Sugimoto Naoshi 杉本直志

Researcher Number	10447956
Other IDs
Affiliation (Current)	2025: 京都大学, iPS細胞研究所, 特定准教授
Affiliation (based on the past Project Information) *help	2022 – 2023: 京都大学, iPS細胞研究所, 特定拠点准教授 2021: 京都大学, iPS細胞研究所, 特定拠点講師 2017 – 2018: 香川大学, 医学部附属病院, 助教 2016: 京都大学, iPS細胞研究所, 特定拠点助教 2015: 京都大学, iPS細胞研究所, 特任研究員
Review Section/Research Field	Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Hematology Except Principal Investigator Broad Section I
Keywords	Principal Investigator 免疫寛容 / HLA / ライブ動態解析 / 免疫抑制分子 / プロテオミック解析 / TGFβ / ヒト化マウス / TGF-β / NK細胞 / 遺伝子編集 … More / HLAクラスI / 血小板 / iPS細胞 / 造腫瘍性 / 自然免疫 / 核酸センシング / 血液細胞 / 細胞質内核酸センサー / eIF4F / eIF4GI / eIF4E / 細胞内核酸センサー / 造血器腫瘍 / DDX41 / DHX29 … More Except Principal Investigator 培養槽 / 巨核球 / 脂質膜 / iPS細胞 / バイオリアクター / 乱流 / 血小板 / 造血システム Less

Elucidation of the NK cell immune escape mechanism using iPS cell-derived platelets and development of treatmentPrincipal Investigator
- Principal Investigator
  
  Sugimoto Naoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Kyoto University
Elucidating the fundamental mechanism of platelet biogenesis and its medical application
- Principal Investigator
  
  江藤浩之
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section I
- Research Institution
  Kyoto University
The role of the nucleic acid sensor molecule DHX29 in hematopoietic cell immune responses and hematopoietic tumorsPrincipal Investigator
- Principal Investigator
  
  Sugimoto Naoshi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kagawa University
  Kyoto University

All 2024 2023 2022 2021 2019

All Journal Article Presentation

[Journal Article] A let-7 microRNA-RALB axis links the immune properties of iPSC-derived megakaryocytes with platelet producibility2024
- Author(s)
  Chen Si Jing、Hashimoto Kazuya、Fujio Kosuke、Hayashi Karin、Paul Sudip Kumar、Yuzuriha Akinori、Qiu Wei-Yin、Nakamura Emiri、Kanashiro Maria Alejandra、Kabata Mio、Nakamura Sou、Sugimoto Naoshi、Kaneda Atsushi、Yamamoto Takuya、Saito Hirohide、Takayama Naoya、Eto Koji
- Journal Title
  
  Nature Communications
  
  Volume: 15 Issue: 1 Pages: 2588-2588
- DOI
  10.1038/s41467-024-46605-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K18299, KAKENHI-PROJECT-22K15124, KAKENHI-PROJECT-21H05047
[Journal Article] Humanized mouse models with endogenously developed human natural killer cells for in?vivo immunogenicity testing of HLA class I-edited iPSC-derived cells2023
- Author(s)
  Flahou Charlotte、Morishima Tatsuya、Higashi Natsumi、Hayashi Yoshikazu、Xu Huaigeng、Wang Bo、Zhang Chaoqi、Ninomiya Atsushi、Qiu Wei-Yin、Yuzuriha Akinori、Suzuki Daisuke、Nakamura Sou、Manz Markus、Kaneko Shin、Hotta Akitsu、Takizawa Hitoshi、Eto Koji、Sugimoto Naoshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 662 Pages: 76-83
- DOI
  10.1016/j.bbrc.2023.04.067
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K18299, KAKENHI-PROJECT-21K08397, KAKENHI-PROJECT-21K08413, KAKENHI-PROJECT-21H05047
[Journal Article] Ex vivo manufacturing of platelets: beyond the first-in-human clinical trial using autologous iPSC-platelets2023
- Author(s)
  Si Jing Chen, Naoshi Sugimoto, Koji Eto
- Journal Title
  
  International Journal of Hematology
  
  Volume: 117 Issue: 3 Pages: 349-355
- DOI
  10.1007/s12185-022-03512-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15124, KAKENHI-PROJECT-23K18299, KAKENHI-PROJECT-21H05047
[Journal Article] 血小板の再生医療2022
- Author(s)
  杉本直志、江藤浩之
- Journal Title
  
  日本医師会雑誌
  
  Volume: 151 Pages: 605-608
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H05047
[Journal Article] Production and nonclinical evaluation of an autologous iPSC?derived platelet product for the iPLAT1 clinical trial2022
- Author(s)
  Sugimoto Naoshi、Nakamura Sou、Shimizu Shin、Shigemasa Akiko、Kanda Junya、Matsuyama Nobuki、Tanaka Mitsunobu、Hayashi Tomoya、Fuchizaki Akihiro、Nogawa Masayuki、Watanabe Naohide、Okamoto Shinichiro、Handa Makoto、Sawaguchi Akira、Momose Dai、Koh Ki-Ryang、Tani Yoshihiko、Takaori-Kondo Akifumi、Eto Koji
- Journal Title
  
