MOTOHARA TAKESHI 本原剛志

… Alternative Names

MOTOHARA Takeshi 本原剛志

Less

Researcher Number	10457591
Other IDs
Affiliation (Current)	2025: 熊本大学, 病院, 講師
Affiliation (based on the past Project Information) *help	2019 – 2024: 熊本大学, 病院, 講師 2018: 熊本大学, 大学院生命科学研究部(医), 助教 2018: 熊本大学, 大学院生命科学研究部(医), 講師 2017: 熊本大学, 医学部附属病院, その他 2017: 熊本大学, 生命科学研究部, 助教 … More 2015 – 2016: 熊本大学, 大学院生命科学研究部(医), 助教 2012 – 2015: 熊本大学, 大学院生命科学研究部, 助教 2013: 熊本大学, 生命科学研究部, 助教 2011: 熊本大学, 医学部附属病院, 医員 Less
Review Section/Research Field	Principal Investigator Basic Section 56040:Obstetrics and gynecology-related / Obstetrics and gynecology Except Principal Investigator Obstetrics and gynecology / Basic Section 56040:Obstetrics and gynecology-related
Keywords	Principal Investigator 卵巣癌 / 癌幹細胞 / EpCAM / 抗癌剤治療抵抗性 / 癌肝細胞ニッチ / 癌肝細胞 / 腫瘍 / 腫瘍微小環境 / マクロファージ / 癌幹細胞ニッチ … More / EpCAM陽性細胞 / アポトーシス / 抗癌剤抵抗性 / ＥｐＣＡＭ … More Except Principal Investigator 卵巣癌 / 卵巣癌治療 / 卵巣表層上皮 / 癌幹細胞 / 卵巣癌モデル / 上皮性卵巣癌 / 発癌 / タルク / アスベスト / 環境物質 / HPV / Hippo経路 / YAP / 子宮頸癌 / 高度扁平上皮内病変 HSIL / ヒトパピローマウイルス（HPV） / HSIL / 高度扁平上皮内病変 / ヒトパピローマウイルス（HPV / 高度扁平上皮内病変（HSIL) / YAP1 / HIPPO経路 / 内分泌環境 / ヒトパピローマウイルス(HPV) / 高度扁平上皮内病変(HSIL) / 子宮頸癌前癌状態 / マクロファージ / 癌幹細胞ニッチ / CD44 / 癌治療 / 遺伝子異常 / 内分泌学的異常 / 子宮内膜癌 / 癌 Less

Elucidation of molecular mechanisms for Ccrosstalk between cancer stem cells and their niches in ovarian cancer omental metastasisPrincipal Investigator
- Principal Investigator
  
  本原剛志
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kumamoto University
子宮頸癌前癌病変におけるYAP1活性化と内分泌環境因子との関連について
- Principal Investigator
  
  田代浩徳
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kumamoto University
Strategies for ovarian cancer prevention: Evaluation of the impact of exposure of environmental carcinogenic substances to the ovary
- Principal Investigator
  
  Katabuchi Hidetaka
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kumamoto University
Development of novel therapeutic strategies for ovarian cancer by regulating the immunological dynamics of tumor-associated macrophagesPrincipal Investigator
- Principal Investigator
  
  Motohara Takeshi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Kumamoto University
Elucidation of interactions between cancer stem cells and their niche: Dual-targeted therapy in ovarian cancer patients
- Principal Investigator
  
  Katabuchi Hidetaka
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kumamoto University
Novel therapeutic strategy targeting EpCAM-positive ovarian cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  Motohara Takeshi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kumamoto University
Novel therapeutic strategy targeting ovarian cancer stem cells and their niche
- Principal Investigator
  
  Katabuchi Hidetaka
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kumamoto University
Establishment of a novel categorization and a therapeutic strategy based on genetic and endocrine abnormality
- Principal Investigator
  
  TASHIRO Hironori
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kumamoto University
Functional analysis of cancer stem cell marker EpCAM in ovarian cancerPrincipal Investigator
- Principal Investigator
  
  MOTOHARA Takeshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kumamoto University
The development of novel therapeutic strategies for targeting ovarian cancer stem cells
- Principal Investigator
  
  KATABUCHI Hidetaka
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kumamoto University

