradation2010

    • Author(s)
      Wu w
    • Journal Title

      Cancer Research

      Volume: 70 Pages: 6384-6392

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590318
  • [Journal Article] chemosensitivity of basal-like breast cancer based on BRCA1 dysfunction.2009

    • Author(s)
      Ohta T, Wu W, Koike A, Koizumi H, Fukuda M
    • Journal Title

      Breast Cancer Research. 16

      Pages: 268-74

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590318
  • [Journal Article] pathways by proteasome inhibitors corresponds to enhanced chemosensitivity of cells to DNA damage-inducing agents.2009

    • Author(s)
      Takeshita T, Wu Wu W, Koike A, Fukuda M. Ohta T
    • Journal Title

      Cancer Chemother Pharmacol. 64

      Pages: 1039-46

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590318
  • [Journal Article] BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity.2009

    • Author(s)
      Nishikawa H, Wu W, Koike A, Kojima R, Gomi H, Fukuda M, Ohta T
    • Journal Title

      Cancer Res. 69

      Pages: 111-119

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590318
  • [Journal Article] Modification of the Hepatic Mito-chondrial Proteome in Response to Ischemic Preconditioning following Ischemia-Reperfusion Injury of the Rat Liver.2008

    • Author(s)
      Oshima R, Nakano H, Katayama M, Sakurai J, Wu W, Koizumi S, Asano T, Watanabe T, Asakura T, Ohta T, Otsubo T
    • Journal Title

      Eur Surg Res. 40

      Pages: 247-255

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590318
  • [Journal Article] The ubiquitin E3 ligase activity of BRCA1 and its biological functions.2008

    • Author(s)
      Wu W, Koike A, Takeshita T, hta T
    • Journal Title

      Cell Div. 3:1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590318
  • [Presentation] PARP阻害剤耐性獲得に対する治療戦略.2019

    • Author(s)
      太田智彦, 朱明章, 呉文文.
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08676
  • [Presentation] HERC2 regulates the status of Ser33-phosphorylated RPA2 through both induction and ubiquitin-dependent degradation.2019

    • Author(s)
      Wu Wenwen.
    • Organizer
      The ubiquitin system: Biology, mechanisms and roles in disease(EMBO Workshop)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08676
  • [Presentation] HERC2 ubiquitinates RPA2 in ATR dependent manner and promotes RPA to suppress G-quadruplex DNA.2019

    • Author(s)
      Yongqiang Lai, Mingzhang Zhu, Wenwen Wu, Yukiko Togashi, Tomohiko Ohta.
    • Organizer
      11th AACR-JCA Joint Conference onBreakthroughs in Cancer Research
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08676
  • [Presentation] HERC2はグアニン四重鎖(G4)の主要な制御因子としてG4安定化剤の感受性を左右する.2018

    • Author(s)
      呉文文, 竹内淳, 頼勇強, 三好康雄, 鈴木直, 佐伯泰, 田中啓二, 朱明章, 太田智彦.
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08676
  • [Presentation] Resistance of Fbxo22 knockout cancer cells to poly(ADP-ribose)polymerase(PARP)inhibitor2017

    • Author(s)
      頼勇強, 呉文文, 梁偉新, 太田智彦
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08676
  • [Presentation] HERC2による姉妹染色分体交換とグアニン四量体の抑制2016

    • Author(s)
      呉文文、六反田奈和、竹内淳、冨樫由希子、賴勇強、西川裕之、 佐伯泰、田中啓二、太田智彦
    • Organizer
      平成28年度の「ユビキチン制御」班会議
    • Place of Presentation
      シャトレーゼ ガトーキングダム サッポロ(北海道札幌市)
    • Year and Date
      2016-11-16
    • Data Source
      KAKENHI-PROJECT-26460402
  • [Presentation] ヒストンメチル化を介したBRCA1による相同組換え修復機構2015

    • Author(s)
      呉文文、福田貴代、敦賀智子、太田智彦、津川浩一郎
    • Organizer
      第23回日本乳癌学会学術総会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-07-02
    • Data Source
      KAKENHI-PROJECT-26460402
  • [Presentation] ユビキチンリガーゼHERC2とRecQヘリガーゼBLMの相互作用2015

