Honda Hiroe 本田裕恵

… Alternative Names

本田裕恵ホンダヒロエ

HONDA Hiroe 本田裕恵

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Researcher Number	10463134
Other IDs
Affiliation (Current)	2025: 富山県薬事総合研究開発センター, その他部局等, 課長
Affiliation (based on the past Project Information) *help	2022 – 2023: 富山県薬事総合研究開発センター, その他部局等, 課長 2021: 富山県薬事総合研究開発センター, 副主幹研究員 2021: 富山県薬事総合研究開発センター, その他部局等, 副主幹研究員 2020: 富山県薬事総合研究開発センター, その他部局等, 主任研究員 2019: 富山県薬事総合研究開発センター, 創薬研究開発センター, 主任研究員 … More 2015 – 2017: 富山県薬事研究所, 主任研究員 2009: 富山県薬事研究所, 主任研究員 2008: 富山県, 薬事研究所, 主任研究員 2007: 富山県薬事研究所, 主任研究員 Less
Review Section/Research Field	Principal Investigator Basic Section 47030:Pharmaceutical hygiene and biochemistry-related / Biological pharmacy Except Principal Investigator Biological Sciences
Keywords	Principal Investigator NLRP3インフラマソーム / カンゾウ / インフラマソーム / イソリクイリチゲニン / IL-1β / Isoliquiritigenin / 線維化 / NASH / 慢性炎症 / 糖尿病 / NLRP3 … More Except Principal Investigator … More トランスジェニックマウス / I-A拘束性 / Th1抗原ペプチド / 細胞障害活性 / CD40-CD40L / アジュバント効果 / IFN--γ / 免疫学 / 癌 / 結核菌 / アジュバント活性 / IFN-γ / 抗腫瘍免疫増強 / クロスプレゼンテーション / 抗原提示細胞 / Th2 / Th1 / Peptide-25 / Ag85B Less

NLRP3インフラマソーム阻害作用を持つ天然物を活用した創薬研究への展開Principal Investigator
- Principal Investigator
  
  本田裕恵
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Toyama Prefectural Institute for Pharmaceutical Research
Research on drug development utilizing natural products with both anti-NLRP3 inflammasome and anti-fibrosis propertiesPrincipal Investigator
- Principal Investigator
  
  Honda Hiroe
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  Toyama Prefectural Institute for Pharmaceutical Research
Search for the target molecule of the licorice component inhibiting NLRP3 inflammasome and development into drug discovery researchPrincipal Investigator
- Principal Investigator
  
  HONDA Hiroe
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Toyama Prefectural Institute. for Pharmaceutical Research.
Enhancement of Th1 and antitumor immunity by Ag85B and Peptide-25.
- Principal Investigator
  
  TAKATSU Kiyoshi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Toyama
  The University of Tokyo

All 2024 2022 2021 2019 2018 2017 2016 2008

All Journal Article Presentation Book Patent

[Book] Chapter 8 Isoliquiritigenin: A unique licorice component that attenuates adipose tissue inflammation and fibrosis by targeting the innate immune sensors. In “Biological activities and action mechanisms of licorice ingredients” (ed. H. Sakagami)2017
- Author(s)
  Nagai Y, Watanabe Y, Honda H, Takatsu K
- Total Pages
  14
- Publisher
  InTech
- Data Source
  KAKENHI-PROJECT-15K07960
[Book] Chapter 30 Potential therapeutic natural products for the treatment of obesity-associated inflammation by targeting TLRs and inflammasomes. In “Chronic Inflammation-Mechanisms and Regulation-” (M. Miyasaka and K. Takatsu), pp. 379-3972016
- Author(s)
  Nagai Y, Honda H, Watanabe Y, Takatsu K.
- Total Pages
  19
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-15K07960
[Journal Article] Isoliquiritigenin inhibits <scp>NLRP3</scp> inflammasome activation with <scp>CAPS</scp> mutations by suppressing caspase‐1 activation and mutated <scp>NLRP3</scp> aggregation2024
- Author(s)
  Usui‐Kawanishi Fumitake、Kani Koudai、Karasawa Tadayoshi、Honda Hiroe、Takayama Nobuyuki、Takahashi Masafumi、Takatsu Kiyoshi、Nagai Yoshinori
- Journal Title
  
