Uzawa Akiyuki 鵜沢顕之

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UZAWA Akiyuki 鵜沢顕之

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Researcher Number	10533317
Other IDs
Affiliation (Current)	2025: 千葉大学, 医学部附属病院, 助教
Affiliation (based on the past Project Information) *help	2015 – 2023: 千葉大学, 医学部附属病院, 助教 2012 – 2013: 千葉大学, 医学部附属病院, 助教 2011: 千葉大学, 医学部・附属病院, 医員 2010 – 2011: 千葉大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Neurology / Experimental pathology Except Principal Investigator Basic Section 51030:Pathophysiologic neuroscience-related / Medium-sized Section 52:General internal medicine and related fields / Neurology
Keywords	Principal Investigator 新規治療 / 視神経脊髄炎 / 重症筋無力症 / 動物モデル / 自己免疫疾患 / 多発性硬化症 / サイトカイン / 血液脳関門 / MuSK抗体 / 融合タンパク … More / アセチルコリン受容体抗体 / 病原性B細胞 / 自己抗体 / 融合蛋白 / B細胞 / 損傷関連分子パター / 神経免疫 / 神経科学 / 髄液 / 免疫染色 / EAE / CD45 / 炎症 / ペルオキシレドキシン / GFAP / モデル動物 / モノクローナル抗体 / 実験的自己免疫性脳脊髄炎 / HMGB1 / 接着因子 / インターロイキン6 / アクアポリン4 / モデルマウス / 疾患モデル動物 … More Except Principal Investigator 視神経脊髄炎 / SEREX / SEREX法 / 神経免疫疾患 / 自己抗体 / 神経免疫 / シングルセルRNA解析 / single cell RNA解析 / 重症筋無力症 / 新規治療 / 免疫グロブリン / 融合タンパク質 / アクアポリン4 / B細胞 / 融合タンパク / アクアポリン４ / 自己免疫 / 抗体 / FACS / フローサイトメトリー / プロテインアレイ法 / talin / バイオマーカー / 抗talin-1抗体 / ｔａｌｉｎ１ / talin-1 / 多発性硬化症 Less

MuSK抗体陽性重症筋無力症に対する標的抗原Fc融合タンパクを用いた革新的治療法開発Principal Investigator
- Principal Investigator
  
  鵜沢顕之
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Chiba University
シングルセルRNA解析を用いた重症筋無力症の分子病態解明
- Principal Investigator
  
  赤嶺博行
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Chiba University
Development of innovative therapy for autoantibody-related disorders using fusion proteins combining IgG1Fc and extracellular domains of target antigen.
- Principal Investigator
  
  Masahiro Mori
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Chiba University
Elucidation of the action mechanism in vivo of AChR-Fc, a novel treatment for myasthenia gravisPrincipal Investigator
- Principal Investigator
  
  Uzawa Akiyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Chiba University
Comprehensive search of autoantibies in neuroimmunological disorders using a novel hybrid SEREX-FACS method
- Principal Investigator
  
  Masahiro Mori
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  Chiba University
Development of novel treatment against peroxiredoxin in central nervous system demyelinating diseasesPrincipal Investigator
- Principal Investigator
  
  Uzawa Akiyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Chiba University
Novel therapeutic strategies for multiple sclerosis targeting autoantibodies against talin.
- Principal Investigator
  
  Masahiro Mori
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Chiba University
High-mobility group box 1 is involved in neuromyelitis optica pathogensesis and could be a therapeutic target.Principal Investigator
- Principal Investigator
  
  UZAWA Akiyuki
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Chiba University
Development of mouse model of neuromyelitis optica induced by aquaporin-4 protein immunizationPrincipal Investigator
- Principal Investigator
  
  UZAWA Akiyuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Chiba University

[Book] Fc融合蛋白による重症筋無力症の革新的治療2019
- Author(s)
  鵜沢　顕之，山下　潤二，桑原　聡
- Total Pages
  6
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-19K07954
[Journal Article] Silent progression of brain atrophy in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder.2022
- Author(s)
  Masuda H, Mori M, Yokouchi H, Uzawa A, Uchida T, Muto M, Ohtani R, Aoki R, Yamamoto S, Kuwabara S.
- Journal Title
  
  J Neurol Neurosurg Psychiatry.
  
  Volume: 93 Issue: 1 Pages: 32-40
- DOI
  10.1136/jnnp-2021-326386
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19438
[Journal Article] Complete Relief of Painful Tonic Seizures in Neuromyelitis Optica Spectrum Disorder by Satralizumab Treatment2022
- Author(s)
  Uzawa Akiyuki、Mori Masahiro、Iwai Yuta、Masuda Hiroki、Kuwabara Satoshi
- Journal Title
  
  Intern. Med.
  
  Volume: 61 Issue: 18 Pages: 2785-2787
- DOI
  10.2169/internalmedicine.9036-21
- NAID
  130008158377
- ISSN
  0918-2918, 1349-7235
- Year and Date
  2022-09-15
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K19438
[Journal Article] AQP4-IgG autoimmunity in Japan and Germany: Differences in clinical profiles and prognosis in seropositive neuromyelitis optica spectrum disorders.2021
- Author(s)
  Asseyer S, Masuda H, Mori M, Bellmann-Strobl J, Ruprecht K, Siebert N, Cooper G, Chien C, Duchow A, Schliebeit J, Liu J, Sugimoto K, Uzawa A, Ohtani R, Paul F, Brandt AU, Kuwabara S, Zimmermann HG.
- Journal Title
  
  Mult Scler J Exp Transl Clin.
  
