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OKAMURA Ayako  岡村 文子

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… Alternative Names

出町文子

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Researcher Number 10546948
Other IDs
Affiliation (based on the past Project Information) *help 2024: 愛知県がんセンター(研究所), 腫瘍免疫制御TR分野, 主任研究員
2019 – 2022: 愛知県がんセンター(研究所), 腫瘍免疫制御TR分野, 主任研究員
2018: 愛知県がんセンター(研究所), 腫瘍免疫応答研究分野, 主任研究員
2015 – 2017: 愛知県がんセンター(研究所), 腫瘍免疫学部, 主任研究員
2011 – 2014: 愛知県がんセンター(研究所), 腫瘍免疫学部, 研究員
2013: 愛知県がんセンター研究所, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 55040:Respiratory surgery-related / Basic Section 55020:Digestive surgery-related / Tumor therapeutics / Immunology / Tumor immunology
Except Principal Investigator
Medium-sized Section 90:Biomedical engineering and related fields / Basic Section 50020:Tumor diagnostics and therapeutics-related / Digestive surgery
Keywords
Principal Investigator
CTL / オートファジー / 腫瘍免疫 / TCR / エピトープ / 膵臓癌 / 免疫 / がん / 肺癌 / T細胞 … More / MR1 / K-RAS / エピトープペプチド / 膵臓がん / 免疫療法 / K-ras / 膵癌 / マススペクトロメトリー / 抗原提示 / 細胞傷害性Tリンパ球 … More
Except Principal Investigator
T細胞受容体 / 一細胞シークエンス / 免疫細胞受容体 / 一細胞計測 / 機械学習 / ベイズモデル / ペプチドHLA複合体 / タンパク質デザイン / TCR / 補体 / 膜侵襲複合体 / がん特異的TCR / 親和性の成熟 / T細胞受容体 / ナチュラルキラーT細胞 / 免疫療法 / 樹状細胞 / NKT細胞 / がん / 癌 / 免疫 / 膵臓癌 / 外科 Less
  • Research Projects

    (8 results)
  • Research Products

    (33 results)
  • Co-Researchers

    (14 People)
  •  Analysis on T cells that are specific for MR1-restricted targets derived from tumorsPrincipal Investigator

    • Principal Investigator
      岡村 文子 (出町文子)
    • Project Period (FY)
      2024 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55040:Respiratory surgery-related
    • Research Institution
      Aichi Cancer Center Research Institute
  •  Development of protein design methods for T cell receptors with immune single cell sequencing data analysis

    • Principal Investigator
      Yamaguchi Rui
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 90:Biomedical engineering and related fields
    • Research Institution
      Aichi Cancer Center Research Institute
  •  Investigation of CTL epitopes specific for autophagy-activated pancreatic cancerPrincipal Investigator

    • Principal Investigator
      Demachi-Okamura Ayako
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Aichi Cancer Center Research Institute
  •  Affinity maturation of cancer-specific TCRs by in vitro cell display methods and their application to drug discovery.

    • Principal Investigator
      OHTA RIEKO
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Nagoya City University
  •  Investigation of immunotherapy targeting an epitope generated through autophagy.Principal Investigator

    • Principal Investigator
      DEMACHI-OKAMURA Ayako
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor therapeutics
    • Research Institution
      Aichi Cancer Center Research Institute
  •  Analysis of antigen presentation mediated with constitutively active autophagy that induced by K-ras mutationPrincipal Investigator

    • Principal Investigator
      Demachi-Okamura Ayako
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Immunology
    • Research Institution
      Aichi Cancer Center Research Institute
  •  Invariant NKT cell-based effector T cell expressing a tumor reactive T cell receptor, as a possible cell medicine for pancreatic cancer

    • Principal Investigator
      UEMURA Yasushi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Aichi Cancer Center Research Institute
  •  Identification of CTL epitope using mass spectrometer.Principal Investigator

    • Principal Investigator
      OKAMURA Ayako
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Tumor immunology
    • Research Institution
      Aichi Cancer Center Research Institute

