TOKUOKA Hirofumi 徳岡宏文

Researcher Number	10452020
Other IDs
Affiliation (based on the past Project Information) *help	2011 – 2013: 東京工業大学, 生命理工学研究科, 助教 2011: 東京工業大学, 大学院・理工学研究科, 助教 2007 – 2011: Tokyo Institute of Technology, 大学院・生命理工学研究科, 助教
Review Section/Research Field	Principal Investigator Neuroscience in general / Neuroscience in general / Neurochemistry/Neuropharmacology Except Principal Investigator Neuroscience in general
Keywords	Principal Investigator チロシン水酸化酵素 / ドーパミン / 線条体 / Nr4a / Nurr1 / 中脳 / アデノ随伴ウィルス / アデノ随伴ウイルス / ノックアウトマウス / 遺伝子ノックアウトマウス … More / 大脳基底核 / 黒質 / 神経活動 / シナプス / 神経細胞 / 神経科学 … More Except Principal Investigator タンパク質 / 生理学 / 蛋白質 / 医療・福祉 / 神経科学 / 脳神経疾患 / 臨床神経科学 Less

モノアミン神経伝達物質による神経回路の発達と機能調節Principal Investigator
- Principal Investigator
  
  徳岡宏文
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Tokyo Institute of Technology
Molecular mechanisms for the control of monoamine levels in the brain and the etiology of PTSD using serotonin-deficient mice.
- Principal Investigator
  
  ICHINOSE Hiroshi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neuroscience in general
- Research Institution
  Tokyo Institute of Technology
Regulation, maintenance, and plasticity of central dopaminergic synapsesPrincipal Investigator
- Principal Investigator
  
  TOKUOKA Hirofumi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neuroscience in general
- Research Institution
  Tokyo Institute of Technology
Activity-dependent development, maintenance and plasticity of dopaminergic synapsesPrincipal Investigator
- Principal Investigator
  
  TOKUOKA Hirofumi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Tokyo Institute of Technology

All 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] The role of tetrahydrobiopterin and catecholamines in the developmental regulation of tyrosine hydroxylase level in the brain.2013
- Author(s)
  Homma, D., Katoh, S., Tokuoka, H. & Ichinose, H.
- Journal Title
  
  Journal of Neurochemistry
  
  Volume: (in press) Issue: 1 Pages: 70-81
- DOI
  10.1111/jnc.12287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500305, KAKENHI-PROJECT-24700317
[Journal Article] 疾患患者の脳脊髄液における還元型プテリジンレベルの測定:臨床試料中の還元型プテリジン測定へのポストカラム酸化法の応用2011
- Author(s)
  小柴梢子、徳岡宏文、横山照夫、堀内恵美子、長谷川一子、一瀬宏
- Journal Title
  
  ビタミン
  
  Volume: 85 Pages: 63-69
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700347
[Journal Article] Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain2011
- Author(s)
  Homma D, Sumi-Ichinose C, Tokuoka H, Ikemoto K, Nomura T, Kondo K, Katoh S, Ichinose H
- Journal Title
  
  J Biol Chem
  
  Volume: 286 Pages: 1445-1452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700347
[Journal Article] Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection. J Biol Chem2011
- Author(s)
  Tokuoka H, Muramatsu S, Sumi-Ichinose C, Sakane H, Kojima M, Aso Y, Nomura T, Metzger D, Ichinose H
- Journal Title
  
  published on-line
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700347
[Journal Article] Biopterin levels in the cerebrospinal fluid of patients with PARK8 (I2020T)2011
- Author(s)
  Koshiba S, Tokuoka H, Yokoyama T, Horiuchi E, Ichinose H, Hasegawa K
- Journal Title
  
  Journal of Neural Transmission
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700347
[Journal Article] Biopterin levels in the cerebrospinal fluid of patients with PARK8(I2020T)2011
- Author(s)
  Koshiba S, Tokuoka H, Yokoyama T, Horiuchi E, Ichinose H, Hasegawa K
- Journal Title
  