  Blood Advances
  
  Volume: 6 Issue: 23 Pages: 6056-6069
- DOI
  10.1182/bloodadvances.2022008512
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18169, KAKENHI-PROJECT-21H05047
[Journal Article] iPS細胞由来血小板の臨床応用2022
- Author(s)
  杉本直志、江藤浩之
- Journal Title
  
  臨床血液
  
  Volume: 63 Pages: 1430-1439
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H05047
[Journal Article] iPLAT1: the first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study2022
- Author(s)
  Sugimoto N, Nakamura S, Shimizu S, Shigemasa A, Kanda J, Matsuyama N, Tanaka M, Hayashi T, Fuchizaki A, Nogawa M, Watanabe N, Okamoto S, Handa M, Sawaguchi A, Momose D, Koh KR, Tani Y, Takaori-Kondo A, Eto K
- Journal Title
  
  Blood
  
  Volume: 140 Issue: 22 Pages: 2398-2402
- DOI
  10.1182/blood.2022017296
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K18169, KAKENHI-PROJECT-21H05047, KAKENHI-PROJECT-21H02956
[Journal Article] Fit-For-All iPSC-Derived Cell Therapies and Their Evaluation in Humanized Mice With NK Cell Immunity.2021
- Author(s)
  Flahou C, Morishima T, Takizawa H, Sugimoto N.
- Journal Title
  
  Front Immunol
  
  Volume: 12 Pages: 662360-662360
- DOI
  10.3389/fimmu.2021.662360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08397, KAKENHI-PROJECT-21K08413
[Journal Article] iPS細胞技術を応用した血液疾患およびがんに対する治療戦略2021
- Author(s)
  杉本直志、江藤浩之
- Journal Title
  
  先進医療Navigator
  
  Volume: 8 Pages: 20-23
- Data Source
  KAKENHI-PROJECT-21K08413
[Journal Article] Development of platelet replacement therapy using human induced pluripotent stem cells2021
- Author(s)
  Nakamura Sou、Sugimoto Naoshi、Eto Koji
- Journal Title
  
  Development, Growth & Differentiation
  
  Volume: 63 Issue: 2 Pages: 178-186
- DOI
  10.1111/dgd.12711
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22675, KAKENHI-PROJECT-18K18365, KAKENHI-PROJECT-18H04164, KAKENHI-PROJECT-21K08413
[Journal Article] Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs2021
- Author(s)
  Sone Masamitsu、Nakamura Sou、Umeda Sachiko、Ginya Harumi、Oshima Motohiko、Kanashiro Maria Alejandra、Paul Sudip Kumar、Hashimoto Kanae、Nakamura Emiri、Harada Yasuo、Tsujimura Kyoko、Saraya Atsunori、Yamaguchi Tomoyuki、Sugimoto Naoshi、Sawaguchi Akira、Iwama Atsushi、Eto Koji、Takayama Naoya
- Journal Title
  
  Stem Cell Reports
  
  Volume: 16 Issue: 12 Pages: 2861-2870
- DOI
  10.1016/j.stemcr.2021.11.001
- NAID
  120007177810
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K18365, KAKENHI-PROJECT-20H03740, KAKENHI-PROJECT-20K08705, KAKENHI-PROJECT-21K08413, KAKENHI-PROJECT-21H05047
[Journal Article] Extracellular laminin regulates hematopoietic potential of pluripotent stem cells through integrin β1-ILK-β-catenin-JUN axis2021
- Author(s)
  Yuzuriha Akinori、Nakamura Sou、Sugimoto Naoshi、Kihara Shunsuke、Nakagawa Masato、Yamamoto Takuya、Sekiguchi Kiyotoshi、Eto Koji
- Journal Title
  
  Stem Cell Research
  
  Volume: 53 Pages: 102287-102287
- DOI
  10.1016/j.scr.2021.102287
- NAID
  120007006753
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K18365, KAKENHI-PROJECT-18H04164, KAKENHI-PROJECT-21H04957, KAKENHI-PROJECT-21K08413
[Journal Article] iPS細胞技術を応用した血液疾患およびがんに対する治療戦略2021
- Author(s)
  杉本直志、江藤浩之
- Journal Title
  
  先進医療Navigator
  
  Volume: 8 Pages: 20-23
- Data Source
  KAKENHI-PROJECT-21H05047
[Journal Article] Generation and manipulation of human iPSC-derived platelets2021
- Author(s)
  Sugimoto Naoshi、Eto Koji
- Journal Title
  