    • Author(s)
      呉文文
    • Organizer
      新学術領域「ユビキチンネオバイオロジー」平成27年度第2回領域班会議
    • Place of Presentation
      南房総富浦ロイヤルホテル(千葉県南房総市)
    • Year and Date
      2015-12-16
    • Data Source
      KAKENHI-PROJECT-26460402
  • [Presentation] BRCA1-BACH1およびBRCA1-CtIP複合体のDNA損傷部位 への集積機序の解析2015

    • Author(s)
      敦賀智子、呉文文、福田貴代、黒田貴子、永澤慧、 太田智彦、津川浩一郎
    • Organizer
      第23回日本乳癌学会学術総会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-07-02
    • Data Source
      KAKENHI-PROJECT-26460402
  • [Presentation] BRCTドメインとHP1γの結を介したDNA損傷局所へのBARD1の集積2013

    • Author(s)
      呉文文
    • Organizer
      第2回新学術領域「ユビキチン制御」領域会議
    • Place of Presentation
      熱海
    • Year and Date
      2013-12-11
    • Data Source
      KAKENHI-PROJECT-23590348
  • [Presentation] ヘテロクロマチン領域のDNA損傷応答におけるBRCA1-E3活性の役割2013

    • Author(s)
      呉文文
    • Organizer
      第1回新学術領域「ユビキチン制御」領域会議
    • Place of Presentation
      神戸
    • Year and Date
      2013-01-29
    • Data Source
      KAKENHI-PROJECT-23590348
  • [Presentation] ヘテロクロマチン領域のDNA損傷応答におけるBRCA1-E3活性の役割2013

    • Author(s)
      呉 文文、西川裕之、岡田麻衣子、太田智彦
    • Organizer
      第1回 新学術領域「ユビキチン制御」領域会議
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23590348
  • [Presentation] ユビキチンリガーゼHERC2とBRCA1によるDNA複製およびチェックポイント制御2012

    • Author(s)
      太田智彦、呉 文文、ベンキタラマン アショック
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23590348
  • [Presentation] The E3 ligase activity of HERC2 regulates BRCA1-mediated G2/M checkpoint function independent of BARD12009

    • Author(s)
      呉文文
    • Organizer
      5th Cold Spring Harbor Meeting On The ubiquitin Family
    • Place of Presentation
      Cold Spring Harbor, NY
    • Year and Date
      2009-05-22
    • Data Source
      KAKENHI-PROJECT-20590318
  • [Presentation] THE E3 LIGASE ACTIVITY OF HERC2 REGULATES BRCA1-MEDIATED G2/MCHECKPOINT FUNCTION INDEPENDENT OF BARD12009

    • Author(s)
      Wenwen Wu
    • Organizer
      5th Cold Spring Harbor Meeting On The ubiquitin Family
    • Place of Presentation
      Cold Spring Harbor, NY
    • Year and Date
      2009-04-22
    • Data Source
      KAKENHI-PROJECT-20590318
  • [Presentation] BRCA1を分解するユビキチンリガーゼの同定2008

    • Author(s)
      呉文文
    • Organizer
      第16回乳癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-27
    • Data Source
      KAKENHI-PROJECT-20590318
  • [Presentation] BRCA1/BARD1 retention at sites of DNA damage through HP1gamma interaction with BRCT domain of BARD1

    • Author(s)
      Wu W, Nishikawa H, Fukuda T, Sedukhina AS, Ohta T
    • Organizer
      FEBSEMBO 2014
    • Place of Presentation
      Pairs
    • Year and Date
      2014-08-30 – 2014-09-04
    • Data Source
      KAKENHI-PROJECT-26460402
  • [Presentation] ヒストンH3ジメチル化を介してDNA損傷部位へ集積するBRCA1はRNF168ユビキチン経路と拮抗する

    • Author(s)
      呉 文文, 西川裕之, 福田貴代, 太田智彦
    • Organizer
      第3回新学術領域「ユビキチン制御」領域会議
    • Place of Presentation
      西浦温泉ホテル「たつき」(愛知県蒲郡市)
    • Year and Date
      2014-12-03 – 2014-12-05
    • Data Source
      KAKENHI-PROJECT-26460402
  • 1.  太田 智彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 2.  津川 浩一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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