TADA Masayoshi 他田正義

Researcher Number	10467079
Affiliation (based on the past Project Information) *help	2017: 新潟大学, 脳研究所, 講師 2011 – 2016: 新潟大学, 脳研究所, 助教
Review Section/Research Field	Principal Investigator Neurology Except Principal Investigator Neurology
Keywords	Principal Investigator ポリグルタミン病 / 脊髄小脳変性症 / 評価法 / 小脳性運動失調 / 臨床評価法 / 治療薬開発 / 治療 / 重合体 / 治療法開発 / 脳神経疾患 … More / 定量評価法 / モデル線虫 / oligomer / therapy / polyglutamine disease / ataxia / SCD / 重合体形成 / 新規治療法 / 小脳機能評価法 … More Except Principal Investigator 神経変性 / 重合体 / ポリグルタミン病 / SDD-AGE / C.elegans / DRPLA / oligomer / polyglutamine Less

重合体形成阻害を標的としたポリグルタミン病の新規治療法開発Principal Investigator
- Principal Investigator
  
  他田正義
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Developing new therapeutic drugs that inhibit oligomer formation of polyglutamine disease proteins based on the hypothesis of oligomer toxicity in polyglutamine diseasesPrincipal Investigator
- Principal Investigator
  
  Tada Masayoshi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Polyglutamine oligomers in human brain play a crucial role in the pathogenesis of polyglutamine diseases.
- Principal Investigator
  
  TAKAHASHI Toshiaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Niigata University
Toward developing novel therapeutic drugs that suppress oligomerization ofdisease-causing proteins in poluglutamine diseasesPrincipal Investigator
- Principal Investigator
  
  TADA Masayoshi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Niigata University

All 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

[Book] Pathologies of calcium channels; Chapter 28, IP3 Receptors in Neurodegenerative Disorders: Spinocerebellar Ataxias and Huntington’s and Alzheimer’s Diseases2014
- Author(s)
  Tada M, Nishizawa M, and Onodera O
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-25461272
[Book] アクチュアル脳・神経疾患の臨床；小脳と運動失調：劣性遺伝性小脳失調症2013
- Author(s)
  他田正義
- Total Pages
  336
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-23790982
[Book] 劣性遺伝性小脳失調症.小脳と運動失調:小脳はなにをしているのか2013
- Author(s)
  他田正義,小野寺理
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-23790982
[Book] IP3 Receptors in Neurodegenerative Disorders: Spinocerebellar Ataxias and Huntington's and Alzheimer's Diseases. In Pathologies of Calcium Channels
- Author(s)
  Tada M, Nishizawa M, and Onodera M
- Publisher
  Springer(in press)
- Data Source
  KAKENHI-PROJECT-23790982
[Journal Article] 【遺伝性脊髄小脳失調症の病態と治療展望】本邦における遺伝性脊髄小脳変性症の全体像.2017
- Author(s)
  他田正義, 横関明男, 小野寺理.
- Journal Title
  
  Brain Nerve
  
  Volume: 69 Pages: 879-890
- Data Source
  KAKENHI-PROJECT-16K09670
[Journal Article] 【脊髄小脳変性症(SCD)-最新診療マニュアル】治療と介護の現状　パーキンソニズム.2017
- Author(s)
  他田正義, 小野寺理.
- Journal Title
  
  Clinical Neuroscience
  
  Volume: 35 Pages: 1097-1100
- Data Source
  KAKENHI-PROJECT-16K09670
[Journal Article] 高齢者における小脳失調症に対する診断アプローチ2016
- Author(s)
  高橋茉那, 他田正義, 下畑享良, 西澤正豊.
- Journal Title
  
  Geriat Med
  
  Volume: 54 Pages: 217-223
- Data Source
  KAKENHI-PROJECT-16K09670
[Journal Article] Roles of inositol 1,4,5-trisphosphate receptors in spinocerebellar ataxias.2016
- Author(s)
  Tada M, Nishizawa M, Onodera O.
- Journal Title
  
  Neurochem Int.
  
