Natsume Toyoaki 夏目豊彰

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NATSUME Toyoaki 夏目豊彰

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Researcher Number	10435513
Other IDs
Affiliation (Current)	2025: 公益財団法人東京都医学総合研究所, ゲノム医学研究センター, 主席研究員
Affiliation (based on the past Project Information) *help	2025: 公益財団法人東京都医学総合研究所, ゲノム医学研究センター, 主席研究員 2021 – 2022: 公益財団法人東京都医学総合研究所, ゲノム医学研究センター, 主席研究員 2018 – 2020: 国立遺伝学研究所, 遺伝メカニズム研究系, 助教 2016 – 2017: 国立遺伝学研究所, 分子遺伝研究系, 助教 2013 – 2015: 国立遺伝学研究所, 新分野創造センター, 特任研究員
Review Section/Research Field	Principal Investigator Molecular biology / Basic Section 45010:Genetics-related / Basic Section 43010:Molecular biology-related / Genetics/Chromosome dynamics
Keywords	Principal Investigator オーキシンデグロン法 / SMC5/6 / 細胞周期 / ゲノム編集 / デグロン / アンチクリスパー / 転写調節ネットワーク / シスエレメント / 迅速CRISPR摂動 / ヒト細胞 … More / 染色体 / DNAの絡まり / リボソームDNA / セントロメア / ヘテロクロマチン / DNA超らせん構造 / 転写 / 核内ボディ / 染色体分配 / タンパク質分解 / 細胞周期特異的分解 / SMC5/6複合体 / MCMヘリカーゼ / トポロジカルストレス / コンデンシン / コヒーシン / SMC複合体 / MCM2-7ヘリカーゼ / オーキシン誘導性デグロン / Mcm8-9 / Mcm2-7 / がん化 / 細胞死 / 複製フォーク / DNA複製バックアップシステム / MCM8-9ヘリカーゼ / MCM2-7複製ヘリカーゼ / 非通常型DNA複製 / オーキシン誘導デグロン / DNA複製フォーク再生 / 次世代細胞遺伝学 / Mcm8-9ヘリカーゼ / Mcm2-7ヘリカーゼ / ICL修復 / 複製フォーク再生 / オーキシン誘導デグロン法 / ヒト新細胞遺伝学 Less

転写調節シスエレメントが形成する動的ネットワークの解析：迅速CRISPR摂動を用いてPrincipal Investigator
- Principal Investigator
  
  夏目豊彰
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 45010:Genetics-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Comprehensive and unbiased analysis of the human SMC5/6 complex: Taking advantage of auxin-inducible degron systemPrincipal Investigator
- Principal Investigator
  
  NATSUME Toyoaki
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43010:Molecular biology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
  National Institute of Genetics
Rapid protein degradation reveals functional coupling between the MCM helicase and cohesin, and their pleiotropic functionsPrincipal Investigator
- Principal Investigator
  
  NATSUME Toyoaki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  National Institute of Genetics
Division of labor between MCM2-7 and MCM8-9 helicases in non-canonical DNA replicationPrincipal Investigator
- Principal Investigator
  
  Natsume Toyoaki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Molecular biology
- Research Institution
  National Institute of Genetics
A new cytogenetic approach toward understanding regeneration of DNA replication fork in human cells: Using genome editing and degron technologiesPrincipal Investigator
- Principal Investigator
  
  NATSUME Toyoaki
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Genetics/Chromosome dynamics
- Research Institution
  National Institute of Genetics

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy2022
- Author(s)
  Grange Laura J.、... Natsume Toyoaki、... Stewart Grant S.
- Journal Title
  
  Nature Communications
  
  Volume: 13 Issue: 1 Pages: 6664-6664
- DOI
  10.1038/s41467-022-34349-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06495, KAKENHI-PROJECT-21K15907
[Journal Article] Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G12021
- Author(s)
  Wiegard Anika、Kuzin Vladislav、Cameron Donald P.、Grosser Jan、Ceribelli Michele、Mehmood Rashid、Ballarino Roberto、Valant Francesco、Grochowski Rados?aw、Karabogdan Ivana、Crosetto Nicola、Lindqvist Arne、Bizard Anna Helene、Kouzine Fedor、Natsume Toyoaki、Baranello Laura
- Journal Title
  
