Koyama Hiroshi 小山宏史

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KOYAMA Hiroshi 小山宏史

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Researcher Number	10530462
Other IDs
Affiliation (Current)	2025: 基礎生物学研究所, 初期発生研究部門, 助教
Affiliation (based on the past Project Information) *help	2017 – 2024: 基礎生物学研究所, 初期発生研究部門, 助教 2012 – 2014: 基礎生物学研究所, 初期発生研究部門, 助教
Review Section/Research Field	Principal Investigator Transformative Research Areas, Section (III) / Basic Section 44020:Developmental biology-related / Developmental biology / Biological Sciences / Cell biology Except Principal Investigator Basic Section 44020:Developmental biology-related / Constructive Systems Biology / Developmental biology
Keywords	Principal Investigator 機械的な力 / 力の推定 / 形態形成 / 数理シミュレーション / 力学 / マウス初期胚 / 摩擦力 / 多細胞組織 / 細胞分化 / 発生 … More / 細胞・組織 / 形態パターン / マウス / パターン形成 / シミュレーション / ヒダ / 卵管 / 発生細胞生物学 / 数理 / 細胞動態 / 胚発生 / ミオシンII / 非筋細胞ミオシンII / 多細胞生物 / 細胞質分裂 … More Except Principal Investigator HSPG / PCP / ヘパラン硫酸プロテオグリカン / Wnt / Xenopus / 平面細胞極性 / 細胞外ATP / ツメガエル / 光操作 / アフリカツメガエル / 頂端収縮 / 神経管形成 / カルシウムイオン / 原腸形成 / 胚葉形成 Less

3次元組織におけるメカニカルな力の可視化による細胞分化のトリガーの同定Principal Investigator
- Principal Investigator
  
  小山宏史
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  National Institute for Basic Biology
3次元細胞シミュレーションによる細胞排除のメカニクスの理解Principal Investigator
- Principal Investigator
  
  小山宏史
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  National Institute for Basic Biology
膨張組織における細胞-ECM間の摩擦力による形態形成Principal Investigator
- Principal Investigator
  
  小山宏史
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  National Institute for Basic Biology
Planar cell polarity as self-organization involving localized Wnt protein
- Principal Investigator
  
  三井優輔
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44020:Developmental biology-related
- Research Institution
  Kyoto University
  National Institute for Basic Biology
Mechanics of fold pattern formation of luminal epithelium in mouse oviductPrincipal Investigator
- Principal Investigator
  
  Koyama Hiroshi
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Developmental biology
- Research Institution
  National Institute for Basic Biology
Cellular dynamics during collective cell migration
- Principal Investigator
  
  Ueno Naoto
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Developmental biology
- Research Institution
  National Institute for Basic Biology
Exploring of the principle of epithelial tubulogenesis by intra- and extracellular small molecules
- Principal Investigator
  
  SUZUKI MAKOTO
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Constructive Systems Biology
- Research Institution
  National Institute for Basic Biology
マウス胚発生における細胞間の力学マップの作成と力学的ルールの抽出Principal Investigator
- Principal Investigator
  
  小山宏史
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Basic Biology
Exploration of cytokinesis systems specific in multi-cellular organismsPrincipal Investigator
- Principal Investigator
  
  KOYAMA Hiroshi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  National Institute for Basic Biology

All 2022 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

[Book] 実験医学　イメージングデータ解析　よろず相談所　シリーズ04「顕微観察画像の定量的情報解析とその落とし穴」2019
- Author(s)
  小山　宏史, 加藤　輝
- Publisher
  羊土社
- ISBN
  9784758125246
- Data Source
  KAKENHI-PROJECT-17K15131
[Journal Article] Differential Cellular Stiffness Contributes to Tissue Elongation on an Expanding Surface2022
- Author(s)
  Koyama Hiroshi、Suzuki Makoto、Yasue Naoko、Sasaki Hiroshi、Ueno Naoto、Fujimori Toshihiko
- Journal Title
  
  Frontiers in Cell and Developmental Biology
  
  Volume: 10 Pages: 864135-864135
- DOI
  10.3389/fcell.2022.864135
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15131, KAKENHI-PROJECT-18K19351
[Journal Article] Isotropic expansion of external environment induces tissue elongation and collective cell alignment2020
- Author(s)
  Hiroshi Koyama, Toshihiko Fujimori
- Journal Title
  
  Journal of Theoretical Biology
  
  Volume: 496 Pages: 110248-110248
- DOI
  10.1016/j.jtbi.2020.110248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15131
[Journal Article] Biophysics in oviduct: Planar cell polarity, cilia, epithelial fold and tube morphogenesis, egg dynamics2019
- Author(s)
  Hiroshi Koyama, Dongbo Shi and Toshihiko Fujimori
- Journal Title
  
