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MISHIMA Yuji  三嶋 雄二

ORCIDConnect your ORCID iD *help
Researcher Number 10442550
Affiliation (based on the past Project Information) *help 2011: 公益財団法人がん研究会, がん化学療法センター臨床部, 研究員
2008: Japanese Foundation For Cancer Research, 癌化学療法センター臨床部, 研究員
2007 – 2008: Japanese Foundation For Cancer Research, 癌化学療法センター・臨床部, 研究員
Review Section/Research Field
Principal Investigator
Clinical oncology / Medical pharmacy
Keywords
Principal Investigator
末梢循環腫瘍細胞 / スフェロイド / Her2 / FISH / 蛍光免疫染色 / 末梢循環癌細胞 / イメージング / 薬剤反応性 / 癌 / 共焦点顕微鏡 / 生細胞イメージング / 感受性予測 / 抗体医薬
  • Research Projects

    (2 results)
  • Research Products

    (49 results)
  • Co-Researchers

    (2 People)
  •  細胞トモグラフィーによる分子標的治療効果相関マーカーの探索Principal Investigator

    • Principal Investigator
      三嶋 雄二
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Clinical oncology
    • Research Institution
      Japanese Foundation For Cancer Research
  •  he establishment of the method for prediction of therapeutic antibody and the search of the prognostic factorsPrincipal Investigator

    • Principal Investigator
      MISHIMA Yuji
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical pharmacy
    • Research Institution
      Japanese Foundation For Cancer Research

All 2012 2011 2009 2008 2007

All Journal Article Presentation Book Patent

  • [Book] がん分子標的治療研究実践マニュアル (CDC, ADCC のアッセイ)2009

    • Author(s)
      三嶋雄二 畠清彦
    • Publisher
      金芳堂
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Book] がんの分子標的治療(光イメージング)2008

    • Author(s)
      三嶋雄二
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Book] がんの分子標的治療2008

    • Author(s)
      三嶋雄二 (鶴尾孝編)
    • Total Pages
      44
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Journal Article] High reproducible ADCC analysis revealed a competitive relation between ADCC and CDC and differences between FcγRllla polymorphism.2012

    • Author(s)
      Mishima Y, Terui Y, Mishima Y, Kuniyoshi R, Matsusaka S, Mikuniya M, Kojima K, Hatake K.
    • Journal Title

      Int Immunol.

      Volume: (on line) Issue: 8 Pages: 477-483

    • DOI

      10.1093/intimm/dxs048

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501320
  • [Journal Article] Circulating endothelial progenitors and CXCR4-positive circulating endothelial cells are predictive markers for bevacizumab.2011

    • Author(s)
      Matsusaka S, Mishima Y, Suenaga M, Terui Y, Kuniyoshi R, Mizunuma N, Hatake K.
    • Journal Title

      Cancer

      Volume: 117(17) Issue: 17 Pages: 4026-32

    • DOI

      10.1002/cncr.25977

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501320
  • [Journal Article] The identification of irreversible rituximab-resistant lymphoma caused by CD20 gene mutations2011

    • Author(s)
      Y Mishima, Y Terui, K Takeuchi, Y Matsumoto-Mishima, S Matsusaka, R Utsubo-Kuniyoshi, K Hatake
    • Journal Title

      Blood Cancer Journal

      Volume: 1 Issue: 4 Pages: e15-e15

    • DOI

      10.1038/bcj.2011.11

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501320
  • [Journal Article] Circulating tumor cells as a surrogate marker for determining response to chemotherapy in Japanese patients with metastatic colorectal cancer.2011

    • Author(s)
      Matsusaka S, Suenaga M, Mishima Y, Kuniyoshi R. Takagi K, Terui Y, Mizunuma N, Hatake K.
    • Journal Title

      Cancer Sci.

