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Koyama Hiroshi  小山 宏史

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KOYAMA Hiroshi  小山 宏史

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Researcher Number 10530462
Other IDs
Affiliation (Current) 2025: 基礎生物学研究所, 初期発生研究部門, 助教
Affiliation (based on the past Project Information) *help 2017 – 2024: 基礎生物学研究所, 初期発生研究部門, 助教
2012 – 2014: 基礎生物学研究所, 初期発生研究部門, 助教
Review Section/Research Field
Principal Investigator
Transformative Research Areas, Section (III) / Basic Section 44020:Developmental biology-related / Developmental biology / Biological Sciences / Cell biology
Except Principal Investigator
Basic Section 44020:Developmental biology-related / Constructive Systems Biology / Developmental biology
Keywords
Principal Investigator
機械的な力 / 力の推定 / 形態形成 / 数理シミュレーション / 力学 / マウス初期胚 / 摩擦力 / 多細胞組織 / 細胞分化 / 発生 … More / 細胞・組織 / 形態パターン / マウス / パターン形成 / シミュレーション / ヒダ / 卵管 / 発生細胞生物学 / 数理 / 細胞動態 / 胚発生 / ミオシンII / 非筋細胞ミオシンII / 多細胞生物 / 細胞質分裂 … More
Except Principal Investigator
HSPG / PCP / ヘパラン硫酸プロテオグリカン / Wnt / Xenopus / 平面細胞極性 / 細胞外ATP / ツメガエル / 光操作 / アフリカツメガエル / 頂端収縮 / 神経管形成 / カルシウムイオン / 原腸形成 / 胚葉形成 Less
  • Research Projects

    (9 results)
  • Research Products

    (24 results)
  • Co-Researchers

    (8 People)
  •  3次元組織におけるメカニカルな力の可視化による細胞分化のトリガーの同定Principal Investigator

    • Principal Investigator
      小山 宏史
    • Project Period (FY)
      2024 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 44020:Developmental biology-related
    • Research Institution
      National Institute for Basic Biology
  •  3次元細胞シミュレーションによる細胞排除のメカニクスの理解Principal Investigator

    • Principal Investigator
      小山 宏史
    • Project Period (FY)
      2024 – 2025
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      National Institute for Basic Biology
  •  膨張組織における細胞-ECM間の摩擦力による形態形成Principal Investigator

    • Principal Investigator
      小山 宏史
    • Project Period (FY)
      2024 – 2025
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      National Institute for Basic Biology
  •  Planar cell polarity as self-organization involving localized Wnt protein

    • Principal Investigator
      三井 優輔
    • Project Period (FY)
      2022 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 44020:Developmental biology-related
    • Research Institution
      Kyoto University
      National Institute for Basic Biology
  •  Mechanics of fold pattern formation of luminal epithelium in mouse oviductPrincipal Investigator

    • Principal Investigator
      Koyama Hiroshi
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Developmental biology
    • Research Institution
      National Institute for Basic Biology
  •  Cellular dynamics during collective cell migration

    • Principal Investigator
      Ueno Naoto
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Developmental biology
    • Research Institution
      National Institute for Basic Biology
  •  Exploring of the principle of epithelial tubulogenesis by intra- and extracellular small molecules

    • Principal Investigator
      SUZUKI MAKOTO
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Constructive Systems Biology
    • Research Institution
      National Institute for Basic Biology
  •  マウス胚発生における細胞間の力学マップの作成と力学的ルールの抽出Principal Investigator

    • Principal Investigator
      小山 宏史
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      National Institute for Basic Biology
  •  Exploration of cytokinesis systems specific in multi-cellular organismsPrincipal Investigator

    • Principal Investigator
      KOYAMA Hiroshi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Cell biology
    • Research Institution
      National Institute for Basic Biology

All 2022 2020 2019 2018 2017 2016 2015 2014 2013 Other

All Journal Article Presentation Book

  • [Book] 実験医学 イメージングデータ解析 よろず相談所 シリーズ04「顕微観察画像の定量的情報解析とその落とし穴」2019

    • Author(s)
      小山 宏史, 加藤 輝
    • Publisher
      羊土社
    • ISBN
      9784758125246
    • Data Source
      KAKENHI-PROJECT-17K15131
  • [Journal Article] Differential Cellular Stiffness Contributes to Tissue Elongation on an Expanding Surface2022

