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Ashizawa Tadashi  芦澤 忠

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ASHIZAWA Tadashi  芦澤 忠

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Researcher Number 10443441
Affiliation (Current) 2022: 静岡県立静岡がんセンター(研究所), その他部局等, 研究員
Affiliation (based on the past Project Information) *help 2018 – 2021: 静岡県立静岡がんセンター(研究所), その他部局等, 研究員
2013 – 2014: 静岡県立静岡がんセンター(研究所), その他部局等, その他
2012: 静岡県立静岡がんセンター(研究所), その他部局等, 研究員
Review Section/Research Field
Principal Investigator
Clinical oncology / Basic Section 50020:Tumor diagnostics and therapeutics-related
Except Principal Investigator
Basic Section 56070:Plastic and reconstructive surgery-related
Keywords
Principal Investigator
がん幹細胞治療薬 / 国際情報交換 / PD-L1 / PD-1/PD-L1 inhibitor / PD-1/PD-L inhibitor / 免疫チェックポイント
Except Principal Investigator
皮弁 / 免疫 / リンパ節 / マウス / 免疫療法
  • Research Projects

    (3 results)
  • Research Products

    (20 results)
  • Co-Researchers

    (15 People)
  •  マウスリンパ節付随免疫皮弁モデルを利用した新しいがん免疫療法の開発

    • Principal Investigator
      石井 義剛
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56070:Plastic and reconstructive surgery-related
    • Research Institution
      Shizuoka Cancer Center Research Institute
  •  Identification of small molecular compounds with PD-1 / PD-L1 inhibitory activity by in silicoPrincipal Investigator

    • Principal Investigator
      Ashizawa Tadashi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Shizuoka Cancer Center Research Institute
  •  Development of a novel small-molecule compounds targeting cancer stem cells derived from malignant gliomaPrincipal Investigator

    • Principal Investigator
      ASHIZAWA Tadashi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Clinical oncology
    • Research Institution
      Shizuoka Cancer Center Research Institute

All 2019 2018 2014 2013 2012 Other

All Journal Article Presentation

  • [Journal Article] Impact of combination therapy with anti-PD-1 blockade and a STAT3 inhibitor on the tumor-infiltrating lymphocyte status2019

    • Author(s)
      Ashizawa T, Iizuka A, Maeda C, Tanaka E, Kondou R, Miyata H, Sugino T, Kawata T, Deguchi S, Mitsuya K, Hayashi N, Asai A, Ito M, Yamaguchi K, Akiyama Y.
    • Journal Title

      Immunol Lett

      Volume: 216 Pages: 43-50

    • DOI

      10.1016/j.imlet.2019.10.003

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-18H02559, KAKENHI-PROJECT-17K07209
  • [Journal Article] Identification of a neoantigen epitope in a melanoma patient with good response to anti-PD-1 antibody therapy2019

    • Author(s)
      Nonomura C, Otsuka M, Kondou R, Iizuka A, Miyata H, Ashizawa T, Sakura N, Yoshikawa S, Kiyohara Y, Ohshima K, Urakami K, Nagashima T, Ohnami S, Kusuhara M, Mitsuya K, Hayashi N, Nakasu Y, Mochizuki T, Yamaguchi K, Akiyama Y
    • Journal Title

      Immunol Lett

      Volume: 208 Pages: 52-59

    • DOI

      10.1016/j.imlet.2019.02.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-17K07209
  • [Journal Article] A T-cell-engaging B7-H4/CD3-bispecific Fab-scFv Antibody Targets Human Breast Cancer.2019

    • Author(s)
      Iizuka Akira、Nonomura Chizu、Ashizawa Tadashi、Kondou Ryota、Ohshima Keiichi、Sugino Takashi、Mitsuya Koichi、Hayashi Nakamasa、Nakasu Yoko、Maruyama Kouji、Yamaguchi Ken、Akiyama Yasuto
    • Journal Title

      Clin Cancer Res

      Volume: 25 Pages: 2925-2934

    • DOI

      10.1158/1078-0432.ccr-17-3123

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07235, KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-17K07209
  • [Journal Article] Classification of tumor microenvironment immune types based on immune response-associated gene expression.2019

    • Author(s)
      Kondou R, Iizuka A, Nonomura C, Miyata H, Ashizawa T, Nagashima T, Ohshima K, Urakami K, Kusuhara M, Yamaguchi K, Akiyama Y
    • Journal Title