  Volume: 7 Issue: 2
- DOI
  10.1177/20552173211006862
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19438
[Journal Article] Peroxiredoxins are involved in the pathogenesis of multiple sclerosis and neuromyelitis optica spectrum disorder.2020
- Author(s)
  Uzawa A, Mori M, Masuda H, Ohtani R, Uchida T, Aoki R, Kuwabara S.
- Journal Title
  
  Clin Exp Immunol.
  
  Volume: 202 Issue: 2 Pages: 239-248
- DOI
  10.1111/cei.13487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07387
[Journal Article] Anti-MOG antibody-associated disorders: differences in clinical profiles and prognosis in Japan and Germany.2020
- Author(s)
  Liu J, Mori M, Zimmermann H, Brandt A, Havla J, Tanaka S, Sugimoto K, Oji S, Uzawa A, Asseyer S, Cooper G, Jarius S, Bellmann-Strobl J, Ruprecht K, Siebert N, Masuda H, Uchida T, Ohtani R, Nomura K, Meinl E, Kuempfel T, Paul F, Kuwabara S.
- Journal Title
  
  J Neurol Neurosurg Psychiatry.
  
  Volume: -- Issue: 4 Pages: 377-383
- DOI
  10.1136/jnnp-2020-324422
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07387
[Journal Article] Peripheral blood helper T cell profiles and their clinical relevance in MOG-IgG-associated and AQP4-IgG-associated disorders and MS.2020
- Author(s)
  Liu J, Mori M, Sugimoto K, Uzawa A, Masuda H, Uchida T, Ohtani R, Kuwabara S.
- Journal Title
  
  J Neurol Neurosurg Psychiatry.
  
  Volume: 91 Issue: 2 Pages: 132-139
- DOI
  10.1136/jnnp-2019-321988
- Data Source
  KAKENHI-PROJECT-18K07387
[Journal Article] Serum anti-LRPAP1 is a common biomarker for digestive organ cancers and atherosclerotic diseases.2020
- Author(s)
  Sumazaki M, Shimada H, Ito M, Shiratori F, Kobayashi E, Yoshida Y, Adachi A, Matsutani T, Iwadate Y, Mine S, Machida T, Kamitsukasa I, Mori M, Sugimoto K, Uzawa A, Kuwabara S, et al.
- Journal Title
  
  Cancer Sci.
  
  Volume: 11 Pages: 4453-4464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07387
[Journal Article] The accuracy of flow cytometric cell-based assay to detect anti-myelin oligodendrocyte glycoprotein (MOG) antibodies determining the optimal method for positivity judgement.2019
- Author(s)
  Sugimoto K, Mori M, Liu J, Tanaka S, Kaneko K, Oji S, Takahashi T, Uzawa A, Uchida T, Masuda H, Ohtani R, Nomura K, Hiwasa T, Kuwabara S.
- Journal Title
  
  J Neuroimmunol.
  
  Volume: 336 Pages: 577021-577021
- DOI
  10.1016/j.jneuroim.2019.577021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07387
[Journal Article] Oral corticosteroid dosing regimen and long-term prognosis in generalised myasthenia gravis: a multicentre cross-sectional study in Japan2018
- Author(s)
  Imai Tomihiro、Utsugisawa Kimiaki、Murai Hiroyuki、Tsuda Emiko、Nagane Yuriko、Suzuki Yasushi、Minami Naoya、Uzawa Akiyuki、Kawaguchi Naoki、Masuda Masayuki、Konno Shingo、Suzuki Hidekazu、Akaishi Tetsuya、Aoki Masashi
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: in press Issue: 5 Pages: 513-517
- DOI
  10.1136/jnnp-2017-316625
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09691, KAKENHI-PROJECT-17K09780
[Journal Article] MOG antibody disorders and AQP4 antibody NMO spectrum disorders share a common immunopathogenesis2018
- Author(s)
  Uzawa Akiyuki、Mori Masahiro、Kuwabara Satoshi
- Journal Title
  
  Journal of Neurology, Neurosurgery & Psychiatry
  
  Volume: 89 Issue: 9 Pages: 900-900
- DOI
  10.1136/jnnp-2018-318231
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07387
[Journal Article] Recombinant thrombomodulin ameliorates experimental autoimmune encephalomyelitis by suppressing HMGB1 and inflammatory cytokines2018
- Author(s)
  Uzawa Akiyuki、Mori Masahiro、Masuda Hiroki、Ohtani Ryohei、Uchida Tomohiko、Kuwabara Satoshi
- Journal Title
  
  Clin Exp Immunol
  
  Volume: in press Issue: 1 Pages: 47-54
- DOI
  10.1111/cei.13123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09691, KAKENHI-PROJECT-18K07387
[Journal Article] Risk factors for fingolimod-induced lymphopenia in multiple sclerosis2018
- Author(s)
  Ohtani Ryohei、Mori Masahiro、Uchida Tomohiko、Uzawa Akiyuki、Masuda Hiroki、Liu Jia、Kuwabara Satoshi
- Journal Title
  
