Hinoi Takao 檜井孝夫

… Alternative Names

HINOI Takao 檜井孝夫

HINO Takao 桧井孝夫

檜井孝夫ヒノイタカオ

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Researcher Number	10444689
Other IDs
Affiliation (Current)	2025: 広島大学, 病院(医), 教授
Affiliation (based on the past Project Information) *help	2021 – 2024: 広島大学, 病院(医), 教授 2019 – 2020: 広島大学, 病院(医), 特任教授 2018: 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, その他 2016: 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, 臨床研究部室長 2015 – 2016: 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, その他 … More 2012 – 2014: 広島大学, 大学病院, 講師 2010 – 2012: 広島大学, 病院, 講師 2007 – 2008: Hiroshima University, 大学院・医歯薬学総合研究科, 寄附講座講師 Less
Review Section/Research Field	Principal Investigator Digestive surgery / Basic Section 55020:Digestive surgery-related Except Principal Investigator Digestive surgery
Keywords	Principal Investigator マウスモデル / 大腸癌 / 遺伝子改変マウス / 大腸癌マウスモデル / 小腸大腸肛門外科学 / バイオマーカー / 新規分子標的 / 発癌の分子病態 / 治療抵抗性大腸癌 / サブクラス分類 … More / オルガノイド / CMS分類 / RASシグナル伝達 / FAP / 分子腫瘍学 / 大腸癌のサブタイプ分類 / 大腸癌のマウスモデル / ラット / genome editing system / CRISPR / CAS 9 / 動物モデル / MSI大腸癌マウスモデル / KRAS変異型大腸癌 / TGFbeta / Kras / TGFbetaRII / RAS / 大腸癌幹細胞 / 腸上皮細胞 / iPS細胞 / 大腸癌転移マウスモデル … More Except Principal Investigator マウスモデル / 遺伝子変異 / 大腸癌 Less

Identification of novel driver genes in treatment-resistant colorectal cancer subtypes and development of therapeutic strategiesPrincipal Investigator
- Principal Investigator
  
  檜井孝夫
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Hiroshima University
Establishment of mouse models and organoids corresponding to colorectal cancer molecular subtypes and their clinical applicationPrincipal Investigator
- Principal Investigator
  
  Hinoi Takao
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Hiroshima University
  Department of Clinical Research, National Hospital Organization Kure Medical Center
Establishment of new colon cancer animal model using CRISPR / CAS 9 genome editing systemPrincipal Investigator
- Principal Investigator
  
  Hinoi Takao
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Department of Clinical Research, National Hospital Organization Kure Medical Center
Establishment of a novel mouse colon cancer disease model with different genome instability useful for subclass classificationPrincipal Investigator
- Principal Investigator
  
  Hinoi Takao
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Department of Clinical Research, National Hospital Organization Kure Medical Center
  Hiroshima University
Investigation of metastasis related genes based on conditinoal knock out mouse model
- Principal Investigator
  
  SHIMOMURA Manabu
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Hiroshima University
Establishment of the novel mouse model of metastatic colorectalcancer and identification of the biomarker for tissue-specific metastasisPrincipal Investigator
- Principal Investigator
  
  HINOI Takao
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Hiroshima University
Generation of intestinal epithelial cell line from induced pluripotent stem cell and establishment of colorectal cancer stem cell modelPrincipal Investigator
- Principal Investigator
  
  HINOI Takao
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Hiroshima University
Mouse model of colonic adenoma-carcinoma progressionPrincipal Investigator
- Principal Investigator
  
  HINO Takao
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Hiroshima University

[Book] 遺伝性大腸癌診療ガイドライン 2020年版2020
- Author(s)
  大腸癌研究会遺伝性大腸癌診療ガイドライン作成委員会、石田秀行, 冨田尚裕, 山口達郎, 田中屋宏爾, 赤木究, 石川秀樹, 川崎優子, 隈元謙介, 下平秀樹, 関根茂樹, 高山哲治, 田中敏明, 田村和朗, 田村智英子, 千野晶子, 土井悟, 中島健, 中山佳子, 長谷川博俊, 檜井孝夫, 平沢晃, 宮倉安幸
- Total Pages
  152
- Publisher
  金原出版
- ISBN
  4307204158
- Data Source
  KAKENHI-PROJECT-18K08694
[Book] 診療ガイドライン UP-TO-DATE 2016-20172016
- Author(s)
  檜井孝夫　 (監修　門脇　孝　他）
- Total Pages
  968
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-25293284
[Journal Article] A case of Turcot’s syndrome type 1 with loss of immunoexpression of MSH6 in colon cancer and liver metastasis due to secondary somatic mutation in coding mononucleotide (C)8 tract: a case report2020
- Author(s)
  Akabane Shintaro、Hinoi Takao、Akagi Kiwamu、Yamamoto Hideki、Sada Haruki、Shimizu Yosuke、Shimizu Wataru、Sudo Takeshi、Onoe Takashi、Ishiyama Kohei、Suzuki Takahisa、Tazawa Hirofumi、Hadano Naoto、Misumi Toshihiro、Kojima Masato、Kubota Haruna、Taniyama Daiki、Kuraoka Kazuya、Tashiro Hirotaka
- Journal Title
  
