MISHIMA Yuji 三嶋雄二

Researcher Number	10442550
Affiliation (based on the past Project Information) *help	2011: 公益財団法人がん研究会, がん化学療法センター臨床部, 研究員 2008: Japanese Foundation For Cancer Research, 癌化学療法センター臨床部, 研究員 2007 – 2008: Japanese Foundation For Cancer Research, 癌化学療法センター・臨床部, 研究員
Review Section/Research Field	Principal Investigator Clinical oncology / Medical pharmacy
Keywords	Principal Investigator 末梢循環腫瘍細胞 / スフェロイド / Her2 / FISH / 蛍光免疫染色 / 末梢循環癌細胞 / イメージング / 薬剤反応性 / 癌 / 共焦点顕微鏡 / 生細胞イメージング / 感受性予測 / 抗体医薬

細胞トモグラフィーによる分子標的治療効果相関マーカーの探索Principal Investigator
- Principal Investigator
  
  三嶋雄二
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Japanese Foundation For Cancer Research
he establishment of the method for prediction of therapeutic antibody and the search of the prognostic factorsPrincipal Investigator
- Principal Investigator
  
  MISHIMA Yuji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Japanese Foundation For Cancer Research

All 2012 2011 2009 2008 2007

All Journal Article Presentation Book Patent

[Book] がん分子標的治療研究実践マニュアル (CDC, ADCC のアッセイ)2009
- Author(s)
  三嶋雄二畠清彦
- Publisher
  金芳堂
- Data Source
  KAKENHI-PROJECT-19590170
[Book] がんの分子標的治療(光イメージング)2008
- Author(s)
  三嶋雄二
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-19590170
[Book] がんの分子標的治療2008
- Author(s)
  三嶋雄二 (鶴尾孝編)
- Total Pages
  44
- Publisher
  南山堂
- Data Source
  KAKENHI-PROJECT-19590170
[Journal Article] High reproducible ADCC analysis revealed a competitive relation between ADCC and CDC and differences between FcγRllla polymorphism.2012
- Author(s)
  Mishima Y, Terui Y, Mishima Y, Kuniyoshi R, Matsusaka S, Mikuniya M, Kojima K, Hatake K.
- Journal Title
  
  Int Immunol.
  
  Volume: (on line) Issue: 8 Pages: 477-483
- DOI
  10.1093/intimm/dxs048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501320
[Journal Article] Circulating endothelial progenitors and CXCR4-positive circulating endothelial cells are predictive markers for bevacizumab.2011
- Author(s)
  Matsusaka S, Mishima Y, Suenaga M, Terui Y, Kuniyoshi R, Mizunuma N, Hatake K.
- Journal Title
  
  Cancer
  
  Volume: 117(17) Issue: 17 Pages: 4026-32
- DOI
  10.1002/cncr.25977
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501320
[Journal Article] The identification of irreversible rituximab-resistant lymphoma caused by CD20 gene mutations2011
- Author(s)
  Y Mishima, Y Terui, K Takeuchi, Y Matsumoto-Mishima, S Matsusaka, R Utsubo-Kuniyoshi, K Hatake
- Journal Title
  
  Blood Cancer Journal
  
  Volume: 1 Issue: 4 Pages: e15-e15
- DOI
  10.1038/bcj.2011.11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501320
[Journal Article] Circulating tumor cells as a surrogate marker for determining response to chemotherapy in Japanese patients with metastatic colorectal cancer.2011
- Author(s)
  Matsusaka S, Suenaga M, Mishima Y, Kuniyoshi R. Takagi K, Terui Y, Mizunuma N, Hatake K.
- Journal Title
  
  Cancer Sci.
  
