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Mizutani Osamu  水谷 治

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水谷 治  ミズタニ オサム

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Researcher Number 10443996
Other IDs
Affiliation (Current) 2025: 琉球大学, 農学部, 准教授
Affiliation (based on the past Project Information) *help 2025: 琉球大学, 農学部, 准教授
2017 – 2022: 琉球大学, 農学部, 准教授
2015 – 2016: 独立行政法人酒類総合研究所, 研究部門, 主任研究員
2013 – 2014: 独立行政法人酒類総合研究所, その他部局等, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 38020:Applied microbiology-related / Basic Section 38060:Applied molecular and cellular biology-related / Applied biochemistry / Applied molecular and cellular biology
Keywords
Principal Investigator
人工ヌクレアーゼ (TALEN) / 麹菌 / DNA 二本鎖切断修復 / 人工ヌクレアーゼ (TALENs) / ligD / CRISPR/Cas9 / 黄麹菌 / ゲノム編集 / 遺伝子工学 / DNA 修復機構 … More / 黒麹菌 / 非相同末端結合 / 育種 / ゲノム修復 / DNA 修復 / DNA 切断修復 / 大規模欠失 / TALEN / Aspergillus oryzae / 遺伝子組換え / Cre/loxP システム / マーカーリサイクリング Less
  • Research Projects

    (4 results)
  • Research Products

    (22 results)
  • Co-Researchers

    (1 People)
  •  ニゲラン生産株が有する棘様構造の産生メカニズムの解明とその意義についてPrincipal Investigator

    • Principal Investigator
      水谷 治
    • Project Period (FY)
      2025 – 2028
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 38020:Applied microbiology-related
    • Research Institution
      University of the Ryukyus
  •  Study on DNA repair mechanism via large-scale deletion in Aspergillus oryzae caused by genome editing due to error of non-homologous end-joining repair.Principal Investigator

    • Principal Investigator
      Mizutani Osamu
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 38060:Applied molecular and cellular biology-related
    • Research Institution
      University of the Ryukyus
  •  Elucidation of the mechanism for large deletions in Aspergillus oryzae caused by genome editing via error of non-homologous end-joining repair.Principal Investigator

    • Principal Investigator
      MIZUTANI Osamu
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Applied biochemistry
    • Research Institution
      University of the Ryukyus
      National Research Institute of Brewing
  •  Elucidation of the mechanism of Cre-loxP recombination by direct introduction of Cre recombinase and application to artificial nuclease (TALENs) in Aspergillus oryzaePrincipal Investigator

    • Principal Investigator
      Mizutani Osamu
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Applied molecular and cellular biology
    • Research Institution
      National Research Institute of Brewing

All 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Book

  • [Book] Genome Engineering via CRISPR-Cas9 System 1st Edition (担当範囲: 5. Targeted genome editing using CRISPR-Cas9 system in fungi)2020

    • Author(s)
      Arazoe T., Mizutani O.
    • Total Pages
      384
    • Publisher
      Elsevier
    • Data Source
      KAKENHI-PROJECT-19K05952
  • [Journal Article] Development of an itraconazole resistance gene as a dominant selectable marker for transformation in Aspergillus oryzae and Aspergillus luchuensis2021

    • Author(s)
      Tokashiki Jikian、Toyama Hirohide、Mizutani Osamu
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 85 Issue: 3 Pages: 722-727

    • DOI

      10.1093/bbb/zbaa080

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K05952, KAKENHI-PROJECT-20J11473
  • [Journal Article] Construction of transcription factor gene deletion library of <i>Aspergillus luchuensis</i>2021

    • Author(s)
      Yamada Osamu、Nishibori Naoko、Hayashi Risa、Arima Toshihide、Mizutani Osamu
    • Journal Title

      J. Gen. Appl. Microbiol.

      Volume: 67 Issue: 3 Pages: 118-123

    • DOI

      10.2323/jgam.2020.09.001

    • NAID

      130008069742

    • ISSN
      0022-1260, 1349-8037
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K05952
  • [Journal Article] Identification of Genes Involved in the Synthesis of the Fungal Cell Wall Component Nigeran and Regulation of Its Polymerization in Aspergillus luchuensis2021

    • Author(s)
      Uechi Keiko、Yaguchi Hajime、Tokashiki Jikian、Taira Toki、Mizutani Osamu
    • Journal Title