  BMC Medical Genetics
  
  Volume: 21 Issue: 1 Pages: 141-141
- DOI
  10.1186/s12881-020-01079-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08694
[Journal Article] Oncogenic mutation in RAS‐RAF axis leads to increased expression of GREB1, resulting in tumor proliferation in colorectal cancer2020
- Author(s)
  Kochi Masatoshi、Hinoi Takao、Niitsu Hiroaki、Miguchi Masashi、Saito Yasufumi、Sada Haruki、Sentani Kazuhiro、Sakamoto Naoya、Oue Naohide、Tashiro Hirotaka、Sotomaru Yusuke、Yasui Wataru、Ohdan Hideki
- Journal Title
  
  Cancer Science
  
  Volume: 111 Issue: 10 Pages: 3540-3549
- DOI
  10.1111/cas.14558
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-19H03443, KAKENHI-PROJECT-18K07016, KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-18K08694, KAKENHI-PROJECT-19H01056
[Journal Article] Clinicopathological significance of RCAN2 production in gastric carcinoma.2019
- Author(s)
  Hattori Y, Sentani K, Shinmei S, Oo HZ, Hattori T, Imai T, Sekino Y, Sakamoto N, Oue N, Niitsu H, Hinoi T, Ohdan H, Yasui W.
- Journal Title
  
  Histopathology
  
  Volume: 74 Issue: 3 Pages: 430-442
- DOI
  10.1111/his.13764
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-18K07016, KAKENHI-PROJECT-18K08694, KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-19H03443
[Journal Article] Synbiotics Suppress Colitis-Induced Tumorigenesis in a Colon-Specific Cancer Mouse Model2019
- Author(s)
  Saito Y, Hinoi T, Adachi T, Miguchi M, Niitsu H, Kochi M, Sada H, Sotomaru Y, Sakamoto N, Sentani K, Oue N, Yasui W, Tashiro H, Ohdan H.
- Journal Title
  
  PLoS One
  
  Volume: 14 Issue: 6 Pages: 0216393-0216393
- DOI
  10.1371/journal.pone.0216393
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07017, KAKENHI-PROJECT-18K08694, KAKENHI-PROJECT-19K07434, KAKENHI-PROJECT-19H03443
[Journal Article] Signal regulatory protein alpha blockade potentiates tumoricidal effects of macrophages on gastroenterological neoplastic cells in syngeneic immunocompetent mice2018
- Author(s)
  Abe Tomoyuki、Tanaka Yuka、Piao Jinlian、Tanimine Naoki、Oue Naohide、Hinoi Takao、Garcia Noel Verjan、Miyasaka Masayuki、Matozaki Takashi、Yasui Wataru、Ohdan Hideki
- Journal Title
  
  Annals of Gastroenterological Surgery
  
  Volume: 2 Issue: 6 Pages: 451-462
- DOI
  10.1002/ags3.12205
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07016, KAKENHI-PROJECT-18K08694, KAKENHI-PROJECT-18H04032
[Journal Article] KIF11 Is Required for Spheroid Formation by Oesophageal and Colorectal Cancer Cells.2017
- Author(s)
  Imai T, Oue N, Sentani K, Sakamoto N, Uraoka N, Egi H, Hinoi T, Ohdan H, Yoshida K, Yasui W.
- Journal Title
  
  Anticancer Res.
  
  Volume: 37 Pages: 47-55
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293284
[Journal Article] Choline Deficiency Causes Colonic Type II Natural Killer T (NKT) Cell Loss and Alleviates Murine Colitis under Type I NKT Cell Deficiency.2017
- Author(s)
  Sagami S, Ueno Y, Tanaka S, Fujita A, Niitsu H, Hayashi R, Hyogo H, Hinoi T, Kitadai Y, Chayama K.
- Journal Title
  
  PLoS One
  
  Volume: 12
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293284
[Journal Article] Increased Calcineurin A Expression Is Associated with a Lower Relapse-Free Survival Rate after Colorectal Cancer Surgery.2016
- Author(s)
  Niitsu H, Hinoi T, Sentani K, Mukai S, Adachi T, Saito Y, Miguchi M, Kochi M, Sada H, Oue N, Yasui W, Ohdan H.
- Journal Title
  
  Pathobiology
  
  Volume: 83 Issue: 6 Pages: 308-15
- DOI
  10.1159/000445121
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293284, KAKENHI-PROJECT-16K08691
[Journal Article] Mouse model of proximal colon-specific tumorigenesis driven by microsatellite instability-induced Cre-mediated inactivation of Apc and activation of Kras.2016
- Author(s)
  Kawaguchi Y, Hinoi T, Saito Y, Adachi T, Miguchi M, Niitsu H, Sasada T, Shimomura M, Egi H, Oka S, Tanaka S, Chayama K, Sentani K, Oue N, Yasui W, Ohdan H.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 51 Issue: 5 Pages: 447-457
- DOI
  10.1007/s00535-015-1121-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460416, KAKENHI-PROJECT-25293284, KAKENHI-PROJECT-16K08691
[Journal Article] Gasdermin C Is Upregulated by Inactivation of Transforming Growth Factor β Receptor Type II in the Presence of Mutated Apc, Promoting Colorectal Cancer Proliferation.2016
- Author(s)
  Miguchi M, Hinoi T, Shimomura M, Adachi T, Saito Y, Niitsu H, Kochi M, Sada H, Sotomaru Y, Ikenoue T, Shigeyasu K, Tanakaya K, Kitadai Y, Sentani K, Oue N, Yasui W, Ohdan H.
- Journal Title
  
  PLoS One
  
  Volume: 11
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293284
[Journal Article] KRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancer.2016
- Author(s)
  Niitsu H, Hinoi T, Kawaguchi Y, Sentani K, Yuge R, Kitadai Y, Sotomaru Y, Adachi T, Saito Y, Miguchi M, Kochi M, Sada H, Shimomura M, Oue N, Yasui W, Ohdan H.
- Journal Title
  
  Oncogenesis.
  