  Volume: 102(6) Issue: 6 Pages: 1188-92
- DOI
  10.1111/j.1349-7006.2011.01926.x
- NAID
  10029294517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501320
[Journal Article] Identification of CD20 C-terminal deletion mutations associated with loss of CD20 expression in non-Hodgkin's lymphoma2009
- Author(s)
  Terui Y, Mishima Y, et.al
- Journal Title
  
  Clinical Cancer Research 15(7)
  
  Pages: 2523-2523
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590170
[Journal Article] An Imaging-Based Rapid Evaluation Method for Complement-Dependent Cytotoxicity Discriminated Clinical Response to Rituximab-Containing Chemotherapy2009
- Author(s)
  Mishima Y, Sugimura N, et al
- Journal Title
  
  Clinical Cancer Research (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590170
[Journal Article] Identification of CD20 C-terminal deletion mutations as sociated with loss of CD20 expression in non-Hodgkin's lymphoma2009
- Author(s)
  Terui Y, Mishima Y, et. al.
- Journal Title
  
  Clinical Cancer Research 15(7)
  
  Pages: 12523-2563
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590170
[Journal Article] An Imaging-Based Rapid Evaluation Method for Complement-Dependent Cytotoxicity Discriminated Clinical Response to Rituximab-Containing Chemotherapy2009
- Author(s)
  Mishima Y, Sugimura N, et al
- Journal Title
  
  Clinical Cancer Research 15(10)
  
  Pages: 3624-3624
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590170
[Journal Article] がんトランスレーショナルリサーチにおけるバイオイメージングの役割2008
- Author(s)
  三嶋雄二, 畠清彦
- Journal Title
  
  がん分子標的治療 6(2)
  
  Pages: 92-100
- Data Source
  KAKENHI-PROJECT-19590170
[Journal Article] 予後とCirculating Endothelial cells2008
- Author(s)
  三嶋雄二、松阪諭、畠清彦
- Journal Title
  
  Cancer Frontier
  
  Pages: 10-10
- Data Source
  KAKENHI-PROJECT-19590170
[Journal Article] がんトランスレーショナルリサーチにおけるバイオイメージングの役割2008
- Author(s)
  三嶋雄二
- Journal Title
  
  がん分子標的治療 6(2)
- Data Source
  KAKENHI-PROJECT-19590170
[Journal Article] 予後と Circulating Endothelial cells2008
- Author(s)
  三嶋雄二, 松阪論, 畠清彦
- Journal Title
  
  Cancer Frontier 10
  
  Pages: 131-136
- Data Source
  KAKENHI-PROJECT-19590170
[Journal Article] CD5 expression is potentially predictive of poor outcome among biomarkers in patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP t herapy2008
- Author(s)
  Ennishi D, Mishima Y, et. al.
- Journal Title
  
  Annals oncology 19(11)
  
  Pages: 1921-1926
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590170
[Journal Article] Autophagy and autophagic cell death are next targets for elimination of the resistance to tyrosine kinase inhibitors2008
- Author(s)
  Mishima Y, Terui Y, et al
- Journal Title
  
  Cancer Science 99(11)
  
  Pages: 2200-2208
- NAID
  10024012990
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590170
[Journal Article] CD5 expression is potentially predictive of poor outcome among biomarkers in patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP therapy2008
- Author(s)
  Ennishi D, Mishima Y, et.al
- Journal Title
  
  Annals oncology 19(10)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590170
[Journal Article] がんトランスレーショナルリサーチにおけるバイオイメージングの役割2008
- Author(s)
  三嶋雄二、畠清彦
- Journal Title
  
  がん分子標的治療 6(2)
  
  Pages: 92-92
- Data Source
  KAKENHI-PROJECT-19590170
[Journal Article] in vivo 光イメージング2007
- Author(s)
  三嶋雄二、畠清彦
- Journal Title
  
  病理と臨床 25(6)
  
  Pages: 526-526
- Data Source
  KAKENHI-PROJECT-19590170
[Journal Article] in vivo cell biology2007
- Author(s)
  三嶋雄二、畠清彦
- Journal Title
  
