Saga Ayami 嵯峨礼美

Researcher Number	10535925
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 特任研究員(常勤)
Affiliation (based on the past Project Information) *help	2025: 大阪大学, 大学院医学系研究科, 特任研究員(常勤) 2022 – 2023: 大阪大学, 大学院医学系研究科, 特任研究員(常勤) 2018 – 2021: 大阪大学, 医学系研究科, 特任研究員(常勤)
Review Section/Research Field	Principal Investigator Basic Section 53050:Dermatology-related / Basic Section 53020:Cardiology-related
Keywords	Principal Investigator 乾癬 / 動脈硬化 / 心筋障害 / 脂肪肝炎 / Ｔ細胞 / コレステロール / 酸化ステロール / 酸化コレステロール / IL-17 / IL-23 / 7-ketocholesterol

乾癬様皮膚炎モデルにおける動脈硬化病変マクロファージの泡沫化促進メカニズムの解析Principal Investigator
- Principal Investigator
  
  嵯峨礼美
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  The University of Osaka
Elucidation of the molecular mechanisms of the cross-talk between psoriasis, steatohepatitis, and atherosclerosis/myocardial damage.Principal Investigator
- Principal Investigator
  
  Saga Ayami
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Osaka University
Analysis of the mechanism of exacerbation of psoriasis by the epidermal basal cell proliferation-enhancing effect of diet-derived oxidized sterolsPrincipal Investigator
- Principal Investigator
  
  Saga Ayami
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Anti-GPIHBP1 Antibody-Positive Autoimmune Hyperchylomicronemia and Immune Thrombocytopenia2023
- Author(s)
  Tanaka Katsunao、Koseki Masahiro、Kato Hisashi、Miyashita Kazuya、Okada Takeshi、Kanno Kotaro、Saga Ayami、Chang Jiuyang、Omatsu Takashi、Inui Hiroyasu、Ohama Tohru、Nishida Makoto、Yamashita Shizuya、Sakata Yasushi
- Journal Title
  
  Journal of Atherosclerosis and Thrombosis
  
  Volume: 30 Issue: 1 Pages: 100-104
- DOI
  10.5551/jat.63348
- NAID
  130008161257
- ISSN
  1340-3478, 1880-3873
- Year and Date
  2023-01-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K17149, KAKENHI-PROJECT-21K08323, KAKENHI-PROJECT-21K20870, KAKENHI-PROJECT-22K08670, KAKENHI-PROJECT-20K21893, KAKENHI-PROJECT-21K08371
[Journal Article] Pemafibrate suppresses NLRP3 inflammasome activation in the liver and heart in a novel mouse model of steatohepatitis-related cardiomyopathy2022
- Author(s)
  Kanno Kotaro、Koseki Masahiro、Chang Jiuyang、Saga Ayami、Inui Hiroyasu、Okada Takeshi、Tanaka Katsunao、Asaji Masumi、Zhu Yinghong、Ide Seiko、Saito Shigeyoshi、Higo Tomoaki、Okuzaki Daisuke、Ohama Tohru、Nishida Makoto、Kamada Yoshihiro、Ono Masafumi、Saibara Toshiji、Yamashita Shizuya、Sakata Yasushi
- Journal Title
  