  Volume: 5 Issue: 8 Pages: 8-8
- DOI
  10.1038/oncsis.2016.47
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293284, KAKENHI-PROJECT-16K08691, KAKENHI-PROJECT-15H02567
[Journal Article] Regulation of multidrug resistance 1 expression by CDX2 in ovarian mucinous adenocarcinoma.2016
- Author(s)
  Koh I, Hinoi T, Sentani K, Hirata E, Nosaka S, Niitsu H, Miguchi M, Adachi T, Yasui W, Ohdan H, Kudo Y.
- Journal Title
  
  Cancer Med
  
  Volume: 5 Issue: 7 Pages: 1546-55
- DOI
  10.1002/cam4.697
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25293284, KAKENHI-PROJECT-16K08691
[Journal Article] Chlorinated Water Modulates the Development of Colorectal Tumors with Chromosomal Instability and Gut Microbiota in Apc-Deficient Mice.2015
- Author(s)
  Sasada T, Hinoi T, Saito Y, Adachi T, Takakura Y, Kawaguchi Y, Sotomaru Y, Sentani K, Oue N, Yasui W, Ohdan H.
- Journal Title
  
  PLoS One.
  
  Volume: 10 Issue: 7 Pages: e0132435-e0132435
- DOI
  10.1371/journal.pone.0132435
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460416, KAKENHI-PROJECT-25293284, KAKENHI-PROJECT-15H02567
[Journal Article] Colonoscopy as a tool for evaluating colorectal tumor development in a mouse model2014
- Author(s)
  Adachi T, Hinoi T, Sasaki Y, Niitsu H, Saito Y, Miguchi M, Shimomura M, Ohdan H
- Journal Title
  
  Int J Colorectal Dis
  
  Volume: 29 Issue: 2 Pages: 217-223
- DOI
  10.1007/s00384-013-1791-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293284
[Journal Article] Preservation of peritoneal fibrinolysis owing to decreased transcription of plasminogen activator inhibitor-1 in peritoneal mesothelial cells suppresses postoperative adhesion formation in laparoscopic surgery.2013
- Author(s)
  Shimomura M, Hinoi T, Ikeda S, Adachi T, Kawaguchi Y, Tokunaga M, Sasada T, Egi H, Tanabe K, Okajima M, Ohdan H.
- Journal Title
  
  Surgery. 2013 Mar
  
  Volume: 153(3) Issue: 3 Pages: 344-56
- DOI
  10.1016/j.surg.2012.07.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390257
[Journal Article] Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer2012
- Author(s)
  Sakamoto N, Oue N, Sentani K, Anami K, Uraoka N, Naito Y, Oo HZ, Hinoi T, Ohdan H, Yanagihara K, Aoyagi K, Sasaki H, Yasui W.
- Journal Title
  
  Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer
  
  Volume: 103(9) Issue: 9 Pages: 1744-50
- DOI
  10.1111/j.1349-7006.2012.02353.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390257, KAKENHI-PROJECT-23790401, KAKENHI-PROJECT-23790402, KAKENHI-PROJECT-24390088, KAKENHI-PROJECT-24659163
[Journal Article] Primary lung cancer presenting with metastasis to the colon: a case report.2012
- Author(s)
  Sakai H, Egi H, Hinoi T, Tokunaga M, Kawaguchi Y, Shinomura M, Adachi T, Arihiro K, Ohdan H.
- Journal Title
  
  World J Surg Oncol
  
  Volume: 10 Issue: 1 Pages: 127-127
- DOI
  10.1186/1477-7819-10-127
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390257
[Journal Article] Submucosal invasive micropapillary carcinoma of the colon with massive lymph node metastases: a case report2012
- Author(s)
  Mukai S, Takakura Y, Egi H, Hinoi T, Saito Y, Tanimine N, Miguchi M, Adachi T, Shimomura M, Ohdan H.
- Journal Title
  
  Case Rep Oncol.
  
  Volume: 5(3) Issue: 3 Pages: 608-15
- DOI
  10.1159/000345566
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390257
[Journal Article] Reg IV is a direct target of intestinal transcriptional factor CDX2 in gastric cancer.2012
- Author(s)
  Naito Y, Oue N, Hinoi T, Sakamoto N, Sentani K, Ohdan H, Yanagihara K, Sasaki, H, Yasui W.
- Journal Title
  
  PLoS One
  
  Volume: 7(11) Issue: 11 Pages: 47545-47545
- DOI
  10.1371/journal.pone.0047545
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390257, KAKENHI-PROJECT-23790401, KAKENHI-PROJECT-23790402, KAKENHI-PROJECT-24390088, KAKENHI-PROJECT-24659163
[Journal Article] Identification of patients likely to benefit from metastasectomy in stage IV colorectal cancer.2012
- Author(s)
  Shimomura M, Okajima M, Hinoi T, Egi H, Takakura Y, Kawaguchi Y, Tokunaga M, Adachi T, Tashiro H, Ohdan H.
- Journal Title
  
  Int J Colorectal Dis.
  