  Mult Scler J Exp Transl Clin
  
  Volume: 4 Issue: 1 Pages: 205521731875969-205521731875969
- DOI
  10.1177/2055217318759692
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09691
[Journal Article] Soluble CD40 ligand disrupts the blood?brain barrier and exacerbates inflammation in experimental autoimmune encephalomyelitis2018
- Author(s)
  Masuda Hiroki、Mori Masahiro、Umehara Kenta、Furihata Tomomi、Uchida Tomohiko、Uzawa Akiyuki、Kuwabara Satoshi
- Journal Title
  
  J Neuroimmunol
  
  Volume: 316 Pages: 117-120
- DOI
  10.1016/j.jneuroim.2018.01.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09691, KAKENHI-PROJECT-17K16109
[Journal Article] Serum anti-JCV antibody indexes in Japanese patients with multiple sclerosis: elevations along with fingolimod treatment duration2018
- Author(s)
  Aoyama Shinji、Mori Masahiro、Uzawa Akiyuki、Uchida Tomohiko、Masuda Hiroki、Ohtani Ryohei、Kuwabara Satoshi
- Journal Title
  
  J Neurol
  
  Volume: in press Issue: 5 Pages: 1145-1150
- DOI
  10.1007/s00415-018-8813-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09691, KAKENHI-PROJECT-18K07387
[Journal Article] Validation of the Modified Fatigue Impact Scale and the relationships among fatigue, pain and serum interleukin-6 levels in patients with neuromyelitis optica spectrum disorder2018
- Author(s)
  Masuda Hiroki、Mori Masahiro、Uzawa Akiyuki、Uchida Tomohiko、Ohtani Ryohei、Kobayashi Shigeo、Kuwabara Satoshi
- Journal Title
  
  J Neurol Sci
  
  Volume: 385 Pages: 64-68
- DOI
  10.1016/j.jns.2017.11.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09691
[Journal Article] Neuroimmunology of a natural disaster2017
- Author(s)
  Kuwabara Satoshi、Uzawa Akiyuki、Mori Masahiro
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: 88 Issue: 4 Pages: 283-283
- DOI
  10.1136/jnnp-2016-314198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09691
[Journal Article] Comparison of cognitive and brain grey matter volume profiles between multiple sclerosis and neuromyelitis optica spectrum disorder2017
- Author(s)
  Masuda Hiroki、Hirano Shigeki、Takahashi Nobuyoshi、Hatsugano Etsuko、Uzawa Akiyuki、Uchida Tomohiko、Ohtani Ryohei、Kuwabara Satoshi、Mori Masahiro
- Journal Title
  
  PLoS One
  
  Volume: 12 Issue: 8 Pages: e0184012-e0184012
- DOI
  10.1371/journal.pone.0184012
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09691
[Journal Article] Interleukin-6 analysis of 572 consecutive CSF samples from neurological disorders: A special focus on neuromyelitis optica2017
- Author(s)
  Uzawa A, Mori M, Masuda H, Ohtani R, Uchida T, Sawai S, Kuwabara S
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: in press Pages: 144-149
- DOI
  10.1016/j.cca.2017.03.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09691
[Journal Article] Early fast-acting treatment strategy against generalized myasthenia gravis2017
- Author(s)
  Utsugisawa Kimiaki、Nagane Yuriko、Akaishi Tetsuya、Suzuki Yasushi、Imai Tomihiro、Tsuda Emiko、Minami Naoya、Uzawa Akiyuki、Kawaguchi Naoki、Masuda Masayuki、Konno Shingo、Suzuki Hidekazu、Murai Hiroyuki、Aoki Masashi
- Journal Title
  
  Muscle Nerve
  
  Volume: 55 Issue: 6 Pages: 794-801
- DOI
  10.1002/mus.25397
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09691
[Journal Article] Geographical differences in preventative therapies for neuromyelitis optica spectrum disorder2017
- Author(s)
  Mori Masahiro、Uzawa Akiyuki、Kuwabara Satoshi
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: 88 Issue: 8 Pages: 620-620
- DOI
  10.1136/jnnp-2017-315769
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09691
[Journal Article] Serum soluble Talin-1 levels are elevated in patients with multiple sclerosis, reflecting its disease activity.2017
- Author(s)
  Mayumi Muto, Masahiro　Moti,　Jia　Liu,　Tomohiko　Uchida,　Hiroki　Masuda,　Ryohei　Ohtani,　Kazuo　Sugimoto,　Sathoshi Kuwabara
- Journal Title
  
  Journal of Neuroimmunology
  
  Volume: 305 Pages: 131-134
- DOI
  10.1016/j.jneuroim.2017.02.008
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K09333, KAKENHI-PROJECT-16K09691
[Journal Article] Association of serum levels of antibodies against MMP1, CBX1, and CBX5 with transient ischemic attack and cerebral infarction2017
- Author(s)
  Wang H,Zhang X-M,Tomiyoshi G,Nakamura R,Shinmen N,Kuroda H,Kimura R,Mine S,Kamitsukasa I,Wada T,Aotsuka A,Yoshida Y,Kobayashi E,Matsutani T,Iwadate Y,Sugimoto K,Mori M,Uzawa A,Muto M,Kuwabara S,Takemoto M,Kobayashi K,Kawamura H,Ishibashi R,Yokote K,Ohno M,
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 5 Pages: 5600-5613
- DOI
  10.18632/oncotarget.23789
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09229, KAKENHI-PROJECT-16K09691, KAKENHI-PROJECT-16K10750, KAKENHI-PROJECT-17K09575, KAKENHI-PROJECT-17H01558, KAKENHI-PROJECT-17H04048, KAKENHI-PROJECT-15K09333, KAKENHI-PROJECT-16K15216
[Journal Article] Increased cerebrospinal fluid metalloproteinase-2 and interleukin-6 are associated with albumin quotient in neuromyelitis optica: Their possible role on blood-brain barrier disruption.2017
- Author(s)
  Uchida T, Mori M, Uzawa A, Masuda H, Muto M, Ohtani R, Kuwabara S
- Journal Title
  