  Genes to Cells
  
  Volume: - Issue: 5 Pages: 423-431
- DOI
  10.1111/gtc.13108
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K06627, KAKENHI-PROJECT-23K07558
[Journal Article] Roles of Macrophages in Advanced Liver Fibrosis, Identified Using a Newly Established Mouse Model of Diet-Induced Non-Alcoholic Steatohepatitis2022
- Author(s)
  Tada Yuki、Kasai Kaichi、Makiuchi Nana、Igarashi Naoya、Kani Koudai、Takano Shun、Honda Hiroe、Yanagibashi Tsutomu、Watanabe Yasuharu、Usui-Kawanishi Fumitake、Furusawa Yukihiro、Ichimura-Shimizu Mayuko、Tabuchi Yoshiaki、Takatsu Kiyoshi、Tsuneyama Koichi、Nagai Yoshinori
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 21 Pages: 13251-13251
- DOI
  10.3390/ijms232113251
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05466, KAKENHI-PROJECT-22K06627, KAKENHI-PROJECT-22K07005, KAKENHI-PROJECT-22K08685
[Journal Article] Isoliquiritigenin Attenuates Adipose Tissue Inflammation and Metabolic Syndrome by Modifying Gut Bacteria Composition in Mice2022
- Author(s)
  Ishibashi Riko、Furusawa Yukihiro、Honda Hiroe、Watanabe Yasuharu、Fujisaka Shiho、Nishikawa Miyu、Ikushiro Shinichi、Kurihara Shin、Tabuchi Yoshiaki、Tobe Kazuyuki、Takatsu Kiyoshi、Nagai Yoshinori
- Journal Title
  
  Molecular Nutrition & Food Research
  
  Volume: - Issue: 10 Pages: 2101119-2101119
- DOI
  10.1002/mnfr.202101119
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07076, KAKENHI-PROJECT-19K09019, KAKENHI-PROJECT-20H03730, KAKENHI-PROJECT-20K08882, KAKENHI-PROJECT-22K07005
[Journal Article] Betulin Attenuates TGF-β1- and PGE<sub>2</sub>-Mediated Inhibition of NK Cell Activity to Suppress Tumor Progression and Metastasis in Mice2022
- Author(s)
  Ogasawara Masaru、Yamasaki-Yashiki Shino、Hamada Masahiro、Yamaguchi-Miyamoto Tomomi、Kawasuji Toru、Honda Hiroe、Yanagibashi Tsutomu、Ikutani Masashi、Watanabe Yasuharu、Fujimoto Ryota、Matsunaga Takayuki、Nakajima Noriyuki、Nagai Yoshinori、Takatsu Kiyoshi
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 45 Issue: 3 Pages: 339-353
- DOI
  10.1248/bpb.b21-00921
- NAID
  130008165815
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2022-03-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07076, KAKENHI-PROJECT-19K09019, KAKENHI-PROJECT-21K05466
[Journal Article] Bidirectional Crosstalk Between Neutrophils and Adipocytes Promotes Adipose Tissue Inflammation2019
- Author(s)
  Watanabe Y, Nagai Y, Honda H, Okamoto N, Yanagibashi T, Ogasawara M, Yamamoto S, Imamura R, Takasaki I, Hara H, Sasahara M, Arita M, Hida S, Taniguchi S, Suda T, Takatsu K.
- Journal Title
  
  FASEB J.
  
  Volume: 33(11) Issue: 11 Pages: 11821-11835
- DOI
  10.1096/fj.201900477rr
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07365, KAKENHI-PROJECT-19K07076, KAKENHI-PROJECT-19K09019, KAKENHI-PROJECT-17H04062, KAKENHI-PROJECT-17K08389
[Journal Article] Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex2017
- Author(s)
  Okamoto N, Mizote K, Honda H, Saeki A, Watanabe Y, Yamaguchi-Miyamoto T, Fukui R, Tanimura N, Motoi Y, Akashi-Takamura S, Kato T, Fujishita S, Kimura T, Ohto U, Shimizu T, Hirokawa T, Miyake K, Fukase K, Fujimoto Y, Nagai Y, Takatsu K
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 292 Issue: 37 Pages: 15378-15394
- DOI
  10.1074/jbc.m117.791780
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19532, KAKENHI-PLANNED-15H05836, KAKENHI-PUBLICLY-17H05991, KAKENHI-PROJECT-16H01885, KAKENHI-PROJECT-17H02207, KAKENHI-PROJECT-15K07960, KAKENHI-PROJECT-15K08527, KAKENHI-PROJECT-16K19596, KAKENHI-PROJECT-15K09491
[Journal Article] Eplerenone prevented obesity-induced inflammasome activation and glucose intolerance2017
- Author(s)
  Wada T, Ishikawa A, Watanabe E, Nakamura Y, Aruga Y, Hasegawa H, Onogi Y, Honda H, Nagai Y, Takatsu K, Ishii Y, Sasahara M, Koya D, Tsuneki H, Sasaoka T
- Journal Title
  
  J Endocrinol.
  