[Book] Emerging role of CD44 variant 6 in driving the metastatic journey of ovarian cancer stem cells. Cell Biology of the Ovary.2018
- Author(s)
  Motohara T, Katabuchi H.
- Total Pages
  166
- Publisher
  Springer
- ISBN
  9789811079405
- Data Source
  KAKENHI-PROJECT-15K20151
[Book] Emerging role of CD44 variant 6 in driving the metastatic journey of ovarian cancer stem cells. Cell Biology of the Ovary.2018
- Author(s)
  Motohara T, Katabuchi H
- Total Pages
  166
- Publisher
  Springer
- ISBN
  9789811079405
- Data Source
  KAKENHI-PROJECT-16H05473
[Journal Article] Advantages and limitations of estrogen replacement therapy on hypogonadal survivors of childhood cancer2023
- Author(s)
  Nakamura Miwa、Ohba Takashi、Sasaki Rumi、Saito Fumitaka、Yamaguchi Munekage、Motohara Takeshi、Mabe Hiroyo、Lu Xi、Katabuchi Hidetaka、Kondoh Eiji
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 28 Issue: 11 Pages: 1563-1572
- DOI
  10.1007/s10147-023-02405-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09673
[Journal Article] Surgical efficacy and quality of wide resection of the pelvic peritoneum in patients with epithelial ovarian cancer2023
- Author(s)
  Nishimura Akiho、Motohara Takeshi、Morinaga Jun、Iwagoi Yutaka、Yamamoto Mayuko、Yamaguchi Munekage、Miyahara Yo、Tashiro Hironori、Katabuchi Hidetaka
- Journal Title
  
  Surgical Oncology
  
  Volume: 48 Pages: 101946-101946
- DOI
  10.1016/j.suronc.2023.101946
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09621, KAKENHI-PROJECT-20K09673
[Journal Article] Changes in HPV16/18 Prevalence among Unvaccinated Women with Cervical Intraepithelial Neoplasia in Japan: Assessment of Herd Effects following the HPV Vaccination Program.2022
- Author(s)
  Onuki M, Matsumoto K, et al. for The Mint Study Group.
- Journal Title
  
  Vaccines (Basel)
  
  Volume: 10 Issue: 2 Pages: 181-181
- DOI
  10.3390/vaccines10020188
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11297, KAKENHI-PROJECT-17K11309, KAKENHI-PROJECT-19H03795, KAKENHI-PROJECT-19K09826, KAKENHI-PROJECT-20K09682, KAKENHI-PROJECT-20K09677, KAKENHI-PROJECT-22K09630
[Journal Article] Maternal thrombocytopenia precedes fetal death associated with COVID-192022
- Author(s)
  Sagara A, Yamaguchi M, Mikami Y, Motohara T, Ohba T, Kondoh E.
- Journal Title
  
  J Obstet Gynaecol Res.
  
  Volume: Ahead of print. Issue: 6 Pages: 1475-1479
- DOI
  10.1111/jog.15223
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09826
[Journal Article] Fertility-sparing surgery for early-stage cervical cancer: A case series study on the efficacy and feasibility of cervical conization followed by pelvic lymphadenectomy2022
- Author(s)
  Yamamoto M, Motohara T, Iwagoi Y, Tayama S, Tashiro H, Kondoh E, Katabuchi H.
- Journal Title
  
  J Obstet Gynaecol Res .
  
  Volume: Ahead of print Issue: 6 Pages: 1444-1450
- DOI
  10.1111/jog.15215
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09826, KAKENHI-PROJECT-20K09673, KAKENHI-PROJECT-20K09621
[Journal Article] Human papillomavirus vaccine effectiveness by age at first vaccination among Japanese women.2022
- Author(s)
  Onuki M, Matsumoto K, et al. for The MINT Study Group.
- Journal Title
  
  Cancer Science
  
  Volume: 113 Issue: 4 Pages: 1428-1434
- DOI
  10.1111/cas.15270
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11297, KAKENHI-PROJECT-17K11309, KAKENHI-PROJECT-18H02947, KAKENHI-PROJECT-19H03795, KAKENHI-PROJECT-19K09826, KAKENHI-PROJECT-20K09682, KAKENHI-PROJECT-20K18157, KAKENHI-PROJECT-20K09677
[Journal Article] Angiopoietin-like protein 2 decreases peritoneal metastasis of ovarian cancer cells by suppressing anoikis resistance.2021
- Author(s)
  Takeshita Y, Motohara T, Kadomatsu T, Doi T, Obayashi K, Oike Y, Katabuchi H, Endo M.
- Journal Title
  
  Biochem Bioph Res Commun
  
  Volume: 561 Pages: 26-32
- DOI
  10.1016/j.bbrc.2021.05.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H04825, KAKENHI-PROJECT-19K09826, KAKENHI-PROJECT-20K08530, KAKENHI-PROJECT-20K09673, KAKENHI-PROJECT-21K07101, KAKENHI-PROJECT-20K18223
[Journal Article] Adipocyte-like signature in ovarian cancer minimal residual disease identifies metabolic vulnerabilities of tumor-initiating cells2021
- Author(s)
  Artibani M, Masuda K, Hu Z, Rauher PC, Mallett G, Wietek N, Morotti M, Chong K, KaramiNejadRanjbar M, Zois CE, Dhar S, El-Sahhar S, Campo L, Blagden SP, Damato S, Pathiraja PN, Nicum S, Gleeson F, Laios A, Alsaadi A, Santana Gonzalez L, Motohara T, et al.
- Journal Title
  
  JCI Insight.
  