All 2024 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

  • [Book] がん免疫療法の個別化を支える新・腫瘍免疫学2019

    • Author(s)
      高橋祐介、岡村文子、松下博和
    • Total Pages
      267
    • Publisher
      羊土社
    • ISBN
      9784758103817
    • Data Source
      KAKENHI-PROJECT-19K09232
  • [Book] 臨床免疫・アレルギー科2014

    • Author(s)
      岡村文子、葛島清隆
    • Total Pages
      4
    • Publisher
      科学評論社
    • Data Source
      KAKENHI-PROJECT-25871227
  • [Journal Article] Candidate tumor-specific CD8+ T cell subsets identified in the malignant pleural effusion of advanced lung cancer patients by single-cell analysis2024

    • Author(s)
      Sugita Y, Muraoka D, Demachi-Okamura A, Komuro H, Masago K, Sasaki E, Fukushima Y, Matsui T, Shinohara S, Takahashi Y, Yamaguchi T, Horio Y, Hashimoto K, Tanaka I, Hamana H, Kishi H, Miura D, Tanaka Y, Onoue K, Onoguchi K, Yamashita Y, Stratford R, Clancy T, Yamaguchi R, Kuroda H, Ishibashi H, Okubo K, Matsushita H.
    • Journal Title

      Oncoimmunology

      Volume: 13(1) Issue: 1 Pages: 2371556-2371556

    • DOI

      10.1080/2162402x.2024.2371556

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K24195, KAKENHI-PROJECT-21K18261, KAKENHI-PROJECT-23K27423, KAKENHI-PROJECT-24K12042
  • [Journal Article] New evaluation of the tumor immune microenvironment of non-small cell lung cancer and its association with prognosis2022

    • Author(s)
      Shinohara Shuichi、Takahashi Yusuke、Demachi-Okamura Ayako et al.
    • Journal Title

      Journal for ImmunoTherapy of Cancer

      Volume: 10 Issue: 4 Pages: e003765-e003765

    • DOI

      10.1136/jitc-2021-003765

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09232, KAKENHI-PROJECT-19H03528, KAKENHI-PROJECT-20K09187
  • [Journal Article] Identification of neoantigens and development of antigen-specific immunotherapy2020

    • Author(s)
      Shinohara S., Takahashi Y., Demachi-Okamura A., Matsuhita H.
    • Journal Title

      Rinsho Ketsueki

      Volume: 61 Issue: 9 Pages: 1433-1439

    • DOI

      10.11406/rinketsu.61.1433

    • NAID

      130007937112

    • ISSN
      0485-1439, 1882-0824
    • Language
      Japanese
    • Data Source
      KAKENHI-PROJECT-19K09232
  • [Journal Article] Improving TCR affinity on 293T cells2019

    • Author(s)
      Ohta Rieko、Demachi-Okamura Ayako、Akatsuka Yoshiki、Fujiwara Hiroshi、Kuzushima Kiyotaka
    • Journal Title

      Journal of Immunological Methods

      Volume: 466 Pages: 1-8

    • DOI

      10.1016/j.jim.2018.11.010

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07285, KAKENHI-PROJECT-18K08341, KAKENHI-PROJECT-18K08361, KAKENHI-PROJECT-16K07192, KAKENHI-PROJECT-17K07238
  • [Journal Article] Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas2019

    • Author(s)
      Kataoka Keisuke, Miyoshi Hiroaki, Sakata Seiji, Dobashi Akito, Couronne Lucile, Kogure Yasunori, Sato Yasuharu, Nishida Kenji, Gion Yuka, Shiraishi Yuichi, Tanaka Hiroko, et al
    • Journal Title

      Leukemia

      Volume: Epub ahead of print Issue: 7 Pages: 1687-1699

    • DOI

      10.1038/s41375-019-0380-5

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07205, KAKENHI-PROJECT-17K10136, KAKENHI-PLANNED-15H05909, KAKENHI-PLANNED-15H05912, KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-16H05338, KAKENHI-PROJECT-19K09232, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-19H01053, KAKENHI-PROJECT-17K18335
  • [Journal Article] ネオアンチゲンはがんに対するナチュラルに誘導されるあるいは治療により誘導される免疫応答の重要な標的である2019