  Molecular Cell
  
  Volume: 81 Issue: 24 Pages: 5007-5024.e9
- DOI
  10.1016/j.molcel.2021.10.015
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06495
[Journal Article] Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase2020
- Author(s)
  Venegas Andres Bueno、Natsume Toyoaki、Kanemaki Masato、Hickson Ian D.
- Journal Title
  
  Cell Reports
  
  Volume: 31 Issue: 3 Pages: 107533-107533
- DOI
  10.1016/j.celrep.2020.107533
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04719, KAKENHI-PROJECT-19K06495
[Journal Article] Chk1-mediated Cdc25A degradation as a critical mechanism for normal cell cycle progression.2019
- Author(s)
  Goto H., Natsume T., Kanemaki M.T., Kaito A., Wang S., Gabazza E.C., Inagaki M., Mizoguchi A.
- Journal Title
  
  J. Cell Sci.
  
  Volume: 132 Issue: 2
- DOI
  10.1242/jcs.223123
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06927, KAKENHI-PUBLICLY-18H04719, KAKENHI-PROJECT-18H02170, KAKENHI-PROJECT-17K15068
[Journal Article] Generation of conditional auxin-inducible degron (AID) cells and tight control of degron-fused proteins using the degradation inhibitor auxinole2019
- Author(s)
  Yesbolatova A, Natsume T, Hayashi K, Kanemaki MT
- Journal Title
  
  Methods
  
  Volume: 印刷中 Pages: 73-80
- DOI
  10.1016/j.ymeth.2019.04.010
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15068, KAKENHI-PROJECT-19K06495, KAKENHI-PUBLICLY-18H04719, KAKENHI-PROJECT-18H02170
[Journal Article] Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib.2019
- Author(s)
  Morii, I., Iwabuchi, Y., Mori, S., Suekuni, M., Natsume, T., Yoshida, K., Sugimoto, N., Kanemaki, MT. and Fujita, M.
- Journal Title
  
  Cancer Science
  
  Volume: 110 Issue: 3 Pages: 1044-1053
- DOI
  10.1111/cas.13941
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07201, KAKENHI-PROJECT-17K15065, KAKENHI-PROJECT-17K15068
[Journal Article] Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity2018
- Author(s)
  Eaton Joshua D.、Davidson Lee、Bauer David L.V.、Natsume Toyoaki、Kanemaki Masato T.、West Steven
- Journal Title
  
  Genes & Development
  
  Volume: 32 Issue: 2 Pages: 127-139
- DOI
  10.1101/gad.308528.117
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15068, KAKENHI-PROJECT-16K15095
[Journal Article] Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms2018
- Author(s)
  Takagi Masatoshi、Ono Takao、Natsume Toyoaki、Sakamoto Chiyomi、Nakao Mitsuyoshi、Saitoh Noriko、Kanemaki Masato T.、Hirano Tatsuya、Imamoto Naoko
- Journal Title
  
  Journal of Cell Science
  
  Volume: 131 Pages: 212092-212092
- DOI
  10.1242/jcs.212092
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07399, KAKENHI-PROJECT-17K15068, KAKENHI-INTERNATIONAL-15K21744, KAKENHI-PROJECT-26251003, KAKENHI-PLANNED-15H05929, KAKENHI-PLANNED-25116009, KAKENHI-PROJECT-15H04707, KAKENHI-PROJECT-16K15095, KAKENHI-PROJECT-18K19310, KAKENHI-PUBLICLY-18H04719, KAKENHI-PROJECT-16H04744, KAKENHI-PROJECT-18H02170, KAKENHI-PROJECT-16K07455
[Journal Article] Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble2018
- Author(s)
  Okumura Masako、Natsume Toyoaki、Kanemaki Masato T、Kiyomitsu Tomomi
- Journal Title
  
  eLife
  
  Volume: 7 Pages: 1-24
- DOI
  10.7554/elife.36559
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04719, KAKENHI-PROJECT-18H02170, KAKENHI-PROJECT-17H05002, KAKENHI-PROJECT-17K15068
[Journal Article] Conditional Degrons for Controlling Protein Expression at the Protein Level2017
- Author(s)
  Natsume Toyoaki、Kanemaki Masato T.
- Journal Title
  