  Volume: 6
- DOI
  10.1172/jci.insight.147929
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09826, KAKENHI-PROJECT-20K18174
[Journal Article] Omental metastasis as a predictive risk factor for unfavorable prognosis in patients with stage III-IV epithelial ovarian cancer2021
- Author(s)
  Iwagoi Y, Motohara T, Hwang S, Fujimoto K, Ikeda T, Katabuchi H.
- Journal Title
  
  Int J Clin Oncol
  
  Volume: 26 Issue: 5 Pages: 995-1004
- DOI
  10.1007/s10147-021-01866-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09826, KAKENHI-PROJECT-20K09673
[Journal Article] The hallmarks of ovarian cancer stem cells and niches: Exploring their harmonious interplay in therapy resistance2021
- Author(s)
  Motohara T, Yoshida GJ, Katabuchi H.
- Journal Title
  
  Semin Cancer Biol
  
  Volume: in press Pages: 182-193
- DOI
  10.1016/j.semcancer.2021.03.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09826, KAKENHI-PROJECT-20K09673
[Journal Article] Human papillomavirus genotype contribution to cervical cancer and precancer: Implications for screening and vaccination in Japan2020
- Author(s)
  Onuki M, Matsumoto K, Iwata T, Yamamoto K, Aoki Y, Maenohara S, Tsuda N, Kamiura S, Takehara K, Horie K, Tasaka N, Yahata H, Takei Y, Aoki Y, Kato H, Motohara T, Nakamura K, Ishikawa M, Kato T, Yoshida H, Matsumura N, Nakai H, Shigeta S, Takahashi F, Noda K, Yaegashi N, Yoshikawa H.
- Journal Title
  
  Cancer Sci
  
  Volume: 117 Issue: 7 Pages: 2546-2557
- DOI
  10.1111/cas.14445
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09826, KAKENHI-PROJECT-20K09677
[Journal Article] An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment.2019
- Author(s)
  Motohara T, Masuda K, Morotti M, Zheng Y, El-Sahhar S, Chong KY, Wietek N, Alsaadi A, Karaminejadranjbar M, Hu Z, Artibani M, Gonzalez LS, Katabuchi H, Saya H, Ahmed AA.
- Journal Title
  
  Oncogene
  
  Volume: 38 Issue: 16 Pages: 2885-2898
- DOI
  10.1038/s41388-018-0637-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05473, KAKENHI-PROJECT-15K20151
[Journal Article] Ovarian cancer stemness: biological and clinical implications for metastasis and chemotherapy resistance2019
- Author(s)
  Motohara T, Katabuchi H.
- Journal Title
  
  Cancers
  
  Volume: 11 Issue: 7 Pages: 907-907
- DOI
  10.3390/cancers11070907
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K09826
[Journal Article] Radical resection of an endometrioid carcinoma arising from endometriosis in the round ligament within the right canal of Nuck: a case report and literature review.2018
- Author(s)
  Motooka Y, Motohara T, Honda R, Tashiro H, Mikami Y, Katabuchi H.
- Journal Title
  
  Gynecologic Oncology Reports
  
  Volume: 24 Pages: 61-64
- DOI
  10.1016/j.gore.2018.01.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05473, KAKENHI-PROJECT-16K11145, KAKENHI-PROJECT-15K20151
[Journal Article] The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer.2017
- Author(s)
  Tayama S, Motohara T, Narantuya D, Li C, Fujimoto K, Sakaguchi I, Tashiro H, Saya H, Nagano O, Katabuchi H
- Journal Title
  
  Oncotarget
  
  Volume: 8 Issue: 27 Pages: 44312-44325
- DOI
  10.18632/oncotarget.17871
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11145, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-16H05473
[Journal Article] CD44 variant 6 as a predictive biomarker for distant metastasis in patients with epithelial ovarian cancer.2016
- Author(s)
  11.Motohara T, Fujimoto K, Tayama S, Narantuya D, Guo J, Sakaguchi I, Tashiro H, Katabuchi H.
- Journal Title
  
  Epub ahead of print
  
  Volume: Epub ahead of print
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293344
[Journal Article] Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche.2016
- Author(s)
  Miranda F, Motohara T (35人中33番目), et al.
- Journal Title
  
  Cancer Cell
  
  Volume: 30 Pages: 273-289
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K20151
[Journal Article] Rapid growing cystic ovarian metastasis from pancreatic cancer.2016
- Author(s)
  Nomoto D, Hashimoto D, Motohara T, Chikamoto A, Nitta H, Beppu T, Katabuchi H
- Journal Title
  
  J Gastroenterol Hepatol
  
  Volume: 31 Issue: 4 Pages: 707-707
- DOI
  10.1111/jgh.13164
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K20151
[Journal Article] CD44 Variant 6 as a Predictive Biomarker for Distant Metastasis in Patients With Epithelial Ovarian Cancer.2016
- Author(s)
  Motohara T, Fujimoto K, Tayama S, Narantuya D, Sakaguchi I, Tashiro H, Katabuchi H.
- Journal Title
  
  Obstet Gynecol.
  
