Ashizawa Tadashi 芦澤忠

… Alternative Names

ASHIZAWA Tadashi 芦澤忠

Less

Researcher Number	10443441
Affiliation (Current)	2025: 静岡県立静岡がんセンター(研究所), その他部局等, 研究員
Affiliation (based on the past Project Information) *help	2018 – 2023: 静岡県立静岡がんセンター(研究所), その他部局等, 研究員 2013 – 2014: 静岡県立静岡がんセンター(研究所), その他部局等, その他 2012: 静岡県立静岡がんセンター(研究所), その他部局等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Clinical oncology Except Principal Investigator Basic Section 56070:Plastic and reconstructive surgery-related
Keywords	Principal Investigator 免疫チェックポイント / PD-1/PD-L inhibitor / PD-1/PD-L1 inhibitor / PD-1/PD-L1 / PD-L1 / 国際情報交換 / がん幹細胞治療薬 Except Principal Investigator 免疫療法 / マウス / リンパ節 / 免疫 / 皮弁

マウスリンパ節付随免疫皮弁モデルを利用した新しいがん免疫療法の開発
- Principal Investigator
  
  羽賀義剛 (石井義剛 / 石井義剛)
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56070:Plastic and reconstructive surgery-related
- Research Institution
  Tokyo Medical and Dental University
  Shizuoka Cancer Center Research Institute
Identification of small molecular compounds with PD-1 / PD-L1 inhibitory activity by in silicoPrincipal Investigator
- Principal Investigator
  
  Ashizawa Tadashi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Shizuoka Cancer Center Research Institute
Development of a novel small-molecule compounds targeting cancer stem cells derived from malignant gliomaPrincipal Investigator
- Principal Investigator
  
  ASHIZAWA Tadashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Shizuoka Cancer Center Research Institute

All 2021 2020 2019 2018 2017 2014 2013 2012 Other

All Journal Article Presentation Patent

[Journal Article] Mutational concordance analysis provides supportive information for double cancer Diagnosis.2021
- Author(s)
  Hatakeyama, K, Nagashima T, Notsu, A, Ohshima K, Ohnami S, Ohnami, S, Shimoda Y, Naruoka A, Maruyama K, Iizuka A, Ashizawa T, Kenmotsu T, Mochizuki T, Urakami K, Akiyama Y and Yamaguchi K.
- Journal Title
  
  BMC Cancer
  
  Volume: 21 Issue: 1 Pages: 181-181
- DOI
  10.1186/s12885-021-07899-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07315
[Journal Article] Alpha-type-1 polarized dendritic cell-based vaccination in newly diagnosed high-grade glioma: A phase II clinical trial2020
- Author(s)
  Mitsuya K, Akiyama Y, et al.
- Journal Title
  
  Anticancer Res
  
  Volume: 40 Issue: 11 Pages: 6473-6484
- DOI
  10.21873/anticanres.14669
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07649, KAKENHI-PROJECT-18K07315
[Journal Article] Characterization of tumors with ultralow tumor mutational burden in Japanese cancer patients2020
- Author(s)
  Hatakeyama K, Akiyama Y, et al.
- Journal Title
  
  Cancer Sci
  
  Volume: 111 Issue: 10 Pages: 3893-3901
- DOI
  10.1111/cas.14572
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07649, KAKENHI-PROJECT-18K07315
[Journal Article] Effect of preoperative chemoradiotherapy on the immunological status of rectal cancer patients.2020
- Author(s)
  Yasui K, Kondou R, Iizuka A, Miyata H, Tanaka E, Ashizawa T, Nagashima T, Ohshima K, Urakami K, Kusuhara M, Muramatsu K, Sugino T, Yamguchi K, Mori K, Harada H, Nishimura T, Kagawa H, Yamakawa Y, Hino H, Shiomi A, Akiyama Y.
- Journal Title
  
  J Radiat Res.
  
  Volume: 61 Issue: 5 Pages: 766-775
- DOI
  10.1093/jrr/rraa041
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07315
[Journal Article] Antitumor activity of the PD-1/PD-L1 binding inhibitor BMS-202 in the humanized MHC-double knockout NOG mouse2019
- Author(s)
  Ashizawa T, Iizuka A, Tanaka E, Kondou R, Miyata H, Maeda C, Sugino T, Yamaguchi K, Ando T, Ishikawa Y, Ito M, Akiyama Y.
- Journal Title
  
  Biomed. Res.
  
