Kobayashi Yusuke 小林佑介

Researcher Number	10439763
Other IDs
Affiliation (Current)	2025: 筑波大学, 医学医療系, 准教授
Affiliation (based on the past Project Information) *help	2024: 筑波大学, 医学医療系, 准教授 2022: 慶應義塾大学, 医学部(信濃町), 専任講師 2019 – 2022: 慶應義塾大学, 医学部(信濃町), 講師 2019: 慶應義塾大学, 医学部(信濃町), 専任講師 2016 – 2018: 慶應義塾大学, 医学部(信濃町), 助教 2017: 慶應義塾大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology
Keywords	Principal Investigator 卵巣癌 / スタチン / ドラッグリポジショニング / 脂質親和性 / TCA回路 / HDRA / 細胞増殖抑制 / LDLRAP1遺伝子 / VDAC1遺伝子 / 奏効予測マーカー … More / ワールブルク効果 / がん代謝 / 婦人科腫瘍 / L-778123 / ビスフォスフォネート / メバロン酸合成経路阻害剤 / 酸化的リン酸化シフト / ワールブルグ効果回避 / メバロン酸合成経路 / 創薬 Less

Investigation of Lipid Affinity and Statin Regulation of TCA Cycle in Ovarian CancerPrincipal Investigator
- Principal Investigator
  
  小林佑介
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  University of Tsukuba
Clinicopathological and molecular biological characteristics of ovarian cancer associated with response to statins for dyslipidemiaPrincipal Investigator
- Principal Investigator
  
  Kobayashi Yusuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Keio University
New drug discovery against ovarian cancer focusing on the multifaceted effects of statins and their effects on the Warburg effectPrincipal Investigator
- Principal Investigator
  
  Kobayashi Yusuke
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Keio University
Translational research for clinical application using statins as a prevention drugs against ovarian cancerPrincipal Investigator
- Principal Investigator
  
  Kobayashi Yusuke
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Keio University

All 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation

[Journal Article] Response Predictive Markers and Synergistic Agents for Drug Repositioning of Statins in Ovarian Cancer2022
- Author(s)
  Kobayashi Y, Takeda T, Kunitomi H, Chiwaki F, Komatsu M, Nagai S, Nogami Y, Tsuji K, Masuda K, Ogiwara H, Sasaki H, Banno K, Aoki D.
- Journal Title
  
  Pharmaceuticals (Basel)
  
  Volume: 15 Issue: 2 Pages: 124-124
- DOI
  10.3390/ph15020124
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09652, KAKENHI-PROJECT-21K15576
[Journal Article] Current state and outlook for drug repositioning anticipated in the field of ovarian cancer2019
- Author(s)
  Kobayashi Yusuke、Banno Kouji、Kunitomi Haruko、Tominaga Eiichiro、Aoki Daisuke
- Journal Title
  
  Journal of Gynecologic Oncology
  
  Volume: 30 Issue: 1
- DOI
  10.3802/jgo.2019.30.e10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16780
[Journal Article] Warburg effect in Gynecologic cancers2019
- Author(s)
  Kobayashi Yusuke、Banno Kouji、Kunitomi Haruko、Takahashi Takayuki、Takeda Takashi、Nakamura Kanako、Tsuji Kosuke、Tominaga Eiichiro、Aoki Daisuke
- Journal Title
  
  Journal of Obstetrics and Gynaecology Research
  
  Volume: 45 Issue: 3 Pages: 542-548
- DOI
  10.1111/jog.13867
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K16780
[Journal Article] Is antidyslipidemic statin use for cancer prevention a promising drug repositioning approach?2019
- Author(s)
  Kobayashi Yusuke, Banno Kouji, Kunitomi Haruko, Nagai Shimpei, Takahashi Takayuki, Anko Mayuka, Iijima Moito, Takeda Takashi, Matoba Yusuke, Nakamura Kanako, Tsuji Kosuke, Tominaga Eiichiro, Aoki Daisuke.
- Journal Title
  
  European Journal of Cancer Prevention
  
  Volume: 28 Issue: 6 Pages: 562-567
- DOI
  10.1097/cej.0000000000000497
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09298, KAKENHI-PROJECT-18K16780
[Journal Article] 卵巣がん　卵巣癌の治療　新たな薬物療法2018
- Author(s)
  小林佑介, 青木大輔
- Journal Title
  