      Int J Oncol

      Volume: 54 Pages: 219-228

    • DOI

      10.3892/ijo.2018.4617

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07209, KAKENHI-PROJECT-18K07315
  • [Journal Article] Antitumor activity of the PD-1/PD-L1 binding inhibitor BMS-202 in the humanized MHC-double knockout NOG mouse2019

    • Author(s)
      Ashizawa T, Iizuka A, Tanaka E, Kondou R, Miyata H, Maeda C, Sugino T, Yamaguchi K, Ando T, Ishikawa Y, Ito M, Akiyama Y.
    • Journal Title

      Biomedical Research

      Volume: 40 Issue: 6 Pages: 243-250

    • DOI

      10.2220/biomedres.40.243

    • NAID

      130007761178

    • ISSN
      0388-6107, 1880-313X
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-17K07209
  • [Journal Article] Immune response-associated gene profiling in Japanese melanoma patients using multi-omics analysis.2018

    • Author(s)
      Akiyama Yasuto、Kiyohara Yoshio、Yoshikawa Shusuke、Otsuka Masaki、Kondou Ryota、Nonomura Chizu、Miyata Haruo、Iizuka Akira、Ashizawa Tadashi、Ohshima Keiichi、Urakami Kenichi、Nagashima Takeshi、Kusuhara Masatoshi、Sugino Takashi、Yamaguchi Ken
    • Journal Title

      Oncol Rep

      Volume: 39 Pages: 1125-1131

    • DOI

      10.3892/or.2017.6173

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08727, KAKENHI-PROJECT-16K10523, KAKENHI-PROJECT-17K07209, KAKENHI-PROJECT-18K07315
  • [Journal Article] Anti-vascular endothelial growth factor receptor (VEGFR) 2 autoantibody identification in glioblastoma patient using single B cell-based antibody gene cloning2014

    • Author(s)
      Iizuka A, Komiyama M, Oshita C, Kume A, Ashizawa T, Mitsuya K, Hayashi N, Nakasu Y, Yamaguchi K and Akiyama Y
    • Journal Title

      Immunol Lett.

      Volume: 159 Pages: 15-22

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24501362
  • [Journal Article] Effect of the STAT3 inhibitor STX-0119 on the proliferation of temozolomide-resistant glioblastoma cell line2014

    • Author(s)
      Ashizawa T, Akiyama Y, Miyata H, Iizuka A, Komiyama M, Kume A, Omiya M, Sugino T, Asai A, Hayashi N, Mitsuya K, Nakasu Y, Yamaguchi K
    • Journal Title

      Int. J. Oncology

      Volume: 45 Pages: 411-418

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24501362
  • [Journal Article] Novel cancer-testis antigen expression on glioma cell lines derived from high-grade glioma patients2014

    • Author(s)
      Akiyama Y, Komiyama M, Miyata H, Yagoto M, Ashizawa T, Iizuka A, Oshita C, Kume A, Nogami M, Ito I, Watanabe R, Sugino T, Mitsuya K, Hayashi N, Nakasu Y, Yamaguchi K.
    • Journal Title

      Oncology reports

      Volume: 31 Pages: 1683-1690

    • DOI

      10.3892/or.2014.3049

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24501318, KAKENHI-PROJECT-24501362, KAKENHI-PROJECT-26430178
  • [Journal Article] YK-40 downregulation is a key factor to overcome temozolomide resisitance in a glioblastoma cell line2014

    • Author(s)
      Akiyama Y, Ashizawa T, Komiyama M, Miyata H, Oshita C, Omiya M, Iizuka A, Kume A, Sugino T, Hayashi N, Mitsuya K, Nakasu Y, Yamaguchi K.
    • Journal Title

      Oncology Rep.

      Volume: 32 (1) Pages: 159-166

    • DOI

      10.3892/or.2014.3195

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24501318, KAKENHI-PROJECT-24501362, KAKENHI-PROJECT-25430166
  • [Journal Article] Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma2013

    • Author(s)
      Tadashi Ashizawa, Haruo Miyata, Akira Iizuka, Masaru Komiyama, Chie Oshita, Akiko Kume, Masahiro Nogami, Mika Yagoto, Ichiro Ito, Takuma Oishi, Reiko Watanabe, Koichi Mitsuya, Kenji Matsuno, Toshio Furuya, Tadashi Okawara, Masami Otsuka, Naohisa Ogo, Akira Asai, Yoko Nakasu, Ken Yamaguchi Yasuto Akiyama
    • Journal Title

