Mizutani Osamu 水谷治

… Alternative Names

水谷治ミズタニオサム

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Researcher Number	10443996
Other IDs
Affiliation (Current)	2025: 琉球大学, 農学部, 准教授
Affiliation (based on the past Project Information) *help	2025: 琉球大学, 農学部, 准教授 2017 – 2022: 琉球大学, 農学部, 准教授 2015 – 2016: 独立行政法人酒類総合研究所, 研究部門, 主任研究員 2013 – 2014: 独立行政法人酒類総合研究所, その他部局等, 研究員
Review Section/Research Field	Principal Investigator Basic Section 38020:Applied microbiology-related / Basic Section 38060:Applied molecular and cellular biology-related / Applied biochemistry / Applied molecular and cellular biology
Keywords	Principal Investigator 人工ヌクレアーゼ (TALEN) / 麹菌 / DNA 二本鎖切断修復 / 人工ヌクレアーゼ (TALENs) / ligD / CRISPR/Cas9 / 黄麹菌 / ゲノム編集 / 遺伝子工学 / DNA 修復機構 … More / 黒麹菌 / 非相同末端結合 / 育種 / ゲノム修復 / DNA 修復 / DNA 切断修復 / 大規模欠失 / TALEN / Aspergillus oryzae / 遺伝子組換え / Cre/loxP システム / マーカーリサイクリング Less

ニゲラン生産株が有する棘様構造の産生メカニズムの解明とその意義についてPrincipal Investigator
- Principal Investigator
  
  水谷治
- Project Period (FY)
  2025 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 38020:Applied microbiology-related
- Research Institution
  University of the Ryukyus
Study on DNA repair mechanism via large-scale deletion in Aspergillus oryzae caused by genome editing due to error of non-homologous end-joining repair.Principal Investigator
- Principal Investigator
  
  Mizutani Osamu
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 38060:Applied molecular and cellular biology-related
- Research Institution
  University of the Ryukyus
Elucidation of the mechanism for large deletions in Aspergillus oryzae caused by genome editing via error of non-homologous end-joining repair.Principal Investigator
- Principal Investigator
  
  MIZUTANI Osamu
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  University of the Ryukyus
  National Research Institute of Brewing
Elucidation of the mechanism of Cre-loxP recombination by direct introduction of Cre recombinase and application to artificial nuclease (TALENs) in Aspergillus oryzaePrincipal Investigator
- Principal Investigator
  
  Mizutani Osamu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  National Research Institute of Brewing

All 2021 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation Book

[Book] Genome Engineering via CRISPR-Cas9 System 1st Edition (担当範囲: 5. Targeted genome editing using CRISPR-Cas9 system in fungi)2020
- Author(s)
  Arazoe T., Mizutani O.
- Total Pages
  384
- Publisher
  Elsevier
- Data Source
  KAKENHI-PROJECT-19K05952
[Journal Article] Development of an itraconazole resistance gene as a dominant selectable marker for transformation in Aspergillus oryzae and Aspergillus luchuensis2021
- Author(s)
  Tokashiki Jikian、Toyama Hirohide、Mizutani Osamu
- Journal Title
  
  Bioscience, Biotechnology, and Biochemistry
  
  Volume: 85 Issue: 3 Pages: 722-727
- DOI
  10.1093/bbb/zbaa080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K05952, KAKENHI-PROJECT-20J11473
[Journal Article] Construction of transcription factor gene deletion library of <i>Aspergillus luchuensis</i>2021
- Author(s)
  Yamada Osamu、Nishibori Naoko、Hayashi Risa、Arima Toshihide、Mizutani Osamu
- Journal Title
  
  J. Gen. Appl. Microbiol.
  
  Volume: 67 Issue: 3 Pages: 118-123
- DOI
  10.2323/jgam.2020.09.001
- NAID
  130008069742
- ISSN
  0022-1260, 1349-8037
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05952
[Journal Article] Identification of Genes Involved in the Synthesis of the Fungal Cell Wall Component Nigeran and Regulation of Its Polymerization in Aspergillus luchuensis2021
- Author(s)
  Uechi Keiko、Yaguchi Hajime、Tokashiki Jikian、Taira Toki、Mizutani Osamu
- Journal Title
  