  Scientific Reports
  
  Volume: 12 Issue: 1 Pages: 2996-2996
- DOI
  10.1038/s41598-022-06542-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K17149, KAKENHI-PROJECT-21K08323, KAKENHI-PROJECT-21K20870, KAKENHI-PROJECT-22K07445, KAKENHI-PROJECT-20K21893, KAKENHI-PROJECT-20K08383
[Journal Article] A Dietary Oxysterol, 7-Ketocholesterol, Exacerbates Imiquimod-Induced Psoriasis-like Dermatitis in Steatohepatitic Mice2022
- Author(s)
  Saga Ayami、Koseki Masahiro、Kanno Kotaro、Chang Jiuyang、Higo Tomoaki、Yamashita Shizuya、Sakata Yasushi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 24 Pages: 15855-15855
- DOI
  10.3390/ijms232415855
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08323, KAKENHI-PROJECT-22K07445, KAKENHI-PROJECT-22K08670, KAKENHI-PROJECT-20K08383, KAKENHI-PROJECT-20K21893, KAKENHI-PROJECT-21K20870
[Journal Article] Dietary oxysterol, 7-Ketocholesterol accelerates hepatic lipid accumulation and macrophage infiltration in obese Mice2021
- Author(s)
  J. Chang, M. oseki, A. Saga, K. Kanno, T. Higo, D. Okuzaki, T. Okada, H. Inui, K. Tanaka, M. Asaji, Y. Zhu, K. Yamada, M. Ono, T. Saibara, I Ichi, T. Ohama, M. Nishida, S. Yamashita, Y. Sakata
- Journal Title
  
  Front Endocrinol (Lausanne)
  
