NAIKI Yoshikazu 内記良一

Researcher Number	10434622
Other IDs	https://orcid.org/0000-0001-5913-2436
Affiliation (Current)	2025: 愛知学院大学, 歯学部, 講師
Affiliation (based on the past Project Information) *help	2020 – 2024: 愛知学院大学, 歯学部, 講師 2021: 愛知医科大学, 医学部, 講師 2015 – 2019: 愛知医科大学, 医学部, 講師 2014: 愛知医科大学, 医学部, 助教 2007 – 2008: Aichi Medical University, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 57030:Conservative dentistry-related / Immunology Except Principal Investigator Basic Section 57030:Conservative dentistry-related / Basic Section 57020:Oral pathobiological science-related / Periodontology / Eating habits, studies on eating habits
Keywords	Principal Investigator IL-17A / 動脈硬化 / 動脈硬化症 / 誤嚥性肺炎 / Porphyromonas gingivalis / Chlamydia pneumoniae / autophagy / TGFーベータ / TGF-ベータ / TLR(Toll様受容) / 細胞内シグナル伝達 … More Except Principal Investigator … More 実験的歯周炎 / 線毛 / Porphyromonas gingivalis / P. gingivalis / 大腸がんモデルマウス / ペリオドンタルメディスン / ペリオドンタルメディシン / 化学物質誘導大腸がんモデルマウス / 自然発症型大腸がんモデルマウス / ANGPTL2 / 遺伝子型 / 病原因子 / 歯周病 / Mfa5 / Mfa1 / 病原性 / Mfa1線毛 / Porpyhromonas gingivitis / 歯周病原菌 / Porphyromonas gingivitis / 混合感染 / Streptococcus pneumoniae / 炎症性サイトカイン / 混合感染による肺炎モデルマウス / IL-35 / IL-17 / S. pneumoniae / 誤嚥性肺炎 / 歯周病と肺炎 / 咽頭細菌叢 / 唾液細菌叢 / 咽頭常在菌 / 咽頭上皮細胞 / プラーク細菌 / 歯周病原細菌 / リガンド / ナチュラルリガンド / インバリアントNKT細胞 / 構造 / スフィンゴ糖脂質 / 米糠 / Rice bran / Sphingoglycolipid / Natural ligand / Invariant NKT cell Less

異なる遺伝子型のP.gingivalis経口投与が大腸がんモデルマウスへ与える影響
- Principal Investigator
  
  山本弦太
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Aichi Gakuin University
キーストーン細菌である歯周病菌は肺炎クラミジア感染や動脈硬化を増悪化するか？Principal Investigator
- Principal Investigator
  
  内記良一
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Aichi Gakuin University
自然発症型大腸がんモデルマウスにおけるLPS誘導実験的歯周炎の影響
- Principal Investigator
  
  山本弦太
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Aichi Gakuin University
Analysis of the correlation between the novel mfa types of P. gingivalis fimbriae and their functions
- Principal Investigator
  
  Hasegawa Yoshiaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Aichi Gakuin University
Role of IL-35 in pneumonia model mixed infected with Streptococcus pneumoniae and Porphyromonas gingivalis in Ebi3-/- mice.
- Principal Investigator
  
  MITANI Akio
- Project Period (FY)
  2019 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57030:Conservative dentistry-related
- Research Institution
  Aichi Gakuin University
Biological response to inhabiting of a periodontal pathogen in pharynx
- Principal Investigator
  
  Hayashi Jun-ichiro
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Periodontology
- Research Institution
  Aichi Gakuin University
Identification of natural ligand for invariant NKT cells
- Principal Investigator
  
  EMOTO Masashi
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Eating habits, studies on eating habits
- Research Institution
  Gunma University
Transforming Growth Factor-β1 down-regulates Interferon Regulatory Factor 7 signalingPrincipal Investigator
- Principal Investigator
  
  NAIKI Yoshikazu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Aichi Medical University

All 2023 2022 2021 2020 2009 2008 2007

All Journal Article Presentation

[Journal Article] Effects of cleaning sports mouthguards with ethylene-vinyl acetate on oral bacteria.2022
- Author(s)
  Hayashi H, Naiki Y, Murakami M, Oishi A, Takeuchi R, Nakagawa M, Kimoto S, Hasegawa Y, Araki A.
- Journal Title
  