  Volume: 127 Issue: 6 Pages: 1003-11
- DOI
  10.1097/aog.0000000000001420
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05473, KAKENHI-PROJECT-16K11145
[Journal Article] High-dose oral tegafur-uracil maintenance therapy in patients with uterine cervical cancer.2015
- Author(s)
  Sakaguchi I., Motohara T., Saito F., Takaishi K., Fukumatsu Y., Tohya T., Shibata S., Mimori H., Tashiro H., Katabuchi H.
- Journal Title
  
  J Gynecol Oncol.
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24592522
[Journal Article] Low-grade漿液性腺癌の臨床病理・ゲノムと治療法.2015
- Author(s)
  本原剛志, 坂口勲, 片渕秀隆.
- Journal Title
  
  臨婦産.
  
  Volume: 69 Pages: 118-123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293344
[Journal Article] CD44 variant 6 is correlated with peritoneal dissemination and poor prognosis in patients with advanced epithelial ovarian cancer.2015
- Author(s)
  Tjhay F, Motohara T, Tayama S, Narantuya D, Fujimoto K, Guo J, Sakaguchi I, Honda R, Tashiro H, Katabuchi H.
- Journal Title
  
  Cancer Sci
  
  Volume: 106 Issue: 10 Pages: 1421-1428
- DOI
  10.1111/cas.12765
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K20151, KAKENHI-PROJECT-25293344
[Journal Article] 卵巣癌における癌幹細胞マーカーEpCAMの機能解析: 卵巣癌新規治療戦略の開発.2014
- Author(s)
  本原剛志.
- Journal Title
  
  産と婦.
  
  Volume: 81 Pages: 95-96
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791713
[Journal Article] -難治性卵巣癌の克服を目指して- 卵巣癌幹細胞および癌幹細胞ニッチとして機能する骨盤腹膜を標的とした新たな治療戦略.2014
- Author(s)
  本原剛志.
- Journal Title
  
  日産婦誌.
  
  Volume: 66 Pages: 2761-2770
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791713
[Journal Article] 正常大卵巣に局在し抗NMDA受容体脳炎を惹起した成熟嚢胞性奇形腫の1例.2014
- Author(s)
  田山親吾, 田代浩徳, 本原剛志, 山口宗影, 本原研一, 大場隆, 片渕秀隆.
- Journal Title
  
  日婦腫瘍会誌.
  
  Volume: 32 Pages: 257-262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791713
[Journal Article] 正常大卵巣に局在し抗NMDA受容体脳炎を惹起した成熟嚢胞性奇形腫の1例.2014
- Author(s)
  田山親吾, 田代浩徳, 本原剛志, 山口宗影, 本原研一, 大場隆, 片渕秀隆.
- Journal Title
  
  日婦腫瘍会誌.
  
  Volume: 32 Pages: 257-262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293344
[Journal Article] Low-grade漿液性腺癌の病態と治療.2014
- Author(s)
  本原剛志, 片渕秀隆
- Journal Title
  
  産婦の実際.
  
  Volume: 63 Pages: 959-965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293344
[Journal Article] Low-grade漿液性腺癌の病態と治療. 産婦の実際.2014
- Author(s)
  本原剛志, 片渕秀隆.
- Journal Title
  
  産婦の実際.
  
  Volume: 63 Pages: 959-965
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791713
[Journal Article] xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma2013
- Author(s)
  Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, Onishi N, Masuko T, Yoshizawa K, Kawashiri S, Mukai M, Asoda S, Kawana H, Nakagawa T, Saya H, Nagano O
- Journal Title
  
  Cancer Res
  
  Volume: 73(6) Issue: 6 Pages: 1855-1866
- DOI
  10.1158/0008-5472.can-12-3609-t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592100, KAKENHI-PROJECT-23659941, KAKENHI-PROJECT-23790376, KAKENHI-PROJECT-24591912, KAKENHI-PROJECT-24592965, KAKENHI-PROJECT-24791713, KAKENHI-PROJECT-24792194, KAKENHI-PROJECT-25293344, KAKENHI-PROJECT-25870730, KAKENHI-PLANNED-22130007
[Journal Article] Anti-N-methyl-D-aspartate receptor encephalitis associated with mature cystic teratoma: clinical presentation, diagnosis, treatment, and surgical management2013
- Author(s)
  Takeshi Motohara, Hironori Tashiro, Shingo Tayama, Dashdemberel Narantuya, Hidetaka Katabuchi
- Journal Title
  
