ARAKI MITSUGU 荒木望嗣

… Alternative Names

Araki Mitsugu 荒木望嗣

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Researcher Number	10452492
Other IDs
Affiliation (Current)	2025: 京都大学, 医学研究科, 特定准教授
Affiliation (based on the past Project Information) *help	2018 – 2024: 京都大学, 医学研究科, 特定准教授
Review Section/Research Field	Principal Investigator Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related Except Principal Investigator Medium-sized Section 50:Oncology and related fields / Basic Section 52020:Neurology-related
Keywords	Principal Investigator 遺伝子変異 / 分子動力学計算 / 薬剤応答性 / 統計解析 / タンパク質-化合物結合親和性 / 分子動力学シミュレーション / 非小細胞肺がん / 情報科学的解析 / キナーゼ / 薬剤耐性変異 / ALKキナーゼ … More Except Principal Investigator … More 分子標的薬 / 遺伝子変異 / 分子動力学シミュレーション / キナーゼ / シナプス / アミロイドβタンパク質 / アルツハイマー病創薬 Less

Development research for Alzheimer's disease therapeutics targeting the mechanism of amyloid beta protein production at synapses
- Principal Investigator
  
  葛谷聡
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Kyoto University
Searching druggable target sites by developing refined molecular dynamic simulations
- Principal Investigator
  
  片山量平
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Japanese Foundation for Cancer Research
Mutation-induced drug sensitivity prediction based on long timescale molecular dynamics simulationPrincipal Investigator
- Principal Investigator
  
  荒木望嗣
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Kyoto University
Drug sensitivity prediction for anaplastic lymphoma kinase mutants using molecular dynamics simulation and its informatics analysisPrincipal Investigator
- Principal Investigator
  
  Araki Mitsugu
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
- Research Institution
  Kyoto University

All 2024 2023 2022 2021 2020 2019 2018 Other

All Journal Article Presentation Patent Other

[Journal Article] A macrocyclic kinase inhibitor overcomes triple resistant mutations in EGFR-positive lung cancer2024
- Author(s)
  Suzuki Mai、Uchibori Ken、Oh-hara Tomoko、Nomura Yumi、Suzuki Ryusei、Takemoto Ai、Araki Mitsugu、Matsumoto Shigeyuki、Sagae Yukari、Kukimoto-Niino Mutsuko、Kawase Yusuke、Shirouzu Mikako、Okuno Yasushi、Nishio Makoto、Fujita Naoya、Katayama Ryohei
- Journal Title
  
  npj Precision Oncology
  
  Volume: 8 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41698-024-00542-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K16205, KAKENHI-PROJECT-21K06510
[Journal Article] LTK mutations responsible for resistance to lorlatinib in non-small cell lung cancer harboring CLIP1-LTK fusion2024
- Author(s)
  Mori S, Izumi H, Araki M, Liu J, Tanaka Y, Kagawa Y, Sagae Y, Ma B, Isaka Y, Sasakura Y, Kumagai S, Sakae Y, Tanaka K, Shibata Y, Udagawa H, Matsumoto S, Yoh K, Okuno Y, Goto K, Kobayashi S
- Journal Title
  
  Communications Biology
  
  Volume: 7(412) Issue: 1 Pages: 1-10
- DOI
  10.1038/s42003-024-06116-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06510
[Journal Article] タンパク質の分子動力学シミュレーションに基づく創薬計算技術の開発とゲノム医療分野での応用研究2023
- Author(s)
  荒木　望嗣
- Journal Title
  
  SAR News
  
  Volume: 45 Pages: 10-18
- Data Source
  KAKENHI-PROJECT-21K06510
[Journal Article] Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis2022
- Author(s)
  Tabata J, Nakaoku T, Araki M, Yoshino R, Kohsaka S, Otsuka A, Ikegami M, Ui A, Kanno S, Miyoshi K, Matsumoto S, Sagae Y, Yasui A, Sekijima M, Mano H, Okuno Y, Okamoto A, Kohno T
- Journal Title
  