  Annual Review of Genetics
  
  Volume: 51 Issue: 1 Pages: 83-102
- DOI
  10.1146/annurev-genet-120116-024656
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15068, KAKENHI-PROJECT-16K15095
[Journal Article] Acute Inactivation of the Replicative Helicase in Human Cells Triggers MCM8-9-dependent DNA Synthesis2017
- Author(s)
  Natsume T, Nishimura K, Minocherhomji S, Bhwmick R, Hickson ID, Kanemaki MT
- Journal Title
  
  Genes & Development
  
  Volume: advanced online Issue: 8 Pages: 816-829
- DOI
  10.1101/gad.297663.117
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15095, KAKENHI-PROJECT-17K15041, KAKENHI-PROJECT-17K15068
[Journal Article] Acute Inactivation of the Replicative Helicase in Human Cells Triggers MCM8-9-dependent DNA Synthesis2017
- Author(s)
  Natsume T, Nishimura K, Minocherhomji S, Bhwmick R, Hickson ID, Kanemaki MT
- Journal Title
  
  Genes & Development
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18482
[Journal Article] Conditional Degrons for Controlling Protein Expression at the Protein Level2017
- Author(s)
  Natsume T, Kanemaki MT
- Journal Title
  
  Annual Review of Genetics
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K18482
[Journal Article] Prichromosomal protein Ki67 supports mitotic chromosome architecture.2016
- Author(s)
  Takagi M, Natsume T, Kanemaki MT, Imamoto N.
- Journal Title
  
  Genes to Cells
  
  Volume: 21(10) Issue: 10 Pages: 1113-1124
- DOI
  10.1111/gtc.12420
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26650070, KAKENHI-PROJECT-15K18482, KAKENHI-PROJECT-16K15095
[Journal Article] Rapid Protein Depletion in Human Cells by Auxin-Inducible Degron Tagging with Short Homology Donors2016
- Author(s)
  Natsume T, Kiyomitsu T, Saga Y, Kanemaki MT
- Journal Title
  
  Cell Reports
  
  Volume: 15 Issue: 1 Pages: 210-218
- DOI
  10.1016/j.celrep.2016.03.001
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K18482, KAKENHI-PROJECT-16K15095
[Journal Article] Relative contribution of four nucleases, CtIP, Dna2, Exo1 and Mre11, to the initial step of DNA double‐strand break repair by homologous recombination in both the chicken DT40 and human TK6 cell lines2015
- Author(s)
  Hoa NN, Akagawa R, Yamasaki T, Hirota K, Sasa K, Natsume T, Kobayashi J, Sakuma T, Yamamoto T, Komatsu K, Kanemaki MT, Pommier Y, Takeda S, Sasanuma H
- Journal Title
  