  International Cancer Conference Jornal
  
  Volume: 未定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791713
[Journal Article] 婦人科がん ―最新の研究動向―　卵巣癌の臨床病理学卵巣癌・子宮体癌の重複癌.2012
- Author(s)
  本原剛志, 田代浩徳, 片渕秀隆.
- Journal Title
  
  日本臨床
  
  Volume: 74 Pages: 523-527
- Data Source
  KAKENHI-PROJECT-24791713
[Journal Article] Synchronous primary ovarian and endometrial carcinomas.2012
- Author(s)
  Motohara T, Tashiro H, Katabuchi H.
- Journal Title
  
  Nihon Rinsho
  
  Volume: 70 Suppl 4 Pages: 523-527
- Data Source
  KAKENHI-PROJECT-24592522
[Journal Article] Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells2011
- Author(s)
  Motohara T, et al
- Journal Title
  
  Carcinogenesis
  
  Volume: 32 Pages: 1597-1606
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390454
[Journal Article] Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells2011
- Author(s)
  T. Motohara, S. Masuko, T. Ishimoto, T. Yae, N. Onishi, T. Muraguchi, A. Hirao, Y. Matsuzaki, H. Tashiro, H. Katabuchi, H. Saya, O Nagano
- Journal Title
  
  Carcinogenesis
  
  Volume: 32 Pages: 1597-1696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390454
[Journal Article] CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(-) and thereby promotes tumor growth2011
- Author(s)
  T. Ishimoto, O. Nagano, T. Yae, M. Tamada, T. Motohara, H. Oshima, M. Oshima, T. Ikeda, R. Asaba, H. Yagi, T. Masuko, T. Shimizu, T. Ishikawa, K. Kai, E. Takahashi, Y. Imamura, Y. Baba, M. Ohmura, M. Suematsu, H. Baba, H. Saya
- Journal Title
  
  Cancer Cell
  
  Volume: 19 Pages: 387-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390454
[Journal Article] Immunohistochemical analysis of 17β-hydroxysteroid dehydrogenase isozymes in human ovarian surface epithelium and epithelial ovarian carcinoma2010
- Author(s)
  K. Motohara, H. Tashiro, Y. Taura, T. Ohba, H. Katabuchi
- Journal Title
  
  Med Mol Morphol
  
  Volume: 43 Pages: 197-203
- NAID
  10027752277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390454
[Journal Article] Long-term oncological outcomes of ovarian serous carcinomas with psammoma bodies : A novel insight into the molecular pathogenesis of ovarian epithelial carcinoma2010
- Author(s)
  T. Motohara, H. Tashiro, Y. Miyahara, I. Sakaguchi, H. Ohtake, H. Katabuchi
- Journal Title
  
  Cancer Science
  
  Volume: 101 Pages: 1550-1556
- NAID
  10026594146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390454
[Journal Article] Long-term oncological outcomes of ovarian serous carcinomas with psammoma bodies : a novel insight to the molecular pathogenesis of ovarian epithelial carcinoma.2010
- Author(s)
  T.Motohara, H.Tashiro, et al.
- Journal Title
  
  Cancer Science
  
  Volume: 101 Pages: 1550-1556
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390454
[Journal Article] Long-term oncological outcomes of ovarian serous carcinomas with psammoma bodies : A novel insight into the molecular pathogenesis of ovarian epithelial carcinoma2010
- Author(s)
  Motohara T., et al.
- Journal Title
  
  Cancer Science 1(Epub(電子書籍))
- NAID
  10026594146
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390454
[Journal Article] The immunohistochemical analysis of 17β-hydroxysteroid dehydrogenase-isozymes in human ovarian surface epithelium and epithelial ovarian carcinoma.2010
- Author(s)
  K.Motohara, H.Tashiro, et al.
- Journal Title
  
