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Kumagai Kenichi  熊谷 賢一

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KUMAGAI Kenichi  熊谷 賢一

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Researcher Number 10518129
Other IDs
Affiliation (Current) 2022: 東京大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help 2020 – 2022: 東京大学, 医学部附属病院, 助教
2011 – 2019: 鶴見大学, 歯学部, 助教
Review Section/Research Field
Principal Investigator
Surgical dentistry / Basic Section 57060:Surgical dentistry-related
Except Principal Investigator
Basic Section 57060:Surgical dentistry-related / Surgical dentistry / Social dentistry / Basic Section 57020:Oral pathobiological science-related
Keywords
Principal Investigator
T細胞受容体 / 口腔がん / 口腔粘膜 / 白板症 / 癌化 / 癌幹細胞 / 口腔粘膜疾患 / ErbB family gene / 口腔白板症 / 口腔扁平苔癬 … More / 口腔癌 / 前癌病変 / EGFR / 上皮増殖因子 / 網羅的 T 細胞受容体 / サイトケラチン / TCR / 金属アレルギー / 経口免疫寛容 / 免疫チェックポイント阻害剤 / ネオエピトープ … More
Except Principal Investigator
TCR / T細胞受容体 / 菌叢解析 / 腸内細菌叢 / 腸管免疫応答 / 変形性顎関節症 / STR/Ortマウス / 顎関節OA / STR/Ort マウス / 免疫学 / 実験動物学 / 臨床免疫学 / マーモセット / 免疫 / MHC classⅡ / う蝕モデル / アマルガム / サイトカイン / MHC / チタンアレルギー / NK T細胞 / MAIT細胞 / 金属アレルギー / 唾液腺摘出 / 組織学的変化 / 絨毛 / 唾液 / 口腔がん / ネオアンチゲン / 網羅的T細胞受容体解析 / 口腔癌 / T細胞受容体 / 完全個別化医療 / PARP阻害剤 / 化学療法誘発粘膜炎 / 薬剤関連顎骨壊死 / 口腔内細菌叢 Less
  • Research Projects

    (11 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (14 People)
  •  免疫統合オミックス解析を用いた口腔がん免疫療法の予後予測モデルの構築Principal Investigator

    • Principal Investigator
      熊谷 賢一
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      The University of Tokyo
  •  免疫変調をきたす腸内細菌叢の制御による顎骨壊死に対する治療法の開発

    • Principal Investigator
      佐藤 光一郎
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Tsurumi University
  •  Basic research of PARP inhibitor effects for chemotherapy induced mucositis

    • Principal Investigator
      藤原 久子
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Tsurumi Junior College
  •  Basic research on novel therapeutic strategies for metal allergy with oral tolerancePrincipal Investigator

    • Principal Investigator
      熊谷 賢一
    • Project Period (FY)
      2019 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      The University of Tokyo
      Tsurumi University
  •  Investigation of saliva effect on intestinal immune response based on intestinal flora analysis

    • Principal Investigator
      Kawaguchi Kouji
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 57020:Oral pathobiological science-related
    • Research Institution
      Tsurumi University
  •  Exploring of neoantigen and immune response in Patients with Oral Cancer

    • Principal Investigator
      HAMADA YOSHIKI
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Tsurumi University
  •  Immunological analysis of pathogenesis and immune response in titanium allergy

    • Principal Investigator
      HAMADA Yoshiki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Tsurumi University
  •  Establishment of early diagnosis and immunological oral cancerPrincipal Investigator

    • Principal Investigator
      KUMAGAI Kenichi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Tsurumi University
  •  Immunoligical research of dental amalgam using the common marmoset

    • Principal Investigator
      SUZUKI Ryuji
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Social dentistry
    • Research Institution
      Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital
  •  Spontaneously developed osteoarthritis in the temporomandibular joint in STR/ort mice

    • Principal Investigator
      HAMADA Yoshiki
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Tsurumi University
  •  The analysis of the carcinogenesis and aquired immunity in the oral mucosa lesionPrincipal Investigator

    • Principal Investigator
      KUMAGAI Kenichi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Tsurumi University