  Cancer Research,
  
  Volume: 82(20) Pages: 3751-3762
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K06510
[Journal Article] Exploring ligand binding pathways on proteins using hypersound-accelerated molecular dynamics2021
- Author(s)
  Araki Mitsugu、Matsumoto Shigeyuki、Bekker Gert-Jan、Isaka Yuta、Sagae Yukari、Kamiya Narutoshi、Okuno Yasushi
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1-10
- DOI
  10.1038/s41467-021-23157-1
- NAID
  120007041708
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06594, KAKENHI-PROJECT-20H03229, KAKENHI-PROJECT-21K06510
[Journal Article] Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity2021
- Author(s)
  Yoshizawa Takahiro、Uchibori Ken、Araki Mitsugu、Matsumoto Shigeyuki、Ma Biao、Kanada Ryo、Seto Yosuke、Oh-hara Tomoko、Koike Sumie、Ariyasu Ryo、Kitazono Satoru、Ninomiya Hironori、Takeuchi Kengo、Yanagitani Noriko、Takagi Satoshi、Kishi Kazuma、Fujita Naoya、Okuno Yasushi、Nishio Makoto、Katayama Ryohei
- Journal Title
  
  npj Precision Oncology
  
  Volume: 5 Issue: 1 Pages: 32-32
- DOI
  10.1038/s41698-021-00170-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K22572, KAKENHI-PROJECT-18K15936, KAKENHI-PROJECT-18K06594, KAKENHI-PROJECT-20K21554, KAKENHI-PROJECT-20K16370, KAKENHI-PLANNED-17H06327, KAKENHI-PROJECT-19H03524
[Journal Article] Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer2021
- Author(s)
  Mizuta Hayato、Okada Koutaroh、Araki Mitsugu、Adachi Jun、Takemoto Ai、Kutkowska Justyna、Maruyama Kohei、Friboulet Luc、Katayama Kazuhiro、Ma Biao、Sasakura Yoko、Sagae Yukari、Kukimoto-Niino Mutsuko、Shirouzu Mikako、Takagi Satoshi、Simizu Siro、Nishio Makoto、Okuno Yasushi、Fujita Naoya、Katayama Ryohei, et al
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 1261-1261
- DOI
  10.1038/s41467-021-21396-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21554, KAKENHI-PLANNED-17H06327, KAKENHI-PROJECT-19H03524, KAKENHI-PROJECT-18K06137, KAKENHI-PROJECT-19K22572, KAKENHI-PROJECT-18K06594, KAKENHI-ORGANIZER-17H06324
[Journal Article] Improvement in predicting drug sensitivity changes associated with protein mutations using a molecular dynamics based alchemical mutation method2020
- Author(s)
  Fumie Ono, Shuntaro Chiba, Yuta Isaka, Shigeyuki Matsumoto, Biao Ma, Ryohei Katayama, Mitsugu Araki, Yasushi Okuno
- Journal Title
  
  Scientific Reports
  
  Volume: 10(1) Pages: 1-10
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06594
[Journal Article] E487K-Induced Disorder in Functionally Relevant Dynamics of Mitochondrial Aldehyde Dehydrogenase 2.2020
- Author(s)
  Matsumoto S, Araki M, Isaka Y, Ono F, Hirohashi K, Ohashi S, Muto M, Okuno Y.
- Journal Title
  
  Biophysical Journal
  
  Volume: 119(3) Pages: 628-637
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06594
[Journal Article] Landscape and function of multiple mutations within individual oncogene2020
- Author(s)
  Yuki Saito, Junji Koya, Mitsugu Araki, Yasunori Kogure, Sumito Shingaki, Mariko Tabata, Marni B. McClure, Kota Yoshifuji, Shigeyuki Matsumoto, Yuta Isaka, Hiroko Tanaka, Takanori Kanai, Satoru Miyano, Yuichi Shiraishi, Yasushi Okuno, Keisuke Kataoka
- Journal Title
  
  Nature
  
  Volume: 582 Pages: 95-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06594
[Journal Article] Structural modification of indomethacin toward selective inhibition of COX-2 with a significant increase in van der Waals contributions2019
- Author(s)
  Ikeda A, Funakoshi E, Araki M, Ma B, Karuo Y, Tarui A, Sato K, Okuno Y, Kawai K, Omote M.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27(9) Pages: 1789-1794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06594
[Journal Article] Dynamic Docking of a Medium Sized Molecule to its Receptor by Multicanonical MD Simulations2019
- Author(s)
  Bekker, G; Araki, M; Oshima, K; Okuno, Y; Kamiya, N
- Journal Title
  