  Volume: 27(10) Pages: 1339-46
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390257
[Journal Article] Malignant peripheral nerve sheath tumor arising from the greater omentum : case report2011
- Author(s)
  Miguchi M, Takakura Y, Egi H, Hinoi T, Adachi T, Kawaguchi Y, Shinomura M, Tokunaga M, Okajima M, Ohdan H
- Journal Title
  
  World J Surg Oncol., Mar
  
  Volume: 21 Pages: 9-33
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659242
[Journal Article] External Validation of two nomograms for predicting patients survival after hepatic resection for metastatic colorectal cancer2011
- Author(s)
  Takakura Y, Okajima M, Kanemitsu Y, Kuroda S, Egi H, Hinoi T, Tashiro H, Ohdan H
- Journal Title
  
  World J Surg
  
  Volume: 35 Issue: 10 Pages: 2275-2282
- DOI
  10.1007/s00268-011-1194-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591748, KAKENHI-PROJECT-22390257, KAKENHI-PROJECT-23249064
[Journal Article] External validation of two nomograms for predicting patient survival after hepatic resection for metastatic colorectal cancer2011
- Author(s)
  Takakura Y, Okajima M, Kanemitsu Y, Kuroda S, Egi H, Hinoi T, Tashiro H, Ohdan H
- Journal Title
  
  World J Surg
  
  Volume: 35(10) Pages: 2275-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659242
[Journal Article] Malignant peripheral nerve sheath tumor arising from the greater omentum: case report.2011
- Author(s)
  Miguchi M, Takakura Y, Egi H, Hinoi T, Adachi T, Kawaguchi Y, Shinomura M,Tokunaga M, Okajima M, Ohdan H.
- Journal Title
  
  World J Surg Oncol.
  
  Volume: 9 Issue: 1 Pages: 33-33
- DOI
  10.1186/1477-7819-9-33
- NAID
  120003692468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390257
[Journal Article] Adequate lymph node examination isessential to ensure the prognostic valueof the lymph node ratio in patients withstage iii colorectal cancer2011
- Author(s)
  Shimomura M, Ikeda S, Takakura Y, Kawaguchi Y, Tokunaga M, Egi H, Hinoi T, Okajima M, Ohdan H.
- Journal Title
  
  Surg Today
  
  Volume: 41(10) Pages: 1370-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659242
[Journal Article] Adequate lymph node examination is essential to ensure the prognostic value of the lymph node ratio in patients with stage III colorectal cancer.2011
- Author(s)
  Shimomura M, Ikeda S, Takakura Y, Kawaguchi Y, Tokunaga M, Egi H, Hinoi T, Okajima M, Ohdan H
- Journal Title
  
  Surg Today
  
  Volume: 41(10) Issue: 10 Pages: 1370-9
- DOI
  10.1007/s00595-010-4446-2
- NAID
  10030228776
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390257
[Journal Article] Immunohistochemical analysis of colorectal cancer with gastric phenotype : claudin-18 is associated with poor prognosis2010
- Author(s)
  Matsuda M, Sentani K, Noguchi T, Hinoi T, Okajima M, Matsusaki K, Sakamoto N, Anami K, Naito Y, Oue N, Yasui W
- Journal Title
  
  Pathol Int
  
  Volume: 60(10) Pages: 673-80
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659242
[Journal Article] Gastrointestinal stromal tumors of the small intestine in pediatric populations : a case report and literature review2010
- Author(s)
  Shimomura M, Ikeda S, Takakura Y, Kawaguchi Y, Tokunaga M, Takeda H, Sumitani D, Yoshimitsu M, Hinoi T, Okajima M, Ohdan H
- Journal Title
  
  Pediatr Surg Int
  
  Volume: 26(6) Pages: 649-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659242
[Journal Article] Search for transmembrane protein in gastric cancer by the Escherichia coli ampicillin secretion trap: expression of DSC2 in gastric cancer with intestinal phenotype2010
- Author(s)
  Anami K, Oue N, Noguchi T, Sakamoto N, Sentani K, Hayashi T, Hinoi T, Okajima M, Graff JM, Yasui W.
- Journal Title
  
  J Pathol.
  
  Volume: 221(3) Issue: 3 Pages: 275-84
- DOI
  10.1002/path.2717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390257
[Journal Article] Immunohistochemical analysis of colorectal cancer with gastric phenotype: claudin-18 is associated with poor prognosis.2010
- Author(s)
  Matsuda M, Sentani K, Noguchi T, Hinoi T, Okajima M, Matsusaki K, Sakamoto N, Anami K, Naito Y, Oue N, Yasui W.
- Journal Title
  
  Pathol Int.
  
  Volume: 60(10) Issue: 10 Pages: 673-80
- DOI
  10.1111/j.1440-1827.2010.02587.x
- NAID
  10031123396
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390257
[Journal Article] Gastrointestinal stromal tumors of the small intestine in pediatric populations: a case report and literature review.2010
- Author(s)
  Shimomura M, Ikeda S, Takakura Y, Kawaguchi Y, Tokunaga M, Takeda H, Sumitani D, Yoshimitsu M, Hinoi T, Okajima M, Ohdan H.
- Journal Title
  
  Pediatr Surg Int.
  
  Volume: 26(6) Issue: 6 Pages: 649-54
- DOI
  10.1007/s00383-010-2596-3
- NAID
  120002598772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390257
[Journal Article] CDX2 regulates multidrug resistance 1 gene expression in malignant intestinal epithelium.2010
- Author(s)
  Takakura Y, Hinoi T, Oue N, Sasada T, Kawaguchi Y, Okajima M, Akyol A, Fearon ER, Yasui W, Ohdan H.
- Journal Title
  
  Cancer Res.
  