  Mult Scler
  
  Volume: in press Issue: 8 Pages: 1072-1084
- DOI
  10.1177/1352458516672015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09691
[Journal Article] Soluble CD40 ligand contributes to blood brain barrier breakdown and central nervous system inflammation in multiple sclerosis and neuromyelitis optica spectrum disorder2017
- Author(s)
  Masuda H, Mori M, Uchida T, Uzawa A, Ohtani R, Kuwabara S.
- Journal Title
  
  J Neuroimmnol
  
  Volume: 305 Pages: 102-107
- DOI
  10.1016/j.jneuroim.2017.01.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09691, KAKENHI-PROJECT-17K16109
[Journal Article] A clinical predictive score for postoperative myasthenic crisis2017
- Author(s)
  Kanai Tetsuya、Uzawa Akiyuki、et al.
- Journal Title
  
  Ann Neurol
  
  Volume: 82 Issue: 5 Pages: 841-849
- DOI
  10.1002/ana.25087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09691, KAKENHI-PROJECT-17K16111
[Journal Article] Seronegative neuromyelitis optica spectrum disorder patients diagnosed using new diagnostic criteria2016
- Author(s)
  Uzawa A, Mori M, Uchida T, Masuda H, Ohtani R, Kuwabara S
- Journal Title
  
  Mult Scler
  
  Volume: 22 Issue: 10 Pages: 1371-1375
- DOI
  10.1177/1352458515615954
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09691
[Journal Article] Increased levels of CSF CD59 in neuromyelitis optica and multiple sclerosis2016
- Author(s)
  Uzawa A, Mori M, Uchida T, Masuda H, Ohtani R, Kuwabara S
- Journal Title
  
  Clinica Chimica Acta
  
  Volume: 453 Pages: 131-133
- DOI
  10.1016/j.cca.2015.12.013
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09691
[Journal Article] Novel serum autoantibodies against talin1 in multiple sclerosis: Possible pathogenetic roles of the antibodies2015
- Author(s)
  Muto M, Mori M, Hiwasa T, Takiguchi M, Iwadate Y, Uzawa A, Uchida T, Masuda H, Sugimoto K, Kuwabara S.
- Journal Title
  
  Journal of Neuroimmunology
  
  Volume: 284 Pages: 30-36
- DOI
  10.1016/j.jneuroim.2015.05.005
- NAID
  120007088198
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09333, KAKENHI-PROJECT-26460505, KAKENHI-PROJECT-25670115
[Journal Article] Neuromyelitis optica: concept, immunology and treatment.2014
- Author(s)
  Uzawa A, Mori M, Kuwabara S.
- Journal Title
  
  J Clin Neurosci.
  
  Volume: 21 Issue: 1 Pages: 12-21
- DOI
  10.1016/j.jocn.2012.12.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591232, KAKENHI-PROJECT-24790873
[Journal Article] "Bright spotty lesions" on spinal magnetic resonance imaging differentiate neuromyelitis optica from multiple sclerosis.2014
- Author(s)
  Yonezu T, Ito S, Mori M, Ogawa Y, Makino T, Uzawa A, Kuwabara S.
- Journal Title
  
  Mult Scler.
  
  Volume: 20 Issue: 3 Pages: 331-337
- DOI
  10.1177/1352458513495581
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591232, KAKENHI-PROJECT-24790873
[Journal Article] Serum Cytokine and Chemokine Profiles in Patients with Myasthenia Gravis2014
- Author(s)
  Uzawa A, Kawaguchi N, Himuro K, Kanai T, Kuwabara S
- Journal Title
  
  Clin Exp Immunol.
  
  Volume: (in press) Issue: 2 Pages: 232-237
- DOI
  10.1111/cei.12272
- Data Source
  KAKENHI-PROJECT-24790873
[Journal Article] Cytokines and chemokines in neuromyelitis optica: pathogenetic and therapeutic implications.2014
- Author(s)
  Uzawa A, Mori M, Kuwabara S
- Journal Title
  
  Brain Pathol
  
  Volume: 24 Issue: 1 Pages: 67-73
- DOI
  10.1111/bpa.12097
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790873
[Journal Article] Cerebrospinal fluid interleukin-6 and glial fibrillary acidic protein levels are increased during initial neuromyelitis optica attacks.2013
- Author(s)
  Uzawa A, Mori M, Sawai S, Masuda S, Muto M, Uchida T, Ito S, Nomura F, Kuwabara S.
- Journal Title
  
  Clin Chim Acta.
  