      Volume: 102(6) Issue: 6 Pages: 1188-92

    • DOI

      10.1111/j.1349-7006.2011.01926.x

    • NAID

      10029294517

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501320
  • [Journal Article] Identification of CD20 C-terminal deletion mutations associated with loss of CD20 expression in non-Hodgkin's lymphoma2009

    • Author(s)
      Terui Y, Mishima Y, et.al
    • Journal Title

      Clinical Cancer Research 15(7)

      Pages: 2523-2523

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Journal Article] An Imaging-Based Rapid Evaluation Method for Complement-Dependent Cytotoxicity Discriminated Clinical Response to Rituximab-Containing Chemotherapy2009

    • Author(s)
      Mishima Y, Sugimura N, et al
    • Journal Title

      Clinical Cancer Research (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Journal Article] Identification of CD20 C-terminal deletion mutations as sociated with loss of CD20 expression in non-Hodgkin's lymphoma2009

    • Author(s)
      Terui Y, Mishima Y, et. al.
    • Journal Title

      Clinical Cancer Research 15(7)

      Pages: 12523-2563

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Journal Article] An Imaging-Based Rapid Evaluation Method for Complement-Dependent Cytotoxicity Discriminated Clinical Response to Rituximab-Containing Chemotherapy2009

    • Author(s)
      Mishima Y, Sugimura N, et al
    • Journal Title

      Clinical Cancer Research 15(10)

      Pages: 3624-3624

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Journal Article] がんトランスレーショナルリサーチにおけるバイオイメージングの役割2008

    • Author(s)
      三嶋雄二, 畠清彦
    • Journal Title

      がん分子標的治療 6(2)

      Pages: 92-100

    • Data Source
      KAKENHI-PROJECT-19590170
  • [Journal Article] 予後とCirculating Endothelial cells2008

    • Author(s)
      三嶋雄二、松阪諭、畠清彦
    • Journal Title

      Cancer Frontier

      Pages: 10-10

    • Data Source
      KAKENHI-PROJECT-19590170
  • [Journal Article] がんトランスレーショナルリサーチにおけるバイオイメージングの役割2008

    • Author(s)
      三嶋雄二
    • Journal Title

      がん分子標的治療 6(2)

    • Data Source
      KAKENHI-PROJECT-19590170
  • [Journal Article] 予後と Circulating Endothelial cells2008

    • Author(s)
      三嶋雄二, 松阪論, 畠清彦
    • Journal Title

      Cancer Frontier 10

      Pages: 131-136

    • Data Source
      KAKENHI-PROJECT-19590170
  • [Journal Article] CD5 expression is potentially predictive of poor outcome among biomarkers in patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP t herapy2008

    • Author(s)
      Ennishi D, Mishima Y, et. al.
    • Journal Title

      Annals oncology 19(11)

      Pages: 1921-1926

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Journal Article] Autophagy and autophagic cell death are next targets for elimination of the resistance to tyrosine kinase inhibitors2008

    • Author(s)
      Mishima Y, Terui Y, et al
    • Journal Title

      Cancer Science 99(11)

      Pages: 2200-2208

    • NAID

      10024012990

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Journal Article] CD5 expression is potentially predictive of poor outcome among biomarkers in patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP therapy2008

    • Author(s)
      Ennishi D, Mishima Y, et.al
    • Journal Title

      Annals oncology 19(10)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Journal Article] がんトランスレーショナルリサーチにおけるバイオイメージングの役割2008

    • Author(s)
      三嶋雄二、畠清彦
    • Journal Title

      がん分子標的治療 6(2)

      Pages: 92-92

    • Data Source
      KAKENHI-PROJECT-19590170
  • [Journal Article] in vivo 光イメージング2007

    • Author(s)
      三嶋雄二、畠清彦
    • Journal Title

      病理と臨床 25(6)

      Pages: 526-526

    • Data Source
      KAKENHI-PROJECT-19590170
  • [Journal Article] in vivo cell biology2007

    • Author(s)
      三嶋 雄二、畠 清彦
    • Journal Title

      病理と臨床 25(6)

      Pages: 526-532

    • Data Source
      KAKENHI-PROJECT-19590170
  • [Journal Article] 抗体医薬の補体依存性,抗体依存性殺細胞効果2007

    • Author(s)
      三嶋 雄二
    • Journal Title

      Pharma Medica 25(3)