  PeerJ
  
  Volume: Dec 5;10 Pages: e14480-e14480
- DOI
  10.7717/peerj.14480
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09931
[Journal Article] Porphyromonas gingivalis Fimbriae Induce Osteoclastogenesis via Toll-like Receptors in RAW264 Cells2022
- Author(s)
  Suzuki Yuki、Kikuchi Takeshi、Goto Hisashi、Takayanagi Yuhei、Kawamura Shotaro、Sawada Noritaka、Naiki Yoshikazu、Kondo Hisataka、Hayashi Jun-ichiro、Hasegawa Yoshiaki、Mitani Akio
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 23 Pages: 15293-15293
- DOI
  10.3390/ijms232315293
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10138, KAKENHI-PROJECT-20K09985, KAKENHI-PROJECT-20K09931
[Journal Article] Porphyromonas gingivalis components/secretions synergistically enhance pneumonia caused by Streptococcus pneumoniae in mice.2021
- Author(s)
  Okabe, T., Kamiya, Y., Kikuchi, T., Goto, H., Umemura, M., Suzuki, Y., Sugita, Y., Naiki, Y., Hasegawa, Y., Hayashi, J., Kawamura, S., Sawada, N., Takayanagi, Y., Fujimura, T., Higuchi, N., Mitani, A.
- Journal Title
  
  Int. J. Mol. Sci.
  
  Volume: 22 Issue: 23 Pages: 12704-12715
- DOI
  10.3390/ijms222312704
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07117, KAKENHI-PROJECT-19K10138, KAKENHI-PROJECT-20K09931, KAKENHI-PROJECT-20K09985, KAKENHI-PROJECT-21K07028
[Journal Article] Porphyromonas gingivalis Mfa1 Induces Chemokine and Cell Adhesion Molecules in Mouse Gingival Fibroblasts via Toll-Like Receptors2020
- Author(s)
  Takayanagi Yuhei、Kikuchi Takeshi、Hasegawa Yoshiaki、Naiki Yoshikazu、Goto Hisashi、Okada Kousuke、Okabe Iichiro、Kamiya Yosuke、Suzuki Yuki、Sawada Noritaka、Okabe Teppei、Suzuki Yuki、Kondo Shun、Ohno Tasuku、Hayashi Jun-Ichiro、Mitani Akio
- Journal Title
  
  Journal of Clinical Medicine
  
  Volume: 9 Issue: 12 Pages: 4004-4004
- DOI
  10.3390/jcm9124004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K10138, KAKENHI-PROJECT-20K09931, KAKENHI-PROJECT-20K09985, KAKENHI-PROJECT-17K11999
[Journal Article] TLRシグナルのTGF-βによる制御2009
- Author(s)
  内記良一
- Journal Title
  
  臨床免疫アレルギー科 51巻
  
  Pages: 262-265
- Data Source
  KAKENHI-PROJECT-19790366
[Journal Article] 臨床免疫・アレルギー科2009
- Author(s)
  内記良一、横地高志
- Journal Title
  
  51(3)
  