  J Neural Transm
  
  Volume: 118 Pages: 899-903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700347
[Journal Article] Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain2011
- Author(s)
  Homma, D., Sumi-Ichinose, C., Tokuoka, H., Ikemoto, K., Nomura, T., Kondo, K., Katoh, S., and Ichinose, H.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Issue: 2 Pages: 1445-1452
- DOI
  10.1074/jbc.m110.159426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500305
[Journal Article] Biopterin levels in the cerebrospinal fluid of patients with PARK8 (I2020T)2011
- Author(s)
  Koshiba, S., Tokuoka, H., Yokoyama, T., Horiuchi, E., Ichinose, H., andHasegawa, K.
- Journal Title
  
  Journal of Neural Transmission
  
  Volume: 118 Issue: 6 Pages: 899-903
- DOI
  10.1007/s00702-011-0587-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500305
[Journal Article] Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection.2011
- Author(s)
  Tokuoka et al.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Pages: 43549-43558
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500305
[Journal Article] Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection2011
- Author(s)
  Tokuoka, H., Muramatsu, S., Sumi- Ichinose, C., Sakane, H., Kojima, M., Aso, Y., Nomura, T., Metzger, D., and Ichinose, H.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Issue: 50 Pages: 43549-43558
- DOI
  10.1074/jbc.m111.284729
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21500305, KAKENHI-PROJECT-21700347, KAKENHI-PROJECT-23590473
[Journal Article] Partial biopterin deficiency disturbs postnatal development of the dopa minergic system in the brain. J Biol Chem 286:1445-14522011
- Author(s)
  Homma D, Sumi-Ichinose C, Tokuoka H, Ikemoto K, Nomura T, Kondo K, Katoh S, Ichinose H
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 286 Pages: 1445-1452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700347
[Journal Article] Accumulation of phosphorylated tyrosine hydroxylase into insoluble protein aggregates by inhibition of an ubiquitin-proteasome system in PC12D cells2009
- Author(s)
  Kawahata I, Tokuoka H, Parvez H, Ichinose H
- Journal Title
  
  J Neural Transm 116
  
  Pages: 1571-1578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700347
[Journal Article] Accumulation of phosphorylated tyrosine hydroxylase into insoluble protein aggregates by inhibition of an ubiquitin-proteasome system in PC12D cells2009
- Author(s)
  Kawahata I, Tokuoka H, Parvez H, Ichinose H
- Journal Title
  
  J Neural Transm
  
  Volume: 116 Pages: 1171-1578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21700347
[Journal Article] Activity-dependent coordination of presynaptic release probability and postsynaptic GluR2 abundance at single synapses.2008
- Author(s)
  Tokuoka H, Goda Y
- Journal Title
  
  Proc Natl Acad Sci USA 105
  
  Pages: 14656-14661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800012
[Journal Article] Activity-dependent coordination of presynaptic release probability and postsynaptic GluR2 abundance at single synapses2008
- Author(s)
  Tokuoka H and Goda Y
- Journal Title
  