      Int J Oncol

      Volume: 43 Pages: 219-217

    • DOI

      10.3892/ijo.2013.1916

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390028, KAKENHI-PROJECT-23510281, KAKENHI-PROJECT-24501362, KAKENHI-PROJECT-24659048
  • [Journal Article] α-type-1 polarized dendritic cell-based vaccination in recurrent high-grade glioma: a phase I clinical trial2012

    • Author(s)
      Akiyama Y, Oshita C, Kume A, Iizuka A, Miyata H, Komiyama M, Ashizawa T, Yagoto M, Abe Y, Mitsuya K, Watanabe R, Sugino T, Yamaguchi K, Nakasu Y.
    • Journal Title

      BMC Cancer

      Volume: 27;12 Pages: 1-10

    • DOI

      10.1186/1471-2407-12-623

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24501318, KAKENHI-PROJECT-24501362
  • [Journal Article] Dendritic cell-based vaccination in metastatic melanoma patients: phase II clinical trial2012

    • Author(s)
      Oshita C, Takikawa M, Kume A, Miyata H, Ashizawa T, Iizuka A, Kiyohara Y, Yoshikawa S, Tanosaki R, Yamazaki N, Yamamoto A, Takesako K, Yamaguchi K and Akiyama Y
    • Journal Title

      Oncol Rep

      Volume: 28 Pages: 1131-8

    • DOI

      10.3892/or.2012.1956

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24501362
  • [Journal Article] Identification of novel MAGE-A6- and MAGE-A12-derived HLA-A24-restricted cytotoxic T lymphocyte epitopes using an in silico peptide-docking assay2012

    • Author(s)
      Akiyama Y, Komiyama M, Nakamura Y, Iizuka A, Oshita C, Kume A, Nogami M, Miyata H, Ashizawa T, Yoshikawa S, Kiyohara Y and Yamaguchi K
    • Journal Title

      Cancer Immunol Immunother

      Volume: 61 Pages: 2311-9

    • DOI

      10.1007/s00262-012-1298-1

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24501362
  • [Presentation] ヒト化MHCダブルノックアウトNOGマウスを用いたPD-1/PD-L1結合阻害剤BMS-202の抗腫瘍効果2019

    • Author(s)
      芦澤 忠、飯塚 明、丸山 宏二、安藤 隆幸、山口 建、秋山 靖人
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07315
  • [Presentation] 抗B7-H4二重特異性抗体を用いたヒト乳癌治療モデル2019

    • Author(s)
      飯塚 明、芦澤 忠、田中絵美子、大島 啓一、山口 建、秋山 靖人
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07315
  • [Presentation] B7-H4抗原を標的としたT細胞関連付けFab-scFv二重特異性抗体2018

    • Author(s)
      飯塚 明、芦澤 忠、大島 啓一、楠原 正俊、山口 建、秋山 靖人
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07315
  • [Presentation] ヒト化MHC-dKO NOGマウスを用いた抗PD-1抗体とSTAT3阻害剤STX-0119の併用抗腫瘍効果2018

    • Author(s)
      芦澤 忠、飯塚 明、丸山 宏二、浅井 章良、山口 建、秋山 靖人
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07315
  • [Presentation] 神経膠芽腫患者由来のがん性幹細胞の増殖に及ぼすSTAT3阻害剤STX-0119の効果2013

    • Author(s)
      芦澤 忠、飯塚 明、小宮山 優、浅井章良、山口 建、秋山靖人
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-24501362
  • [Presentation] テモゾロミド耐性神経膠芽腫細胞に対するSTAT3阻害剤STX-0119のin vitro及びin vivo抗腫瘍効果

    • Author(s)
      芦澤 忠、飯塚 明、小宮山 勝、浅井 章良、山口 建、秋山 靖人
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-24501362
  • 1.  ANDO Takayuki (40402226)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 2.  AKIYAMA Yasuto (70222552)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 16 results
  • 3.  小郷 尚久 (20501307)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  石川 吉伸 (00305004)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 5.  石井 義剛 (60635499)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  荒木 淳 (00508088)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  森 裕晃 (10793292)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  安永 能周 (40596946)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  井上 啓太 (80618520)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  ASAI Akira
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 11.  杉野 隆
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 12.  大島 啓一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  楠原 正俊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  大塚 雅巳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  飯塚 明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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