  Cellular and Molecular Life Sciences
  
  Volume: 78 Issue: 7 Pages: 3385-3401
- DOI
  10.1007/s00018-020-03749-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22675, KAKENHI-PROJECT-18H04164, KAKENHI-PROJECT-21K08413
[Presentation] "Ex vivo production of platelets from iPSCs: The iPLAT1 study and beyond"2023
- Author(s)
  NAOSHI SUGIMOTO
- Organizer
  EHA2023 Hybrid Congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H05047
[Presentation] 再生医療におけるHLA欠失細胞のin vivo免疫原性試験用のNK細胞を含む免疫系ヒト化マウスの確立2023
- Author(s)
  杉本直志, Charlotte Flahou, 森嶋達也, 東奈津美, 徐淮耕, 王博, 金子新, 堀田秋津, 滝澤仁, 江藤浩之
- Organizer
  第23回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-21K08413
[Presentation] Establishment of human immune system mice for evaluation of rejection of HLA-depleted cells in regenerative medicine2022
- Author(s)
  杉本直志
- Organizer
  第51回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08413
[Presentation] Developing in vivo preclinical models using human NK cell reconstituted mice for allogeneic regenerative medicine2022
- Author(s)
  杉本直志
- Organizer
  6th International Workshop on Humanized Mice
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08413
[Presentation] HLA-KO iPSC-platelets immune escape from NK cells2022
- Author(s)
  杉本直志
- Organizer
  Cell Symposium: Advances in Therapeutic Applications of Stem Cells
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08413
[Presentation] The first-in-human clinical trial of iPSC-derived platelets (iPLAT1): Autologous transfusion to an aplastic anemia patient with alloimmune platelet transfusion refractoriness2021
- Author(s)
  Naoshi Sugimoto
- Organizer
  63rd Annual Meeting of the American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08413
[Presentation] iPS細胞技術を用いた血小板製造と動脈硬化研究への応用の可能性2021
- Author(s)
  杉本直志
- Organizer
  第53回日本動脈硬化学会学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21H05047
[Presentation] Autologous transfusion to an aplastic anemia patient with alloimmune platelet transfusion refractoriness2021
- Author(s)
  Sugimoto N, Kanda J, Nakamura S, Kitano T, Hishizawa M, Kondo T, Shimizu S, Shigemasa A, Hirai H, Arai Y, Minami M, Tada H, Momose D, Koh KR, Nogawa M, Watanabe N, Okamoto S, Handa M, Sawaguchi A, Matsuyama N, Tanaka M, Hayashi T, Fuchizaki A, Tani Y, Takaori-Kondo A, Eto K
- Organizer
  63rd Annual Meeting of the American Society of Hematology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H05047
[Presentation] iPS細胞技術を用いた血小板製造と動脈硬化研究への応用の可能性2021
- Author(s)
  杉本直志
- Organizer
  第53回日本動脈硬化学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K08413
[Presentation] Elucidating the role of the DExD/H helicase family protein DHX29 in hematological malignancies.2019
- Author(s)
  奥真紀、門脇則光、杉本直志
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-15K09500

1. 江藤浩之 (50286986)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. 中村壮 (50769833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 末次志郎 (70345031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Kadowaki Norimitsu

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Kawahara Masahiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 森嶋達也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. Chen SiJing

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sugimoto Naoshi 杉本 直志

Research Projects

Research Products

Co-Researchers

Elucidation of the NK cell immune escape mechanism using iPS cell-derived platelets and development of treatmentPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the fundamental mechanism of platelet biogenesis and its medical application

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of the nucleic acid sensor molecule DHX29 in hematopoietic cell immune responses and hematopoietic tumorsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A let-7 microRNA-RALB axis links the immune properties of iPSC-derived megakaryocytes with platelet producibility2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Humanized mouse models with endogenously developed human natural killer cells for in?vivo immunogenicity testing of HLA class I-edited iPSC-derived cells2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ex vivo manufacturing of platelets: beyond the first-in-human clinical trial using autologous iPSC-platelets2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 血小板の再生医療2022

Author(s)

Journal Title

Data Source

[Journal Article] Production and nonclinical evaluation of an autologous iPSC?derived platelet product for the iPLAT1 clinical trial2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] iPS細胞由来血小板の臨床応用2022

Author(s)

Journal Title

Data Source

[Journal Article] iPLAT1: the first-in-human clinical trial of iPSC-derived platelets as a phase 1 autologous transfusion study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fit-For-All iPSC-Derived Cell Therapies and Their Evaluation in Humanized Mice With NK Cell Immunity.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] iPS細胞技術を応用した血液疾患およびがんに対する治療戦略2021

Author(s)

Journal Title

Data Source

[Journal Article] Development of platelet replacement therapy using human induced pluripotent stem cells2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Silencing of p53 and CDKN1A establishes sustainable immortalized megakaryocyte progenitor cells from human iPSCs2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Extracellular laminin regulates hematopoietic potential of pluripotent stem cells through integrin β1-ILK-β-catenin-JUN axis2021

Author(s)

Journal Title

DOI

NAID

Sugimoto Naoshi 杉本直志