  Proc Natl Acad Sci USA 105
  
  Pages: 14656-14661
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19800012
[Presentation] Induced expression of Nr4a nuclear receptor by extracellular stimuli in cultured hippocampal neurons2013
- Author(s)
  H. Tokuoka, T. Hatanaka, H. Ichinose
- Organizer
  第36回　日本神経科学大会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-24700317
[Presentation] Distinct regulation mechanism of the dopamine content in the striatum from that in the midbrain2013
- Author(s)
  Y. Iwashita, H. Tokuoka, H. Munezane, S. Muramatsu, H. Ichinose
- Organizer
  第36回　日本神経科学大会
- Place of Presentation
  国立京都国際会館
- Data Source
  KAKENHI-PROJECT-24700317
[Presentation] ジヒドロプテリジン還元酵素ノックアウトマウスにおけるモノアミン低下機構の解析2012
- Author(s)
  原慶賢、松木繁季、堀口美恵子、徳岡宏文、一瀬宏
- Organizer
  第85回　日本生化学会大会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24700317
[Presentation] チロシン水酸化酵素の過剰発現による線条体ドーパミン量への影響2012
- Author(s)
  岩下由佳、宗実悠佳、徳岡宏文、村松慎一、一瀬宏
- Organizer
  第85回　日本生化学会大会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24700317
[Presentation] 培養中枢神経細胞における細胞外刺激依存的なNr4a核内受容体の発現誘導2012
- Author(s)
  徳岡宏文、畑中貴之、一瀬宏
- Organizer
  第85回　日本生化学会大会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24700317
[Presentation] Induced expression of Nr4a nuclear receptor by extracellular stimuli in cultured hippocampal neurons2012
- Author(s)
  Hirofumi Tokuoka, Takayuki Hatanaka, Hiroshi Ichinose
- Organizer
  第35回　日本神経科学大会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-24700317
[Presentation] 線条体におけるドーパミン生合成調節機構について2012
- Author(s)
  徳岡宏文
- Organizer
  厚生労働科学研究費補助金難治性疾患克服研究事業3班合同公開シンポジウム
- Place of Presentation
  帝京大学
- Year and Date
  2012-02-19
- Data Source
  KAKENHI-PROJECT-21700347
[Presentation] 成熟脳におけるNurr1、Nur77の機能解析に用いる遺伝子改変マウスの作成2011
- Author(s)
  畑中貴之、畑中康人、伊藤岳人、五十嵐孝幸、徳岡宏文、村松真一、遠藤毅、廣崎賢、高崎昭彦、林宣宏、Daniel Metzger、一瀬宏
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-09-16
- Data Source
  KAKENHI-PROJECT-21700347
[Presentation] 黒質線条体ドーパミン投射における経軸索的ドーパミン量の代償2011
- Author(s)
  徳岡宏文、村松慎一、鷲見-一瀬千穂、Daniel Metzger、一瀬宏
- Organizer
  第34回日本神経科学大会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-21700347
[Presentation] 初代培養海馬ニューロンへの蛍光標識カルモジュリンの導入とライブイメージング2011
- Author(s)
  門脇広樹、徳岡宏文、細谷悟史、大野敏、横川隆志、西川一八、林宣宏、一瀬宏
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-21700347
[Presentation] 黒質-線条体ドーパミン投射系におけるドーパミン量の制御機構2010
- Author(s)
  徳岡宏文、村松慎一、一瀬宏
- Organizer
  第33回日本神経科学大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-21700347
[Presentation] 黒質-線条体投射におけるドーパミン量制御機構2010
- Author(s)
  徳岡宏文、一瀬宏
- Organizer
  包括脳ワークショップ
- Place of Presentation
  ホテルさっぽろ芸文館
- Year and Date
  2010-07-29
- Data Source
  KAKENHI-PROJECT-21700347
[Presentation] 黒質-線条体ドーパミン投射系におけるドーパミン量の制御機構2010
- Author(s)
  徳岡宏文、村松慎一、一瀬宏
- Organizer
  第33回日本神経科学大会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2010-09-02
- Data Source
  KAKENHI-PROJECT-21700347
[Presentation] 中枢神経黒質-線条体系ドーパミン投射の恒常性維持-チロシン水酸化酵素とドーパミン量の代償的制御2009
- Author(s)
  Tokuoka H, Ichinose H
- Organizer
  日本神経科学学会 2009年年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-21700347
[Presentation] 中枢神経黒質-線条体系ドーパミン投射の恒常性維持-チロシン水酸化酵素とドーパミン量の代償的制御2009
- Author(s)
  徳岡宏文、一瀬宏
- Organizer
  日本神経科学学会2009年年会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2009-09-16
- Data Source
  KAKENHI-PROJECT-21700347
[Presentation] Regulation of tyrosine hydroxylase protein level and DA content in nigrostriatal dopaminergic projection2009
- Author(s)
  Tokuoka H, Ichinose H
- Organizer
  Gordon Research Conference 2009, Catechol Amine
- Place of Presentation
  University of New England, ME, USA
- Data Source
  KAKENHI-PROJECT-21700347
[Presentation] チロシン水酸化酵素のタンパク量と活性の代償的制御-黒質チロシン水酸化酵素遺伝子の破壊による研究2008
- Author(s)
  徳岡宏文
- Organizer
  活性アミンに関するワークショップ
- Place of Presentation
  昭和大学
- Year and Date
  2008-08-29
- Data Source
  KAKENHI-PROJECT-19800012
[Presentation] Developmental alterations of LRRK2 in the mouse brain'2008
- Author(s)
  H. Ichinose, I. Kawahata, W. Sato, K. Mizuno, Y. Kurabayashi, H. Tokuoka, I. Toyoshima, S. Yagishita, K. Hasegawa
- Organizer
  12^<th> International Congress of Parkinson's Disease and Movement Disorders
- Place of Presentation
  Chicago, IL
- Data Source
  KAKENHI-PROJECT-19800012
[Presentation] チロシン水酸化酵素のタンパク量と活性の代償的制御2008
- Author(s)
  徳岡宏文, 他
- Organizer
  第12回活性アミンワークショップ
- Place of Presentation
  昭和大学
- Year and Date
  2008-08-29
- Data Source
  KAKENHI-PROJECT-19800012
[Presentation] プロテアソーム障害によるリン酸化チロシン水酸化酵素の不溶性凝集体の形成2008
- Author(s)
  川畑伊知郎、柳下三郎、長谷川一子、パルベハサン、徳岡宏文、永津郁子、永津俊治、一瀬宏
- Organizer
  第31回日本神経科学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19800012
[Presentation] Presynaptic release probability and GluR2 abundance at individual synapses in cultured hippocampal neurons'2007
- Author(s)
  Tokuoka H, Goda Y.
- Organizer
  第30回日本神経科学会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19800012

