Abe Hikaru 阿部光

… Alternative Names

阿部光アベヒカル

ABE Hikaru 阿部光

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Researcher Number	10462269
Affiliation (Current)	2025: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員
Affiliation (based on the past Project Information) *help	2023: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員 2019 – 2021: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員 2017: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員 2014: 公益財団法人微生物化学研究会, 微生物化学研究所, 研究員 2013: (公財)微生物化学研究会, 微生物化学研究所有機合成研究部, 研究員
Review Section/Research Field	Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 37030:Chemical biology-related Except Principal Investigator Urology / Chemical pharmacy / Living organism molecular science
Keywords	Principal Investigator 類縁体合成 / 間質細胞 / 抗がん剤 / 構造活性相関 / 天然物創薬 / Complex I / 膵がん / AI創薬 / 創薬研究 / Comlex I 阻害剤 … More / ミトコンドリア / キノロン類縁体 / complex I 阻害 / ミトコンドリア呼吸鎖関連楮 / がん細胞増殖阻害活性 / キノロン / ミトコンドリア呼吸鎖関連酵素 / complex I / がん－間質相互作用 … More Except Principal Investigator アンドロゲンレセプター / 前立腺がん / 抗結核薬 / 有機化学 / 抗結核剤 / 触媒的不斉反応 / 天然有機化合物 / 全合成 / 経口投与 / 経口剤 / プロテアソーム阻害剤 / プロテアソーム / インビボイメージング Less

Development of anticancer drug candidates from natural products target for pancreatic cancer cellsPrincipal Investigator
- Principal Investigator
  
  阿部光
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Microbial Chemistry Research Foundation
Depelopment of a new anticancer drug as targeting mitochondriaPrincipal Investigator
- Principal Investigator
  
  Abe Hikaru
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 37030:Chemical biology-related
- Research Institution
  Microbial Chemistry Research Foundation
Elucidation of androgen-dependent growth inhibition mechanism in prostate cancer of novel small molecule compound APA
- Principal Investigator
  
  YAMAZAKI Yohko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  Microbial Chemistry Research Foundation
Development of orally active proteasome inhibitors using in vivo imaging.
- Principal Investigator
  
  MOMOSE Isao
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Living organism molecular science
- Research Institution
  Microbial Chemistry Research Foundation
Catalytic asymmetric total synthesis of caprazamycin, an anti-tuberculosis antibiotic
- Principal Investigator
  
  WATANABE Takumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Microbial Chemistry Research Foundation

All 2021 2020 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment2021
- Author(s)
  J. Yoshida, T. Ohishi, H. Abe, S. Ohba, H. Inoue, I. Usami, M. Amemiya, R. Oriez, C. Sakashita, S. Dan, M. Sugawara, T. Kawaguchi, J. Ueno, Y. Asano, A. Ikeda, M. Takamatsu, G. Amori, Y. Kondoh, K. Honda, H. Osada, T. Noda, T. Watanabe, T. Shimizu, M. Shibasaki and M. Kawada
- Journal Title
  
  iScience
  
  Volume: 24 Issue: 12 Pages: 103497-103497
- DOI
  10.1016/j.isci.2021.103497
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15333, KAKENHI-PROJECT-19K15716, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-20K06956, KAKENHI-PROJECT-16H06276, KAKENHI-PLANNED-17H06412
[Journal Article] Synthesis of Androprostamine A and Resormycin2016
- Author(s)
  H. Abe, Y. Yamazaki, C. Sakashita, I. Momose, T. Watanabe, M. Shibasaki
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 64 Issue: 7 Pages: 982-987
- DOI
  10.1248/cpb.c16-00207
- NAID
  130005160028
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K01811, KAKENHI-PROJECT-15K10615
[Journal Article] Quinofuracins A-E, produced by the fungus Staphylotrichum boninense PF1444, show p53-dependent growth suppression.2015
- Author(s)
  Tatsuda D, Momose I, Someno T, Sawa R, Kubota Y, Iijima M, Kunisada T, Watanabe T, Shibasaki M, Nomoto A.
- Journal Title
  
  J. Nat. Prod.
  
  Volume: 78 Issue: 2 Pages: 188-195
- DOI
  10.1021/np500581m
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23510270, KAKENHI-PROJECT-15K01811
[Journal Article] Antitumor effects of tyropeptin-boronic acid derivatives: New proteasome inhibitors.2014
- Author(s)
  Momose I, Abe H, Watanabe T, Ohba S, Yamazaki K, Dan S, Yamori T, Masuda T, Nomoto A.
- Journal Title
  
  Cancer Sci.
  
