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Yamamoto Naoki  山本 直樹

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YAMAMOTO Naoki  山本 直樹

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Researcher Number 10547780
Other IDs
Affiliation (Current) 2025: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 主任研究員
2025: 公益財団法人東京都医学総合研究所, 感染症医学研究センター, 主任研究員
Affiliation (based on the past Project Information) *help 2020 – 2023: 公益財団法人東京都医学総合研究所, 疾患制御研究分野, 主任研究員
2016 – 2019: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主任研究員
2015: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員
Review Section/Research Field
Principal Investigator
Basic Section 49060:Virology-related / Virology
Keywords
Principal Investigator
cccDNA / HBV / ウイルス持続感染機序 / HBV感染感受性細胞 / HBV cccDNA / 低分子化合物 / 持続感染 / HBx / ウイルス抗原発現制御
  • Research Projects

    (3 results)
  • Research Products

    (7 results)
  • Co-Researchers

    (1 People)
  •  B型肝炎ウイルスのcccDNAを減少に導く細胞内抗ウイルス応答の解明Principal Investigator

    • Principal Investigator
      山本 直樹
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Maintenance mechanisms of the hepatitis B virus cccDNAPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Naoki
    • Project Period (FY)
      2018 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49060:Virology-related
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Regulation of HBs antigen expression in HBV genotype A infectionPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Naoki
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Virology
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science

All 2023 2021 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] Sato Y, Matsui H, Yamamoto N, Sato R, Munakata T, Kohara M, Harashima H. Highly specific delivery of siRNA to hepatocytes circumvents endothelial cell-mediated lipid nanoparticle-associated toxicity leading to the safe and efficacious decrease in the hepatitis B virus2017

    • Author(s)
      Sato Y, Matsui H, Yamamoto N, Sato R, Munakata T, Kohara M, Harashima H
    • Journal Title

      J Control Release

      Volume: 266 Pages: 216-225

    • DOI

      10.1016/j.jconrel.2017.09.044

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08871, KAKENHI-PROJECT-17H05052, KAKENHI-PROJECT-15K19120
  • [Journal Article] Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection2016

    • Author(s)
      Yamamoto, N. Sato, Y. Munakata, T. Kakuni, M. Tateno, C. Sanada, T. Hirata, Y. Murakami, S. Tanaka, Y. Chayama, K. Hatakeyama, H. Hyodo, M. Harashima, H. Kohara, M.
    • Journal Title

      Journal of hepatology

      Volume: 64 Issue: 3 Pages: 547-455

    • DOI

      10.1016/j.jhep.2015.10.014

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19120, KAKENHI-PROJECT-15H04739, KAKENHI-PROJECT-24590565, KAKENHI-PROJECT-26830101, KAKENHI-PUBLICLY-15H01272, KAKENHI-PROJECT-15K15293
  • [Presentation] Hepatic parenchymal cell-tropic innate immune modulator using poly(I:C) reduced HBV cccDNA in the liver of chimeric mice2023

    • Author(s)
      Naoki Yamamoto, Sato Yusuke, Shuko Murakami, Yasuhito Tanaka, Hideyoshi Harashima, Michinori Kohara
    • Organizer
      9th Japan-Taiwan-Korea HBV Research Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23K06578
  • [Presentation] 肝実質細胞指向性自然免疫誘導剤を用いたHBV cccDNAの制御2021

    • Author(s)
      山本直樹
    • Organizer
      第68回ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07160
  • [Presentation] HBV持続感染に最適な培養系の構築2017

    • Author(s)
      山本直樹、棟方翼、小原道法
    • Organizer
      第65回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-15K19120
  • [Presentation] 新規肝臓特異的pH応答性DDS(MEND/HBV-siRNAmix)を用いたHBV持続感染の制御2016

    • Author(s)
      山本直樹
    • Organizer
      第26回抗ウイルス療法学会
    • Place of Presentation
      名古屋東急ホテル、名古屋市立大学大学院医学研究科(愛知県名古屋市)
    • Year and Date
      2016-05-13
    • Data Source
      KAKENHI-PROJECT-15K19120
  • [Presentation] siRNA-based therapies to chronic HBV infection using a novel pH-sensitive multifunctional envelope-type nanodevice2015

    • Author(s)
      Naoki Yamamoto, Yusuke Sato, Tsubasa Munakata, Takahiro Sanada, Masakazu Kakuni, Chise Tateno, Shuko Murakami, Yasuhito Tanaka, Kazuaki Chayama, Hideyoshi Harashima, Michinori Kohara
    • Organizer
      2015 International Meeting on Molecular Biology of Hepatitis B Viruses
    • Place of Presentation
      Bad Nauheim (Germany)
    • Year and Date
      2015-10-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K19120
  • 1.  棟方 翼
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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