  Volume: 235 Issue: 3 Pages: 179-191
- DOI
  10.1530/joe-17-0351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15472, KAKENHI-PROJECT-17H04062, KAKENHI-PROJECT-15K07960, KAKENHI-PROJECT-15K08527
[Journal Article] Isoliquiritigenin attenuates adipose tissue inflammation in vitro and adipose tissue fibrosis through inhibition of innate immune responses in mice.2016
- Author(s)
  Watanabe Y, Nagai Y, Honda H, Okamoto N, Yamamoto S, Hamashima T, Ishii Y, Tanaka M, Suganami T, Sasahara M, Miyake, K, Takatsu K.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 23097-23097
- DOI
  10.1038/srep23097
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07960, KAKENHI-PROJECT-15K08527, KAKENHI-PROJECT-15K09423, KAKENHI-PUBLICLY-15H01371, KAKENHI-PROJECT-25870257, KAKENHI-PROJECT-25293093, KAKENHI-PROJECT-26460360
[Patent] カンゾウエキス及びその製造方法、並びに、腸内細菌調整用組成物、腸管バリア機能増強組成物、抗肥満用組成物、抗糖尿病用組成物、及びNLRP3インフラマソーム活性制御組成物2021
- Inventor(s)
  長井良憲、古澤之裕、髙津聖志、本田裕恵、他
- Industrial Property Rights Holder
  長井良憲、古澤之裕、髙津聖志、本田裕恵、他
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-178401
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-19K07076
[Presentation] イソリクイリチゲニンによる腸内細菌叢の変動を介したメタボリックシンドロームの改善2022
- Author(s)
  石橋璃子、古澤之裕、本田裕恵、渡邉康春、藤坂志帆、戸邉一之、高津聖志、栗原新、田渕圭章、長井良憲
- Organizer
  日本農芸学会2022年度
- Data Source
  KAKENHI-PROJECT-19K07076
[Presentation] イソリクイリチゲニンによる腸内細菌叢の変動を介したメタボリックシンドロームの改善2022
- Author(s)
  石橋璃子, 古澤之裕, 本田裕恵, 渡邉康春, 藤坂志帆, 戸邉一之, 高津聖志, 栗原新, 田渕圭章, 長井良憲
- Organizer
  第43回日本炎症・再生医学会
- Data Source
  KAKENHI-PROJECT-22K06627
[Presentation] イソリクイリチゲニンによる腸内細菌叢の変動を介したメタボリックシンドロームの改善2022
- Author(s)
  石橋璃子, 古澤之裕, 本田裕恵, 渡邉康春, 藤坂志帆, 戸邉一之, 高津聖志, 栗原新, 田渕圭章, 長井良憲
- Organizer
  日本薬学会第142年会大会
- Data Source
  KAKENHI-PROJECT-19K07076
[Presentation] A licorice-derived ingredient ameliorates metabolic syndrome through the alteration of gut microbiota2021
- Author(s)
  Riko Ishibashi, Yukihiro Furusawa, Hiroe Honda, Yoshinori Nagai
- Organizer
  第50回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-19K07076
[Presentation] 糖尿病モデルマウスの内臓脂肪組織に対するイソリクイリチゲニンの抗炎症・抗線維化作用の解析2018
- Author(s)
  本田裕恵, 渡邉康春, 長井良憲, 松永孝之, 岡本直樹, 平井嘉勝, 高津聖志
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-15K07960
[Presentation] Agonistic effects of synthetic derivatives of funiculosin on mouse/human TLR4/MD-22016
- Author(s)
  Okamoto N, Honda H, Akashi-Takamura S, Nagai Y, Takatsu K
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県・宜野湾市）
- Data Source
  KAKENHI-PROJECT-15K07960
[Presentation] 天然薬物イソリクイリチゲニンは自然免疫系に作用し、内臓脂肪組織の線維化を抑制する2016
- Author(s)
  渡邉康春, 長井良憲, 本田裕恵, 高津聖志
- Organizer
  第37回日本肥満学会
- Place of Presentation
  東京ファッションタウン(東京都・江東区）
- Data Source
  KAKENHI-PROJECT-15K07960
[Presentation] 甘草成分イソリクイリチゲニンは内臓脂肪組織の炎症・線維化を抑制する2016
- Author(s)
  本田裕恵, 渡邉康春, 長井良憲, 松永孝之, 岡本直樹, 平井嘉勝, 高津聖志
- Organizer
  日本生薬学会第63回年会
- Place of Presentation
  富山国際会議場（富山県・富山市）
- Data Source
  KAKENHI-PROJECT-15K07960
[Presentation] 甘草成分イソリクイリチゲニンはNLRP3インフラマソーム活性化を阻害し、2型糖尿病の慢性炎症を改善する2016
- Author(s)
  本田裕恵, 長井良憲, 松永孝之, 岡本直樹, 渡邉康春, 常山幸一, 林宏明, 藤井勲, 平井嘉勝, 高津聖志
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-29
- Data Source
  KAKENHI-PROJECT-15K07960
[Presentation] Search for a natural product that regulates innate immunity via TLRs2008
- Author(s)
  Honda, H., et.al.
- Organizer
  38^<th> Japanese Society for Immunology
- Place of Presentation
  Kyoto
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-17013024