    • Author(s)
      Koyama Hiroshi、Suzuki Makoto、Yasue Naoko、Sasaki Hiroshi、Ueno Naoto、Fujimori Toshihiko
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 10 Pages: 864135-864135

    • DOI

      10.3389/fcell.2022.864135

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K15131, KAKENHI-PROJECT-18K19351
  • [Journal Article] Isotropic expansion of external environment induces tissue elongation and collective cell alignment2020

    • Author(s)
      Hiroshi Koyama, Toshihiko Fujimori
    • Journal Title

      Journal of Theoretical Biology

      Volume: 496 Pages: 110248-110248

    • DOI

      10.1016/j.jtbi.2020.110248

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K15131
  • [Journal Article] Biophysics in oviduct: Planar cell polarity, cilia, epithelial fold and tube morphogenesis, egg dynamics2019

    • Author(s)
      Hiroshi Koyama, Dongbo Shi and Toshihiko Fujimori
    • Journal Title

      Biophysics and Physicobiology

      Volume: 16 Issue: 0 Pages: 89-107

    • DOI

      10.2142/biophysico.16.0_89

    • NAID

      130007604498

    • ISSN
      2189-4779
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K15131
  • [Journal Article] Biomechanics of epithelial fold pattern formation in the mouse female reproductive tract2018

    • Author(s)
      Hiroshi Koyama and Toshihiko Fujimori
    • Journal Title

      Current Opinion in Genetics & Development

      Volume: 51 Pages: 59-66

    • DOI

      10.1016/j.gde.2018.06.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K15131
  • [Journal Article] Distinct intracellular Ca2+ dynamics regulate apical constriction and differentially contribute to neural tube closure.2017

    • Author(s)
      Suzuki, M., Sato, M., Koyama, H., Hara, Y., Hayashi, K., Yasue, N., Imamura, H., Fujimori, T., Nagai, T., Campbell, RE., Ueno, N.
    • Journal Title

      Development.

      Volume: 144 Issue: 7 Pages: 1307-1316

    • DOI

      10.1242/dev.141952

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01220, KAKENHI-PLANNED-15H05865, KAKENHI-PROJECT-15H04380, KAKENHI-PROJECT-25291054, KAKENHI-PROJECT-15KT0154, KAKENHI-INTERNATIONAL-15K21726, KAKENHI-ORGANIZER-15H05856, KAKENHI-PROJECT-16K14709, KAKENHI-PROJECT-16H06297, KAKENHI-PROJECT-17H03654
  • [Journal Article] Role of Mechanical Force in Fold Pattern Formation in Oviduct2017

    • Author(s)
      小山宏史,石 東博,藤森俊彦
    • Journal Title

      Seibutsu Butsuri

      Volume: 57 Issue: 5 Pages: 259-261

    • DOI

      10.2142/biophys.57.259

    • NAID

      130006100230

    • ISSN
      0582-4052, 1347-4219
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K15131
  • [Journal Article] Mechanical regulation of three-dimensional epithelial fold pattern formation in the mouse oviduct2016

    • Author(s)
      Koyama, H., Shi, D., Suzuki, M., Ueno, N., Uemura, T., Fujimori, T.
    • Journal Title

      Biophysical Journal

      Volume: 111 Issue: 3 Pages: 650-665

    • DOI

      10.1016/j.bpj.2016.06.032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K07088, KAKENHI-PROJECT-15KT0154
  • [Presentation] 等方的に膨張する場における非対称的な細胞集団運動2019

    • Author(s)
      小山 宏史, 藤森 俊彦
    • Organizer
      日本物理学会2019年秋季大会
    • Data Source
      KAKENHI-PROJECT-17K15131
  • [Presentation] 卵管における管腔上皮のヒダの形成機構2019

    • Author(s)
      小山 宏史, 藤森 俊彦
    • Organizer
      第32回バイオエンジニアリング講演会
    • Data Source
      KAKENHI-PROJECT-17K15131
  • [Presentation] 卵管における管腔上皮のヒダのパターン形成2019

    • Author(s)
      小山 宏史, 藤森 俊彦
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K15131
  • [Presentation] 細胞の硬さの相違が引き起こす細胞集団のパターン形成2019

    • Author(s)
      小山 宏史
    • Organizer
      第29回日本数理生物学会大会
    • Data Source
      KAKENHI-PROJECT-17K15131
  • [Presentation] Tissue elongation and pattern formation of cells induced by isotropic expansion of a field2018