  Volume: 421 Pages: 181-183
- DOI
  10.1016/j.cca.2013.03.020
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591232, KAKENHI-PROJECT-24790873, KAKENHI-PROJECT-25461268
[Journal Article] Isolated ocular flutter2013
- Author(s)
  Nasu S, Uzawa A, Mori M, Kuwabara S
- Journal Title
  
  Neurology
  
  Volume: 80 Issue: 9 Pages: 867-867
- DOI
  10.1212/wnl.0b013e31828407a8
- Data Source
  KAKENHI-PROJECT-24790873
[Journal Article] Neuromyelitis optica: concept, immunology and treatment2013
- Author(s)
  Uzawa A, Mori M, Kuwabara S
- Journal Title
  
  J Clin Neurosci
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790873
[Journal Article] Seasonality of multiple sclerosis and neuromyelitis optica exacerbations in Japan.2013
- Author(s)
  Muto M, Mori M, Sato Y, Uzawa A, Masuda S, Kuwabara S.
- Journal Title
  
  Mult Scler.
  
  Volume: 19 Issue: 3 Pages: 378-379
- DOI
  10.1177/1352458512452332
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591232, KAKENHI-PROJECT-24790873
[Journal Article] Upbeat nystagmus at caudal brainstem lesions in four cases with multiple sclerosis and its related disorders2013
- Author(s)
  Uzawa A, Mori M, Masuda S, Muto M, Uchida T, Kuwabara S
- Journal Title
  
  Clin Exp Neuroimmunol.
  
  Volume: 4 Issue: 2 Pages: 206-9
- DOI
  10.1111/cen3.12013
- Data Source
  KAKENHI-PROJECT-24790873
[Journal Article] Anti-high mobility group box 1 monoclonal antibody ameliorates experimental autoimmune encephalomyelitis.2013
- Author(s)
  Uzawa A, Mori M, Taniguchi J, Masuda S, Muto M, Kuwabara S.
- Journal Title
  
  Clin Exp Immunol
  
  Volume: 172 Issue: 1 Pages: 37-43
- DOI
  10.1111/cei.12036
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790873
[Journal Article] Role of interleukin-6 in the pathogenesis of neuromyelitis optica2013
- Author(s)
  Uzawa A, Mori M, Kuwabara S
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: 4 Issue: 2 Pages: 167-172
- DOI
  10.1111/cen3.12024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790873
[Journal Article] CSF high-mobility group box 1 is associated with intrathecal inflammation and astrocytic damage in neuromyelitis optica.2013
- Author(s)
  Uzawa A, Mori M, Masuda S, Muto M, Kuwabara S.
- Journal Title
  
  J Neurol Neurosurg Psychiatry.
  
  Volume: 84 Issue: 5 Pages: 517-522
- DOI
  10.1136/jnnp-2012-304039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591232, KAKENHI-PROJECT-24790873
[Journal Article] Anti-N-methyl D-aspartate-type glutamate receptor antibody-positive limbic encephalitis in a patient with multiple sclerosis2012
- Author(s)
  Uzawa A, Mori M, Takahashi Y, Ogawa Y, Uchiyama T, Kuwabara S
- Journal Title
  
  Clin Neurol Neurosurg
  
  Volume: (in press) Issue: 4 Pages: 402-404
- DOI
  10.1016/j.clineuro.2011.10.047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790375, KAKENHI-PROJECT-24591537, KAKENHI-PROJECT-24790873
[Journal Article] When is neuromyelitis optica diagnosed after disease onset?2012
- Author(s)
  Uzawa A, Mori M, Muto M, Masuda S, Kuwabara S
- Journal Title
  
  J Neurol
  
  Volume: (in press) Issue: 8 Pages: 1600-5
- DOI
  10.1007/s00415-011-6384-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790375, KAKENHI-PROJECT-24790873
[Journal Article] Seroconversion of anti-aquaporin-4 antibody in NMO spectrum disorder : a case report2012
- Author(s)
  Mori M, Kawaguchi N, Uzawa A, Nemoto Y, Masuda S, Kuwabara S
- Journal Title
  
  J Neurol
  
  Volume: (in press) Issue: 5 Pages: 980-1
- DOI
  10.1007/s00415-011-6288-2
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790375, KAKENHI-PROJECT-24790873
[Journal Article] CSF interleukin-6 level predicts recovery from neuromyelitis optica relapse2012
- Author(s)
  Uzawa A, Mori M, Sato Y, Masuda S, Kuwabara S
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: 82 Issue: 3 Pages: 85-6
- DOI
  10.1136/jnnp.2011.241760
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790375
[Journal Article] 視神経脊髄炎と多発性硬化症の免疫病態の相違2011
- Author(s)
  鵜沢顕之, 森雅裕, 桑原聡
- Journal Title
  
  千葉医学会雑誌
  
  Volume: 87 Pages: 291-4
- NAID
  10030922443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790375
[Journal Article] CSF interleukin-6 level predicts recovery from neuromyelitis optica relapse2011
- Author(s)
  Uzawa A, Mori M, et al
- Journal Title
  
  Journal of Neurology, Neurosurgery and Psychiatry
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790375
[Journal Article] Markedly elevated sICAM-1 and sVCAM-1 levels in neuromyelitis optica : correlations with blood-brain barrier breakdown2011
- Author(s)
  Uzawa A, Mori M, Masuda S, Kuwabara S
- Journal Title
  
  Arch Neurol
  
  Volume: 68 Issue: 7 Pages: 913-7
- DOI
  10.1001/archneurol.2011.148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790375
[Journal Article] Markedly elevated sICAM-1 and sVCAM-1 levels in neuromyelitis optica : correlations with blood-brain barrier breakdown2011
- Author(s)
  Uzawa A, Mori M, et al
- Journal Title
  