  Volume: 94 Pages: 1-8
- DOI
  10.1016/j.neuint.2016.01.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-26117006, KAKENHI-PROJECT-25461272, KAKENHI-PROJECT-16K09670
[Journal Article] 小脳症状をどう捉えるか　小脳機能に基づく小脳症状の再構築2016
- Author(s)
  他田正義, 西澤正豊, 小野寺理.
- Journal Title
  
  MDSJ Letters
  
  Volume: 9 Pages: 4-5
- Data Source
  KAKENHI-PROJECT-16K09670
[Journal Article] 高齢者における小脳失調症に対する診断アプローチ2016
- Author(s)
  高橋茉那, 他田正義, 下畑享良, 西澤正豊
- Journal Title
  
  Geriat Med
  
  Volume: 54 Pages: 217-223
- Data Source
  KAKENHI-PROJECT-25461272
[Journal Article] 小脳症状をどう捉えるか：小脳機能に基づく小脳症状の再構築2016
- Author(s)
  他田正義, 西澤正豊, 小野寺理
- Journal Title
  
  MDSJ Letters
  
  Volume: 9(1) Pages: 4-5
- Data Source
  KAKENHI-PROJECT-25461272
[Journal Article] Redefining cerebellar ataxia in degenerative ataxias: lessons from recent research on cerebellar systems.2015
- Author(s)
  Tada M, Nishizawa M, Onodera O
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: - Issue: 8 Pages: 922-928
- DOI
  10.1136/jnnp-2013-307225
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25461272, KAKENHI-PLANNED-26117006
[Journal Article] A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease.2014
- Author(s)
  Tamiya G, Makino S, Hayashi M, Abe A, Numakura C, Ueki M, Tanaka A, Ito C, Toshimori K, Ogawa N, Terashima T, Maegawa H, Yanagisawa D, Tooyama I, Tada M, Onodera O, Hayasaka K.
- Journal Title
  
  Am J Hum Genet
  
  Volume: 95(3) Pages: 294-300
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461272
[Journal Article] セナタキシン欠損症2014
- Author(s)
  他田正義，西澤正豊
- Journal Title
  
  神経症候群（第2版）
  
  Volume: 27 Pages: 389-393
- Data Source
  KAKENHI-PROJECT-25461272
[Journal Article] Hereditary Diffuse Leukoencephalopathy with Spheroids (HDLS): A Review of the Literature on its Clinical Characteristics and Mutations in the Colony-Stimulating Factor-1 Receptor Gene.2014
- Author(s)
  Konno T, Tada M, Tada M, Nishizawa M, Ikeuchi T.
- Journal Title
  
  Brain Nerve
  
  Volume: 66 Pages: 581-590
- NAID
  40020089061
- Data Source
  KAKENHI-PROJECT-25461272
[Journal Article] Progressive myoclonus epilepsy: extraneuronal brown pigment deposition and system neurodegeneration in the brains of Japanese patients with novel SCARB2 mutations2013
- Author(s)
  Fu YJ, Aida I, Tada M, Tada M, Toyoshima Y, Takeda S, Nakajima T, Naito H, Nishizawa M, Onodera O, Kakita A, and Takahashi H
- Journal Title
  
  Neuropathol Appl Neurobiol
  
  Volume: doi:10.1111/nan.12057. Pages: 12057-12057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461272
[Journal Article] 【小脳の神経学】治療研究に向けた小脳機能評価法の将来2013
- Author(s)
  徳永純, 他田正義, 永井貴大, 西澤正豊, 小野寺理
- Journal Title
  
  神経内科
  
  Volume: 78 Pages: 687-694
- Data Source
  KAKENHI-PROJECT-25461272
[Journal Article] Coexistence of Huntington's disease and amyotrophic lateral sclerosis: a clinicopathologic study2012
- Author(s)
  Tada M, Coon EA, Osmand AP, Kirby PA, Martin W, Wieler M, Shiga A, Shirasaki H, Tada M, Makifuchi T, Yamada M, Kakita A, Nishizawa M, Takahashi H, Paulson HL
- Journal Title
  
  Acta Neuropathol.
  