  Volume: 40 Issue: 6 Pages: 243-250
- DOI
  10.2220/biomedres.40.243
- NAID
  130007761178
- ISSN
  0388-6107, 1880-313X
- Year and Date
  2019-12-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-17K07209
[Journal Article] Impact of combination therapy with anti-PD-1 blockade and a STAT3 inhibitor on the tumor-infiltrating lymphocyte status.2019
- Author(s)
  Ashizawa T, Iizuka A, Maeda C, Tanaka E, Kondou R, Miyata H, Sugino T, Kawata T, Deguchi S, Mitsuya K, Hayashi N, Asai A, Ito M, Yamaguchi K, Akiyama Y.
- Journal Title
  
  Immunol Lett.
  
  Volume: 216 Pages: 43-50
- DOI
  10.1016/j.imlet.2019.10.003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-18H02559, KAKENHI-PROJECT-17K07209
[Journal Article] Identification of a neoantigen epitope in a melanoma patient with good response to anti-PD-1 antibody therapy2019
- Author(s)
  Nonomura C, Otsuka M, Kondou R, Iizuka A, Miyata H, Ashizawa T, Sakura N, Yoshikawa S, Kiyohara Y, Ohshima K, Urakami K, Nagashima T, Ohnami S, Kusuhara M, Mitsuya K, Hayashi N, Nakasu Y, Mochizuki T, Yamaguchi K, Akiyama Y
- Journal Title
  
  Immunol Lett
  
  Volume: 208 Pages: 52-59
- DOI
  10.1016/j.imlet.2019.02.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-17K07209
[Journal Article] A T-cell-engaging B7-H4/CD3-bispecific Fab-scFv Antibody Targets Human Breast Cancer2019
- Author(s)
  Iizuka Akira、Nonomura Chizu、Ashizawa Tadashi、Kondou Ryota、Ohshima Keiichi、Sugino Takashi、Mitsuya Koichi、Hayashi Nakamasa、Nakasu Yoko、Maruyama Kouji、Yamaguchi Ken、Akiyama Yasuto
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 25 Issue: 9 Pages: 2925-2934
- DOI
  10.1158/1078-0432.ccr-17-3123
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07235, KAKENHI-PROJECT-18K07315, KAKENHI-PROJECT-17K07209
[Journal Article] Classification of tumor microenvironment immune types based on immune response-associated gene expression2019
- Author(s)
  Kondou R, Iizuka A, Nonomura C, Miyata H, Ashizawa T, Nagashima T, Ohshima K, Urakami K, Kusuhara M, Yamaguchi K, Akiyama Y
- Journal Title
  
  Int J Oncol
  
  Volume: 54 Pages: 219-228
- DOI
  10.3892/ijo.2018.4617
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07209, KAKENHI-PROJECT-18K07315
[Journal Article] Immune response-associated gene profiling in Japanese melanoma patients using multi-omics analysis2017
- Author(s)
  Akiyama Yasuto、Kiyohara Yoshio、Yoshikawa Shusuke、Otsuka Masaki、Kondou Ryota、Nonomura Chizu、Miyata Haruo、Iizuka Akira、Ashizawa Tadashi、Ohshima Keiichi、Urakami Kenichi、Nagashima Takeshi、Kusuhara Masatoshi、Sugino Takashi、Yamaguchi Ken
- Journal Title
  
  Oncology Reports
  
  Volume: 39 Pages: 1125-1131
- DOI
  10.3892/or.2017.6173
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08727, KAKENHI-PROJECT-16K10523, KAKENHI-PROJECT-17K07209, KAKENHI-PROJECT-18K07315
[Journal Article] Anti-vascular endothelial growth factor receptor (VEGFR) 2 autoantibody identification in glioblastoma patient using single B cell-based antibody gene cloning2014
- Author(s)
  Iizuka A, Komiyama M, Oshita C, Kume A, Ashizawa T, Mitsuya K, Hayashi N, Nakasu Y, Yamaguchi K and Akiyama Y
- Journal Title
  
  Immunol Lett.
  
  Volume: 159 Pages: 15-22
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501362
[Journal Article] Effect of the STAT3 inhibitor STX-0119 on the proliferation of temozolomide-resistant glioblastoma cell line2014
- Author(s)
  Ashizawa T, Akiyama Y, Miyata H, Iizuka A, Komiyama M, Kume A, Omiya M, Sugino T, Asai A, Hayashi N, Mitsuya K, Nakasu Y, Yamaguchi K
- Journal Title
  
  Int. J. Oncology
  
  Volume: 45 Pages: 411-418
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24501362
[Journal Article] Novel cancer-testis antigen expression on glioma cell lines derived from high-grade glioma patients.2014
- Author(s)
  Akiyama Y, Komiyama M, Miyata H, Yagoto M, Ashizawa T, Iizuka A, Oshita C, Kume A, Nogami M, Ito I, Watanabe R, Sugino T, Mitsuya K, Hayashi N, Nakasu Y, Yamaguchi K.
- Journal Title
  
  Oncol Rep.
  