  Archives of Neurology
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790375
[Journal Article] Relapse of Neuromyelitis Optica Spectrum Disorder Associated with Intravenous Lidocaine2011
- Author(s)
  Uzawa A, Mori M, Masuda S, Aoe K, Kuwabara S
- Journal Title
  
  Case Report Med
  
  Volume: 2011 Pages: 1-3
- DOI
  10.1155/2011/405837
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790375
[Journal Article] Detection of mumps virus RNA in cerebrospinal fluid of patients with neuromyelitis optica2011
- Author(s)
  Mori M, Hosoya M, Hiwasa T, Hayakawa S, Uzawa A, Kuwabara S
- Journal Title
  
  Neurol Sci
  
  Volume: 32 Issue: 5 Pages: 795-9
- DOI
  10.1007/s10072-011-0564-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790375
[Journal Article] Isolated abducens and facial nerve palsies due to a facial collicular plaque in multiple sclerosis2011
- Author(s)
  Uzawa A, Mori M, Ito S, Kuwabara S
- Journal Title
  
  J Neurol Neurosurg Psychiatry
  
  Volume: 82 Issue: 1 Pages: 85-6
- DOI
  10.1136/jnnp.2010.206870
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790375
[Journal Article] 視神経脊髄炎と多発性硬化症の免疫病態の相違2011
- Author(s)
  鵜沢顕之
- Journal Title
  
  千葉医学会雑誌
  
  Volume: 87 Pages: 291-294
- NAID
  10030922443
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790375
[Journal Article] Expression of chemokine receptors on peripheral blood lymphocytes in multiple sclerosis and neuromyelitis optica2010
- Author(s)
  Uzawa A, Mori M, Hayakawa S, Masuda S, Nomura F, Kuwabara S
- Journal Title
  
  BMC Neurol
  
  Volume: 10 Issue: 1 Pages: 113-113
- DOI
  10.1186/1471-2377-10-113
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790375
[Journal Article] Cytokine and chemokine profiles in neuromyelitis optica : significance of interleukin-6.2010
- Author(s)
  Uzawa A, Mori M, et al.
- Journal Title
  
  Multiple Sclerosis
  
  Volume: 16 Pages: 1443-1452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790375
[Journal Article] Different responses to interferon beta-1b treatment in patients with neuromyelitis optica and multiple sclerosis2010
- Author(s)
  Uzawa A, Mori M, Hayakawa S, Masuda S, Kuwabara S
- Journal Title
  
  Eur J Neurol
  
  Volume: 17 Issue: 5 Pages: 672-6
- DOI
  10.1111/j.1468-1331.2009.02897.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790375
[Journal Article] Cytokine and chemokine profiles in neuromyelitis optica : significance of interleukin-62010
- Author(s)
  Uzawa A, Mori M, Arai K, Sato Y, Hayakawa S, Masuda S, Taniguchi J, Kuwabara S
- Journal Title
  