1. ICHINOSE Hiroshi (90192492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

TOKUOKA Hirofumi 徳岡 宏文

Research Projects

Research Products

Co-Researchers

モノアミン神経伝達物質による神経回路の発達と機能調節Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms for the control of monoamine levels in the brain and the etiology of PTSD using serotonin-deficient mice.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation, maintenance, and plasticity of central dopaminergic synapsesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Activity-dependent development, maintenance and plasticity of dopaminergic synapsesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] The role of tetrahydrobiopterin and catecholamines in the developmental regulation of tyrosine hydroxylase level in the brain.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 疾患患者の脳脊髄液における還元型プテリジンレベルの測定:臨床試料中の還元型プテリジン測定へのポストカラム酸化法の応用2011

Author(s)

Journal Title

Data Source

[Journal Article] Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain2011

Author(s)

Journal Title

Data Source

[Journal Article] Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection. J Biol Chem2011

Author(s)

Journal Title

Data Source

[Journal Article] Biopterin levels in the cerebrospinal fluid of patients with PARK8 (I2020T)2011

Author(s)

Journal Title

Data Source

[Journal Article] Biopterin levels in the cerebrospinal fluid of patients with PARK8(I2020T)2011

Author(s)

Journal Title

Data Source

[Journal Article] Partial biopterin deficiency disturbs postnatal development of the dopaminergic system in the brain2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biopterin levels in the cerebrospinal fluid of patients with PARK8 (I2020T)2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection.2011

Author(s)

Journal Title

Data Source

[Journal Article] Compensatory regulation of dopamine after ablation of the tyrosine hydroxylase gene in the nigrostriatal projection2011

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Partial biopterin deficiency disturbs postnatal development of the dopa minergic system in the brain. J Biol Chem 286:1445-14522011

Author(s)

Journal Title

Data Source

[Journal Article] Accumulation of phosphorylated tyrosine hydroxylase into insoluble protein aggregates by inhibition of an ubiquitin-proteasome system in PC12D cells2009

Author(s)

Journal Title

Data Source

TOKUOKA Hirofumi 徳岡宏文