  Volume: 124 Pages: 749-760
- Data Source
  KAKENHI-PROJECT-23790982
[Journal Article] Coexistence of Huntington's disease and amyotrophic lateral sclerosis: a clinicopathologic study.2012
- Author(s)
  Tada M, Coon EA, Osmand AP, Kirby PA, Martin W, Wieler M, Shiga A, Shirasaki H, Tada M, Makifuchi T, Yamada M, Kakita A, Nishizawa M, Takahashi H, Paulson HL.
- Journal Title
  
  Acta Neuropathol
  
  Volume: 124 Pages: 749-760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790982
[Journal Article] Genotype-phenotype correlations in early onsetataxia with ocular motor apraxia andhypoalbuminaemia2011
- Author(s)
  Yokoseki A, Ishihara T, Koyama A, Shiga A,Yamada M, Suzuki C, Sekijima Y, Maruta K,Tsuchiya M, Date H, Sato T, Tada M, Ikeuchi T,Tsuji S, Nishizawa M, Onodera O
- Journal Title
  
  Brain
  
  Volume: 134 Pages: 1387-1399
- Data Source
  KAKENHI-PROJECT-23790982
[Presentation] iPatax: iPad Application Software for Evaluating Ataxia.2017
- Author(s)
  Takahiro Nagai, Masayoshi Tada, Jun Tokunaga, Osamu Onodera.
- Organizer
  World Congress of Neurology 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09670
[Presentation] 脊髄小脳変性症に対するバレニクリン酒石酸塩の治療効果の検討2016
- Author(s)
  他田正義，徳永純，徳武孝允，石原智彦，小野寺理，西澤正豊.
- Organizer
  第34回日本神経治療学会総会
- Place of Presentation
  米子コンベンションセンター（鳥取県米子市）
- Data Source
  KAKENHI-PROJECT-16K09670
[Presentation] 脊髄小脳変性症に対するバレニクリン酒石酸塩の治療効果の検討2016
- Author(s)
  他田正義，徳永純，徳武孝允，石原智彦，野崎洋明，関根有美，堅田慎一，横関明男，小野寺理，西澤正豊.
- Organizer
  第57回日本神経学会学術大会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09670
[Presentation] 小脳症状をどう捉えるか：小脳機能に基づく小脳症状の再構築2015
- Author(s)
  他田正義, 小野寺理, 西澤正豊
- Organizer
  第9回パーキンソン病・運動障害疾患コングレス
- Place of Presentation
  品川プリンスホテル（東京都品川区）
- Year and Date
  2015-10-15
- Invited
- Data Source
  KAKENHI-PROJECT-25461272
[Presentation] Kinect を用いた3次元歩行解析システムによる小脳性歩行障害の解析2015
- Author(s)
  他田正義, 徳永純, 小野寺理, 西澤正豊
- Organizer
  第56回日本神経学会学術大会
- Place of Presentation
  朱鷺メッセ（新潟県新潟市）
- Year and Date
  2015-05-20
- Data Source
  KAKENHI-PROJECT-25461272
[Presentation] iPatax：小脳性運動失調の新たな定量評価法．2014
- Author(s)
  徳永純，他田正義，永井貴大，小野寺理，西澤正豊．
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-05-21
- Data Source
  KAKENHI-PROJECT-25461272
[Presentation] SCARB2変異を認めた進行性ミオクローヌスてんかん 2剖検例の臨床病理・生化学的解析．2014
- Author(s)
  他田正義，付永娟，会田泉，他田真理，武田茂樹，豊島靖子，中島孝，内藤明彦，高橋均，小野寺理，西澤正豊．
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡国際会議場
- Year and Date
  2014-05-21
- Data Source
  KAKENHI-PROJECT-25461272
[Presentation] iPatax: A new method for quantitative assessment for motor coordination of ataxia.2014
- Author(s)
  Tada M, Tokunaga J, Nagai T, Nishizawa M, Onodera O.
- Organizer
  AAN Annual Meeting 2014
- Place of Presentation
  Philadelphia, PA
- Year and Date
  2014-05-01
- Data Source
  KAKENHI-PROJECT-25461272
[Presentation] 等速直線運動の速度変動に着手した小脳性運動失調の新たな定量評価法2013
- Author(s)
  徳永純，他田正義，永井貴大，小野寺理，西澤正豊
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25461272
[Presentation] ロシア・ヤクート人との比較によるSCA1発症に関わる環境・遺伝学的要因の検討2012
- Author(s)
  他田正義，ほか
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-23790982
[Presentation] ロシア・ヤクート人との比較によるSCA1発症に関わる環境・遺伝学的要因の検討2012
- Author(s)
  他田正義,徳永純,Maksimova N, Varlamova M,堅田慎一,高橋俊昭, Nikolaeva I, Sukhomyasova A,土屋美由紀,池内健,小寺理,西澤正豊
- Organizer
  日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23790982
[Presentation] ポリグルタミン重合体形成阻害剤のスクリーニングを目的としたモデル線虫の構築2012
- Author(s)
  徳永純,他田正義,高橋俊昭,高橋有香,鹿野智美,小山哲秀,堅田慎一,山中邦俊,小野寺理,西澤正豊
- Organizer
  日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23790982
[Presentation] ポリグルタミン重合体形成阻害剤のスクリーニングを目的としたモデル線虫の構築2012
- Author(s)
  徳永純，他田正義，ほか
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム
- Data Source
  KAKENHI-PROJECT-23790982
[Presentation] ヒト疾患脳におけるポリグルタミン病重合体の検出2011
- Author(s)
  高橋俊昭,石平悠,堅田慎一,他田正義,他田真理,佐藤俊哉,柿田明美,高橋均,小野寺理,西澤正豊
- Organizer
  日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23790982
[Presentation] 重合体形成阻害を標的としたポリグルタミン病の新規治療法開発2011
- Author(s)
  他田正義,高橋俊昭,小野寺理,西澤正豊,Paulson Henry L
- Organizer
  日本神経学会学術大会
- Data Source
  KAKENHI-PROJECT-23790982