      Applied and Environmental Microbiology

      Volume: 87 Issue: 21

    • DOI

      10.1128/aem.01144-21

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20J01321, KAKENHI-PROJECT-20J11473, KAKENHI-PROJECT-19K05952, KAKENHI-PROJECT-19K15737, KAKENHI-PROJECT-20K15881
  • [Journal Article] Phenolic acid decarboxylase of Aspergillus luchuensis plays a crucial role in 4-vinylguaiacol production during awamori brewing2020

    • Author(s)
      Maeda Mayumi、Motosoko Marin、Tokashiki Tatsunori、Tokashiki Jikian、Mizutani Osamu、Uechi Keiko、Goto Masatoshi、Taira Toki
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: 130 Issue: 4 Pages: 352-359

    • DOI

      10.1016/j.jbiosc.2020.05.004

    • NAID

      40022381063

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K05952, KAKENHI-PROJECT-19J10823
  • [Journal Article] Effect of pepA deletion and overexpression in Aspergillus luchuensis on sweet potato shochu brewing2019

    • Author(s)
      Setoguchi Sho、Mizutani Osamu、Yamada Osamu、Futagami Taiki、Iwai Kenichi、Takase Yoshikazu、Tamaki Hisanori
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: 128 Issue: 4 Pages: 456-462

    • DOI

      10.1016/j.jbiosc.2019.03.019

    • NAID

      40022037155

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K05952
  • [Journal Article] Influence of α-1,3-glucan synthase gene agsE on protoplast formation for transformation of Aspergillus luchuensis2019

    • Author(s)
      Tokashiki Jikian、Hayashi Risa、Yano Shigekazu、Watanabe Taisuke、Yamada Osamu、Toyama Hirohide、Mizutani Osamu
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: 印刷中 Issue: 2 Pages: 129-134

    • DOI

      10.1016/j.jbiosc.2019.01.018

    • NAID

      40021976308

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K07706, KAKENHI-PROJECT-19K05952
  • [Journal Article] Cellular responses to the expression of unstable secretory proteins in the filamentous fungus Aspergillus oryzae2017

    • Author(s)
      Jun-ichi Yokota, Daisuke Shiro, Mizuki Tanaka, Yasumichi Onozaki, Osamu Mizutani, Dararat Kakizono, Sakurako Ichinose, Tomoko Shintani, Katsuya Gomi, Takahiro Shintani
    • Journal Title

      Appl. Microbiol. Biotechnol.

      Volume: 101(6) Issue: 6 Pages: 2437-2446

    • DOI

      10.1007/s00253-016-8086-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K07706
  • [Journal Article] Detailed analysis of targeted gene mutations caused by the Platinum-Fungal TALENs in Aspergillus oryzae RIB40 strain and a ligD disruptant2017

    • Author(s)
      Mizutani, O., Arazoe, T., Toshida, K., Hayashi, R., Ohsato, S., Skuma, T., Yamamoto, T., Kuwata, S. and Yamada, O.
    • Journal Title

      Journal of Biotechnology and Bioengineering

      Volume: 3 Issue: 3 Pages: 287-293

    • DOI

      10.1016/j.jbiosc.2016.09.014

    • NAID

      40021152739

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K18647, KAKENHI-PROJECT-16K07706, KAKENHI-PROJECT-16K18478
  • [Journal Article] Self-excising Cre/mutant lox marker recycling system for multiple gene integrations and consecutive gene deletions in Aspergillus oryzae2017

    • Author(s)
      Zhang Silai、Ban Akihiko、Ebara Naoki、Mizutani Osamu、Tanaka Mizuki、Shintani Takahiro、Gomi Katsuya
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: 123 Issue: 4 Pages: 403-411

    • DOI

      10.1016/j.jbiosc.2016.11.001

    • NAID

      40021178785

    • Data Source
      KAKENHI-PROJECT-16K07706
  • [Presentation] 麹菌で利用可能なイトラコナゾール耐性マーカーの構築2021

    • Author(s)
      渡嘉敷 直杏, 外山 博英, 水谷 治
    • Organizer
      第 73 回日本生物工学会大会
    • Data Source
      KAKENHI-PROJECT-19K05952
  • [Presentation] 麹菌におけるイトラコナゾール耐性を指標とした形質転換用マーカーの開発2020

    • Author(s)
      ○渡嘉敷直杏, 水谷 治, 外山博英
    • Organizer
      日本農芸化学会 2020 年度大会
    • Data Source
      KAKENHI-PROJECT-19K05952
  • [Presentation] 黒麹菌 Aspergillus luchuensis のエレクトロポレーション法による形質転換系の開発2019