  Volume: 11 Pages: 614692-614692
- DOI
  10.3389/fendo.2020.614692
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K02383, KAKENHI-PROJECT-20K08356, KAKENHI-PROJECT-20K21893, KAKENHI-PROJECT-20K17149, KAKENHI-PROJECT-18H03532, KAKENHI-PROJECT-18K16026, KAKENHI-PROJECT-20K08383
[Presentation] The Existence of Psoriasis-like Dermatitis Promotes Atherosclerosis in Mice2024
- Author(s)
  Ayami Saga, Masahiro Koseki, Hiroshi Sawabe, Sae Nishihara, Takashi Omatsu, Katsunao Tanaka, Takeshi Okada, Hiroyasu Inui, Tohru Ohama, Makoto Nishida, Yasushi Sakata
- Organizer
  第88回日本循環器学会総会
- Data Source
  KAKENHI-PROJECT-21K08323
[Presentation] 食事誘導性脂肪肝炎モデルマウスにおけるトホグリフロジンの肝臓内脂質に及ぼす影響の検討2023
- Author(s)
  西原紗恵、小関正博、田中克尚、尾松卓、嵯峨礼美、乾洋勉、大濱透、西田誠、坂田泰史
- Organizer
  第55回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K08323
[Presentation] 脂肪肝モデルマウスにおける、糖・脂質異常症治療薬の作用メカニズム2023
- Author(s)
  西原紗恵、小関正博、田中克尚、尾松卓、嵯峨礼美、冠野昂太郎、常久洋、大濱透、西田誠、坂田泰史
- Organizer
  第55回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K08323
[Presentation] High Fat Diet Containing 7-Ketocholesterol Induces Steatohepatitis and Cardiac Inflammation in STZ-Induced Diabetic Mice2021
- Author(s)
  Masahiro Koseki、Juyang Chang、Kotaro Kanno、Ayami Saga、Hiroyasu Inui、Takeshi Okada、Shigeyoshi Saito、Tomoaki Higo、Seiko Ide、Katsunao Tanaka、Yinghong Zhu、Toru Ohhama、Makoto Nishida、Shizuya Yamashita、Yasushi Sakata
- Organizer
  第85回日本循環器学会学術集会
- Data Source
  KAKENHI-PROJECT-18K16026
[Presentation] 食餌由来7-ketocholesterolはイミキモド誘導乾癬様皮膚炎を憎悪させる2021
- Author(s)
  嵯峨礼美, 小関正博, 冠野昂太郎, 常久洋, 田中克尚, 朝治真澄, 岡田健志, 鎌田佳宏, 乾洋勉, 朱穎竑, 大濱透, 西田誠, 山下静也, 坂田泰史
- Organizer
  第63回　日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-21K08323
[Presentation] 7-ketocholesterolは食餌誘導性脂肪肝炎モデルマウスにおいて乾癬様皮膚炎を促進させる2021
- Author(s)
  嵯峨礼美, 小関正博, 冠野昂太郎, 常久洋, 田中克尚, 尾松卓, 朝治真澄, 岡田健志, 鎌田佳宏, 乾洋勉, 朱穎こう, 大濱透, 西田誠, 山下静也, 坂田泰史
- Organizer
  第53回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K08323
[Presentation] 7-ketocholesterol exacerbates psoriasis-like dermatitis in diet-induced steatosis mice2021
- Author(s)
  Saga A, Koseki M, Kanno K, Chang J, Tanaka K, Omatsu T, Nishihara S, Asaji M, Okada T, Kamada Y, Zhu Y, Inui H, Ohama T, Nishida M, Yamashita S, Sakata Y
- Organizer
  The 19th International Symposium on Atherosclerosis
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K08323
[Presentation] A dietary oxysterol, 7-ketocholesterol, exacerbates imiquimod-induced psoriasis-like dermatitis in steatohepatitis mice2020
- Author(s)
  Saga A, Koseki M, Kanno K, Chang J, Asaji M, Okada T, Inui H, Zhu Y, Ohama T, Nishida M, Yamashita S, Sakata Y.
- Organizer
  日本研究皮膚科学会　第45回年次学術大会・総会
- Data Source
  KAKENHI-PROJECT-18K16026
[Presentation] Dietary oxysterol, 7-ketocholesterol accelerated steatohepatitis and atherosclerosis in Ldlr deficient mice model2020
- Author(s)
  冠野昂太郎、小関正博、嵯峨礼美、常久洋、岡田健志、乾洋勉、朝治真澄、朱穎竑、大濵透、西田誠、山下静也、坂田泰史
- Organizer
  第52回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K16026
[Presentation] Prevalence of Coronary Artery Disease and Achievement of Low-density Lipoprotein Cholesterol Management Targets in Familial Hypercholesterolemia Patients at Osaka University Hospital2020
- Author(s)
  Koseki M, Kanno K, Saga A, Chang J, Inui H, Okada T, Ohama T, Nishida M, Kamada Y, Miyoshi E, Yamashita S, Sakata Y.
- Organizer
  88th European Atherosclerosis Congress
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K16026
[Presentation] 食餌誘発性脂肪肝炎マウスモデルにおいて7-ketocholesterolはイミキモド誘導乾癬様皮膚炎を増悪させる2020
- Author(s)
  嵯峨礼美、小関正博、冠野昂太郎、常久洋、朝治真澄、岡田健志、鎌田佳宏、乾洋勉、朱穎竑、大濵透、西田誠、山下静也、坂田泰史
- Organizer
  第52回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K16026
[Presentation] NAFLD/NASH、動脈硬化進展における外因性酸化ステロール7-ketocholesterolの影響2020
- Author(s)
  小関正博、冠野昂太郎、常久洋、嵯峨礼美、岡田健志、乾洋勉、鎌田佳宏、山下静也、坂田泰史
- Organizer
  第52回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K16026
[Presentation] イミキモド誘導乾癬モデルマウスにおける食事誘導脂肪肝炎の影響2020
- Author(s)
  嵯峨礼美、常久洋、小関正博
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K16026
[Presentation] 食事由来7-ketocholesterolは、Ldl受容体欠損マウスにおいて、脂肪肝炎とアテローム性動脈硬化症を憎悪させる2020
- Author(s)
  冠野昂太郎、小関正博、嵯峨礼美、常久洋、岡田健志、乾洋勉、朝治真澄、朱穎竑、大濵透、鎌田佳宏、西田誠、山下静也、坂田泰史
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-18K16026
[Presentation] 食餌誘導性脂肪肝炎マウスモデルにおいて7-ketocholesterolは乾癬様皮膚炎を促進させる2020
- Author(s)
  嵯峨礼美、小関正博、冠野昂太郎、常久洋、朝治真澄、岡田健志、鎌田佳宏、乾洋勉、朱穎竑、大濵透、西田誠、山下静也、坂田泰史
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-18K16026
[Presentation] The dietary 7-Ketocholesterol accelerated steatohepatitis in ob/ob mice by suppressing autophagy2020
- Author(s)
  常久洋、小関正博、嵯峨礼美
- Organizer
  第56回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-18K16026
[Presentation] The dietary 7-ketocholesterol accelerated steatohepatitis in ob/ob mice.2020
- Author(s)
  Chang J, Koseki M, Saga A, Kanno K, Okada T, Saito S, Kamada Y, Inui H, Asaji M, Zhu Y, Ohama T, Nishida M, Yamashita S, Sakata Y.
- Organizer
  第62回日本脂質生化学会
- Data Source
  KAKENHI-PROJECT-18K16026
[Presentation] 乾癬様皮膚炎マウスモデルにおける外因性酸化ステロールの影響の検討2019
- Author(s)
  嵯峨礼美、小関正博、冠野昂太郎、常久洋、朝治真澄、岡田健志、乾洋勉、朱頴広、大濵透、西田誠、山下静也、坂田泰史
- Organizer
  第51回日本動脈硬化学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K16026