All 2021 2020 2019 2018 2017 2016 2014 2013 2012 2011 Other

All Journal Article Presentation Book

  • [Book] 金属アレルギー発症モデルマウスによる病態解明と新規診断・治療法への可能性2021

    • Author(s)
      熊谷 賢一, 松原 陵太, 濱田 良樹, 鈴木 隆二
    • Total Pages
      5
    • Publisher
      アレルギーの臨床
    • Data Source
      KAKENHI-PROJECT-19K10371
  • [Journal Article] Clonal Expansion of Tumor-Infiltrating T Cells and Analysis of the Tumor Microenvironment within Esophageal Squamous Cell Carcinoma Relapsed after Definitive Chemoradiation Therapy2021

    • Author(s)
      Mori Takahiro、Kumagai Kenichi、Nasu Keisuke、Yoshizawa Takamasa、Kuwano Koji、Hamada Yoshiki、Kanazawa Hideki、Suzuki Ryuji
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Pages: 1098-1098

    • DOI

      10.3390/ijms22031098

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H03008
  • [Journal Article] Cross-Reactivity of Palladium in a Murine Model of Metal-induced Allergic Contact Dermatitis2020

    • Author(s)
      Shigematsu Hiroaki、Kumagai Kenichi、Suzuki Motoaki、Eguchi Takanori、Matsubara Ryota、Nakasone Yasunari、Nasu Keisuke、Yoshizawa Takamasa、Ichikawa Haruno、Mori Takahiro、Hamada Yoshiki、Suzuki Ryuji
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Pages: 4061-4061

    • DOI

      10.3390/ijms21114061

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K10371, KAKENHI-PROJECT-19K18980
  • [Journal Article] A Case of Focal Osteoporotic Bone Marrow Defect of the Mandible2020

    • Author(s)
      馬杉亮彦, 江口貴紀, 宮田幸長, 熊谷賢一, 雨宮剛志, 重松宏昭, 中島敏文, 齋藤知之, 濱田良樹
    • Journal Title

      Japanese Journal of Oral Diagnosis / Oral Medicine

      Volume: 33 Issue: 1 Pages: 15-19

    • DOI

      10.15214/jsodom.33.15

    • NAID

      130007806280

    • ISSN
      0914-9694, 2188-2843
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K09543
  • [Journal Article] Characterization of T cell receptors in a novel murine model of nickel-induced intraoral metal contact allergy.2018

    • Author(s)
      Nakasone Y, Kumagai K, Matsubara R, Shigematsu H, Kitaura K, Suzuki S, Satoh M, Hamada Y, and Suzuki R.
    • Journal Title

      PLoS One

      Volume: 13

    • DOI

      10.1371/journal.pone.0209248

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08791, KAKENHI-PROJECT-18K09543, KAKENHI-PROJECT-16K21347
  • [Journal Article] Possible involvement of invariant natural killer T cells and mucosal-associated invariant T cells in a murine model of titanium allergy2018

    • Author(s)
      Kenichi Kumagai, Ryota Matsubara, Yasunari Nakasone, Hiroaki Shigematsu, Kazutaka Kitaura, Satsuki Suzuki, Yoshiki Hamada, and Ryuji Suzuki
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: 30 Pages: 1-9

    • DOI

      10.1016/j.ajoms.2017.08.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K11329
  • [Journal Article] Possible Immune Regulation of Natural Killer T Cells in a Murine Model of Metal Ion-Induced Allergic Contact Dermatitis2016

    • Author(s)
      Kumagai K, Horikawa T, Shigematsu H, Matsubara R, Kitaura K, Eguchi T, Kobayashi H, Nakasone Y, Sato K, Yamada H, Suzuki S, Hamada Y, Suzuki R.
    • Journal Title

      Int J Mol Sci.