  The Journal of Physical Chemistry B
  
  Volume: 123(11) Pages: 2479-2490
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06594
[Journal Article] Prediction of ALK mutations mediating ALK-TKIs resistance and drug re-purposing to overcome the resistance2019
- Author(s)
  Okada K, Araki M, Sakashita T, Ma B, Kanada R, Yanagitani N, Horiike A, Koike S, Oh-hara T, Watanabe K, Tamai K, Maemondo M, Nishio M, Ishikawa T, Okuno Y, Fujita N, Katayama R
- Journal Title
  
  EBioMedicine
  
  Volume: 41 Pages: 105-119
- NAID
  120006892063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06594
[Journal Article] 非小細胞肺がん（NSCLC）における薬剤耐性獲得メカニズムの予測.2018
- Author(s)
  荒木望嗣, 奥野恭史
- Journal Title
  
  がん分子標的治療
  
  Volume: 16 Pages: 53-58
- Data Source
  KAKENHI-PROJECT-18K06594
[Journal Article] Improving the Accuracy of Protein-Ligand Binding Mode Prediction Using a Molecular Dynamics-Based Pocket Generation Approach2018
- Author(s)
  Araki Mitsugu、Iwata Hiroaki、Ma Biao、Fujita Atsuto、Terayama Kei、Sagae Yukari、Ono Fumie、Tsuda Koji、Kamiya Narutoshi、Okuno Yasushi
- Journal Title
  
  Journal of Computational Chemistry
  
  Volume: 39 Issue: 32 Pages: 2679-2689
- DOI
  10.1002/jcc.25715
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06594
[Patent] 長時間分子動力学シミュレーションよる変異型タンパク質にに対する治療薬探索法2021
- Inventor(s)
  奥野恭史、荒木望嗣、片山量平
- Industrial Property Rights Holder
  奥野恭史、荒木望嗣、片山量平
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-066780
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21K06510
[Presentation] A multiscale molecular simulation approach for assessing the effects of mutation on protein activity and drug sensitivity of oncogenic kinases.2024
- Author(s)
  Mitsugu Araki and Yasushi Okuno
- Organizer
  Biophysical Society 68th annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06510
[Presentation] Structural origins of site-specific inhibitor binding to Dihydrofolate Reductase unveiled by molecular dynamics simulations combined with Markov state modeling2024
- Author(s)
  Mitsugu Araki and Yasushi Okuno
- Organizer
  Spring 2024 ACS National Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06510
[Presentation] A multiscale molecular simulation approach to assess the effects of mutations on functional activity and drug sensitivity in kinases2022
- Author(s)
  Mitsugu Araki and Yasushi Okuno
- Organizer
  Spring 2022 ACS National Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06594
[Presentation] スパコンを用いたタンパク質-医薬品結合親和性・結合解離パスウェイの高精度予測2022
- Author(s)
  荒木望嗣
- Organizer
  第429回CBI学会研究講演会
- Data Source
  KAKENHI-PROJECT-21K06510
[Presentation] プレシジョンメディスンを加速する創薬ビッグデータ統合システムの推進2022
- Author(s)
  荒木望嗣, 奥野恭史
- Organizer
  富岳成果創出加速プログラム　研究交流会
- Data Source
  KAKENHI-PROJECT-18K06594
[Presentation] Hypersound-perturbed molecular dynamics to accelerate slow protein-ligand binding processes.2022
- Author(s)
  Mitsugu Araki and Yasushi Okuno
- Organizer
  第60回日本生物物理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-21K06510
[Presentation] Hypersound-perturbed molecular dynamics for accelerating slow biomolecular interaction processes2022
- Author(s)
  Mitsugu Araki and Yasushi Okuno
- Organizer
  Biophysical Society 67th annual meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06510
[Presentation] プレシジョンメディスンを加速する創薬ビッグデータ統合システムの推進2022
- Author(s)
  荒木望嗣, 奥野恭史
- Organizer
  富岳成果創出加速プログラム　研究交流会
- Data Source
  KAKENHI-PROJECT-21K06510
[Presentation] A multiscale molecular simulation approach to assess the effects of mutations on functional activity and drug sensitivity in kinases2022
- Author(s)
  Mitsugu Araki and Yasushi Okuno
- Organizer
  Spring 2022 ACS National Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06510
[Presentation] スパコンを用いたタンパク質-医薬品結合親和性・結合解離パスウェイの高精度予測2022
- Author(s)
  荒木望嗣
- Organizer
  第429回CBI学会研究講演会
- Data Source
  KAKENHI-PROJECT-18K06594
[Presentation] Hypersound-perturbed molecular dynamics to accelerate slow biomolecular interaction processes2022
- Author(s)
  Mitsugu Araki and Yasushi Okuno
- Organizer
  Biophysics at the Dawn of Exascale Computers
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06510
[Presentation] Protein-drug binding mode prediction from the apo-protein structure using a molecular dynamics-based pocket generation approach2020
- Author(s)
  Mitsugu Araki and Yasushi Okuno
- Organizer
  Biophysical Society 64th annual meeting
- Data Source
  KAKENHI-PROJECT-18K06594
[Presentation] スパコンを用いたタンパク質-化合物結合親和性の高精度予測と医療・創薬への応用2020
- Author(s)
  荒木望嗣, 奥野恭史
- Organizer
  第48回構造活性相関シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-18K06594
[Presentation] Effect of conformational flexibility of protein-ligand binding free energy computation and its significance in predicting mutation-induced drug sensitivity changes in oncogenic kinases2020
- Author(s)
  Mitsugu Araki and Yasushi Okuno
- Organizer
  ACS Fall 2020 Virtual Meeting & Expo
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06594
[Presentation] DRUG RESISTANCE INDUCED BY LOCAL AND ALLOSTERIC CONFORMATIONAL CHANGES IN ONCOGENIC TYROSINE KINASES.2019
- Author(s)
  Mitsugu Araki and Yasushi Okuno
- Organizer
  Biophysical Society 63rd annual meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06594
[Presentation] Protein-ligand binding mode prediction from the apo-protein structure using a molecular dynamics-based pocket generation approach2019
- Author(s)
  Mitsugu Araki and Yasushi Okuno
- Organizer
  Fall 2019 ACS National Meeting
- Data Source
  KAKENHI-PROJECT-18K06594
[Presentation] Drug resistance acquired by local and allosteric conformational changes in oncogenic tyrosine kinases2019
- Author(s)
  Mitsugu Araki and Yasushi Okuno
- Organizer
  Spring 2019 ACS National Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06594
[]