      Pages: 9-13

    • Data Source
      KAKENHI-PROJECT-19590170
  • [Journal Article] 抗体医薬の補体依存性,抗体依存性殺細胞効果2007

    • Author(s)
      三嶋雄二
    • Journal Title

      Pharma Medica 25(3)

      Pages: 9-9

    • Data Source
      KAKENHI-PROJECT-19590170
  • [Patent] METHOD OF ANALYZING GENETICALLY ABNORMAL CELLS2011

    • Inventor(s)
      三嶋雄二 畠清彦 安部隆史
    • Industrial Property Rights Holder
      三嶋雄二 畠清彦 安部隆史
    • Filing Date
      2011
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23501320
  • [Patent] METHOD OF ANALYZING GENETICALLY ABNORMAL CELLS2011

    • Inventor(s)
      三嶋雄二, 畠清彦, 安部隆史
    • Industrial Property Rights Holder
      三嶋雄二, 畠清彦, 安部隆史
    • Filing Date
      2011-11-07
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23501320
  • [Patent] METHOD OF ANALYZING GENETICALLY ABNORMAL CELLS2011

    • Inventor(s)
      三嶋雄二, 畠清彦, 安部隆史
    • Industrial Property Rights Holder
      三嶋雄二, 畠清彦, 安部隆史
    • Filing Date
      2011-11-07
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23501320
  • [Patent] METHOD OF ANALYZING GENETICALLY ABNORMAL CELLS2011

    • Inventor(s)
      三嶋雄二 畠清彦 安部隆史
    • Industrial Property Rights Holder
      三嶋雄二 畠清彦 安部隆史
    • Filing Date
      2011
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23501320
  • [Patent] Fc受容体遺伝子導入NK細胞株、その作製方法、及びこれを用いた抗体依存性細胞障害のアッセイ方法2007

    • Inventor(s)
      杉村 夏彦, 三嶋 雄二, 畠 清彦
    • Industrial Property Rights Holder
      財団法人癌研究会オリンパス株式会社
    • Industrial Property Number
      2007-254099
    • Filing Date
      2007-09-28
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Patent] 抗体医薬感受性検査方法2007

    • Inventor(s)
      杉村 夏彦, 三嶋 雄二, 畠 清彦
    • Industrial Property Rights Holder
      財団法人癌研究会オリンパス株式会社
    • Filing Date
      2007-09-26
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Presentation] Detection of rituximab resistant CD20 mutations and the elucidation of the mechanisms to develop resistant phenotype2011

    • Author(s)
      三嶋雄二、照井康仁、竹内賢吾、三嶋裕子、国吉良子、畠清彦
    • Organizer
      日本癌学会
    • Place of Presentation
      名古屋、愛知県
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-23501320
  • [Presentation] Genetic analysis of circulating tumor cells using 3D immunostain and FISH2011

    • Author(s)
      Yuji Mishima, Satoshi Matsusaka, Yasuhito Terui, Mariko Mikuniya, Nobuyuki Mizunuma, and Kiyohiko Hatake
    • Organizer
      American Association for Cancer Research
    • Place of Presentation
      Orlando, FL, USA
    • Data Source
      KAKENHI-PROJECT-23501320
  • [Presentation] Genetic analysis of circulating tumor cells using 3D immune stain and FISH2011

    • Author(s)
      Yuji Mishima, Satoshi Matsusaka, Yasuhito Terui, Mariko Mikuniya, Nobuyuki Mizunuma, Kiyohiko Hatake
    • Organizer
      American Association for Cancer Research
    • Place of Presentation
      Orlando, FL, USA
    • Year and Date
      2011-04-05
    • Data Source
      KAKENHI-PROJECT-23501320
  • [Presentation] Establishment of evaluation system of the effector mechanisms induced by therapeutic antibodies using confocal time-lapse imaging2011

    • Author(s)
      Yuji Mishima, Kiyohiko Hatake
    • Organizer
      日本バイオイメージング学会
    • Place of Presentation
      千歳市、北海道
    • Year and Date
      2011-09-01
    • Data Source
      KAKENHI-PROJECT-23501320
  • [Presentation] Development of a screening strategy for detecting rituximab-resistant mutations and characterization of mechanisms for acquiring resistant phenotype2011