  Volume: 70(17) Issue: 17 Pages: 6767-78
- DOI
  10.1158/0008-5472.can-09-4701
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390257
[Journal Article] CDX2 regulates multidrug resistance 1 gene expression in malignant intestinal epithelium2010
- Author(s)
  Takakura Y, Hinoi T, Oue N, SasadaT, Kawaguchi Y, Okajima M, Akyol A, Fearon ER, Yasui W, Ohdan H
- Journal Title
  
  Cancer Res
  
  Volume: 70(17) Pages: 6767-78
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659242
[Journal Article] Search for transmembrane protein in gastric cancer by the Escherichia coli ampicillin secretion trap : expression of DSC2 in gastric cancer with intestinal phenotype2010
- Author(s)
  Anami K, Oue N, Noguchi T, Sakamoto N, Sentani K, Hayashi T, Hinoi T, Okajima M, Graff JM, Yasui W
- Journal Title
  
  J Pathol
  
  Volume: 221(3) Pages: 275-84
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659242
[Journal Article] Generating somatic mosaicism with a Cre recombinase-microsatellite sequence transgene2008
- Author(s)
  Akyol, A., Hinoi, T., Feng. Y., Bommer, G.T., Glaser, T.M., Fearon, E.R
- Journal Title
  
  transgene. Nature Methods 5巻
  
  Pages: 231-233
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591544
[Journal Article] Mouse Model of Colonic Adenoma-Carcinoma Piogression Based on Somatic Apc Inactivation2007
- Author(s)
  Takao Hinoi
- Journal Title
  
  Cancer Research 67-20
  
  Pages: 9721-9730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591544
[Journal Article] Drosophila split ends homologue SHARP functions as a positive regular of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation2007
- Author(s)
  Feng, Y., Bommer, G.T., Zhai, Y., Akyol, A. Hinoi, T., Winer, I., Lin H.V., Cadigan, K.M., Cho, K.R., Fearon, E.R
- Journal Title
  
  Cancer Res 67巻
  
  Pages: 482-491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591544
[Journal Article] Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation2007
- Author(s)
  Hinoi, T., Akyol, A., Theisen, B.K., Ferguson, D.O., Greenson, J.K., Williams, B.O., Cho, K.R., Fearon, E.R
- Journal Title
  