  Biophysics and Physicobiology
  
  Volume: 16 Issue: 0 Pages: 89-107
- DOI
  10.2142/biophysico.16.0_89
- NAID
  130007604498
- ISSN
  2189-4779
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15131
[Journal Article] Biomechanics of epithelial fold pattern formation in the mouse female reproductive tract2018
- Author(s)
  Hiroshi Koyama and Toshihiko Fujimori
- Journal Title
  
  Current Opinion in Genetics & Development
  
  Volume: 51 Pages: 59-66
- DOI
  10.1016/j.gde.2018.06.010
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15131
[Journal Article] Distinct intracellular Ca2+ dynamics regulate apical constriction and differentially contribute to neural tube closure.2017
- Author(s)
  Suzuki, M., Sato, M., Koyama, H., Hara, Y., Hayashi, K., Yasue, N., Imamura, H., Fujimori, T., Nagai, T., Campbell, RE., Ueno, N.
- Journal Title
  
  Development.
  
  Volume: 144 Issue: 7 Pages: 1307-1316
- DOI
  10.1242/dev.141952
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01220, KAKENHI-PLANNED-15H05865, KAKENHI-PROJECT-15H04380, KAKENHI-PROJECT-25291054, KAKENHI-PROJECT-15KT0154, KAKENHI-INTERNATIONAL-15K21726, KAKENHI-ORGANIZER-15H05856, KAKENHI-PROJECT-16K14709, KAKENHI-PROJECT-16H06297, KAKENHI-PROJECT-17H03654
[Journal Article] Role of Mechanical Force in Fold Pattern Formation in Oviduct2017
- Author(s)
  小山宏史，石　東博，藤森俊彦
- Journal Title
  
  Seibutsu Butsuri
  
  Volume: 57 Issue: 5 Pages: 259-261
- DOI
  10.2142/biophys.57.259
- NAID
  130006100230
- ISSN
  0582-4052, 1347-4219
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15131
[Journal Article] Mechanical regulation of three-dimensional epithelial fold pattern formation in the mouse oviduct2016
- Author(s)
  Koyama, H., Shi, D., Suzuki, M., Ueno, N., Uemura, T., Fujimori, T.
- Journal Title
  