  Genes to Cells
  
  Volume: 20 Issue: 12 Pages: 1059-1076
- DOI
  10.1111/gtc.12310
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18482, KAKENHI-PUBLICLY-26116518, KAKENHI-PROJECT-23221005, KAKENHI-PROJECT-26550025, KAKENHI-PROJECT-25281021
[Presentation] ヒトSMC5/6と染色体トランスアクションにおけるDNAトポロジカルストレス：DNAの絡まりと超らせん構造2019
- Author(s)
  夏目豊彰
- Organizer
  第37回染色体ワークショップ・第18回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-19K06495
[Presentation] Elucidating a fundamental role of human SMC5/6 in chromosome transactions: from the viewpoint of DNA topological stress2019
- Author(s)
  Toyoaki Natsume
- Organizer
  EMBO Workshop: Organization of bacterial and eukaryotic genomes by SMC complexes
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06495
[Presentation] 染色体制御におけるヒトSMC5/6の独自な役割を探る2019
- Author(s)
  夏目豊彰
- Organizer
  第36回染色体ワークショップ・第17回核ダイナミクス研究会
- Data Source
  KAKENHI-PROJECT-17K15068
[Presentation] 第三のSMC複合体、SMC5/6の染色体トランスアクションにおける役割～DNAトポロジカルストレスの観点から2019
- Author(s)
  夏目豊彰
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K06495
[Presentation] Human SMC5/6 and DNA topological stress during chromosome transactions2019
- Author(s)
  Toyoaki Natsume
- Organizer
  EMBO Workshop: DNA topology and topoisomerases in genome dynamics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06495
[Presentation] ゲノムの安定性を維持するためのヒトMCM8-9依存的な複製フォークの再生機構2018
- Author(s)
  夏目豊彰
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K15068
[Presentation] ヒト染色体の維持における第三のSMC複合体「SMC5/6」の独自な機能を探る2018
- Author(s)
  夏目豊彰
- Organizer
  日本遺伝学会第90回大会
- Data Source
  KAKENHI-PROJECT-17K15068
[Presentation] Elucidating the unique and essential role of human SMC5/6, the yet-to-be-named SMC complex2018
- Author(s)
  Toyoaki Natsume
- Organizer
  The 11th 3R&3C Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15068
[Presentation] 人為的複製フォーク破壊システムから見えてきたヒトMCM8-9 依存的なフォークの再生メカニズム2017
- Author(s)
  夏目豊彰、西村浩平、Ian Hickson、鐘巻将人
- Organizer
  第34回染色体ワークショップ・第15回核ダイナミクス研究会
- Place of Presentation
  かずさアカデミアホール（木更津市）
- Year and Date
  2017-01-11
- Data Source
  KAKENHI-PROJECT-15K18482
[Presentation] Acute degradation of the human SMC complexes using the auxin-inducible degron (AID) technology reveals their distinct cell-cycle specific roles2017
- Author(s)
  Natsume Toyoaki
- Organizer
  SMC Proteins 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15068
[Presentation] Rapid protein depletion in human cells by auxin-inducible degron (AID) tagging with short homology donors2016
- Author(s)
  夏目豊彰、清光智美、相賀裕美子、鐘巻将人
- Organizer
  第68回日本細胞生物学会大会
- Place of Presentation
  京都テルサ（京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-15K18482
[Presentation] Cell-cycle specific perturbation of human MCM2-7 and cohesin complexes by the use of the auxin-inducible degron (AID) technology2016
- Author(s)
  夏目豊彰、鐘巻将人
- Organizer
  The 10th 3R Symposium
- Place of Presentation
  Hotel Ichibata (Matsue)
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18482
[Presentation] 人為的複製フォーク破壊システムを用いたヒト細胞におけるフォーク再生機構の解析2016
- Author(s)
  夏目豊彰
- Organizer
  第33回染色体ワークショップ・第14回核ダイナミクス研究会
- Place of Presentation
  松島一の坊、宮城県松島町
- Year and Date
  2016-01-12
- Data Source
  KAKENHI-PROJECT-15K18482
[Presentation] ヒト細胞における人為的複製フォーク破壊システムから見えてきた Mcm8-9依存的な複製フォークの再生メカニズム2016
- Author(s)
  夏目豊彰、西村浩平、鐘巻将人
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K18482
[Presentation] Artificial destruction of active DNA replication forks reveals the HR-dependent fork recovery involving Mcm8-92015
- Author(s)
  夏目豊彰
- Organizer
  BMB2015
- Place of Presentation
  神戸ポートアイランド、兵庫県神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K18482
[Presentation] 人為的複製フォーク破壊システムを用いたヒト細胞におけるフォーク再生機構の解析2015
- Author(s)
  夏目豊彰
- Organizer
  第23回DNA複製・組換え・修復ワークショップ研究会
- Place of Presentation
  焼津グランドホテル、静岡県焼津市
- Year and Date
  2015-10-19
- Data Source
  KAKENHI-PROJECT-15K18482
[Presentation] A PCR-based tagging method for generation of human conditional mutants by use of the auxin-inducible degron technology2015
- Author(s)
  夏目豊彰
- Organizer
  Genome Engineering: The CRISPR/Cas Revolution
- Place of Presentation
  Cold Spring Harbor Laboratory, New York, USA
- Year and Date
  2015-09-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18482
[Presentation] The Mcm8-9 helicase promotes DNA strand synthesis in recombination repair induced by DNA inter-strand crosslink2014
- Author(s)
  夏目豊彰
- Organizer
  Ramon Areces Foundation International Symposium - Cell Proliferation and Genome Integrity
- Place of Presentation
  Palace of La Magdalena, Santander, Spain
- Data Source
  KAKENHI-PROJECT-25891026
[Presentation] A role of the Mcm8-9 complex in homologous recombination during DNA inter-strand crosslink repair2013
- Author(s)
  夏目豊彰
- Organizer
  29th RBC-NIRS International Symposium
- Place of Presentation
  コープイン京都（京都）
- Data Source
  KAKENHI-PROJECT-25891026
[Presentation] ヒト遺伝子破壊株を用いた複製フォーク再構成におけるMcm8-9複合体の機能解析2013
- Author(s)
  夏目豊彰
- Organizer
  第31回染色体ワークショップ・第12回核ダイナミクス研究会
- Place of Presentation
  ホテルおかだ（箱根）
- Data Source
  KAKENHI-PROJECT-25891026
[Presentation] The Mcm8-9 helicase promotes DNA strand synthesis in recombination repair induced by DNA inter-strand crosslink
- Author(s)
  夏目豊彰
- Organizer
  IIAS Research Conference 2014 - Chromatin Decoding
- Place of Presentation
  国際高等研究所（京都）
- Year and Date
  2014-05-12 – 2014-05-15
- Data Source
  KAKENHI-PROJECT-25891026
[Presentation] ゲノム安定性の維持におけるＤＮＡ複製バックアップシステムの役割
- Author(s)
  夏目豊彰
- Organizer
  「がん研究分野の特性等を踏まえた支援活動」公開シンポジウム
- Place of Presentation
  一橋講堂（東京）
- Year and Date
  2015-01-27 – 2015-01-28
- Data Source
  KAKENHI-PROJECT-25891026
[Presentation] The Mcm8-9 complex promotes DNA strand synthesis in homologous recombination induced by DNA inter-strand crosslinks
- Author(s)
  夏目豊彰
- Organizer
  The 9th 3R Symposium
- Place of Presentation
  御殿場高原時之栖（御殿場）
- Year and Date
  2014-11-17 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-25891026