  日本臨床　婦人科がん（第２版）ー最新の研究動向ー
  
  Volume: 76 Pages: 646-651
- Data Source
  KAKENHI-PROJECT-16K20205
[Journal Article] Drug repositioning of mevalonate pathway inhibitors as antitumor agents for ovarian cancer2017
- Author(s)
  Kobayashi Yusuke、Kashima Hiroyasu、Rahmanto Yohan Suryo、Banno Kouji、Yu Yu、Matoba Yusuke、Watanabe Keiko、Iijima Moito、Takeda Takashi、Kunitomi Haruko、Iida Miho、Adachi Masataka、Nakamura Kanako、Tsuji Kosuke、Masuda Kenta、Nomura Hiroyuki、Tominaga Eiichiro、Aoki Daisuke
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 42 Pages: 72147-72156
- DOI
  10.18632/oncotarget.20046
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K10730, KAKENHI-PROJECT-16K20205
[Presentation] Drug repositioning for ovarian cancer targeting mevalonate pathway2021
- Author(s)
  Yusuke Kobayashi
- Organizer
  The 36th annual meeting of Korean Society of Gynecologic Oncology (KSGO)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09652
[Presentation] ドラッグリポジショニングによるメバロン酸経路を標的とした卵巣癌予防薬・治療薬の創出2020
- Author(s)
  小林佑介
- Organizer
  第72回日本産科婦人科学会学術講演会シンポジウム
- Data Source
  KAKENHI-PROJECT-18K16780
[Presentation] ドラッグリポジショニングによるメバロン酸経路を標的とした卵巣癌予防薬・治療薬の創出2020
- Author(s)
  小林佑介
- Organizer
  第72回日本産科婦人科学会学術講演会　シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K16780
[Presentation] Drug repositioning for ovarian cancer targeting mevalonate pathway.2019
- Author(s)
  Yusuke Kobayashi, Haruko Kunitomi, Kouji Banno, Shimpei Nagai, Mayuka Anko, Takayuki Takahashi, Moito Iijima, Takashi Takeda, Keiko Watanabe, Yusuke Matoba, Kanako Nakamura, Kosuke Tsuji, Eiichiro Tominaga, Mamoru Tanaka, Daisuke Aoki.
- Organizer
  Royal College of Obstetricians & Gynaecologists (RCOG) World Congress 2019.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16780
[Presentation] Drug repositioning for ovarian cancer targeting mevalonate pathway2019
- Author(s)
  Yusuke Kobayashi, Haruko Kunitomi, Kouji Banno, Shimpei Nagai, Mayuka Anko, Takayuki Takahashi, Moito Iijima, Takashi Takeda, Keiko Watanabe, Yusuke Matoba, Kanako Nakamura, Kosuke Tsuji, Eiichiro Tominaga, Mamoru Tanaka, Daisuke Aoki
- Organizer
  Royal College of Obstetricians & Gynaecologists (RCOG) World Congress 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16780
[Presentation] Drug repositioning strategy for ovarian cancer2019
- Author(s)
  Yusuke Kobayashi
- Organizer
  Asian Society of Gynecologic Oncology (ASGO) 5th Workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16780
[Presentation] Bisphosphonates, another candidate of drug repositioning for ovarian cancer.2018
- Author(s)
  Yusuke Kobayashi, Kouji Banno, Haruko Kunitomi, Keiko Watanabe, Yusuke Matoba, Moito Iijima, Takashi Takeda, Masataka Adachi, Miho Iida, Kanako Nakamura, Kosuke Tsuji, Eiichiro Tominaga, Mamoru Tanaka, Daisuke Aoki.
- Organizer
  第70回日本産科婦人科学会学術講演会 International Session Workshop.
- Data Source
  KAKENHI-PROJECT-18K16780
[Presentation] Drug repositioning strategy for ovarian cancer.2018
- Author(s)
  Yusuke Kobayashi.
- Organizer
  Asian Society of Gynecologic Oncology (ASGO) 5th Workshop.
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16780
[Presentation] Drug repositioning for ovarian cancer targeting mevalonate pathway2018
- Author(s)
  Yusuke Kobayashi
- Organizer
  The 57th Annual Congress & The 7th International Symposium of TAOG
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20205
[Presentation] メバロン酸経路を標的とした卵巣癌新規治療戦略の可能性2017
- Author(s)
  小林佑介　阪埜浩司　國富晴子　的場優介　竹田貴　飯島茂偉人　安達将隆　中村加奈子　辻浩介　冨永英一郎　青木大輔
- Organizer
  第５回　がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-16K20205
[Presentation] メバロン酸経路を標的とした卵巣癌発癌予防を目指した基礎的研究2017
- Author(s)
  小林佑介　阪埜浩司　國富晴子　的場優介　渡辺慶子　飯島茂異人　竹田貴　飯田美穂　安達将隆　中村加奈子　辻浩介　冨永英一郎　青木大輔
- Organizer
  第32回　日本女性医学学会学術集会
- Data Source
  KAKENHI-PROJECT-16K20205
[Presentation] 「最新の分子標的薬・免疫療法と臨床試験」婦人科悪性腫瘍治療に対するドラッグリポジショニングの現状と未来2017
- Author(s)
  小林佑介
- Organizer
  第59回　日本婦人科腫瘍学会学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-16K20205
[Presentation] An investigation of novel treatment for ovarian cancer targeting mevalonate pathway2017
- Author(s)
  Yusuke Kobayashi
- Organizer
  25th Asian & Oceanic Congress of Obstetrics and Gynaecology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K20205
[Presentation] Investigation of the antineoplastic effect of lovastatin on ovarian cancer using metabolomic analysis2016
- Author(s)
  Yusuke Kobayashi
- Organizer
  第68回　日本産科婦人科学会学術講演会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-04-21
- Data Source
  KAKENHI-PROJECT-16K20205
[Presentation] 卵巣癌におけるメバロン酸合成経路を標的としたドラッグリポジショニングを目指した基礎的研究2016
- Author(s)
  小林佑介
- Organizer
  第58回　日本婦人科腫瘍学会学術講演会
- Place of Presentation
  米子コンベンションセンター（鳥取県米子市）
- Year and Date
  2016-07-08
- Invited
- Data Source
  KAKENHI-PROJECT-16K20205
[Presentation] 漿液性卵管上皮内癌モデルマウスを用いた卵巣癌に対するドラッグリポジショニング研究2016
- Author(s)
  小林佑介
- Organizer
  第48回　日本臨床分子形態学会
- Place of Presentation
  くまもと県民交流館パレア（熊本県熊本市）
- Year and Date
  2016-09-23
- Invited
- Data Source
  KAKENHI-PROJECT-16K20205