    • Author(s)
      松下博和、岡村文子、高橋祐介
    • Journal Title

      癌と化学療法

      Volume: 46 Pages: 1372-1376

    • Data Source
      KAKENHI-PROJECT-19K09232
  • [Journal Article] Induction of HLA-B*40:02-restricted T cells possessing cytotoxic and suppressive functions against haematopoietic progenitor cells from a patient with severe aplastic anaemia.2015

    • Author(s)
      Inaguma Y, Akatsuka Y, Hosokawa K, Maruyama H, Okamoto A, Katagiri T, Shiraishi K, Murayama Y, Tsuzuki-Iba S, Mizutani Y, Nishii C, Yamamoto N, Demachi-Okamura A, Kuzushima K, Ogawa S, Emi N, Nakao S.
    • Journal Title

      Br J Haematol.

      Volume: in press Issue: 1 Pages: 131-134

    • DOI

      10.1111/bjh.13464

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24591435, KAKENHI-PROJECT-15K09512, KAKENHI-PROJECT-26462701, KAKENHI-PROJECT-15K15360, KAKENHI-PROJECT-14F04419, KAKENHI-PROJECT-25871227, KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-26221308
  • [Journal Article] Identification of a naturally processed HLA-Cw7-binding peptide that cross-reacts with HLA-A24-restricted ovarian cancer-specific CTLs.2015

    • Author(s)
      Yamada E, Demachi-Okamura A, Kondo S, Akatsuka Y, Suzuki S, Shibata K, Kikkawa F, Kuzushima K.
    • Journal Title

      Tissue Antigens

      Volume: 86(3) Issue: 3 Pages: 164-71

    • DOI

      10.1111/tan.12607

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K20138, KAKENHI-PROJECT-25871227
  • [Journal Article] An HLA-modified ovarian cancer cell line induced CTL responses specific to an epitope derived from claudin-1 presented by HLA-A*24:02 molecules2013

    • Author(s)
      Kondo S, Demachi-Okamura A, Hirosawa T, Maki H, Fujita M, Uemura Y, Akatsuka Y, Yamamoto E, Shibata K, Ino K, Kikkawa F, Kuzushima K.
    • Journal Title

      Hum Immunol

      Volume: 74 Issue: 9 Pages: 1103-1110

    • DOI

      10.1016/j.humimm.2013.06.030

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592022, KAKENHI-PROJECT-24591435, KAKENHI-PROJECT-24659727, KAKENHI-PROJECT-25871227
  • [Journal Article] Zoledronate sensitizes neuroblastoma-derived tumor-initiating cells to cytolysis mediated by humanγδT cells2012

    • Author(s)
      Nishio N., Fujita M., Tanaka Y., Maki H., Zhang R, Hirosawa T., Demachi-Okamura A., Uemura Y., Taguchi O., Takahashi Y., Kojima S., Kuzushima K.
    • Journal Title

      J . Immunother.

      Volume: 35 Pages: 598-606

    • Data Source
      KAKENHI-PROJECT-23592022
  • [Journal Article] Autophagy creates a CTL epitope that mimics tumor-associated antigens.2012

    • Author(s)
      Demachi-Okamura A
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 10 Pages: e47126-e47126

    • DOI

      10.1371/journal.pone.0047126

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23701079
  • [Presentation] Single Cell解析を活用した非小細胞性肺癌におけるネオ抗原および癌・精巣抗原特異的なCD8+T細胞集団の同定2022

    • Author(s)
      小室裕康、篠原周一、福嶋恭啓、杉田裕介、松井琢哉、高橋祐介、岡村文子、村岡大輔、福山隆、浜名洋、岸裕幸、田中雄希、尾上広祐、小野口和英、山下慶子、山口類、黒田浩章、岩田尚、松下博和
    • Organizer
      第26回日本がん免疫学会総会
    • Data Source
      KAKENHI-PROJECT-21K19939
  • [Presentation] HLA-B1501肺癌患者におけるKK-LC-1に対するTCRの取得2021