  Cancer Res 67巻
  
  Pages: 9721-9730
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591544
[Presentation] Transcriptomic analysis of mucinous adenocarcinoma in genetically-engineered mouse model2023
- Author(s)
  Haruki Sada, Hiroaki Niitsu, Hikaru Nakahara, Masashi Miguchi, Naoya Sakamoto, Naohide Oue, Hirotaka Tashiro, Hideki Ohdan, Takao Hinoi
- Organizer
  AACR annual meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K21448
[Presentation] 遺伝子改変マウスモデルにおける粘液産生大腸癌のトランスクリプトーム解析2022
- Author(s)
  佐田春樹、檜井孝夫、新津宏明、中原　輝、三口真司、坂本直也、大上直秀、田代裕尊、大段秀樹
- Organizer
  第33回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-23K21448
[Presentation] Genetically-engineered mouse model for colonic neoplasia presenting mucinous2022
- Author(s)
  Haruki Sada, Takao Hinoi, Hiroaki Niitsu, Hikaru Nakahara, Masashi Miguchi, Naoya Sakamoto, Naohide Oue, Hirotaka Tashiro, Hideki Ohdan
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-23K21448
[Presentation] Genetically-engineered mouse model for colonic neoplasia presenting mucinous and microsatellite unstable phenotype2022
- Author(s)
  Haruki Sada, Takao Hinoi， Hiroaki Niitsu, Masatoshi Miguchi, Naoya Sakamoto, Naohide Oue, Hirotaka Tashiro, Hideki Ohdan
- Organizer
  2022年 AACR ANNUAL MEETING
- Data Source
  KAKENHI-PROJECT-23K21448
[Presentation] 日本人の遺伝性びまん性胃がんにおけるCDH1遺伝子生殖細胞系列変異2020
- Author(s)
  山田英孝、胡徳、石野佳子、太田力、岩泉守哉、檜井孝夫、櫻井晃洋、田中屋宏爾、織田信弥、古庄知己、菅野康吉、吉田輝彦、椙村春彦
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08694
[Presentation] BRAF mutation leads to increased expression of GeneX (GREB1) resulting in tumor proliferation in colorectal cancer2020
- Author(s)
  Masatoshi Kochi, Takao Hinoi, Yasufumi Saito, Hiroaki Niitsu, Haruki Sada, Naoya Sakamoto, Kazuhiro Sentani, Naohide Oue, Wataru Yasui, Hideki Ohdan
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08694
[Presentation] 大腸上皮特異的転写活性配列を応用した新規大腸癌発癌マウスモデルの確立と発癌関連遺伝子の機能解析2019
- Author(s)
  檜井孝夫
- Organizer
  第28回　日本癌病態治療治療研究会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08694
[Presentation] The functional analysis of Pten haploinsufficient colon cancer derived from mouse model using organoids2019
- Author(s)
  Sada H, Hinoi T, Kochi M, Niitsu H, Ishikawa A, Sakamoto N, Sentani K, Oue N, Yasui W, Tashiro H, Ohdan H
- Organizer
  第30回　日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-18K08694
[Presentation] 新規遺伝子改変大腸癌マウスモデルから確立したPtenハプロ不全型大腸癌オルガノイドの作成とその機能解析2019
- Author(s)
  佐田春樹、檜井孝夫、坂本直也、仙谷和弘、大上直秀、安井弥、田代尊裕、大段秀樹
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K08694
[Presentation] Identification of novel colon cancer biomarkers by a new complex genetically modified mouse models2019
- Author(s)
  檜井孝夫
- Organizer
  第74回　日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-18K08694
[Presentation] Establishment of novel conditional Apc-knockout colorectal cancer mouse models with distinct genomic stability and its application to clinical diagnosis and therapy.2016
- Author(s)
  Takao HINOI, Eric R. FEARON, Wataru YASUI, Hideki OHDAN
- Organizer
  K-INT
- Place of Presentation
  Kure, Japan
- Year and Date
  2016-07-21
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293284
[Presentation] CDX2P-CreERT2:Apcflox/flox;KrasG12D　マウスモデルを用いたタモキシフェン投与量依存性腫瘍発育速度の検討2016
- Author(s)
  佐田春樹、檜井孝夫
- Organizer
  第75回日本癌学会
- Place of Presentation
  横浜、日本
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-25293284
[Presentation] The generation and analysis of Transforming growth factor beta receptor II (TGFBR2) mutant colorectal cancer mouse model2016
- Author(s)
  三口真司，檜井孝夫，下村学，安達智洋，斎藤保文，新津宏明，伊地知秀明，田中屋宏爾，北台靖彦，仙谷和弘，大上直秀，安井弥，大段秀樹
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-25293284
[Presentation] ２つのドライバー遺伝子による複合的遺伝子改変によるマウス大腸癌モデルの確立とその臨床応用2016
- Author(s)
  檜井孝夫、安達智洋、斉藤保文、三口真司、新津宏明、河内雅年、下村　学、石崎康代、惠木裕之、大段秀樹
- Organizer
  第70回日本消化器外科学会総会
- Place of Presentation
  浜松市
- Year and Date
  2016-07-15
- Data Source
  KAKENHI-PROJECT-25293284
[Presentation] 大腸がんの治療開発に有用な自然発生型大腸がんマウスモデルの確立2016
- Author(s)
  檜井孝夫、安達智洋、斉藤保文、三口真司、新津宏明、河内雅年、下村　学、外丸祐介、仙谷和弘、大上直秀、安井　弥、大段秀樹
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2016-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-25293284
[Presentation] 大腸癌自然発生マウスモデルを用いたKRAS変異型大腸癌の遺伝子発現プロファイル解析2016
- Author(s)
  新津宏明、檜井孝夫、川口康夫、仙谷和弘、大上直秀、安達智洋、斉藤保文、三口真司、下村学、安井弥、大段秀樹
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-25293284
[Presentation] 消化管癌の発生・病態におけるCDX2の機能解析とそれを応用した大腸癌マウスモデルの確立2016
- Author(s)
  檜井孝夫、安達智洋、斉藤保文、三口真司、河内雅年、佐田春樹、仙谷和弘、大上直秀、安井弥、大段秀樹
- Organizer
  第47回日本臨床分子形態学会総会・学術集会
- Place of Presentation
  長崎
- Year and Date
  2016-09-18
- Invited
- Data Source
  KAKENHI-PROJECT-25293284
[Presentation] CDX2P-CreERT2:Apcflox/flox;KrasG12D　マウスモデルを用いた大腸癌発生速度の検討2016
- Author(s)
  河内雅年, 檜井孝夫, 安達智洋, 斎藤保文, 三口真司, 新津宏明, 佐田春樹, 坂本直也, 仙谷和弘, 大上直秀, 安井弥, 大段秀樹
- Organizer
  第27回日本消化器癌発生学会
- Place of Presentation
  鹿児島
- Year and Date
  2016-09-15
- Data Source
  KAKENHI-PROJECT-25293284
[Presentation] The generation of colorectal cancer mouse model based on microsatellite instability and the identification of transforming2015
- Author(s)
  Miguchi M, Hinoi T, Shimomura M, Tomohiro Adachi, Yasufumi Saito, Hiroaki Niitsu, Masatoshi Kochi, Yusuke Sotomaru, Hideaki Ijichi, Tsuneo Ikenoue, Kunitoshi Shigeyasu,Kohji Tanakaya, Kazuhiro Sentani, Naohide Oue, Wataru Yasui,　Hideki Ohdan
- Organizer
  AACR annual meeting 2015
- Place of Presentation
  フィラデルフィア (USA)
- Year and Date
  2015-04-18
- Data Source
  KAKENHI-PROJECT-25861190
[Presentation] マイクロサテライト不安定大腸癌マウスモデルの作製とTGF-βシグナルの同定2015
- Author(s)
  三口真司、檜井孝夫、下村　学、安達智洋、斎藤保文、新津宏明、河内雅年、伊地知秀明、田中屋宏爾、大段秀樹
- Organizer
  第70回日本消化器外科学会総会
- Place of Presentation
  浜松
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-25861190
[Presentation] Oncogenic K-rasmutation associates with GLUT1 expression in mice and human colorectal cancer2013
- Author(s)
  KawaguchiY, Hinoi T, Sasada T, Adachi T, Saito Y, Miguchi S, Niitsu H, Ohdan H