  病理と臨床 25(6)
  
  Pages: 526-532
- Data Source
  KAKENHI-PROJECT-19590170
[Journal Article] 抗体医薬の補体依存性,抗体依存性殺細胞効果2007
- Author(s)
  三嶋雄二
- Journal Title
  
  Pharma Medica 25(3)
  
  Pages: 9-13
- Data Source
  KAKENHI-PROJECT-19590170
[Journal Article] 抗体医薬の補体依存性,抗体依存性殺細胞効果2007
- Author(s)
  三嶋雄二
- Journal Title
  
  Pharma Medica 25(3)
  
  Pages: 9-9
- Data Source
  KAKENHI-PROJECT-19590170
[Patent] METHOD OF ANALYZING GENETICALLY ABNORMAL CELLS2011
- Inventor(s)
  三嶋雄二　畠清彦　安部隆史
- Industrial Property Rights Holder
  三嶋雄二　畠清彦　安部隆史
- Filing Date
  2011
- Overseas
- Data Source
  KAKENHI-PROJECT-23501320
[Patent] METHOD OF ANALYZING GENETICALLY ABNORMAL CELLS2011
- Inventor(s)
  三嶋雄二, 畠清彦, 安部隆史
- Industrial Property Rights Holder
  三嶋雄二, 畠清彦, 安部隆史
- Filing Date
  2011-11-07
- Overseas
- Data Source
  KAKENHI-PROJECT-23501320
[Patent] METHOD OF ANALYZING GENETICALLY ABNORMAL CELLS2011
- Inventor(s)
  三嶋雄二, 畠清彦, 安部隆史
- Industrial Property Rights Holder
  三嶋雄二, 畠清彦, 安部隆史
- Filing Date
  2011-11-07
- Overseas
- Data Source
  KAKENHI-PROJECT-23501320
[Patent] METHOD OF ANALYZING GENETICALLY ABNORMAL CELLS2011
- Inventor(s)
  三嶋雄二　畠清彦　安部隆史
- Industrial Property Rights Holder
  三嶋雄二　畠清彦　安部隆史
- Filing Date
  2011
- Overseas
- Data Source
  KAKENHI-PROJECT-23501320
[Patent] Fc受容体遺伝子導入NK細胞株、その作製方法、及びこれを用いた抗体依存性細胞障害のアッセイ方法2007
- Inventor(s)
  杉村夏彦, 三嶋雄二, 畠清彦
- Industrial Property Rights Holder
  財団法人癌研究会オリンパス株式会社
- Industrial Property Number
  2007-254099
- Filing Date
  2007-09-28
- Data Source
  KAKENHI-PROJECT-19590170
[Patent] 抗体医薬感受性検査方法2007
- Inventor(s)
  杉村夏彦, 三嶋雄二, 畠清彦
- Industrial Property Rights Holder
  財団法人癌研究会オリンパス株式会社
- Filing Date
  2007-09-26
- Overseas
- Data Source
  KAKENHI-PROJECT-19590170
[Presentation] Detection of rituximab resistant CD20 mutations and the elucidation of the mechanisms to develop resistant phenotype2011
- Author(s)
  三嶋雄二、照井康仁、竹内賢吾、三嶋裕子、国吉良子、畠清彦
- Organizer
  日本癌学会
- Place of Presentation
  名古屋、愛知県
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-23501320
[Presentation] Genetic analysis of circulating tumor cells using 3D immunostain and FISH2011
- Author(s)
  Yuji Mishima, Satoshi Matsusaka, Yasuhito Terui, Mariko Mikuniya, Nobuyuki Mizunuma, and Kiyohiko Hatake
- Organizer
  American Association for Cancer Research
- Place of Presentation
  Orlando, FL, USA
- Data Source
  KAKENHI-PROJECT-23501320
[Presentation] Genetic analysis of circulating tumor cells using 3D immune stain and FISH2011
- Author(s)
  Yuji Mishima, Satoshi Matsusaka, Yasuhito Terui, Mariko Mikuniya, Nobuyuki Mizunuma, Kiyohiko Hatake
- Organizer
  American Association for Cancer Research
- Place of Presentation
  Orlando, FL, USA
- Year and Date
  2011-04-05
- Data Source
  KAKENHI-PROJECT-23501320
[Presentation] Establishment of evaluation system of the effector mechanisms induced by therapeutic antibodies using confocal time-lapse imaging2011
- Author(s)
  Yuji Mishima, Kiyohiko Hatake
- Organizer
  日本バイオイメージング学会
- Place of Presentation
  千歳市、北海道
- Year and Date
  2011-09-01
- Data Source
  KAKENHI-PROJECT-23501320
[Presentation] Development of a screening strategy for detecting rituximab-resistant mutations and characterization of mechanisms for acquiring resistant phenotype2011
- Author(s)
  Yuji Mishima, Yasuhito Terui, Yuko Mishima, Mariko Mikuniya, Kiyohiko Hatake
- Organizer
  Molecular Target and Cancer Therapeutics
- Place of Presentation
  SanFrancisco, CA, USA
- Year and Date
  2011-11-14
- Data Source
  KAKENHI-PROJECT-23501320