1. 小関正博 (10467582)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. ICHI Ikuyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 岡田健志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Saga Ayami 嵯峨 礼美

Research Projects

Research Products

Co-Researchers

乾癬様皮膚炎モデルにおける動脈硬化病変マクロファージの泡沫化促進メカニズムの解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular mechanisms of the cross-talk between psoriasis, steatohepatitis, and atherosclerosis/myocardial damage.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the mechanism of exacerbation of psoriasis by the epidermal basal cell proliferation-enhancing effect of diet-derived oxidized sterolsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Anti-GPIHBP1 Antibody-Positive Autoimmune Hyperchylomicronemia and Immune Thrombocytopenia2023

Author(s)

Journal Title

DOI

NAID

ISSN

Year and Date

Language

Data Source

[Journal Article] Pemafibrate suppresses NLRP3 inflammasome activation in the liver and heart in a novel mouse model of steatohepatitis-related cardiomyopathy2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Dietary Oxysterol, 7-Ketocholesterol, Exacerbates Imiquimod-Induced Psoriasis-like Dermatitis in Steatohepatitic Mice2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dietary oxysterol, 7-Ketocholesterol accelerates hepatic lipid accumulation and macrophage infiltration in obese Mice2021

Author(s)

Journal Title

DOI

Data Source

[Presentation] The Existence of Psoriasis-like Dermatitis Promotes Atherosclerosis in Mice2024

Author(s)

Organizer

Data Source

[Presentation] 食事誘導性脂肪肝炎モデルマウスにおけるトホグリフロジンの肝臓内脂質に及ぼす影響の検討2023

Author(s)

Organizer

Data Source

[Presentation] 脂肪肝モデルマウスにおける、糖・脂質異常症治療薬の作用メカニズム2023

Author(s)

Organizer

Data Source

[Presentation] High Fat Diet Containing 7-Ketocholesterol Induces Steatohepatitis and Cardiac Inflammation in STZ-Induced Diabetic Mice2021

Author(s)

Organizer

Data Source

[Presentation] 食餌由来7-ketocholesterolはイミキモド誘導乾癬様皮膚炎を憎悪させる2021

Author(s)

Organizer

Data Source

[Presentation] 7-ketocholesterolは食餌誘導性脂肪肝炎モデルマウスにおいて乾癬様皮膚炎を促進させる2021

Author(s)

Organizer

Data Source

[Presentation] 7-ketocholesterol exacerbates psoriasis-like dermatitis in diet-induced steatosis mice2021

Author(s)

Organizer

Data Source

[Presentation] A dietary oxysterol, 7-ketocholesterol, exacerbates imiquimod-induced psoriasis-like dermatitis in steatohepatitis mice2020

Author(s)

Organizer

Data Source

[Presentation] Dietary oxysterol, 7-ketocholesterol accelerated steatohepatitis and atherosclerosis in Ldlr deficient mice model2020

Author(s)

Saga Ayami 嵯峨礼美