  Volume: 105 Issue: 12 Pages: 1609-1615
- DOI
  10.1111/cas.12542
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23510270
[Journal Article] Catalytic asymmetric total synthesis of (+)-caprazol2014
- Author(s)
  Gopinath, P., Wang, L., Abe, H., Ravi, G., Masuda, T., Watanabe, T., Shibasaki, M.
- Journal Title
  
  Org. Lett
  
  Volume: 16 Issue: 12 Pages: 3364-3367
- DOI
  10.1021/ol501397b
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590037
[Journal Article] Catalytic eiantioselective desymmetrization of meso-glutaric anhydrides using a stable Ni_2-Schiff base catalys2012
- Author(s)
  Gopinath, P., Watanabe, T., Shibasaki, M.
- Journal Title
  
  Org.Lett.
  
  Volume: 14 Issue: 5 Pages: 1358-1361
- DOI
  10.1021/ol3002078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01520, KAKENHI-PROJECT-23590037
[Journal Article] Studies on Catalytic Enantioselective Total Synthesis of Caprazamycin B : Construction of the Western Zone2012
- Author(s)
  Gopinath, P., Watanabe, T. & Shibasaki M
- Journal Title
  
  J. Org. Chem.
  
  Volume: 77 Issue: 20 Pages: 9260-9267
- DOI
  10.1021/jo301803h
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01520, KAKENHI-PROJECT-23590037
[Presentation] がん－間質相互作用に干渉するLeucinostatin A類縁体のがん細胞増殖阻害機構2020
- Author(s)
  阿部　光、大石智一、坂下千春、Uzama Saqib、Mirzza S. Baig、大庭俊一、井上裕幸、渡辺　匠、川田　学、柴﨑　正勝
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K15716
[Presentation] AS1936: A new inhibitor of androgen receptor function in prostate cancer2017
- Author(s)
  Yohko Yamazaki, Shun-ichi Ohba, Hikaru Abe, Takumi Watanabe, Isao Momose, Manabu Kawada, Masakatsu Shibasaki
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-15K10615
[Presentation] Study on catalytic asymmetric total synthesis of caprazamycin B2013
- Author(s)
  Takumi Watanabe, Purushothaman Gopinath, Takashi Masuda, Gandamala Ravi, Masakatsu Shibasaki
- Organizer
  18th European symposium on organic chemistry
- Place of Presentation
  Palais du Pharo (Marseille,France)
- Year and Date
  2013-07-08
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] Antitumor activity of new proteasome inhibitors, tyropeptin-boronic acid derivatives.2013
- Author(s)
  Isao Momose, Hikaru Abe, Takumi Watanabe, Shun-ichi Ohba, Masatomi Iijima, Yohko Yamazaki, Tohru Masuda, Akio Nomoto
- Organizer
  Ninth AACR-Japanese Cancer Association Joint Conference
- Place of Presentation
  ハイアットリージェンシーマウイ（アメリカ）
- Data Source
  KAKENHI-PROJECT-23510270
[Presentation] Study on catalytic asymmetric total synthesis of caprazamycin B2012
- Author(s)
  T akumi Watanabe, Purushothaman Gopinath, Masakatsu Shibasaki
- Organizer
  19th Intrnational conference on organic synthesis
- Place of Presentation
  Melbourne Convention & Exhibition Centre (Melbourne,Australia)
- Year and Date
  2012-07-04
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] Study on catalytic asymmetric total synthesis of caprazamycin B2012
- Author(s)
  Takumi Watanabe, Purushothaman Gopinath, Takashi Masuda, Masakatsu Shibasaki
- Organizer
  第6回武田科学振興財団薬科学シンポジウム
- Place of Presentation
  武田薬品工業㈱研修所(吹田市)
- Year and Date
  2012-09-13
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] プロテアソーム阻害剤チロぺプチンボロン酸誘導体の抗腫瘍活性2012
- Author(s)
  百瀬　功、阿部　光、渡辺　匠、大庭俊一、増田　徹、池田大四郎、赤松　穰
- Organizer
  日本薬学会
- Place of Presentation
  北海道大学、札幌
- Data Source
  KAKENHI-PROJECT-23510270
[Presentation] Antitumor effects of tyropeptin-boronic acid derivatives: New proteasome inhibitors.2011
- Author(s)
  Isao Momose, Hikaru Abe, Takumi Watanabe, Shun-ichi Ohba, Masatomi Iijima, Tohru Masuda, Akio Nomoto
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  京王プラザホテル東京、東京
- Data Source
  KAKENHI-PROJECT-23510270
[Presentation] Structure-activity relationship of tyropeptin-boronic acid derivatives: New proteasome inhibitors.2011
- Author(s)
  Hikaru Abe, Takumi Watanabe, Isao Momose, Yoshikazu Takahashi, Daishiro Ikeda, Yuzuru Akamatsu
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  京王プラザホテル東京、東京
- Data Source
  KAKENHI-PROJECT-23510270
[Presentation] Study on catalytic asymmetric total synthesis of caprazamycin B
- Author(s)
  Takumi Watanabe, Purushothaman Gopinath, Takashi Masuda, Masakatsu Shibasaki
- Organizer
  第6回武田科学技術振興財団薬科学シンポジウム
- Place of Presentation
  大阪・吹田市（武田薬品工業（株）研修所）
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] Study on catalytic asymmetric total synthesis of caprazamycin B
- Author(s)
  Takumi Watanabe, Purushothaman Gopinath, Masakatsu Shibasaki
- Organizer
  19th International Conference on Organic Synthesis
- Place of Presentation
  オーストラリア・メルボルン（Melbourne Convention & Exhibition Centre）
- Data Source
  KAKENHI-PROJECT-23590037
[Presentation] Study on Catalytic Asymmetric Total Synthesis of Caprazamycin B
- Author(s)
  Takumi Watanabe, Purushothaman Gopinath, Takashi Masuda, Gandamala Ravi, Masakatsu Shibasaki
- Organizer
  18th European Symposium on Organic Chemistry
- Place of Presentation
  Marseille (Palais du Pharo), France
- Data Source
  KAKENHI-PROJECT-23590037