    • Author(s)
      Hiroshi Koyama and Toshihiko Fujimori
    • Organizer
      Joint Meeting of JSCB 70th & JSDB 51st
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15131
  • [Presentation] Distinct intracellular Ca2+ dynamics regulate apical constriction and differentially contribute to neural tube closure2017

    • Author(s)
      Makoto Suzuki, Masanao Sato, Hiroshi Koyama, Naoto Ueno.
    • Organizer
      第27回日本数理生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15KT0154
  • [Presentation] 場の膨張に伴う多細胞集団の移動の数理的解析2017

    • Author(s)
      小山宏史、藤森俊彦
    • Organizer
      第30 回バイオエンジニアリング講演会
    • Data Source
      KAKENHI-PROJECT-17K15131
  • [Presentation] 生物の形態の多様性の力学的な基盤 ~理論、実験、力の推定を用いた研究~2017

    • Author(s)
      小山宏史
    • Organizer
      第4回IoLコロキウムー特別講演会ー (4th Internetwork of Lifemolecules Research Center Colloquium)
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K15131
  • [Presentation] Inference of cell mechanical state/environment by using microscopic live imaging during morphogenesis2017

    • Author(s)
      Hiroshi Koyama, Toshihiko Fujimori
    • Organizer
      2017年度 生命科学系学会合同年次大会
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15131
  • [Presentation] 胚発生における細胞動態と動力学的状態について2015

    • Author(s)
      小山宏史
    • Organizer
      基礎生物学研究所 重点共同利用研究 「哺乳類着床前胚の発生動態解析システムの構築とその応用」 研究会
    • Place of Presentation
      愛知県岡崎市 基礎生物学研究所
    • Year and Date
      2015-01-19
    • Data Source
      KAKENHI-PUBLICLY-25111733
  • [Presentation] Cell and Tissue Dynamics of Neural Tube Formation.2015

    • Author(s)
      Naoto Ueno, Makoto Suzuki, Hiroshi Koyama and Yasuhiro Inoue.
    • Organizer
      iCeMS International Symposium
    • Place of Presentation
      Yoshida Campus, Kyoto University, 京都府京都市
    • Year and Date
      2015-09-23
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04380
  • [Presentation] 細胞核間の力学的相互作用の理論的な推定2014

    • Author(s)
      小山 宏史
    • Organizer
      「動く細胞と場のクロストークによる秩序の形成」 第8回領域班会議
    • Place of Presentation
      慶応大学日吉キャンパス 来往舎(神奈川県)
    • Data Source
      KAKENHI-PUBLICLY-25111733
  • [Presentation] 細胞核間の”引力・斥力”の理論的な推定2013

    • Author(s)
      小山 宏史
    • Organizer
      「動く細胞と場のクロストークによる秩序の形成」 第7回領域班会議
    • Place of Presentation
      名古屋大学野依記念学術交流館(愛知県)
    • Data Source
      KAKENHI-PUBLICLY-25111733
  • [Presentation] マウス胚発生における力学推定の数理的基盤について2013

    • Author(s)
      小山 宏史
    • Organizer
      「動く細胞と場のクロストークによる秩序の形成」 第3回若手の会
    • Place of Presentation
      ラフォーレ那須(栃木県)
    • Data Source
      KAKENHI-PUBLICLY-25111733
  • [Presentation] 胚発生における胚と細胞の力学的状態の推定

    • Author(s)
      小山宏史
    • Organizer
      新学術領域「動く細胞と秩序」 第4回若手の会
    • Place of Presentation
      熊本県熊本市火の国ハイツ
    • Year and Date
      2014-09-04 – 2014-09-05
    • Data Source
      KAKENHI-PUBLICLY-25111733
  • [Presentation] 胚発生における細胞間の動力学的関係 と、それに基づい た細胞動態の数理的解析

    • Author(s)
      小山宏史
    • Organizer
      新学術領域「動く細胞と秩序」 第9回班会議
    • Place of Presentation
      愛知県知多郡東浦町 あいち健康の森健康科学総合センター『あいち健康プラザ』
    • Year and Date
      2015-01-25 – 2015-01-27
    • Data Source
      KAKENHI-PUBLICLY-25111733
  • 1.  Ueno Naoto (40221105)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 2.  SUZUKI MAKOTO (10533193)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 3.  SANO Masaki (40150263)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  TANAKA Motomu (00706814)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  KATO Kagayaki (30391915)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  三井 優輔 (70634129)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  YASUE Naoko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  藤森 俊彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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