[Presentation] 治療前CDC感受性評価法の確立と rituximan 治療効果予測における有用性2008
- Author(s)
  三嶋雄二, ら
- Organizer
  日本血液学会
- Place of Presentation
  京都
- Year and Date
  2008-10-10
- Data Source
  KAKENHI-PROJECT-19590170
[Presentation] Establishment of an assay system for ADCC activity and search for factors that affect ADCC activity2008
- Author(s)
  三嶋雄二, ら
- Organizer
  日本癌学会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-29
- Data Source
  KAKENHI-PROJECT-19590170
[Presentation] ADCCアッセイシステムの確立とADCC抵抗性因子の探索2008
- Author(s)
  三嶋雄二, ら
- Organizer
  がん分子標的治療研究会
- Place of Presentation
  東京
- Year and Date
  2008-06-27
- Data Source
  KAKENHI-PROJECT-19590170
[Presentation] Prediction of clinical response of rituximab containing chemotherapy using newly established live-cell-imaging procedure for estimating CDC susceptibility2008
- Author(s)
  Yuji Mishima
- Organizer
  Molecular Targetand Cancer Therapeutics
- Place of Presentation
  Geneva, Switzerland
- Data Source
  KAKENHI-PROJECT-19590170
[Presentation] ADCCアッセイシステムの確立とADCC抵抗性因子の探索2008
- Author(s)
  三嶋雄二
- Organizer
  がん分子標的治療研究会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590170
[Presentation] 治療前CDC感受性評価法の確立とrituximab 治療効果予測における有用性2008
- Author(s)
  三嶋雄二
- Organizer
  第70回日本血液学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19590170
[Presentation] Prediction of clinical response of rituximab containing chemotherapy using newly established live-cell-imaging procedure for estimating CDC susceptibility2008
- Author(s)
  Mishima Y, et. al
- Organizer
  EORTC-NCI-AACR Molecular Target and Cancer therapeutics
- Place of Presentation
  Geneva, Switzerland
- Year and Date
  2008-10-21
- Data Source
  KAKENHI-PROJECT-19590170
[Presentation] Establishment of an assay system for ADCC activity and search for factors that affect ADCC activity2008
- Author(s)
  三嶋雄二
- Organizer
  第67回日本癌学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-19590170
[Presentation] Development of rapid evaluation system of the Rituximab-mediated complement-dependent cytotoxicity2007
- Author(s)
  Mishima Y, Terui, Y, et. al.
- Organizer
  MabThera Expert Invetigator Forum
- Place of Presentation
  SanFrancisco
- Year and Date
  2007-04-21
- Data Source
  KAKENHI-PROJECT-19590170
[Presentation] Establishment of reproducible ADCC assay system2007
- Author(s)
  Mishima Y, Terui, Y, et. al.
- Organizer
  Molecular Targetand Cancer Therapeutics
- Place of Presentation
  SanFrancisco
- Year and Date
  2007-10-24
- Data Source
  KAKENHI-PROJECT-19590170
[Presentation] ライブセルイメージングを用いた抗体医薬の予後予測システムの開発2007
- Author(s)
  三嶋雄二
- Organizer
  ダイアローグイメージングセミナー
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590170
[Presentation] Estabhshment of reproducible ADCC assay system2007
- Author(s)
  三嶋雄二、照井康仁, 他
- Organizer
  第66回日本癌学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-19590170
[Presentation] Establishment of reproducible ADCC assay system2007
- Author(s)
  Yuji Mishima
- Organizer
  abthera Expert investigator Forum
- Place of Presentation
  Lisbon, Portugal
- Data Source
  KAKENHI-PROJECT-19590170
[Presentation] Establishment of reproducible ADCC assay system2007
- Author(s)
  三嶋雄二
- Organizer
  第66回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-19590170
[Presentation] Establishment of reproducible ADCC assay system2007
- Author(s)
  Yuji Mishima
- Organizer
  Molecular Targetand Cancer Therapeutics
- Place of Presentation
  San Francisco, USA
- Data Source
  KAKENHI-PROJECT-19590170