  Biophysical Journal
  
  Volume: 111 Issue: 3 Pages: 650-665
- DOI
  10.1016/j.bpj.2016.06.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K07088, KAKENHI-PROJECT-15KT0154
[Presentation] 等方的に膨張する場における非対称的な細胞集団運動2019
- Author(s)
  小山　宏史, 藤森　俊彦
- Organizer
  日本物理学会2019年秋季大会
- Data Source
  KAKENHI-PROJECT-17K15131
[Presentation] 卵管における管腔上皮のヒダの形成機構2019
- Author(s)
  小山　宏史, 藤森　俊彦
- Organizer
  第32回バイオエンジニアリング講演会
- Data Source
  KAKENHI-PROJECT-17K15131
[Presentation] 卵管における管腔上皮のヒダのパターン形成2019
- Author(s)
  小山　宏史, 藤森　俊彦
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K15131
[Presentation] 細胞の硬さの相違が引き起こす細胞集団のパターン形成2019
- Author(s)
  小山　宏史
- Organizer
  第29回日本数理生物学会大会
- Data Source
  KAKENHI-PROJECT-17K15131
[Presentation] Tissue elongation and pattern formation of cells induced by isotropic expansion of a field2018
- Author(s)
  Hiroshi Koyama and Toshihiko Fujimori
- Organizer
  Joint Meeting of JSCB 70th & JSDB 51st
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15131
[Presentation] Distinct intracellular Ca2+ dynamics regulate apical constriction and differentially contribute to neural tube closure2017
- Author(s)
  Makoto Suzuki, Masanao Sato, Hiroshi Koyama, Naoto Ueno.
- Organizer
  第27回日本数理生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-15KT0154
[Presentation] 場の膨張に伴う多細胞集団の移動の数理的解析2017
- Author(s)
  小山宏史、藤森俊彦
- Organizer
  第30 回バイオエンジニアリング講演会
- Data Source
  KAKENHI-PROJECT-17K15131
[Presentation] 生物の形態の多様性の力学的な基盤　～理論、実験、力の推定を用いた研究～2017
- Author(s)
  小山宏史
- Organizer
  第4回IoLコロキウムー特別講演会ー　(4th Internetwork of Lifemolecules Research Center Colloquium)
- Invited
- Data Source
  KAKENHI-PROJECT-17K15131
[Presentation] Inference of cell mechanical state/environment by using microscopic live imaging during morphogenesis2017
- Author(s)
  Hiroshi Koyama, Toshihiko Fujimori
- Organizer
  2017年度　生命科学系学会合同年次大会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K15131
[Presentation] 胚発生における細胞動態と動力学的状態について2015
- Author(s)
  小山宏史
- Organizer
  基礎生物学研究所　重点共同利用研究　「哺乳類着床前胚の発生動態解析システムの構築とその応用」　研究会
- Place of Presentation
  愛知県岡崎市　基礎生物学研究所
- Year and Date
  2015-01-19
- Data Source
  KAKENHI-PUBLICLY-25111733
[Presentation] Cell and Tissue Dynamics of Neural Tube Formation.2015
- Author(s)
  Naoto Ueno, Makoto Suzuki, Hiroshi Koyama and Yasuhiro Inoue.
- Organizer
  iCeMS International Symposium
- Place of Presentation
  Yoshida Campus, Kyoto University, 京都府京都市
- Year and Date
  2015-09-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04380
[Presentation] 細胞核間の力学的相互作用の理論的な推定2014
- Author(s)
  小山　宏史
- Organizer
  「動く細胞と場のクロストークによる秩序の形成」　第８回領域班会議
- Place of Presentation
  慶応大学日吉キャンパス　来往舎（神奈川県）
- Data Source
  KAKENHI-PUBLICLY-25111733
[Presentation] 細胞核間の”引力・斥力”の理論的な推定2013
- Author(s)
  小山　宏史
- Organizer
  「動く細胞と場のクロストークによる秩序の形成」　第７回領域班会議
- Place of Presentation
  名古屋大学野依記念学術交流館（愛知県）
- Data Source
  KAKENHI-PUBLICLY-25111733
[Presentation] マウス胚発生における力学推定の数理的基盤について2013
- Author(s)
  小山　宏史
- Organizer
  「動く細胞と場のクロストークによる秩序の形成」　第3回若手の会
- Place of Presentation
  ラフォーレ那須（栃木県）
- Data Source
  KAKENHI-PUBLICLY-25111733
[Presentation] 胚発生における胚と細胞の力学的状態の推定
- Author(s)
  小山宏史
- Organizer
  新学術領域「動く細胞と秩序」　第4回若手の会
- Place of Presentation
  熊本県熊本市火の国ハイツ
- Year and Date
  2014-09-04 – 2014-09-05
- Data Source
  KAKENHI-PUBLICLY-25111733
[Presentation] 胚発生における細胞間の動力学的関係と、それに基づいた細胞動態の数理的解析
- Author(s)
  小山宏史
- Organizer
  新学術領域「動く細胞と秩序」　第9回班会議
- Place of Presentation
  愛知県知多郡東浦町　あいち健康の森健康科学総合センター『あいち健康プラザ』
- Year and Date
  2015-01-25 – 2015-01-27
- Data Source
  KAKENHI-PUBLICLY-25111733

1. Ueno Naoto (40221105)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. SUZUKI MAKOTO (10533193)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
3. SANO Masaki (40150263)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. TANAKA Motomu (00706814)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KATO Kagayaki (30391915)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 三井優輔 (70634129)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YASUE Naoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 藤森俊彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koyama Hiroshi 小山 宏史

KOYAMA Hiroshi 小山 宏史

Research Projects

Research Products

Co-Researchers

3次元組織におけるメカニカルな力の可視化による細胞分化のトリガーの同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

3次元細胞シミュレーションによる細胞排除のメカニクスの理解Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

膨張組織における細胞-ECM間の摩擦力による形態形成Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Planar cell polarity as self-organization involving localized Wnt protein

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanics of fold pattern formation of luminal epithelium in mouse oviductPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Cellular dynamics during collective cell migration

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploring of the principle of epithelial tubulogenesis by intra- and extracellular small molecules

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マウス胚発生における細胞間の力学マップの作成と力学的ルールの抽出Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploration of cytokinesis systems specific in multi-cellular organismsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 実験医学 イメージングデータ解析 よろず相談所 シリーズ04「顕微観察画像の定量的情報解析とその落とし穴」2019

Author(s)

Publisher

ISBN

Data Source

[Journal Article] Differential Cellular Stiffness Contributes to Tissue Elongation on an Expanding Surface2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Isotropic expansion of external environment induces tissue elongation and collective cell alignment2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Biophysics in oviduct: Planar cell polarity, cilia, epithelial fold and tube morphogenesis, egg dynamics2019

Author(s)

Journal Title

DOI

NAID

ISSN

Koyama Hiroshi 小山宏史

KOYAMA Hiroshi 小山宏史

[Book] 実験医学　イメージングデータ解析　よろず相談所　シリーズ04「顕微観察画像の定量的情報解析とその落とし穴」2019

[Presentation] 生物の形態の多様性の力学的な基盤　～理論、実験、力の推定を用いた研究～2017