1. MOMOSE Isao (10270547)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. WATANABE Takumi (80270544)

# of Collaborated Projects: 2 results

# of Collaborated Products: 13 results
3. MASUDA Toru (90165720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
4. TATSUDA Daisuke (20442569)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. OHBA Shun-ichi (00601600)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. SHIBASAKI Masakatsu (30112767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMAZAKI Yohko (80342690)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. YOSHIDA Junjiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 柴崎正勝

# of Collaborated Projects: 0 results

# of Collaborated Products: 7 results
10. GOPINATH Purushothaman

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results

Abe Hikaru 阿部 光

阿部 光 アベ ヒカル

ABE Hikaru 阿部 光

Research Projects

Research Products

Co-Researchers

Development of anticancer drug candidates from natural products target for pancreatic cancer cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Depelopment of a new anticancer drug as targeting mitochondriaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of androgen-dependent growth inhibition mechanism in prostate cancer of novel small molecule compound APA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of orally active proteasome inhibitors using in vivo imaging.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Catalytic asymmetric total synthesis of caprazamycin, an anti-tuberculosis antibiotic

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of Androprostamine A and Resormycin2016

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Journal Article] Quinofuracins A-E, produced by the fungus Staphylotrichum boninense PF1444, show p53-dependent growth suppression.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Antitumor effects of tyropeptin-boronic acid derivatives: New proteasome inhibitors.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Catalytic asymmetric total synthesis of (+)-caprazol2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Catalytic eiantioselective desymmetrization of meso-glutaric anhydrides using a stable Ni_2-Schiff base catalys2012

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Studies on Catalytic Enantioselective Total Synthesis of Caprazamycin B : Construction of the Western Zone2012

Author(s)

Journal Title

DOI

Data Source

[Presentation] がん－間質相互作用に干渉するLeucinostatin A類縁体のがん細胞増殖阻害機構2020

Author(s)

Organizer

Data Source

[Presentation] AS1936: A new inhibitor of androgen receptor function in prostate cancer2017

Author(s)

Abe Hikaru 阿部光

阿部光アベヒカル

ABE Hikaru 阿部光