  Medical Molecular Morphology
  
  Volume: 43 Pages: 193-203
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390454
[Presentation] バルトリン腺嚢胞の診断で経過観察となり17年の経過を経て外科的切除を行った血管平滑筋腫の1例2024
- Author(s)
  落合みゆき　今村裕子　前田菜々　島田清史郎　下川理沙　中村美和　楠木槙　井上尚美　佐々木瑠美　齋藤文誉　本原剛志　田代浩徳　大場隆　近藤英治
- Organizer
  第245回熊本産科婦人科学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09621
[Presentation] 卵巣癌の初回治療における薬剤選択: PARP阻害剤を吟味する.2022
- Author(s)
  本原剛志
- Organizer
  ゼジューラWEB講演会
- Invited
- Data Source
  KAKENHI-PROJECT-19K09826
[Presentation] 遺伝性乳がん卵巣がん症候群の診断でリスク低減卵管卵巣摘出術を施行しSecretory cell outgrowthがみられた2例2022
- Author(s)
  今村裕子 , 佐々木瑠美 , 本原剛志 , 田山親吾 , 田代浩徳 , 大場隆 , 近藤英治
- Organizer
  第28回日本遺伝性腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-20K09621
[Presentation] 令和時代における卵巣癌治療のベストプラクティス.2022
- Author(s)
  本原剛志
- Organizer
  Ovarian Cancer Forum in Miyazaki
- Invited
- Data Source
  KAKENHI-PROJECT-19K09826
[Presentation] 卵巣癌の治療抵抗性ならびに転移における癌幹細胞とニッチの役割2021
- Author(s)
  本原剛志
- Organizer
  第53回日本臨床分子形態学会総会・学術集会シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-19K09826
[Presentation] Cancer stem cell marker EpCAM is involved in resistance to chemotherapy and poor prognosis in ovarian cancer patients2018
- Author(s)
  Takeshi Motohara
- Organizer
  29th Euro-Global Summit on Cancer Therapy & Radiation Oncology
- Data Source
  KAKENHI-PROJECT-15K20151
[Presentation] CD44 variant 6 is associated with peritoneal metastasis and poor prognosis in advanced ovarian cancer patients2015
- Author(s)
  Takeshi Motohara, Shingo Tayama, Isao Sakaguchi, Hironori Tashiro, Hidetaka Katabuchi
- Organizer
  The 74th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K20151
[Presentation] CD44 variant 6 is associated with peritoneal metastasis and poor prognosis in advanced ovarian cancer patients.2015
- Author(s)
  Takeshi Motohara, Shingo Tayama, Isao Sakaguchi, Hironori Tashiro, Hidetaka Katabuchi.
- Organizer
  The 74th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25293344
[Presentation] 卵巣癌幹細胞および癌幹細胞ニッチを標的した新規治療戦略2014
- Author(s)
  本原　剛志
- Organizer
  第26回女性医学講座
- Place of Presentation
  熊本市
- Year and Date
  2014-09-04
- Invited
- Data Source
  KAKENHI-PROJECT-25293344
[Presentation] 卵巣癌幹細胞および癌幹細胞ニッチを標的とした新規治療戦略2014
- Author(s)
  本原剛志
- Organizer
  第26回熊本女性医学講座
- Place of Presentation
  熊本市
- Year and Date
  2014-09-04
- Invited
- Data Source
  KAKENHI-PROJECT-24791713
[Presentation] 卵巣癌において癌幹細胞マーカーである上皮細胞接着分子(EpCAM)はプラチナ系抗癌剤抵抗性に関与している2013
- Author(s)
  田山親吾, 本原剛志, Tjhay Francisca, 高石清美, 田代浩徳, 片渕秀隆
- Organizer
  第65回日本産科婦人科学会学術講演会
- Place of Presentation
  札幌市　ロイトン札幌、ホテルさっぽろ芸文館、札幌プリンスホテル、札幌市教育文化会館
- Data Source
  KAKENHI-PROJECT-24791713
[Presentation] Survival impact of wide resection of the pelvic peritoneum in patients with ovarian cancer: Novel surgical strategies for the removal of ovarian cancer stem cells and their niche2013
- Author(s)
  Takeshi Motohara
- Organizer
  第65回日本産科婦人科学会学術講演会
- Place of Presentation
  札幌市　ロイトン札幌、ホテルさっぽろ芸文館、札幌プリンスホテル、札幌市教育文化会館
- Data Source
  KAKENHI-PROJECT-24791713
[Presentation] Epithelial cell adhesion molecule, a potential marker of cancer stem cell, is associated with resistance to platinum-based chemotherapy in epithelial ovarian cancer2013
- Author(s)
  Tayama S., Motohara T., Katabuchi H.
- Organizer
  The 99th Annual Congress of Korean Society of Obstetrics and Gynecology
- Place of Presentation
  Grand Hilton,Seoul,Korea
- Data Source
  KAKENHI-PROJECT-25293344
[Presentation] 子宮体部類内膜腺癌症例におけるリンパ節郭清術の省略についての検討～当施設における再発症例からの考察～2012
- Author(s)
  齋藤文誉, 宮原　陽, 高石清美, 本原研一, 本田律生, 田代浩徳, 大場　隆, 片渕秀隆
- Organizer
  第50回日本癌治療学会学術集会
- Place of Presentation
  パシフィコ横浜、横浜
- Data Source
  KAKENHI-PROJECT-24592522
[Presentation] The tumor suppressor p53 trigger the expansion of ovarian stem-like tumor cells in an established mouse model of ovarian cancer2012
- Author(s)
  Motohara T, Tashiro H, Katabuchi H.
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌・さっぽろ芸文館・札幌市教育文化会館、札幌
- Data Source
  KAKENHI-PROJECT-24791713
[Presentation] Long-term oncological outcomes of ovarian serous carcinomas with psammoma bodies2011
- Author(s)
  T. Motohara, H. Tashiro, H. Ohtake, R. Honda, T. Ohba, H. Katabuchi
- Organizer
  The 50th annual congress of Taiwan Association of Obstetrics and Gynecology
- Place of Presentation
  Kaohsiung
- Year and Date
  2011-03-12
- Data Source
  KAKENHI-PROJECT-21390454
[Presentation] Identification of EpCAM as a marker for somatic stem-like cells and cancer stem cells in mouse models of ovarian tumorigenesis2011
- Author(s)
  T. Motohara, O. Nagano, H. Tashiro, H. Saya, H. Katabuchi
- Organizer