      Volume: 12

    • DOI

      10.3390/ijms17010087

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K11329, KAKENHI-PROJECT-26861702, KAKENHI-PROJECT-25871220
  • [Journal Article] Clinicopathological significance and prognostic value of CD133 expression in oral squamous cell carcinoma2014

    • Author(s)
      Keisuke Fujii, Kenichi Kumagai, Ryuji Suzuki, Yoshiki Hamada
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine and Pathology

      Volume: in press

    • DOI

      10.1016/j.ajoms.2014.02.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23792391
  • [Journal Article] Spontaneously developed osteoarthritis in the temporomandibular joint in STR/ort mice International Journal of Oral & Maxillofacial Surgery2014

    • Author(s)
      Kenichi Kumagai, Satsuki Suzuki, Kanri, Yoriaki, Keisuke Fujii, Masahiro Wake, Ryuji Suzuki, and Yoshiki Hamada
    • Volume
      (in submission)
    • Data Source
      KAKENHI-PROJECT-23593004
  • [Journal Article] Clinicopathological significance and prognostic value of CD133 expression in oral squamous cell carcinoma Journal of Oral and Maxillofacial Surgery2014

    • Author(s)
      Keisuke Fujii, Kenichi Kumagai, Ryuji Suzuki, Yoshiki Hamada
    • Journal Title

      Medicine and Pathology

      Volume: (in press)

    • Data Source
      KAKENHI-PROJECT-23792391
  • [Journal Article] Up regulation of epidermal growth factor receptor 4 in oral leukoplakia2013

    • Author(s)
      Hiroshi Kobayashi, Kenichi Kumagai, Akito Gotoh, Takanori Eguchi, Hiroyuki Yamada, Yoshiki Hamada, Satsuki Suzuki, Ryuji Suzuki
    • Journal Title

      International Journal of Oral Science

      Volume: 5(1) Pages: 14-20

    • Data Source
      KAKENHI-PROJECT-23792391
  • [Journal Article] Immune-related gene expression profile in laboratory common marmosets assessed by an accurate quantitative real-time PCR using selected reference genes.2013

    • Author(s)
      Fujii Y
    • Journal Title

      PLoS One.

      Volume: 8

    • DOI

      10.1371/journal.pone.0056296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22380172, KAKENHI-PROJECT-22390093, KAKENHI-PROJECT-22500391, KAKENHI-PROJECT-24300155, KAKENHI-PROJECT-24593183, KAKENHI-PROJECT-24790454, KAKENHI-PLANNED-22133002
  • [Journal Article] Upregulation of epidermal growth factor receptor 4 in oral leukoplakia.2013

    • Author(s)
      Kobayashi H, Kumagai K, Gotoh A, Eguchi T, Yamada H, Hamada Y, Suzuki S, Suzuki R.
    • Journal Title

      International Journal of Oral Science

      Volume: 5 Pages: 14-20

    • DOI

      10.1038/ijos.2013.10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23792391
  • [Presentation] パラジウムアレルギー交差反応マウスモデルにおけるT 細胞免疫応答の解明について2021

    • Author(s)
      重松宏昭, 熊谷賢一,江口貴紀,松原陵太,仲宗根康成,那須啓佑,吉澤孝昌,馬杉亮彦,鈴木隆二,濱田良樹
    • Organizer
      第66回公益社団法人 日本口腔外科学会総会・学術大会
    • Data Source
      KAKENHI-PROJECT-19K10371
  • [Presentation] 自然リンパ球を介したチタンアレルギー免疫応答の解明2021

    • Author(s)
      熊谷賢一, 松原陵太, 仲宗根康成, 那須啓佑, 吉澤孝昌, 江口貴紀, 森隆弘, 鈴木隆二, 濱田良樹
    • Organizer
      第66回公益社団法人 日本口腔外科学会総会・学術大会
    • Data Source
      KAKENHI-PROJECT-19K10371
  • [Presentation] 異種金属間における口腔粘膜金属アレルギー交叉反応の免疫学的解析2019

    • Author(s)
      松原 陵太, 熊谷 賢一, 仲宗根 康成, 江口 貴紀, 重松 宏昭, 北條 秀樹, 吉澤 孝昌, 今村 栄作, 鈴木 隆二, 濱田 良樹
    • Organizer
      第64回公益社団法人 日本口腔外科学会総会・学術大会
    • Data Source
      KAKENHI-PROJECT-19K10371
  • [Presentation] 輝度比を用いた客観的蛍光観察法による上皮性異形成の検出精度2019