  Pages: 262-265
- Data Source
  KAKENHI-PROJECT-19790366
[Presentation] キーストーン細菌である歯周病菌は肺炎クラミジア感染や動脈硬化を増悪化するか?2023
- Author(s)
  内記良一
- Organizer
  乳酸菌研究会
- Data Source
  KAKENHI-PROJECT-23K09192
[Presentation] Porphyromonas gingivalisの新規遺伝子型Mfa1線毛の構造と構成因子の抗原性解析2022
- Author(s)
  藤本実結菜，内記良一，榮宏太朗, 三輪尚慶，永野恵司, 名和弘幸，長谷川義明
- Organizer
  第64回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-20K09931
[Presentation] in vivo における Ethylene-Vinyl Acetate 表面のバイオフィルムへの洗浄効果の検討2022
- Author(s)
  林裕基，内記良一，村上正洋，大石明広，中川昌好，竹内里穂子，木本統，長谷川義明，荒木章純
- Organizer
  愛知学院大学歯学会
- Data Source
  KAKENHI-PROJECT-20K09931
[Presentation] Porphyromonas gingivalisにおけるMfa1線毛の構成因子の抗原性解析2022
- Author(s)
  藤本実結菜、内記良一、榮宏太朗、名和弘幸、長谷川義明
- Organizer
  愛知学院大学歯学会誌
- Data Source
  KAKENHI-PROJECT-20K09931
[Presentation] Porphyromonas gingivalis由来Mfa1線毛の破骨細胞分化に与える影響の検討2022
- Author(s)
  鈴木祐希,菊池毅,長谷川義明,高柳結平,後藤久嗣,内記良一,澤田憲孝,岡部徹平,川村翔太郎,林潤一郎,三谷章雄
- Organizer
  第65回秋季日本歯周病学会学術大会
- Data Source
  KAKENHI-PROJECT-19K10138
[Presentation] Porphyromonas gingivalisにおけるmfa1部位特異的変異導入による線毛形成に及ぼす影響の検討2022
- Author(s)
  大石明広，内記良一，岩瀬智彦，榮宏太朗，長谷川義明
- Organizer
  第64回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-20K09931
[Presentation] EVAシート表面のバイオフィルムへの洗浄効果の検討2021
- Author(s)
  林　裕基，内記良一, 中川昌好, 長谷川義明, 荒木章純
- Organizer
  第98回愛知学院大学歯学会
- Data Source
  KAKENHI-PROJECT-20K09931
[Presentation] Transforming Growth Factor-β1 down-regulates Interferon Regulatory Factor 7 signaling2008
- Author(s)
  内記良一
- Organizer
  第81回日本細菌学会
- Place of Presentation
  京都
- Year and Date
  2008-03-30
- Data Source
  KAKENHI-PROJECT-19790366
[Presentation] TGFベータ1によるIRF7シグナル伝達系におよぼす影響2008
- Author(s)
  内記良一
- Organizer
  日本免疫学会
- Place of Presentation
  京都
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-19790366
[Presentation] Transforming Growth Factor-β1 down-regulates Interferon Regulatory Factor 7 signaling2007
- Author(s)
  内記良一
- Organizer
  第37回日本免疫学会
- Place of Presentation
  東京
- Year and Date
  2007-11-07
- Data Source
  KAKENHI-PROJECT-19790366
[Presentation] トランスフォーミング成長因子-β1はMyD88を介するシグナル伝達を制御する2007
- Author(s)
  内記良一
- Organizer
  第54回毒素シンポジウム
- Place of Presentation
  大阪
- Year and Date
  2007-07-06
- Data Source
  KAKENHI-PROJECT-19790366

1. MITANI Akio (50329611)

# of Collaborated Projects: 5 results

# of Collaborated Products: 3 results
2. Hasegawa Yoshiaki (70460524)

# of Collaborated Projects: 3 results

# of Collaborated Products: 9 results
3. 梅村正幸 (90359985)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 山本弦太 (30421241)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. EMOTO Masashi (70232981)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. FUJIMURA Takao (50209087)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KITA Eiji (90133199)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. FUKUDA Toshio (00173352)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Hayashi Jun-ichiro (30350937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 福田光男 (40156790)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 菊池毅 (40421242)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 永野恵司 (60367620)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 大野祐 (80824151)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. EMOTO Yoshiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. WATANABE Kazuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KOYAMA Yu-ichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NYU Kiyosato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KIYAMA Takajyu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NISHIO Kazumasa

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. Iwamura Yuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. HURWITZ Robert

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. KAUFMANN Stefan H.E.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. MOLLENKOPF Hans

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAIKI Yoshikazu 内記 良一

Research Projects

Research Products

Co-Researchers

異なる遺伝子型のP.gingivalis経口投与が大腸がんモデルマウスへ与える影響

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

キーストーン細菌である歯周病菌は肺炎クラミジア感染や動脈硬化を増悪化するか？Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

自然発症型大腸がんモデルマウスにおけるLPS誘導実験的歯周炎の影響

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the correlation between the novel mfa types of P. gingivalis fimbriae and their functions

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of IL-35 in pneumonia model mixed infected with Streptococcus pneumoniae and Porphyromonas gingivalis in Ebi3-/- mice.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Biological response to inhabiting of a periodontal pathogen in pharynx

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of natural ligand for invariant NKT cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Transforming Growth Factor-β1 down-regulates Interferon Regulatory Factor 7 signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Effects of cleaning sports mouthguards with ethylene-vinyl acetate on oral bacteria.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Porphyromonas gingivalis Fimbriae Induce Osteoclastogenesis via Toll-like Receptors in RAW264 Cells2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Porphyromonas gingivalis components/secretions synergistically enhance pneumonia caused by Streptococcus pneumoniae in mice.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Porphyromonas gingivalis Mfa1 Induces Chemokine and Cell Adhesion Molecules in Mouse Gingival Fibroblasts via Toll-Like Receptors2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] TLRシグナルのTGF-βによる制御2009

Author(s)

Journal Title

Data Source

[Journal Article] 臨床免疫・アレルギー科2009

Author(s)

Journal Title

Data Source

NAIKI Yoshikazu 内記良一

[Presentation] キーストーン細菌である歯周病菌は肺炎クラミジア感染や動脈硬化を増悪化するか?2023