    • Author(s)
      Yuji Mishima, Yasuhito Terui, Yuko Mishima, Mariko Mikuniya, Kiyohiko Hatake
    • Organizer
      Molecular Target and Cancer Therapeutics
    • Place of Presentation
      SanFrancisco, CA, USA
    • Year and Date
      2011-11-14
    • Data Source
      KAKENHI-PROJECT-23501320
  • [Presentation] 治療前CDC感受性評価法の確立と rituximan 治療効果予測における有用性2008

    • Author(s)
      三嶋雄二, ら
    • Organizer
      日本血液学会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Presentation] Establishment of an assay system for ADCC activity and search for factors that affect ADCC activity2008

    • Author(s)
      三嶋雄二, ら
    • Organizer
      日本癌学会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Presentation] ADCCアッセイシステムの確立とADCC抵抗性因子の探索2008

    • Author(s)
      三嶋雄二, ら
    • Organizer
      がん分子標的治療研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-27
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Presentation] Prediction of clinical response of rituximab containing chemotherapy using newly established live-cell-imaging procedure for estimating CDC susceptibility2008

    • Author(s)
      Yuji Mishima
    • Organizer
      Molecular Targetand Cancer Therapeutics
    • Place of Presentation
      Geneva, Switzerland
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Presentation] ADCCアッセイシステムの確立とADCC抵抗性因子の探索2008

    • Author(s)
      三嶋雄二
    • Organizer
      がん分子標的治療研究会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Presentation] 治療前CDC感受性評価法の確立とrituximab 治療効果予測における有用性2008

    • Author(s)
      三嶋雄二
    • Organizer
      第70回日本血液学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Presentation] Prediction of clinical response of rituximab containing chemotherapy using newly established live-cell-imaging procedure for estimating CDC susceptibility2008

    • Author(s)
      Mishima Y, et. al
    • Organizer
      EORTC-NCI-AACR Molecular Target and Cancer therapeutics
    • Place of Presentation
      Geneva, Switzerland
    • Year and Date
      2008-10-21
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Presentation] Establishment of an assay system for ADCC activity and search for factors that affect ADCC activity2008

    • Author(s)
      三嶋雄二
    • Organizer
      第67回日本癌学会総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Presentation] Development of rapid evaluation system of the Rituximab-mediated complement-dependent cytotoxicity2007

    • Author(s)
      Mishima Y, Terui, Y, et. al.
    • Organizer
      MabThera Expert Invetigator Forum
    • Place of Presentation
      SanFrancisco
    • Year and Date
      2007-04-21
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Presentation] Establishment of reproducible ADCC assay system2007

    • Author(s)
      Mishima Y, Terui, Y, et. al.
    • Organizer
      Molecular Targetand Cancer Therapeutics
    • Place of Presentation
      SanFrancisco
    • Year and Date
      2007-10-24
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Presentation] ライブセルイメージングを用いた抗体医薬の予後予測システムの開発2007

    • Author(s)
      三嶋雄二
    • Organizer
      ダイアローグイメージングセミナー
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Presentation] Estabhshment of reproducible ADCC assay system2007

    • Author(s)
      三嶋 雄二、照井 康仁, 他
    • Organizer
      第66回日本癌学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-04
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Presentation] Establishment of reproducible ADCC assay system2007

    • Author(s)
      Yuji Mishima
    • Organizer
      abthera Expert investigator Forum
    • Place of Presentation
      Lisbon, Portugal
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Presentation] Establishment of reproducible ADCC assay system2007

    • Author(s)
      三嶋雄二
    • Organizer
      第66回日本癌学会総会
    • Data Source
      KAKENHI-PROJECT-19590170
  • [Presentation] Establishment of reproducible ADCC assay system2007

    • Author(s)
      Yuji Mishima
    • Organizer
      Molecular Targetand Cancer Therapeutics
    • Place of Presentation
      San Francisco, USA
    • Data Source
      KAKENHI-PROJECT-19590170
  • 1.  照井 康仁 (10285786)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 8 results
  • 2.  松阪 諭 (00372665)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results

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