  Applied and Environmental Microbiology
  
  Volume: 87 Issue: 21
- DOI
  10.1128/aem.01144-21
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20J01321, KAKENHI-PROJECT-20J11473, KAKENHI-PROJECT-19K05952, KAKENHI-PROJECT-19K15737, KAKENHI-PROJECT-20K15881
[Journal Article] Phenolic acid decarboxylase of Aspergillus luchuensis plays a crucial role in 4-vinylguaiacol production during awamori brewing2020
- Author(s)
  Maeda Mayumi、Motosoko Marin、Tokashiki Tatsunori、Tokashiki Jikian、Mizutani Osamu、Uechi Keiko、Goto Masatoshi、Taira Toki
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 130 Issue: 4 Pages: 352-359
- DOI
  10.1016/j.jbiosc.2020.05.004
- NAID
  40022381063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05952, KAKENHI-PROJECT-19J10823
[Journal Article] Effect of pepA deletion and overexpression in Aspergillus luchuensis on sweet potato shochu brewing2019
- Author(s)
  Setoguchi Sho、Mizutani Osamu、Yamada Osamu、Futagami Taiki、Iwai Kenichi、Takase Yoshikazu、Tamaki Hisanori
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 128 Issue: 4 Pages: 456-462
- DOI
  10.1016/j.jbiosc.2019.03.019
- NAID
  40022037155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K05952
[Journal Article] Influence of α-1,3-glucan synthase gene agsE on protoplast formation for transformation of Aspergillus luchuensis2019
- Author(s)
  Tokashiki Jikian、Hayashi Risa、Yano Shigekazu、Watanabe Taisuke、Yamada Osamu、Toyama Hirohide、Mizutani Osamu
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 印刷中 Issue: 2 Pages: 129-134
- DOI
  10.1016/j.jbiosc.2019.01.018
- NAID
  40021976308
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07706, KAKENHI-PROJECT-19K05952
[Journal Article] Cellular responses to the expression of unstable secretory proteins in the filamentous fungus Aspergillus oryzae2017
- Author(s)
  Jun-ichi Yokota, Daisuke Shiro, Mizuki Tanaka, Yasumichi Onozaki, Osamu Mizutani, Dararat Kakizono, Sakurako Ichinose, Tomoko Shintani, Katsuya Gomi, Takahiro Shintani
- Journal Title
  
  Appl. Microbiol. Biotechnol.
  
  Volume: 101(6) Issue: 6 Pages: 2437-2446
- DOI
  10.1007/s00253-016-8086-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07706
[Journal Article] Detailed analysis of targeted gene mutations caused by the Platinum-Fungal TALENs in Aspergillus oryzae RIB40 strain and a ligD disruptant2017
- Author(s)
  Mizutani, O., Arazoe, T., Toshida, K., Hayashi, R., Ohsato, S., Skuma, T., Yamamoto, T., Kuwata, S. and Yamada, O.
- Journal Title
  
  Journal of Biotechnology and Bioengineering
  
  Volume: 3 Issue: 3 Pages: 287-293
- DOI
  10.1016/j.jbiosc.2016.09.014
- NAID
  40021152739
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K18647, KAKENHI-PROJECT-16K07706, KAKENHI-PROJECT-16K18478
[Journal Article] Self-excising Cre/mutant lox marker recycling system for multiple gene integrations and consecutive gene deletions in Aspergillus oryzae2017
- Author(s)
  Zhang Silai、Ban Akihiko、Ebara Naoki、Mizutani Osamu、Tanaka Mizuki、Shintani Takahiro、Gomi Katsuya
- Journal Title
  