  Volume: 31 Issue: 4 Pages: 1683-1690
- DOI
  10.3892/or.2014.3049
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24501318, KAKENHI-PROJECT-24501362, KAKENHI-PROJECT-26430178
[Journal Article] YKL-40 downregulation is a key factor to overcome temozolomide resistance in a glioblastoma cell line.2014
- Author(s)
  Akiyama Y, Ashizawa T, Komiyama M, Miyata H, Oshita C, Omiya M, Iizuka A, Kume A, Sugino T, Hayashi N, Mitsuya K, Nakasu Y, Yamaguchi K.
- Journal Title
  
  Oncol Rep
  
  Volume: 32 (1) Issue: 1 Pages: 159-166
- DOI
  10.3892/or.2014.3195
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501318, KAKENHI-PROJECT-24501362, KAKENHI-PROJECT-25430166
[Journal Article] Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma2013
- Author(s)
  Tadashi Ashizawa, Haruo Miyata, Akira Iizuka, Masaru Komiyama, Chie Oshita, Akiko Kume, Masahiro Nogami, Mika Yagoto, Ichiro Ito, Takuma Oishi, Reiko Watanabe, Koichi Mitsuya, Kenji Matsuno, Toshio Furuya, Tadashi Okawara, Masami Otsuka, Naohisa Ogo, Akira Asai, Yoko Nakasu, Ken Yamaguchi Yasuto Akiyama
- Journal Title
  
  International Journal of Oncology
  
  Volume: 43 Issue: 1 Pages: 219-227
- DOI
  10.3892/ijo.2013.1916
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390028, KAKENHI-PROJECT-23510281, KAKENHI-PROJECT-24501362, KAKENHI-PROJECT-24659048
[Journal Article] α-type-1 polarized dendritic cell-based vaccination in recurrent high-grade glioma: a phase I clinical trial.2012
- Author(s)
  Akiyama Y, Oshita C, Kume A, Iizuka A, Miyata H, Komiyama M, Ashizawa T, Yagoto M, Abe Y, Mitsuya K, Watanabe R, Sugino T, Yamaguchi K, Nakasu Y.
- Journal Title
  
  BMC Cancer
  
  Volume: 27;12 Issue: 1 Pages: 623-623
- DOI
  10.1186/1471-2407-12-623
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501318, KAKENHI-PROJECT-24501362
[Journal Article] Dendritic cell-based vaccination in metastatic melanoma patients: phase II clinical trial2012
- Author(s)
  Oshita C, Takikawa M, Kume A, Miyata H, Ashizawa T, Iizuka A, Kiyohara Y, Yoshikawa S, Tanosaki R, Yamazaki N, Yamamoto A, Takesako K, Yamaguchi K and Akiyama Y
- Journal Title
  
  Oncol Rep
  
  Volume: 28 Issue: 4 Pages: 1131-8
- DOI
  10.3892/or.2012.1956
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501362
[Journal Article] Identification of novel MAGE-A6- and MAGE-A12-derived HLA-A24-restricted cytotoxic T lymphocyte epitopes using an in silico peptide-docking assay2012
- Author(s)
  Akiyama Y, Komiyama M, Nakamura Y, Iizuka A, Oshita C, Kume A, Nogami M, Miyata H, Ashizawa T, Yoshikawa S, Kiyohara Y and Yamaguchi K
- Journal Title
  