    • Author(s)
      中村那々美, 川口浩司, 藤原久子, 長谷部充彦, 岸悠太, 安川仁章, 熊谷賢一, 雨宮剛志, 濱田良樹
    • Organizer
      第43回日本頭頸部癌学会
    • Data Source
      KAKENHI-PROJECT-18K09543
  • [Presentation] ErbB4は口腔扁平上皮癌における頸部リンパ節転移の危険因子である2018

    • Author(s)
      熊谷賢一, 大橋祥浩, 中村那々美, 仲宗根 康成, 市川はるの, 川口浩司, 堀江彰久, 鈴木隆二, 濱田良樹
    • Organizer
      第63回日本口腔外科学会総会・学術大会
    • Data Source
      KAKENHI-PROJECT-18H03008
  • [Presentation] ErbB4は口腔扁平上皮癌における頸部リンパ節転移の危険因子である2018

    • Author(s)
      熊谷賢一、大橋祥浩、中村那々美、仲宗根 康成、市川はるの、川口浩司、堀江彰久、鈴木隆二、濱田良樹
    • Organizer
      第63回日本口腔外科学会総会・学術大会
    • Data Source
      KAKENHI-PROJECT-18K09543
  • [Presentation] 輝度比を用いた客観的蛍光観察法による上皮性異形成の検出精度2018

    • Author(s)
      中村那々美, 川口浩司, 藤原久子, 長谷部充彦, 熊谷賢一, 濱田良樹
    • Organizer
      第72回NPO法人日本口腔科学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K09543
  • [Presentation] チタンアレルギー発症に関与する T細胞の解明について2017

    • Author(s)
      熊谷賢一, 松原陵太, 重松宏昭, 仲宗根康成, 鈴木隆二, 濱田良樹
    • Organizer
      第71回 NPO法人日本口腔科学会学術集会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2017-04-27
    • Data Source
      KAKENHI-PROJECT-15K11329
  • [Presentation] チタンアレルギー発症に関与するT細胞の解明について2017

    • Author(s)
      熊谷賢一, 松原陵太, 重松宏昭, 仲宗根康成, 鈴木隆二, 濱田良樹
    • Organizer
      第71回NPO法人日本口腔科学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K20570
  • [Presentation] チタンアレルギー発症に関与するT細胞の解明について2017

    • Author(s)
      熊谷賢一, 松原陵太, 重松宏昭, 仲宗根康成, 鈴木隆二, 濱田良樹
    • Organizer
      第71回NPO法人日本口腔科学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K11329
  • [Presentation] 口腔扁平上皮癌におけるCD44およびCD133発現と頸部リンパ節転移に関する臨床病理学的検討2014

    • Author(s)
      熊谷賢一, 藤井惠介, 重松宏昭, 中岡雅典, 安川仁章, 川口浩司, 山田浩之, 鈴木隆二, 濱田良樹
    • Organizer
      第68回NPO法人日本口腔科学会学術集会
    • Year and Date
      2014-05-08
    • Data Source
      KAKENHI-PROJECT-23792391
  • [Presentation] Clinicopathological significance and prognostic value of CD133 expression in oral squamous cell carcinoma 642014

    • Author(s)
      Kenichi Kumagai, Tsuyoshi Amemiya, Koji Kawaguchi, Ryuji Suzuki, Keisuke Fujii, Hiroaki Shigematsu, Hiroyuki Yamada, Yoshiki Hamada
    • Organizer
      Kongress der Deutschen Gesellschaft für Mund-, Kiefer- und Gesichtschirurgie
    • Place of Presentation
      Maintz, Germany
    • Data Source
      KAKENHI-PROJECT-23792391
  • [Presentation] 口腔扁平上皮癌におけるCD133の発現と頸部リンパ節転移に関する臨床病理学的検討2013