  Journal of Bioscience and Bioengineering
  
  Volume: 123 Issue: 4 Pages: 403-411
- DOI
  10.1016/j.jbiosc.2016.11.001
- NAID
  40021178785
- Data Source
  KAKENHI-PROJECT-16K07706
[Presentation] 麹菌で利用可能なイトラコナゾール耐性マーカーの構築2021
- Author(s)
  渡嘉敷直杏, 外山博英, 水谷治
- Organizer
  第 7３回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-19K05952
[Presentation] 麹菌におけるイトラコナゾール耐性を指標とした形質転換用マーカーの開発2020
- Author(s)
  ○渡嘉敷直杏, 水谷治, 外山博英
- Organizer
  日本農芸化学会 2020 年度大会
- Data Source
  KAKENHI-PROJECT-19K05952
[Presentation] 黒麹菌 Aspergillus luchuensis のエレクトロポレーション法による形質転換系の開発2019
- Author(s)
  ○上元優, 玉井萌子, 渡嘉敷直杏, 外山博英, 水谷治
- Organizer
  第 19 回糸状菌分子生物学コンファレンス
- Data Source
  KAKENHI-PROJECT-19K05952
[Presentation] 麹菌 ligD 遺伝子がゲノム編集に起因する大規模欠失変異に与える影響2018
- Author(s)
  上元優, 林梨咲, 渡嘉敷直杏, 荒添貴之, 山田修, 外山博英, 水谷治
- Organizer
  第３回ゲノム編集学会
- Data Source
  KAKENHI-PROJECT-16K07706
[Presentation] ゲノム編集時に引き起こされる麹菌 Aspergillus oryzae の大規模欠失機構に関する研究2018
- Author(s)
  水谷治, 林梨咲, 渡嘉敷直杏, 上里優希, 上元優, 玉井萌子, 荒添貴之, 山田修, 外山博英
- Organizer
  日本農芸化学会 2018 年度大会
- Data Source
  KAKENHI-PROJECT-16K07706
[Presentation] 麹菌における Cre-loxP システムの利用と TALEN を用いたゲノム編集2017
- Author(s)
  水谷治, 山田修, 家藤治幸
- Organizer
  第 69 回日本生物工学会大会
- Data Source
  KAKENHI-PROJECT-16K07706
[Presentation] 麹菌における TALENs と CRISPR/Cas9 の違いによる大規模欠失変異の比較2017
- Author(s)
  水谷治, 利田賢次, 林梨咲, 渡嘉敷直杏, 荒添貴之, 西田敬二, 和田悠作, 織田健, 岩下和裕, 山田　修, 外山博英
- Organizer
  第 2 回ゲノム編集学会
- Data Source
  KAKENHI-PROJECT-16K07706
[Presentation] 非相同末端結合に関与する遺伝子破壊株における麹菌の TALENs を用いたゲノム編集2016
- Author(s)
  水谷　治, 荒添貴之, 利田賢次, 林梨咲, 大里修一, 佐久間哲史, 山本　卓, 桑田茂, 山田　修
- Organizer
  第 68 回日本生物工学会大会
- Place of Presentation
  富山
- Year and Date
  2016-09-28
- Data Source
  KAKENHI-PROJECT-16K07706
[Presentation] 麹菌のCre組換え酵素直接導入法における応用開発2016
- Author(s)
  利田賢次、林梨咲、五味勝也、山田修、水谷治
- Organizer
  日本農芸化学会 2016 年度大会
- Place of Presentation
  札幌
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25871247
[Presentation] 麹菌野生株及び ligD 遺伝子破壊株を宿主とした Platinum-Fungal TALENs を用いたゲノム編集2016
- Author(s)
  水谷　治, 荒添貴之, 利田賢次, 林梨咲, 大里修一, 佐久間哲史, 山本　卓, 桑田茂, 山田　修
- Organizer
  日本ゲノム編集学会第１回大会
- Place of Presentation
  広島
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-16K07706
[Presentation] Platinum-Fungal TALENs を用いた麹菌におけるゲノム編集2015
- Author(s)
  水谷　治, 荒添貴之, 利田賢次, 林梨咲, 大里修一, 佐久間哲史, 山本　卓, 桑田茂, 山田　修
- Organizer
  第 67 回日本生物工学会大会
- Place of Presentation
  鹿児島
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-25871247
[Presentation] TALEN を用いた麹菌 Aspergillus oryzae におけるゲノム編集
- Author(s)
  水谷治、荒添貴之、利田賢次、林梨咲、大里修一、佐久間哲史、山本卓、桑田茂、山田修
- Organizer
  第4回ゲノム編集研究会
- Place of Presentation
  広島
- Year and Date
  2014-10-06 – 2014-10-07
- Data Source
  KAKENHI-PROJECT-25871247

1. 荒添貴之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mizutani Osamu 水谷 治

水谷 治 ミズタニ オサム

Research Projects

Research Products

Co-Researchers

ニゲラン生産株が有する棘様構造の産生メカニズムの解明とその意義についてPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on DNA repair mechanism via large-scale deletion in Aspergillus oryzae caused by genome editing due to error of non-homologous end-joining repair.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism for large deletions in Aspergillus oryzae caused by genome editing via error of non-homologous end-joining repair.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of the mechanism of Cre-loxP recombination by direct introduction of Cre recombinase and application to artificial nuclease (TALENs) in Aspergillus oryzaePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Genome Engineering via CRISPR-Cas9 System 1st Edition (担当範囲: 5. Targeted genome editing using CRISPR-Cas9 system in fungi)2020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Development of an itraconazole resistance gene as a dominant selectable marker for transformation in Aspergillus oryzae and Aspergillus luchuensis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Construction of transcription factor gene deletion library of <i>Aspergillus luchuensis</i>2021

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Identification of Genes Involved in the Synthesis of the Fungal Cell Wall Component Nigeran and Regulation of Its Polymerization in Aspergillus luchuensis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phenolic acid decarboxylase of Aspergillus luchuensis plays a crucial role in 4-vinylguaiacol production during awamori brewing2020

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Effect of pepA deletion and overexpression in Aspergillus luchuensis on sweet potato shochu brewing2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Influence of α-1,3-glucan synthase gene agsE on protoplast formation for transformation of Aspergillus luchuensis2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Cellular responses to the expression of unstable secretory proteins in the filamentous fungus Aspergillus oryzae2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Detailed analysis of targeted gene mutations caused by the Platinum-Fungal TALENs in Aspergillus oryzae RIB40 strain and a ligD disruptant2017

Author(s)

Journal Title

DOI

NAID

Mizutani Osamu 水谷治

水谷治ミズタニオサム

[Presentation] 麹菌における Cre-loxP システムの利用と TALEN を用いたゲノム編集2017