- Organizer
  AACR Annual Meeting 2013
- Place of Presentation
  Washington DC USA
- Data Source
  KAKENHI-PROJECT-22390257
[Presentation] ChlorinatedDrinking Water Alters Carcinogenesis in a Mouse Model of Colon Cancer2012
- Author(s)
  Sasada T, Hinoi T, et al
- Organizer
  AACR Annual Meeting 2012
- Place of Presentation
  Chicago IL USA
- Data Source
  KAKENHI-PROJECT-22390257
[Presentation] 2種類の遺伝子不安定性大腸癌の新規マウスモデルの作製とその解析2012
- Author(s)
  檜井孝夫
- Organizer
  日本消化器病学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22390257
[Presentation] Chlorinated drinking water alters carcinogenesis in a mice model of colon cancer2012
- Author(s)
  Sasada T, Hinoi T
- Organizer
  American Association for Cancer Research Annual meeting 2012
- Place of Presentation
  Chicago IL, US
- Data Source
  KAKENHI-PROJECT-22390257
[Presentation] トランスレーショナルリサーチに有用な右側および左側結腸進行癌マウスモデルの構築:臓器特異的Apcコンディショナル・ノックアウトマウスの作製とその臨床応用2011
- Author(s)
  檜井孝夫
- Organizer
  日本外科学会
- Place of Presentation
  東京
- Year and Date
  2011-05-25
- Data Source
  KAKENHI-PROJECT-22390257
[Presentation] ChlorinatedDrinking Water Alters Carcinogenesis in a Mouse Model of Colon Cancer2011
- Author(s)
  Sasada T, Hinoi T, Oue H, Yasui W, et al
- Organizer
  6thInternational Society of Gastroenterological Carcinogenesis (ISGC)
- Place of Presentation
  Houston TX USA
- Data Source
  KAKENHI-PROJECT-22390257
[Presentation] Chlorinated Drinking Water Alters Carcinogenesis in a Mouse Model of Colon Cancer2011
- Author(s)
  佐々田達成、檜井孝夫
- Organizer
  6th International Society of Gastroenterological Carcinogenesis
- Place of Presentation
  ヒューストン(米国)
- Year and Date
  2011-01-06
- Data Source
  KAKENHI-PROJECT-22390257
[Presentation] 大腸癌の遺伝子レベルでの解明と分子標的治療へのとりくみ2008
- Author(s)
  檜井孝夫
- Organizer
  第109回、日本外科学会定期学術集会
- Place of Presentation
  長崎市
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19591544
[Presentation] 大腸癌の遺伝子レベルでの解明と分子標的治療へのとりくみ2008
- Author(s)
  檜井孝夫
- Organizer
  日本外科学会定期学術集会
- Place of Presentation
  長崎
- Year and Date
  2008-05-16
- Data Source
  KAKENHI-PROJECT-19591544
[Presentation] マウス大腸上皮特異的プロモーターを応用した新しい大腸関連疾患(大腸癌)マウスモデルの開発2007
- Author(s)
  檜井孝夫
- Organizer
  第107回日本外科学会定期学術集会
- Place of Presentation
  大阪
- Year and Date
  2007-04-13
- Data Source
  KAKENHI-PROJECT-19591544
[Presentation] Sulindac delayed and suppressed the tumor progression, was not effective on inhibition of tumor initiation in a human colorectal cancer mouse model (CPC;Apc mouse)
- Author(s)
  Tomohiro Adachi, Takao Hinoi, Yuu Sasaki, Manabu Shimomura, Yasufumi Saito, Masashi Miguchi, Hiroaki Niitsu, Yuusuke Sotomaru, Naohide Oue, Wataru Yasui, Hideki Ohdan
- Organizer
  American Association for Cancer Research Annual Meeting 2014
- Place of Presentation
  San Diego, CA, USA
- Data Source
  KAKENHI-PROJECT-25293284
[Presentation] 大腸癌自然発生マウスモデルの腫瘍発生における飲用水中塩素濃度の影響
- Author(s)
  齊藤保文、檜井孝夫、佐々田達成、川口康夫、下村学、安達智洋、三口真司、新津宏明、大段秀樹
- Organizer
  第114回日本外科学会
- Place of Presentation
  京都、日本
- Year and Date
  2014-04-03 – 2014-04-05
- Data Source
  KAKENHI-PROJECT-25293284
[Presentation] 左側結腸癌モデル(CPC;Apc)マウスを使用した大腸癌発育浸潤因子の同定と臨床応用にむけて
- Author(s)
  安達智洋、檜井孝夫、齊藤保文、佐々田達成、川口康夫、下村学、三口真司、新津宏明、大段秀樹
- Organizer
  日本消化器癌発生学会
- Place of Presentation
  福岡、日本
- Year and Date
  2014-11-13 – 2014-11-14
- Data Source
  KAKENHI-PROJECT-25293284
[Presentation] 左側結腸癌マウス（CPC;Apc)モデルのDSS単独投与による発癌の影響について
- Author(s)
  安達智洋、檜井孝夫、齊藤保文、佐々田達成、川口康夫、下村学、三口真司、新津宏明、大段秀樹
- Organizer
  第114回日本外科学会
- Place of Presentation
  京都、日本
- Year and Date
  2014-04-03 – 2014-04-05
- Data Source
  KAKENHI-PROJECT-25293284
[Presentation] Impact of synbiotics administration on tumorigenesis of colon cancer mouse model
- Author(s)
  Yasufumi Saito, Takao Hinoi, Tomohiro Adachi, Manabu Shimomura, Masashi Miguchi, Hiroaki Niitsu, Masatishi Kochi, Hideki Ohdan, Kazuhiro Sentani, Naohide Oue, Wataru Yasui
- Organizer
  AACR 2015
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-18 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-25293284
[Presentation] Impact of Synbiotics administration on tumorigenesis of colon cancer mouse model
- Author(s)
  斉藤保文　檜井孝夫　恵木浩之　下村学　安達智洋　三口真司新津宏明　澤田紘幸　河内雅年　大上直秀　安井弥　大段秀樹
- Organizer
  第25回消化器癌発生学会
- Place of Presentation
  福岡、日本
- Year and Date
  2014-11-11 – 2014-11-14
- Data Source
  KAKENHI-PROJECT-25293284
[Presentation] Gene expression profiling for oncogenic Kras mutation in mice and human colorectal cancer
- Author(s)
  Hiroaki Niitsu, Takao Hinoi, Yasuo Kawaguchi, Kazuhiro Sentani, Naohide Oue, Yusuke Sotomaru, Tomohiro Adachi, Yasufumi Saito, Masashi Miguchi, Masatoshi Kochi, Manabu Shimomura, Wataru Yasui, and Hideki Ohdan
- Organizer
  AACR 2015
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-18 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-25293284
[Presentation] Sulindac delayed and suppressed the tumor progression, was not effective on inhibition of tumor initiation in a human colorectal cancer mouse model (CPC;Apc mouse).
- Author(s)
  Tomohiro Adachi, Takao Hinoi, Naohide Oue, Yusuke Sotomaru,Yasufumi Saito, Masashi Miguchi,Hiroaki Niitsu, Masatoshi Kochi, Manabu Shimomura, Wataru Yasui, and Hideki Ohdan
- Organizer
  AACR 2014
- Place of Presentation
  SanDiego, USA
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-25293284
[Presentation] The generation of colorectal cancer mouse model based on microsatellite instability and the identification of transforming growth factor-beta signal target
- Author(s)
  Masashi Miguchi, Takao Hinoi, Manabu Shimomura, Tomohiro Adachi, Yasufumi Saito, Hiroaki Niitsu, Masatoshi Kochi, Yusuke Sotomaru, Hideaki Ijichi, Tsuneo Ikenoue, Kunitoshi Shigeyasu, Kohji Tanakaya, Kazuhiro Sentani, Naohide Oue, Wataru Yasui, Hideki Ohdan
- Organizer
  AACR 2015
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2015-04-18 – 2015-04-22
- Data Source
  KAKENHI-PROJECT-25293284