  1^<st> Asan Kumamoto-Joint Symposium on Gynecologic Cancer
- Place of Presentation
  Seoul、Korea
- Year and Date
  2011-02-19
- Data Source
  KAKENHI-PROJECT-21390454
[Presentation] Long-term oncological outcomes of ovarian serous carcinomas with psammoma bodies.2011
- Author(s)
  T.Motohara, H.Tashiro, et al.
- Organizer
  The 50^<th> annual congress of Taiwan Association of Obstetrics and Gynecology
- Place of Presentation
  Kaohsiung, Taiwan
- Year and Date
  2011-03-12
- Data Source
  KAKENHI-PROJECT-21390454
[Presentation] A subpopulation of EpCAM-positive cancer cells is involved in chemoresistance and prevents platinum anticancer drug-induced apoptosis in epithelial ovarian cancer
- Author(s)
  Shingo Tayama, Takeshi Motohara, Francisca Tjhay, Isao Sakaguchi, Hironori Tashiro, Hidetaka Katabuchi
- Organizer
  第66回日本産科婦人科学会学術講演会
- Place of Presentation
  東京国際フォーラム、東京都
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-24592522
[Presentation] Epithelial cell adhesion molecule, a potential marker of cancer stem cell, is associated with resistance to platinum-based chemotherapy in epithelial ovarian cancer
- Author(s)
  Tayama S., Motohara T., Tjhay F., Narantuya D., Takaishi K., Tashiro T., Katabuchi H.
- Organizer
  The 4th Asan-Kumamoto Joint Symposium
- Place of Presentation
  阿蘇リゾートグランヴィリオホテル、Kumamoto, Japan
- Data Source
  KAKENHI-PROJECT-25293344
[Presentation] 卵巣癌幹細胞および癌幹細胞ニッチとして機能する骨盤腹膜を標的とした新たな治療戦略
- Author(s)
  本原　剛志
- Organizer
  第66回　日本産科婦人科学会学術講演会
- Place of Presentation
  東京都
- Year and Date
  2014-04-18 – 2014-04-20
- Invited
- Data Source
  KAKENHI-PROJECT-25293344
[Presentation] 卵巣癌におけるEpCAM陽性細胞は抗アポトーシス作用を介した抗がん剤治療抵抗性を有する
- Author(s)
  田山親吾, 本原剛志, 坂口勲, 田代浩徳, 片渕秀隆
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24791713
[Presentation] Survival impact of wide resection of the pelvic peritoneum in patients with epithelial ovarian cancer：Towards the development of novel surgical strategies for the removal of ovarian cancer stem cells and their niche
- Author(s)
  Motohara T., Tayama S., Saito F., Tjhay F., Takaishi K., Sakaguchi I., Tashiro H., Katabuchi K.
- Organizer
  The 4th Asan-Kumamoto Joint Symposium
- Place of Presentation
  阿蘇リゾートグランヴィリオホテル、Kumamoto, Japan
- Data Source
  KAKENHI-PROJECT-25293344
[Presentation] 卵巣癌における EpCAM 陽性細胞は抗アポトーシス作用を介した抗がん剤治療抵抗性を有する
- Author(s)
  田山親吾、本原剛志、坂口勲、田代浩徳、片渕秀隆
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜、横浜市
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24592522
[Presentation] Transient Suppression of p53 followed by transduction of defined oncogenes converts ovarian stem-like cells into tumor-initiating cells
- Author(s)
  Motohara T, Tayama S, Tjhay F, Sakaguchi I, Tashiro H, Katabuchi H.
- Organizer
  14th Biennial Meeting of the International Gynecologic Caner Society
- Place of Presentation
  Vancouver　Convention Centre,Canada
- Data Source
  KAKENHI-PROJECT-24791713
[Presentation] CLINICOPATHOLOGICAL STUDY OF PROGNOSTIC FACTORS IN UTERINE CARCINOSARCOMA: A COMPARISON WITH GRADE 3 ENDOMETRIOID
- Author(s)
  Y. Motooka, T. Motohara, K. Takaishi, F. Saito, R. Honda, H. Tashiro, T. Ohba, H. Katabuchi
- Organizer
  The 15th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2014)
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2014-11-08 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-24592522
[Presentation] 卵巣癌におけるEpCAM陽性細胞は抗アポトーシス作用を介した抗がん剤治療抵抗性を有する
- Author(s)
  田山　親吾、本原　剛志、坂口　勲、田代　浩徳、片渕　秀隆
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2014-09-24 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25293344
[Presentation] A CLINICOPATHOLOGICAL ANALYSIS OF 48 MALIGNANT OVARIAN GERM CELL TUMOR CASES
- Author(s)
  K. Takaishi, F. Saito, T. Motohara, H. Tashiro, H. Katabuchi
- Organizer
  The 15th Biennial Meeting of the International Gynecologic Cancer Society (IGCS 2014)
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2014-11-08 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-24592522
[Presentation] Involvement of CD44 variant, a cancer stem cell marker, in peritoneal metastasis and poor prognosis in patients with epithelial ovarian cancer
- Author(s)
  Francisca Tjhay, Takeshi Motohara, Shingo Tayama, Isao Sakaguchi, Hironori Tashiro, Hidetaka Katabuchi
- Organizer
  第66回日本産科婦人科学会学術講演会
- Place of Presentation
  東京国際フォーラム、東京都
- Year and Date
  2014-04-18 – 2014-04-20
- Data Source
  KAKENHI-PROJECT-24592522
[Presentation] 卵巣癌幹細胞および癌幹細胞ニッチとして機能する骨盤腹膜を標的とした新たな治療戦略
- Author(s)
  本原剛志
- Organizer
  第66回日本産科婦人科学会学術講演会
- Place of Presentation
  東京都
- Year and Date
  2014-04-18 – 2014-04-20
- Invited
- Data Source
  KAKENHI-PROJECT-24791713