    • Author(s)
      ○上元 優, 玉井萌子, 渡嘉敷直杏, 外山博英, 水谷 治
    • Organizer
      第 19 回糸状菌分子生物学コンファレンス
    • Data Source
      KAKENHI-PROJECT-19K05952
  • [Presentation] 麹菌 ligD 遺伝子がゲノム編集に起因する大規模欠失変異に与える影響2018

    • Author(s)
      上元 優, 林 梨咲, 渡嘉敷直杏, 荒添貴之, 山田 修, 外山博英, 水谷 治
    • Organizer
      第3回ゲノム編集学会
    • Data Source
      KAKENHI-PROJECT-16K07706
  • [Presentation] ゲノム編集時に引き起こされる麹菌 Aspergillus oryzae の大規模欠失機構に関する研究2018

    • Author(s)
      水谷 治, 林 梨咲, 渡嘉敷直杏, 上里優希, 上元 優, 玉井萌子, 荒添貴之, 山田 修, 外山博英
    • Organizer
      日本農芸化学会 2018 年度大会
    • Data Source
      KAKENHI-PROJECT-16K07706
  • [Presentation] 麹菌における Cre-loxP システムの利用と TALEN を用 いたゲノム編集2017

    • Author(s)
      水谷 治, 山田 修, 家藤治幸
    • Organizer
      第 69 回日本生物工学会大会
    • Data Source
      KAKENHI-PROJECT-16K07706
  • [Presentation] 麹菌における TALENs と CRISPR/Cas9 の違いによる大規模欠失変異の比較2017

    • Author(s)
      水谷 治, 利田賢次, 林梨咲, 渡嘉敷直杏, 荒添貴之, 西田敬二, 和田悠作, 織田健, 岩下和裕, 山田 修, 外山博英
    • Organizer
      第 2 回ゲノム編集学会
    • Data Source
      KAKENHI-PROJECT-16K07706
  • [Presentation] 非相同末端結合に関与する遺伝子破壊株における麹菌の TALENs を用いたゲノム編集2016

    • Author(s)
      水谷 治, 荒添貴之, 利田賢次, 林梨咲, 大里修一, 佐久間哲史, 山本 卓, 桑田茂, 山田 修
    • Organizer
      第 68 回日本生物工学会大会
    • Place of Presentation
      富山
    • Year and Date
      2016-09-28
    • Data Source
      KAKENHI-PROJECT-16K07706
  • [Presentation] 麹菌のCre組換え酵素直接導入法における応用開発2016

    • Author(s)
      利田 賢次、林 梨咲、五味 勝也、山田 修、水谷 治
    • Organizer
      日本農芸化学会 2016 年度大会
    • Place of Presentation
      札幌
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-25871247
  • [Presentation] 麹菌野生株及び ligD 遺伝子破壊株を宿主とした Platinum-Fungal TALENs を用いたゲノム編集2016

    • Author(s)
      水谷 治, 荒添貴之, 利田賢次, 林梨咲, 大里修一, 佐久間哲史, 山本 卓, 桑田茂, 山田 修
    • Organizer
      日本ゲノム編集学会第1回大会
    • Place of Presentation
      広島
    • Year and Date
      2016-09-06
    • Data Source
      KAKENHI-PROJECT-16K07706
  • [Presentation] Platinum-Fungal TALENs を用いた麹菌におけるゲノム編集2015

    • Author(s)
      水谷 治, 荒添貴之, 利田賢次, 林梨咲, 大里修一, 佐久間哲史, 山本 卓, 桑田茂, 山田 修
    • Organizer
      第 67 回日本生物工学会大会
    • Place of Presentation
      鹿児島
    • Year and Date
      2015-10-26
    • Data Source
      KAKENHI-PROJECT-25871247
  • [Presentation] TALEN を用いた麹菌 Aspergillus oryzae におけるゲノム編集

    • Author(s)
      水谷 治、荒添貴之、利田賢次、林 梨咲、大里 修一、佐久間哲史、山本 卓、 桑田 茂、山田 修
    • Organizer
      第4回 ゲノム編集研究会
    • Place of Presentation
      広島
    • Year and Date
      2014-10-06 – 2014-10-07
    • Data Source
      KAKENHI-PROJECT-25871247
  • 1.  荒添 貴之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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