1. SOTOMARU Yusuke (90309352)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. IKENOUE Tsuneo (80396712)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
3. OUE Naohide (60346484)

# of Collaborated Projects: 2 results

# of Collaborated Products: 22 results
4. SHIMOMURA Manabu (60457249)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. SAITO Yasufumi

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
6. MIGUCHI Masashi

# of Collaborated Projects: 2 results

# of Collaborated Products: 20 results
7. OKAJIMA Masazumi (90274068)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
8. MIYAMOTO Kazuaki (30332373)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TOMONAGA Takeshi (80227644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OHDAN Hideki (10363061)

# of Collaborated Projects: 1 results

# of Collaborated Products: 22 results
11. 坂本直也 (20571798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
12. 仙谷和弘 (30508164)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. 高倉有二 (20581698)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ADACHI Tomohiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
15. NIITSU Hiroaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 20 results
16. 田代裕尊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hinoi Takao 檜井 孝夫

HINOI Takao 檜井 孝夫

HINO Takao 桧井 孝夫

檜井 孝夫 ヒノイ タカオ

Research Projects

Research Products

Co-Researchers

Identification of novel driver genes in treatment-resistant colorectal cancer subtypes and development of therapeutic strategiesPrincipal Investigator

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Establishment of mouse models and organoids corresponding to colorectal cancer molecular subtypes and their clinical applicationPrincipal Investigator

Principal Investigator

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Review Section

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Establishment of new colon cancer animal model using CRISPR / CAS 9 genome editing systemPrincipal Investigator

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Establishment of a novel mouse colon cancer disease model with different genome instability useful for subclass classificationPrincipal Investigator

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Investigation of metastasis related genes based on conditinoal knock out mouse model

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Establishment of the novel mouse model of metastatic colorectalcancer and identification of the biomarker for tissue-specific metastasisPrincipal Investigator

Principal Investigator

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Generation of intestinal epithelial cell line from induced pluripotent stem cell and establishment of colorectal cancer stem cell modelPrincipal Investigator

Principal Investigator

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Mouse model of colonic adenoma-carcinoma progressionPrincipal Investigator

Principal Investigator

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[Book] 遺伝性大腸癌診療ガイドライン 2020年版2020

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[Book] 診療ガイドライン UP-TO-DATE 2016-20172016

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[Journal Article] A case of Turcot’s syndrome type 1 with loss of immunoexpression of MSH6 in colon cancer and liver metastasis due to secondary somatic mutation in coding mononucleotide (C)8 tract: a case report2020

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[Journal Article] Oncogenic mutation in RAS‐RAF axis leads to increased expression of GREB1, resulting in tumor proliferation in colorectal cancer2020

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[Journal Article] Clinicopathological significance of RCAN2 production in gastric carcinoma.2019

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Hinoi Takao 檜井孝夫

HINOI Takao 檜井孝夫

HINO Takao 桧井孝夫

檜井孝夫ヒノイタカオ