  Mult Scler
  
  Volume: 16 Issue: 12 Pages: 1443-52
- DOI
  10.1177/1352458510379247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790375
[Presentation] MuSK抗体陽性重症筋無力症に対する新規治療－ Fc融合タンパク―2023
- Author(s)
  鵜沢顕之
- Organizer
  日本神経免疫学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K06921
[Presentation] AChR-Fc融合蛋白による治療がMG動物モデルのサイトカイン動態に与える変化2020
- Author(s)
  小澤由希子、鵜沢顕之、安田真人、Bibinu Maimaitiming、小島雄太、山下潤二、成田匡邦、中島謙治、千種誠史、桑原聡
- Organizer
  第32回日本神経免疫学会
- Data Source
  KAKENHI-PROJECT-19K07954
[Presentation] A possible new treatment for MG: Fc fusion protein, AChR-Fc2019
- Author(s)
  鵜沢顕之
- Organizer
  日本神経学会
- Invited
- Data Source
  KAKENHI-PROJECT-19K07954
[Presentation] 中枢神経炎症性脱髄疾患病態におけるペルオキシレドキシンの関与2019
- Author(s)
  鵜沢顕之
- Organizer
  日本神経学会
- Data Source
  KAKENHI-PROJECT-16K09691
[Presentation] SOLUBLE TALIN-1 AND ANTI-TALIN-1 ANTIBODY ARE ASSOCIATED WITH PATHOGENESIS OF MULTIPLE CLEROSIS AND MAY BE AS BIOMARKER FOR THE DISEASE.2017
- Author(s)
  L. Jia, M. Muto, M. Mori, A. Uzawa, T. Uchida, H. Masuda, R. Ohtani, K. Sugimoto, S. Kuwabara.
- Organizer
  The XXIII World Congress of Neurology (WCN 2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09333
[Presentation] CSF CD59 UPREGULATION IN NEUROMYELITIS OPTICA AND MULTIPLE SCLEROSIS2017
- Author(s)
  Akiyuki Uzawa
- Organizer
  International Taiwanese Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09691
[Presentation] 重症筋無力症の革新的治療法：融合蛋白AChR-Fc2017
- Author(s)
  鵜沢顕之
- Organizer
  日本神経治療学会総会
- Data Source
  KAKENHI-PROJECT-16K09691
[Presentation] CSF IL-6 study in neurological disorders with a special focus on neuromyelitis optica2017
- Author(s)
  Akiyuki Uzawa
- Organizer
  World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09691
[Presentation] リコンビナントトロンボモジュリンの多発性硬化症治療への応用2017
- Author(s)
  鵜沢顕之
- Organizer
  日本神経免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K09691
[Presentation] Implication of damage-associated molecular patterns in myasthenia gravis2016
- Author(s)
  Akiyuki Uzawa, Tetsuya Kanai, Naoki Kawaguchi, Fumiko Oda, Yukiko Ozawa, Keiichi Himuro, Satoshi Kuwabara
- Organizer
  the 15th Asian and Oceanian Congress of Neurology
- Place of Presentation
  Kuala Lumpur City Centre (Kuala Lumpur, Malaysia）
- Year and Date
  2016-08-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09691
[Presentation] 重症筋無力症におけるダメージ関連分子パターンとサイトカインの関連2016
- Author(s)
  鵜沢顕之、金井哲也、川口直樹、織田史子、小澤由希子、氷室圭一、桑原聡
- Organizer
  日本神経免疫学会学術集会
- Place of Presentation
  長崎ブリックホール（長崎県、長崎市）
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-16K09691
[Presentation] 視神経脊髄炎の髄液HMGB1濃度は中枢神経内の炎症とアストロサイト障害と関連する2013
- Author(s)
  鵜沢顕之,森雅裕,谷口順子,増田冴子,武藤真弓 ,内田智彦,枡田大生,桑原聡
- Organizer
  第54回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790873
[Presentation] 多発性硬化症・視神経脊髄炎に対する新規治療ターゲットとしてのHMGB1の可能性2013
- Author(s)
  鵜沢顕之
- Organizer
  神経免疫班会議
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790873
[Presentation] 多発性硬化症・視神経脊髄炎に対する新規治療ターゲットとしてのHMGB1の可能性2013
- Author(s)
  桑原聡、鵜沢顕之、森雅裕、谷口順子、増田冴子、武藤真弓、内田智彦
- Organizer
  平成24年度免疫性神経疾患に関する調査研究班班会議
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790873
[Presentation] High-mobility group box 1could be a therapeutic target in neuromyelitis optica and multiple sclerosis2013
- Author(s)
  Akiyuki Uzawa, Masahiro Mori, Junko Taniguchi, Saeko Masuda, Mayumi Muto, Tomohiko Uchida, Hiroki Masuda, Satoshi Kuwabara
- Organizer
  The 6th Pan Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS)
- Place of Presentation
  JAPAN, KYOTO
- Data Source
  KAKENHI-PROJECT-24790873
[Presentation] エナラプリルはブラジキニンの上昇を介してEAEの重症度を抑制する2013
- Author(s)
  鵜沢顕之、森雅裕、谷口順子、増田冴子、武藤真弓、内田智彦、枡田大生、桑原聡
- Organizer
  第25回日本神経免疫学会学術集会
- Place of Presentation
  山口
- Data Source
  KAKENHI-PROJECT-24790873
[Presentation] 視神経脊髄炎の髄液HMGB1濃度は中枢神経内の炎症とアストロサイト障害と関連する2013
- Author(s)
  鵜沢顕之
- Organizer
  日本神経学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790873
[Presentation] High-mobility group box 1could be a therapeutic target in neuromyelitis optica and multiple sclerosis2013
- Author(s)
  Akiyuki Uzawa
- Organizer
  Pan Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS) 2013
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-24790873
[Presentation] Markedly elevated sICAM-1 and sVCAM-1 levels in neuromyelitis optica : correlations with blood-brain barrier disruption2012
- Author(s)
  Akiyuki Uzawa, Masahiro Mori, Saeko Masuda, Satoshi Kuwabara
- Organizer
  The 13th Asian Oceanian Congress of Neurology
- Place of Presentation
  Australia
- Data Source
  KAKENHI-PROJECT-24790873
[Presentation] 抗HMGB1抗体はEAEの重症度を抑制する：多発性硬化症に対する新規治療応用の可能性2012
- Author(s)
  鵜沢顕之
- Organizer
  日本神経免疫学会学術集会
- Place of Presentation
  軽井沢
- Data Source
  KAKENHI-PROJECT-24790873
[Presentation] 抗HMGB1抗体は EAEの重症度を抑制する : 多発性硬化症に対する新規治療応用の可能性2012
- Author(s)
  鵜沢顕之、森雅裕、谷口順子、増田冴子、武藤真弓、内田智彦、桑原聡
- Organizer
  第24回日本神経免疫学会学術集会
- Place of Presentation
  長野
- Data Source
  KAKENHI-PROJECT-24790873
[Presentation] Peptide array法によるAQP4上のimmunogenic site同定の試み2012
- Author(s)
  森雅裕, 鵜沢顕之, 増田冴子, 武藤真弓, 桑原聡
- Organizer
  免疫性神経疾患に関する調査研究班班会議
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22790375
[Presentation] NMOの臨床経過-2006年版改定診断基準の有用性の検討-2012
- Author(s)
  鵜沢顕之,森雅裕,増田冴子,武藤真弓 ,桑原聡
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790873
[Presentation] Markedly elevated sICAM-1 and sVCAM-1 levels in neuromyelitis optica: correlations with blood-brain barrier disruption2012
- Author(s)
  Akiyuki Uzawa
- Organizer
  Asian Oceanian Congress of Neurology
- Place of Presentation
  Melbourne, Australia
- Data Source
  KAKENHI-PROJECT-24790873
[Presentation] 視神経脊髄炎のサイトカイン・ケモカインプロファイル2011
- Author(s)
  鵜沢顕之, 森雅裕, 桑原聡
- Organizer
  免疫性神経疾患に関する調査研究班班会議
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22790375
[Presentation] MOでの可溶性ICAM-1、VCAM-1の上昇:血液脳関門破綻との関連2011
- Author(s)
  鵜沢顕之, 森雅裕, 増田冴子, 桑原聡
- Organizer
  日本神経免疫学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22790375
[Presentation] 髄液サイトカインと視神経脊髄炎の予後に関する検討2011
- Author(s)
  鵜沢顕之, 森雅裕, 増田冴子, 桑原聡
- Organizer
  日本神経学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22790375
[Presentation] ペプチドを用いた抗アクアポリン4抗体の抗原認識部位の探査2011
- Author(s)
  森雅裕, 鵜沢顕之, 増田冴子, 桑原聡
- Organizer
  日本神経学会総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22790375
[Presentation] 免疫吸着療法による抗aquaporin-4抗体の除去能の検討2011
- Author(s)
  森雅裕, 鵜沢顕之, 増田冴子, 武藤真弓
- Organizer
  日本神経免疫学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22790375
[Presentation] NMOでの可溶性ICAM-1、VCAM-1の上昇:血液脳関門破綻との関連2011
- Author(s)
  鵜沢顕之
- Organizer
  日本神経免疫学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22790375
[Presentation] MSの経過中に抗GluR抗体陽性辺縁系脳炎を合併し、ステロイド治療が奏功した34歳女性例2011
- Author(s)
  鵜沢顕之, 森雅裕, 内山智之, 小川喜胤, 桑原聡
- Organizer
  日本神経治療学会
- Place of Presentation
  福井
- Data Source
  KAKENHI-PROJECT-22790375
[Presentation] Cytokine Profiles in Neuromyelitis Optica : Significance of Interleukin-62011
- Author(s)
  Akiyuki Uzawa
- Organizer
  Sendai NMO Conference
- Place of Presentation
  Sendai(招待講演)
- Year and Date
  2011-07-16
- Data Source
  KAKENHI-PROJECT-22790375
[Presentation] Cytokine Profiles in Neuromyelitis Optica : Significance of Interleukin-62011
- Author(s)
  Akiyuki Uzawa
- Organizer
  Sendai NMO Conference
- Place of Presentation
  Sendai
- Year and Date
  2011-07-16
- Data Source
  KAKENHI-PROJECT-22790375
[Presentation] NMOとMSにおけるinterferonβ-1b治療反応性の差異に関する検討2010
- Author(s)
  鵜沢顕之
- Organizer
  第51回日本神経学会総会
- Place of Presentation
  東京国際フォーラム(東京)
- Year and Date
  2010-05-22
- Data Source
  KAKENHI-PROJECT-22790375
[]