1. 葛谷聡 (30422950)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 金田大太 (40564795)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 片山量平 (60435542)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 内堀健

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 高木聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

ARAKI MITSUGU 荒木 望嗣

Araki Mitsugu 荒木 望嗣

Research Projects

Research Products

Co-Researchers

Development research for Alzheimer's disease therapeutics targeting the mechanism of amyloid beta protein production at synapses

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Searching druggable target sites by developing refined molecular dynamic simulations

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mutation-induced drug sensitivity prediction based on long timescale molecular dynamics simulationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Drug sensitivity prediction for anaplastic lymphoma kinase mutants using molecular dynamics simulation and its informatics analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A macrocyclic kinase inhibitor overcomes triple resistant mutations in EGFR-positive lung cancer2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] LTK mutations responsible for resistance to lorlatinib in non-small cell lung cancer harboring CLIP1-LTK fusion2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] タンパク質の分子動力学シミュレーションに基づく創薬計算技術の開発とゲノム医療分野での応用研究2023

Author(s)

Journal Title

Data Source

[Journal Article] Novel Calcium-Binding Ablating Mutations Induce Constitutive RET Activity and Drive Tumorigenesis2022

Author(s)

Journal Title

Data Source

[Journal Article] Exploring ligand binding pathways on proteins using hypersound-accelerated molecular dynamics2021

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Microsecond-timescale MD simulation of EGFR minor mutation predicts the structural flexibility of EGFR kinase core that reflects EGFR inhibitor sensitivity2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Gilteritinib overcomes lorlatinib resistance in ALK-rearranged cancer2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Improvement in predicting drug sensitivity changes associated with protein mutations using a molecular dynamics based alchemical mutation method2020

Author(s)

Journal Title

Data Source

[Journal Article] E487K-Induced Disorder in Functionally Relevant Dynamics of Mitochondrial Aldehyde Dehydrogenase 2.2020

Author(s)

Journal Title

Data Source

[Journal Article] Landscape and function of multiple mutations within individual oncogene2020

Author(s)

Journal Title

Data Source

[Journal Article] Structural modification of indomethacin toward selective inhibition of COX-2 with a significant increase in van der Waals contributions2019

Author(s)

Journal Title

Data Source

[Journal Article] Dynamic Docking of a Medium Sized Molecule to its Receptor by Multicanonical MD Simulations2019

ARAKI MITSUGU 荒木望嗣

Araki Mitsugu 荒木望嗣