1. NAGAI Yoshinori (30431761)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
2. TAKATSU Kiyoshi (10107055)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KARIYONE Ai (50114450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. IKUTANI Masashi (40513718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TAMURA Toshiki (40291306)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 渡邉康春

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 高崎一朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 古家大祐

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 柳橋努

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Honda Hiroe 本田 裕恵

本田 裕恵 ホンダ ヒロエ

HONDA Hiroe 本田 裕恵

Research Projects

Research Products

Co-Researchers

NLRP3インフラマソーム阻害作用を持つ天然物を活用した創薬研究への展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research on drug development utilizing natural products with both anti-NLRP3 inflammasome and anti-fibrosis propertiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for the target molecule of the licorice component inhibiting NLRP3 inflammasome and development into drug discovery researchPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Enhancement of Th1 and antitumor immunity by Ag85B and Peptide-25.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] Chapter 8 Isoliquiritigenin: A unique licorice component that attenuates adipose tissue inflammation and fibrosis by targeting the innate immune sensors. In “Biological activities and action mechanisms of licorice ingredients” (ed. H. Sakagami)2017

Author(s)

Total Pages

Publisher

Data Source

[Book] Chapter 30 Potential therapeutic natural products for the treatment of obesity-associated inflammation by targeting TLRs and inflammasomes. In “Chronic Inflammation-Mechanisms and Regulation-” (M. Miyasaka and K. Takatsu), pp. 379-3972016

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Isoliquiritigenin inhibits <scp>NLRP3</scp> inflammasome activation with <scp>CAPS</scp> mutations by suppressing caspase‐1 activation and mutated <scp>NLRP3</scp> aggregation2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Roles of Macrophages in Advanced Liver Fibrosis, Identified Using a Newly Established Mouse Model of Diet-Induced Non-Alcoholic Steatohepatitis2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isoliquiritigenin Attenuates Adipose Tissue Inflammation and Metabolic Syndrome by Modifying Gut Bacteria Composition in Mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Betulin Attenuates TGF-β1- and PGE<sub>2</sub>-Mediated Inhibition of NK Cell Activity to Suppress Tumor Progression and Metastasis in Mice2022

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Bidirectional Crosstalk Between Neutrophils and Adipocytes Promotes Adipose Tissue Inflammation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Funiculosin variants and phosphorylated derivatives promote innate immune responses via the Toll-like receptor 4/myeloid differentiation factor-2 complex2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Eplerenone prevented obesity-induced inflammasome activation and glucose intolerance2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isoliquiritigenin attenuates adipose tissue inflammation in vitro and adipose tissue fibrosis through inhibition of innate immune responses in mice.2016

Honda Hiroe 本田裕恵

本田裕恵ホンダヒロエ

HONDA Hiroe 本田裕恵