    • Author(s)
      藤井惠介, 熊谷賢一, 重松宏昭, 中岡雅典, 清水一, 馬杉亮彦, 川口浩司, 山田浩之, 鈴木隆二, 濱田良樹
    • Organizer
      第58回(公社)日本口腔外科学会総会・学術大会
    • Year and Date
      2013-10-11
    • Data Source
      KAKENHI-PROJECT-23792391
  • [Presentation] 口腔癌の頚部リンパ節転移における腫瘍免疫応答の解明2012

    • Author(s)
      熊谷賢一, 藤井恵介, 北浦一孝, 江口貴紀, 重松宏昭, 岸悠太, 山田浩之, 川口浩司, 鈴木隆二, 濱田良樹
    • Organizer
      第25回日本口腔診断学会・第22回日本口腔内科学会合同学術大会
    • Data Source
      KAKENHI-PROJECT-23792391
  • [Presentation] STR/Ortマウスにおける変形性顎関節症モデルとしての有用性について2011

    • Author(s)
      熊谷賢一,鈴木さつき,藤井恵介,鈴木隆二,濱田良樹
    • Organizer
      第24回一般社団法人日本顎関節学会総会・学術大会
    • Place of Presentation
      広島
    • Year and Date
      2011-07-22
    • Data Source
      KAKENHI-PROJECT-23593004
  • [Presentation] 口腔白板症および口腔扁平苔癬の病態形成に関わるEGFR familyの発現解析2011

    • Author(s)
      小林浩,熊谷賢一,江口貴紀,重松宏昭,和気昌宏,濱田良樹
    • Organizer
      第56日本口腔外科学会総会
    • Place of Presentation
      大阪
    • Data Source
      KAKENHI-PROJECT-23792391
  • [Presentation] STR/Ortマウスにおける変形性顎関節症モデルとしての有用性について2011

    • Author(s)
      熊谷賢一, 鈴木さつき, 藤井恵介, 鈴木隆二, 濱田良樹
    • Organizer
      第24回一般社団法人日本顎関節学会総会・学術大会
    • Place of Presentation
      広島(広島県民文化センター)
    • Data Source
      KAKENHI-PROJECT-23593004
  • [Presentation] Synchronous modulation of epidermal growth factor receptor family genes in oral premalignant lesions2011

    • Author(s)
      Kenichi Kumagai, Hiroshi Kobayashi, Akito Gotoh, Takanori Eguchi, Hiroyuki Yamada, Ryuji Suzuki, Yoshiki Hamada
    • Organizer
      20th International Conference on Oral and Maxillofacail Surgery
    • Place of Presentation
      Santiago, Chile
    • Data Source
      KAKENHI-PROJECT-23792391
  • [Presentation] 口腔扁平上皮癌におけるCD133の発現と頸部リンパ節転移に関する臨床病理学的検討

    • Author(s)
      藤井惠介, 熊谷 賢一, 重松宏昭, 中岡雅典, 清水 一, 馬杉亮彦, 川口浩司, 山田浩之, 鈴木隆二, 濱田良樹
    • Organizer
      第58回(公社)日本口腔外科学会総会・学術大会
    • Place of Presentation
      福岡国際会議場(福岡県)
    • Data Source
      KAKENHI-PROJECT-23792391
  • [Presentation] 口腔白板症および口腔扁平苔癬の病態形成に関わるEGFR family の発現解析

    • Author(s)
      小林浩, 熊谷賢一, 江口貴紀, 重松宏昭, 和気昌宏, 濱田良樹
    • Organizer
      第56日本口腔外科学会総会
    • Place of Presentation
      大阪(大阪国際会議場)
    • Data Source
      KAKENHI-PROJECT-23792391
  • 1.  HAMADA Yoshiki (70247336)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 20 results
  • 2.  SUZUKI Ryuji (70373470)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 12 results
  • 3.  Kawaguchi Kouji (50277951)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 4.  藤原 久子 (80396746)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 5.  SUZUKI Satsuki (10386253)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 6.  重松 宏昭 (80737198)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 7.  大島 朋子 (50233101)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  伊藤 由美 (00176372)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  佐藤 光一郎 (20728125)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  FUJII Yoshiki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  佐藤 雅
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  松谷 隆治
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  高崎 智彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  倉根 一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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