1. 照井康仁 (10285786)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. 松阪諭 (00372665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results

MISHIMA Yuji 三嶋 雄二

Research Projects

Research Products

Co-Researchers

細胞トモグラフィーによる分子標的治療効果相関マーカーの探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

he establishment of the method for prediction of therapeutic antibody and the search of the prognostic factorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] がん分子標的治療研究実践マニュアル (CDC, ADCC のアッセイ)2009

Author(s)

Publisher

Data Source

[Book] がんの分子標的治療(光イメージング)2008

Author(s)

Publisher

Data Source

[Book] がんの分子標的治療2008

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] High reproducible ADCC analysis revealed a competitive relation between ADCC and CDC and differences between FcγRllla polymorphism.2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circulating endothelial progenitors and CXCR4-positive circulating endothelial cells are predictive markers for bevacizumab.2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The identification of irreversible rituximab-resistant lymphoma caused by CD20 gene mutations2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Circulating tumor cells as a surrogate marker for determining response to chemotherapy in Japanese patients with metastatic colorectal cancer.2011

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Identification of CD20 C-terminal deletion mutations associated with loss of CD20 expression in non-Hodgkin's lymphoma2009

Author(s)

Journal Title

Data Source

[Journal Article] An Imaging-Based Rapid Evaluation Method for Complement-Dependent Cytotoxicity Discriminated Clinical Response to Rituximab-Containing Chemotherapy2009

Author(s)

Journal Title

Data Source

[Journal Article] Identification of CD20 C-terminal deletion mutations as sociated with loss of CD20 expression in non-Hodgkin's lymphoma2009

Author(s)

Journal Title

Data Source

[Journal Article] An Imaging-Based Rapid Evaluation Method for Complement-Dependent Cytotoxicity Discriminated Clinical Response to Rituximab-Containing Chemotherapy2009

Author(s)

Journal Title

Data Source

[Journal Article] がんトランスレーショナルリサーチにおけるバイオイメージングの役割2008

Author(s)

Journal Title

Data Source

[Journal Article] 予後とCirculating Endothelial cells2008

Author(s)

Journal Title

Data Source

[Journal Article] がんトランスレーショナルリサーチにおけるバイオイメージングの役割2008

Author(s)

Journal Title

Data Source

[Journal Article] 予後と Circulating Endothelial cells2008

Author(s)

MISHIMA Yuji 三嶋雄二