    • Author(s)
      小室裕康、高橋祐介、宮本勇作、松本光善、山本裕崇、白橋幸洋、西田玲奈、宮井まなみ、篠原周一、松井琢哉、岡村文子、福山隆、黒田 浩章、松下博和、土井潔、岩田尚
    • Organizer
      第38回日本呼吸器外科学会
    • Data Source
      KAKENHI-PROJECT-21K19939
  • [Presentation] ヒト培養細胞を用いたTCR親和性成熟システムの樹立2018

    • Author(s)
      太田里永子、岡村 文子、赤塚 美樹、葛島 清隆
    • Organizer
      第22回日本がん免疫学会総会
    • Data Source
      KAKENHI-PROJECT-18K07285
  • [Presentation] Frequent somatic alterations involving pro- grammed death ligands in EBV-related lymphomas2017

    • Author(s)
      片岡圭亮、三好寛明、岡村文子、坂田征士、Lucile Couronne、木暮泰寛、土橋映仁、佐藤康晴、西田賢司、白石友一、田中洋子、千葉健一、綿谷陽作、塩澤裕介、吉田健一、真田昌、加藤元博、葛島清隆、宮野悟、大田 泰徳、伊豆津宏二、吉野正、Olivier Hermine、竹内賢吾、赤塚美樹、大島孝一、小川誠司
    • Organizer
      第79回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K07192
  • [Presentation] がん細胞では異常なTAP分子によりエピトープを提示する2016

    • Author(s)
      岡村文子
    • Organizer
      第8回血液疾患免疫療法学会
    • Place of Presentation
      北海道大学学友会館フラテ(札幌市)
    • Data Source
      KAKENHI-PROJECT-16K07192
  • [Presentation] An analysis of TAP-independent epitope created in cancerous cells2015

    • Author(s)
      Ayako Okamura1, Yoshiki Akatsuka, Kiyotaka Kuzushima
    • Organizer
      The 74th Annual Meeting of the Japanese Cancer Association
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-25871227
  • [Presentation] 人工抗原提示細胞を用いたCTLの誘導とがん細胞特異的エピトープ生成過程について2014

    • Author(s)
      岡村文子,葛島清隆
    • Organizer
      日本がん免疫学会
    • Place of Presentation
      ひめぎんホール(松山市)
    • Year and Date
      2014-08-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-25871227
  • [Presentation] TRAILを発現する多能性幹細胞由来ミエロイド細胞を用いた細胞医薬の開発2013

    • Author(s)
      牧寛之, 植村靖史, 張エイ, 竹田和由, 劉天懿, 鈴木元晴, 都築忍, 岡村文子, 赤塚美樹, 西村泰治, 千住覚, 葛島清隆
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜市
    • Data Source
      KAKENHI-PROJECT-23592022
  • [Presentation] TRAILを発現する多能性幹細胞由来ミエロイド細胞を用いた細胞医薬の開発2013

    • Author(s)
      牧寛之, 植村靖史, 張エイ, 竹田和由, 劉天懿, 鈴木元晴, 都築忍, 岡村文子, 赤塚美樹, 西村泰治, 千住覚, 葛島清隆
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Data Source
      KAKENHI-PROJECT-23592022
  • [Presentation] Zoledronate sensitizes neuroblastoma-derived tumor-initiating cells to cytolysis mediated by human gamma-delta T cells2012

    • Author(s)
      西尾信博, 藤田貢, 田中義正, 牧寛之, 張エイ, 岡村文子, 植村靖史, 田口修, 高橋義行, 小島勢二, 葛島清隆
    • Organizer
      第4回造血器腫瘍免疫療法研究会学術集会
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-23592022
  • [Presentation] Tumor-reactive TCR gene-transduced invariant NKT cells as a possible tool for cancer immunotherapy2012

    • Author(s)
      Yasushi Uemura, Junichi Mineno, Hiroaki Ikeda, Tianyi Liu, Hiroyuki Maki, Shinji Kondo, Rong Zhang, Ayako Okamura, Mitsugu Fujita, Yoshiki Akatsuka, Yoshiaki Sonoda, Hiroshi Shiku, and Kiyotaka Kuzushima
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市
    • Data Source
      KAKENHI-PROJECT-23592022
  • [Presentation] Modification of IL-12p70/Osteopontin balance in dendritic cells by ligand activation of invariant NKT cells2012