  Cancer Immunol Immunother
  
  Volume: 61 Issue: 12 Pages: 2311-9
- DOI
  10.1007/s00262-012-1298-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24501362
[Patent] PD-1及び/又はPD-L1の阻害剤2021
- Inventor(s)
  秋山靖人、芦澤忠、飯塚明、井上謙吾、安藤隆幸、石川吉伸
- Industrial Property Rights Holder
  静岡県、PVPSO、静岡県公立大学法人
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-045476
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] 画像診断ソフトウェアを用いた簡易的な腫瘍内浸潤リンパ球（TIL）測定法の開発2020
- Author(s)
  宮田治男、飯塚　明、芦澤　忠、長嶋剛史、下田勇治、田邉智絵、大浪澄子、大浪俊平、大島啓一、浦上研一、山口　建、秋山靖人
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] 全エクソンと全ゲノム解析を用いた超低頻度変異症例の解析2020
- Author(s)
  畠山慶一、大島啓一、長嶋剛史、大浪澄子、大浪俊平、芹澤昌邦、成岡　茜、丸山宏二、飯塚　明、芦澤　忠、剱持裕知、望月　徹、浦上研一、秋山靖人、山口　建
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] 悪性グリオーマに対する活性化樹状細胞ワクチンを用いたがん免疫療法-第2相試験2020
- Author(s)
  前田千恵、飯塚　明、宮田治男、近藤亮太、芦澤　忠、山口　建、秋山靖人
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] ヒト化MHCダブルノックアウトNOGマウスを用いたPD-1/PD-L1結合阻害剤BMS-202の抗腫瘍効果2019
- Author(s)
  芦澤　忠、飯塚　明、丸山　宏二、安藤　隆幸、山口　建、秋山　靖人
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] 抗B7-H4二重特異性抗体を用いたヒト乳癌治療モデル2019
- Author(s)
  飯塚　明、芦澤　忠、田中絵美子、大島　啓一、山口　建、秋山　靖人
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] B7-H4抗原を標的としたT細胞関連付けFab-scFv二重特異性抗体2018
- Author(s)
  飯塚　明、芦澤　忠、大島　啓一、楠原　正俊、山口　建、秋山　靖人
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] ヒト化MHC-dKO　NOGマウスを用いた抗PD-1抗体とSTAT3阻害剤STX-0119の併用抗腫瘍効果2018
- Author(s)
  芦澤　忠、飯塚　明、丸山　宏二、浅井　章良、山口　建、秋山　靖人
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07315
[Presentation] 神経膠芽腫患者由来のがん性幹細胞の増殖に及ぼすSTAT3阻害剤STX-0119の効果2013
- Author(s)
  芦澤　忠、飯塚　明、小宮山　優、浅井章良、山口　建、秋山靖人
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-24501362
[Presentation] テモゾロミド耐性神経膠芽腫細胞に対するSTAT3阻害剤STX-0119のin vitro及びin vivo抗腫瘍効果
- Author(s)
  芦澤　忠、飯塚　明、小宮山　勝、浅井　章良、山口　建、秋山　靖人
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24501362

1. ANDO Takayuki (40402226)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
2. AKIYAMA Yasuto (70222552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
3. 小郷尚久 (20501307)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 石川吉伸 (00305004)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 羽賀義剛 (60635499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 荒木淳 (00508088)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 森裕晃 (10793292)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 安永能周 (40596946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 井上啓太 (80618520)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 杉野隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
11. 大塚雅巳

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 飯塚明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Ashizawa Tadashi 芦澤 忠

ASHIZAWA Tadashi 芦澤 忠

Research Projects

Research Products

Co-Researchers

マウスリンパ節付随免疫皮弁モデルを利用した新しいがん免疫療法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of small molecular compounds with PD-1 / PD-L1 inhibitory activity by in silicoPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel small-molecule compounds targeting cancer stem cells derived from malignant gliomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mutational concordance analysis provides supportive information for double cancer Diagnosis.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Alpha-type-1 polarized dendritic cell-based vaccination in newly diagnosed high-grade glioma: A phase II clinical trial2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of tumors with ultralow tumor mutational burden in Japanese cancer patients2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Effect of preoperative chemoradiotherapy on the immunological status of rectal cancer patients.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antitumor activity of the PD-1/PD-L1 binding inhibitor BMS-202 in the humanized MHC-double knockout NOG mouse2019

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Impact of combination therapy with anti-PD-1 blockade and a STAT3 inhibitor on the tumor-infiltrating lymphocyte status.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of a neoantigen epitope in a melanoma patient with good response to anti-PD-1 antibody therapy2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A T-cell-engaging B7-H4/CD3-bispecific Fab-scFv Antibody Targets Human Breast Cancer2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Classification of tumor microenvironment immune types based on immune response-associated gene expression2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Immune response-associated gene profiling in Japanese melanoma patients using multi-omics analysis2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Anti-vascular endothelial growth factor receptor (VEGFR) 2 autoantibody identification in glioblastoma patient using single B cell-based antibody gene cloning2014

Author(s)

Journal Title

Ashizawa Tadashi 芦澤忠

ASHIZAWA Tadashi 芦澤忠

[Presentation] ヒト化MHC-dKO　NOGマウスを用いた抗PD-1抗体とSTAT3阻害剤STX-0119の併用抗腫瘍効果2018