1. KATABUCHI Hidetaka (90224451)

# of Collaborated Projects: 9 results

# of Collaborated Products: 37 results
2. TASHIRO Hironori (70304996)

# of Collaborated Projects: 7 results

# of Collaborated Products: 29 results
3. SAITO Fumitaka (20555742)

# of Collaborated Projects: 3 results

# of Collaborated Products: 5 results
4. TAKAISHI KIYOMI (00601303)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. SAKAGUCHI ISAO (40448527)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
6. HONDA Ritsuo (10301376)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. MIYAHARA Yo (40404355)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 大竹秀幸 (60336237)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. 山口宗影 (20626535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. Tsuboki Junko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. ASODA Seiji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. YOSHIKAWA Momoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 尾池雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 松本光司

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
15. 佐谷秀行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

MOTOHARA TAKESHI 本原 剛志

MOTOHARA Takeshi 本原 剛志

Research Projects

Research Products

Co-Researchers

Elucidation of molecular mechanisms for Ccrosstalk between cancer stem cells and their niches in ovarian cancer omental metastasisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

子宮頸癌前癌病変におけるYAP1活性化と内分泌環境因子との関連について

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Strategies for ovarian cancer prevention: Evaluation of the impact of exposure of environmental carcinogenic substances to the ovary

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of novel therapeutic strategies for ovarian cancer by regulating the immunological dynamics of tumor-associated macrophagesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of interactions between cancer stem cells and their niche: Dual-targeted therapy in ovarian cancer patients

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel therapeutic strategy targeting EpCAM-positive ovarian cancer stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel therapeutic strategy targeting ovarian cancer stem cells and their niche

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of a novel categorization and a therapeutic strategy based on genetic and endocrine abnormality

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of cancer stem cell marker EpCAM in ovarian cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of novel therapeutic strategies for targeting ovarian cancer stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Emerging role of CD44 variant 6 in driving the metastatic journey of ovarian cancer stem cells. Cell Biology of the Ovary.2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Book] Emerging role of CD44 variant 6 in driving the metastatic journey of ovarian cancer stem cells. Cell Biology of the Ovary.2018

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Advantages and limitations of estrogen replacement therapy on hypogonadal survivors of childhood cancer2023

Author(s)

Journal Title

MOTOHARA TAKESHI 本原剛志

MOTOHARA Takeshi 本原剛志