1. Onodera Osamu (20303167)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
2. TAKAHASHI Toshiaki (70377191)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KATADA Shinnichi (70599167)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TADA Masayoshi 他田 正義

Research Projects

Research Products

Co-Researchers

重合体形成阻害を標的としたポリグルタミン病の新規治療法開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Developing new therapeutic drugs that inhibit oligomer formation of polyglutamine disease proteins based on the hypothesis of oligomer toxicity in polyglutamine diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Polyglutamine oligomers in human brain play a crucial role in the pathogenesis of polyglutamine diseases.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Toward developing novel therapeutic drugs that suppress oligomerization ofdisease-causing proteins in poluglutamine diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] Pathologies of calcium channels; Chapter 28, IP3 Receptors in Neurodegenerative Disorders: Spinocerebellar Ataxias and Huntington’s and Alzheimer’s Diseases2014

Author(s)

Publisher

Data Source

[Book] アクチュアル脳・神経疾患の臨床；小脳と運動失調：劣性遺伝性小脳失調症2013

Author(s)

Total Pages

Publisher

Data Source

[Book] 劣性遺伝性小脳失調症.小脳と運動失調:小脳はなにをしているのか2013

Author(s)

Publisher

Data Source

[Book] IP3 Receptors in Neurodegenerative Disorders: Spinocerebellar Ataxias and Huntington's and Alzheimer's Diseases. In Pathologies of Calcium Channels

Author(s)

Publisher

Data Source

[Journal Article] 【遺伝性脊髄小脳失調症の病態と治療展望】 本邦における遺伝性脊髄小脳変性症の全体像.2017

Author(s)

Journal Title

Data Source

[Journal Article] 【脊髄小脳変性症(SCD)-最新診療マニュアル】 治療と介護の現状 パーキンソニズム.2017

Author(s)

Journal Title

Data Source

[Journal Article] 高齢者における小脳失調症に対する診断アプローチ2016

Author(s)

Journal Title

Data Source

[Journal Article] Roles of inositol 1,4,5-trisphosphate receptors in spinocerebellar ataxias.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 小脳症状をどう捉えるか 小脳機能に基づく小脳症状の再構築2016

Author(s)

Journal Title

Data Source

[Journal Article] 高齢者における小脳失調症に対する診断アプローチ2016

Author(s)

Journal Title

Data Source

[Journal Article] 小脳症状をどう捉えるか：小脳機能に基づく小脳症状の再構築2016

Author(s)

Journal Title

Data Source

[Journal Article] Redefining cerebellar ataxia in degenerative ataxias: lessons from recent research on cerebellar systems.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease.2014

TADA Masayoshi 他田正義

[Journal Article] 【遺伝性脊髄小脳失調症の病態と治療展望】本邦における遺伝性脊髄小脳変性症の全体像.2017

[Journal Article] 【脊髄小脳変性症(SCD)-最新診療マニュアル】治療と介護の現状　パーキンソニズム.2017

[Journal Article] 小脳症状をどう捉えるか　小脳機能に基づく小脳症状の再構築2016

[Journal Article] 【小脳の神経学】治療研究に向けた小脳機能評価法の将来2013