1. Masahiro Mori (70345023)

# of Collaborated Projects: 4 results

# of Collaborated Products: 29 results
2. 桑原聡 (70282481)

# of Collaborated Projects: 4 results

# of Collaborated Products: 19 results
3. 日和佐隆樹 (30260251)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. 八木良二 (20392152)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 星野忠次 (90257220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 赤嶺博行 (30931315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 横山真隆 (20514871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. UCHIDA Tomohiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. MASUDA Hiroki

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
10. OHTANI Ryouhei

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. LIU Jia

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. SUGIMOTO Manabu

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
13. 横手幸太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 竹本稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Uzawa Akiyuki 鵜沢 顕之

UZAWA Akiyuki 鵜沢 顕之

Research Projects

Research Products

Co-Researchers

MuSK抗体陽性重症筋無力症に対する標的抗原Fc融合タンパクを用いた革新的治療法開発Principal Investigator

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シングルセルRNA解析を用いた重症筋無力症の分子病態解明

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Development of innovative therapy for autoantibody-related disorders using fusion proteins combining IgG1Fc and extracellular domains of target antigen.

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Elucidation of the action mechanism in vivo of AChR-Fc, a novel treatment for myasthenia gravisPrincipal Investigator

Principal Investigator

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Review Section

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Comprehensive search of autoantibies in neuroimmunological disorders using a novel hybrid SEREX-FACS method

Principal Investigator

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Development of novel treatment against peroxiredoxin in central nervous system demyelinating diseasesPrincipal Investigator

Principal Investigator

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Novel therapeutic strategies for multiple sclerosis targeting autoantibodies against talin.

Principal Investigator

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High-mobility group box 1 is involved in neuromyelitis optica pathogensesis and could be a therapeutic target.Principal Investigator

Principal Investigator

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Development of mouse model of neuromyelitis optica induced by aquaporin-4 protein immunizationPrincipal Investigator

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[Book] Fc融合蛋白による重症筋無力症の革新的治療2019

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[Journal Article] Silent progression of brain atrophy in aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder.2022

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[Journal Article] Complete Relief of Painful Tonic Seizures in Neuromyelitis Optica Spectrum Disorder by Satralizumab Treatment2022

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[Journal Article] AQP4-IgG autoimmunity in Japan and Germany: Differences in clinical profiles and prognosis in seropositive neuromyelitis optica spectrum disorders.2021

Author(s)

Uzawa Akiyuki 鵜沢顕之

UZAWA Akiyuki 鵜沢顕之