1. BANNO Kouji

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
2. TOMINAGA Eiichiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
3. KUNITOMI Haruko

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Kobayashi Yusuke 小林 佑介

Research Projects

Research Products

Co-Researchers

Investigation of Lipid Affinity and Statin Regulation of TCA Cycle in Ovarian CancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Clinicopathological and molecular biological characteristics of ovarian cancer associated with response to statins for dyslipidemiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New drug discovery against ovarian cancer focusing on the multifaceted effects of statins and their effects on the Warburg effectPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Translational research for clinical application using statins as a prevention drugs against ovarian cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Response Predictive Markers and Synergistic Agents for Drug Repositioning of Statins in Ovarian Cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Current state and outlook for drug repositioning anticipated in the field of ovarian cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Warburg effect in Gynecologic cancers2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Is antidyslipidemic statin use for cancer prevention a promising drug repositioning approach?2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 卵巣がん 卵巣癌の治療 新たな薬物療法2018

Author(s)

Journal Title

Data Source

[Journal Article] Drug repositioning of mevalonate pathway inhibitors as antitumor agents for ovarian cancer2017

Author(s)

Journal Title

DOI

Data Source

[Presentation] Drug repositioning for ovarian cancer targeting mevalonate pathway2021

Author(s)

Organizer

Data Source

[Presentation] ドラッグリポジショニングによるメバロン酸経路を標的とした 卵巣癌予防薬・治療薬の創出2020

Author(s)

Organizer

Data Source

[Presentation] ドラッグリポジショニングによるメバロン酸経路を標的とした卵巣癌予防薬・治療薬の創出2020

Author(s)

Organizer

Data Source

[Presentation] Drug repositioning for ovarian cancer targeting mevalonate pathway.2019

Author(s)

Organizer

Data Source

[Presentation] Drug repositioning for ovarian cancer targeting mevalonate pathway2019

Author(s)

Organizer

Data Source

[Presentation] Drug repositioning strategy for ovarian cancer2019

Author(s)

Organizer

Kobayashi Yusuke 小林佑介

[Journal Article] 卵巣がん　卵巣癌の治療　新たな薬物療法2018

[Presentation] ドラッグリポジショニングによるメバロン酸経路を標的とした卵巣癌予防薬・治療薬の創出2020

[Presentation] 「最新の分子標的薬・免疫療法と臨床試験」婦人科悪性腫瘍治療に対するドラッグリポジショニングの現状と未来2017