1. 川路英哉 (20525406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 後藤英仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 鐘巻将人

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
4. 高木昌俊

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
5. 杉本のぞみ

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Natsume Toyoaki 夏目 豊彰

NATSUME Toyoaki 夏目 豊彰

Research Projects

Research Products

Co-Researchers

転写調節シスエレメントが形成する動的ネットワークの解析：迅速CRISPR摂動を用いてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive and unbiased analysis of the human SMC5/6 complex: Taking advantage of auxin-inducible degron systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Rapid protein degradation reveals functional coupling between the MCM helicase and cohesin, and their pleiotropic functionsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Division of labor between MCM2-7 and MCM8-9 helicases in non-canonical DNA replicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A new cytogenetic approach toward understanding regeneration of DNA replication fork in human cells: Using genome editing and degron technologiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G12021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Inducible Degradation of the Human SMC5/6 Complex Reveals an Essential Role Only during Interphase2020

Author(s)

Journal Title

DOI

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[Journal Article] Chk1-mediated Cdc25A degradation as a critical mechanism for normal cell cycle progression.2019

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[Journal Article] Generation of conditional auxin-inducible degron (AID) cells and tight control of degron-fused proteins using the degradation inhibitor auxinole2019

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[Journal Article] Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib.2019

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[Journal Article] Xrn2 accelerates termination by RNA polymerase II, which is underpinned by CPSF73 activity2018

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[Journal Article] Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms2018

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[Journal Article] Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble2018

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Natsume Toyoaki 夏目豊彰

NATSUME Toyoaki 夏目豊彰