    • Author(s)
      Motoharu Suzuki, Tianyi Liu, Narumi Hirosawa, Yayoi Nobori, Ayako Okamura, Yasushi Sakamoto, Kiyotaka Kuzushima, and Yasushi Uemura
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌市
    • Data Source
      KAKENHI-PROJECT-23592022
  • [Presentation] Regulation of IL-27/Osteopontin balance in dendritic cells by ligand activation of invariant NKT cells2012

    • Author(s)
      Rong Zhang, Tianyi Liu, Motoharu Suzuki, Narumi Hirosawa, Shin Kaneko, Ayako Okamura, Yasushi Sakamoto, Kiyotaka Kuzushima, and Yasushi Uemura
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸市
    • Data Source
      KAKENHI-PROJECT-23592022
  • [Presentation] 人工抗原提示細胞システムを利用した新規腫瘍抗原探索2012

    • Author(s)
      岡村文子
    • Organizer
      第34回日本造血細胞移植学会総会
    • Place of Presentation
      大阪、大阪国際会議場
    • Year and Date
      2012-02-24
    • Data Source
      KAKENHI-PROJECT-23701079
  • [Presentation] 人工抗原提示細胞システムを利用した新規腫瘍抗原探索2012

    • Author(s)
      岡村文子
    • Organizer
      第34回日本造血細胞移植学会総会(招待講演)
    • Place of Presentation
      大阪国際会議場
    • Data Source
      KAKENHI-PROJECT-23701079
  • [Presentation] 内因性HLAの発現を抑制し目的のHLA-A24を発現する人工抗原提示細胞を用いた卵巣がんを傷害するCTLの誘導2011

    • Author(s)
      近藤紳司, 岡村文子, 牧寛之, Zhang Rong ,植村靖史, 藤田貢, 山本英子, 柴田清住, 吉川史隆, 葛島清隆
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      愛知県名古屋市
    • Data Source
      KAKENHI-PROJECT-23592022
  • [Presentation] 膵がん細胞における恒常的高活性オートファジーによるCTLエピトープの産生2011

    • Author(s)
      岡村文子
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋、名古屋国際会議場
    • Year and Date
      2011-10-05
    • Data Source
      KAKENHI-PROJECT-23701079
  • [Presentation] Constitutively active autophagy causes CTL epitope generation in pancreatic cancer cells2011

    • Author(s)
      岡村文子
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Data Source
      KAKENHI-PROJECT-23701079
  • [Presentation] 内因性HLAの発現を抑制し目的のHLA-A24を発現する人工抗原提示細胞を用いた卵巣癌を傷害するCTLの誘導2011

    • Author(s)
      近藤紳司, 岡村文子, 牧寛之, Zhang Rong, 植村靖史, 藤田貢, 山本英子, 柴田清住, 吉川史隆, 葛島清隆
    • Organizer
      第15回日本がん免疫学会総会
    • Place of Presentation
      大阪府豊中市
    • Data Source
      KAKENHI-PROJECT-23592022
  • [Presentation] K-rasの活性化変異に伴う高活性オートファジーによるCTLエピトープの産生

    • Author(s)
      岡村文子、葛島清隆
    • Organizer
      造血器腫瘍免疫療法研究会
    • Place of Presentation
      ウインク愛知(名古屋市)
    • Data Source
      KAKENHI-PROJECT-25871227
  • 1.  KUZUSHIMA Kiyotaka (30311442)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 12 results
  • 2.  UEMURA Yasushi (40364781)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 10 results
  • 3.  SENJU Satoru (50274709)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  OHTA RIEKO (30452460)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  Yamaguchi Rui (90380675)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  今井 優樹 (30440936)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  松下 博和 (80597782)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 8.  吉田 亮 (70401263)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  太田 元規 (40290895)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  黒田 浩章
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  真砂 勝泰
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  赤塚 美樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  坂田 征士
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 14.  鈴木 史朗
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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