Kobayashi Tomoko 小林朋子

… Alternative Names

KOBAYASHI Tomoko 小林朋子

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Researcher Number	10548283
Other IDs
Affiliation (Current)	2025: 日本歯科大学, 生命歯学部, 講師
Affiliation (based on the past Project Information) *help	2020 – 2025: 日本歯科大学, 生命歯学部, 講師 2017 – 2020: 日本歯科大学, 生命歯学部, 助教 2010 – 2013: 日本歯科大学, 生命歯学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 57060:Surgical dentistry-related / Dental engineering/Regenerative dentistry / Morphological basic dentistry Except Principal Investigator Basic Section 57060:Surgical dentistry-related / Basic Section 57040:Regenerative dentistry and dental engineering-related / Medium-sized Section 57:Oral science and related fields / Dental engineering/Regenerative dentistry
Keywords	Principal Investigator 歯性幹細胞 / 臍帯由来細胞 / 間葉系幹細胞 / 再生歯学 / 歯髄幹細胞 / マーカー / 多分化能 / ヒト歯髄幹細胞 / シグナル伝達 / 遺伝子 … More / 分化 / 成体幹細胞 / 歯学 / 再生医学 / 細胞・組織 / マイクロアレイ … More Except Principal Investigator 歯髄幹細胞 / 細胞シート / 間葉系幹細胞 / 無血清培養 / 自己多層化 / 歯の再生 / エナメル上皮細胞 / オルガノイド / 器官培養 / 歯性幹細胞 / 細胞培養 / 再生歯インプラント / バイオ再生歯根 / 幹細胞 / 再生医療 / コラーゲンゲル / 量子ビーム / 機能性コラーゲンゲル / 分化誘導 / 機能性コラーゲン / X線照射 / 唾液腺細胞 / 脂肪幹細胞分泌物 / 放射線傷害 / secretome / 防護作用 / 放射線障害 / 唾液腺 / X線 / HUVEC / edaravone / X線防御効果 / 放射線 / 培養細胞 / エダラボン / エクソンノックイン / 一塩基置換 / 頭蓋縫合早期癒合症 / ゲノム編集 / MAPキナーゼ / FGFR2 / 頭蓋縫合早期癒合症候群 / Crouzon症候群 / 脂肪分化能 / 石灰化能 / DNAマイクロアレイ / 多分化能 / ヒト歯髄幹細胞 Less

自己多層化技術による粘膜組織シート（ＭＴＳ）の開発～口腔粘膜再生のフロンティア
- Principal Investigator
  
  望月真衣
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  The Nippon Dental University
Human tooth regeneration using chimeric organoids of porcine enamel epithelial cells and human dental pulp stem cells
- Principal Investigator
  
  中原貴
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 57:Oral science and related fields
- Research Institution
  The Nippon Dental University
歯科再生医療に向けた臍帯ＭＳＣの歯硬組織形成ポテンシャルを検証するPrincipal Investigator
- Principal Investigator
  
  小林朋子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  The Nippon Dental University
Engineering of test-tube dental implants using dental-derived medicinal regenerative cells
- Principal Investigator
  
  中原貴
- Project Period (FY)
  2021 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  The Nippon Dental University
Characterization of human dental pulp stem cells using radiation-crosslinked gelatin hydrogel.
- Principal Investigator
  
  Tsutsui Takeo
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  The Nippon Dental University
Elucidation of the molecular mechanisms associated with pathogeny of Crouzon syndrome and drug discovery
- Principal Investigator
  
  TORII Daisuke
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57040:Regenerative dentistry and dental engineering-related
- Research Institution
  The Nippon Dental University
Study of effects of radical scavenger edaravone and adipose stem cell exosome on X-Ray induced salivary gland damages
- Principal Investigator
  
  Nasu Masanori
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  The Nippon Dental University
Elucidation of the mechanism of dental pulp regeneration focusing on the function of progenitor cells by novel marker analysisPrincipal Investigator
- Principal Investigator
  
  Kobayashi Tomoko
- Project Period (FY)
  2017 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dental engineering/Regenerative dentistry
- Research Institution
  The Nippon Dental University
The gene regulatory network relating to the differentiation of dental pulp stem cells into odontoblasts
- Principal Investigator
  
  TAKEKI Tsutsui
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dental engineering/Regenerative dentistry
- Research Institution
  The Nippon Dental University
Identification and localization of new human pulpal stem cell markers for regenerative medicine studiesPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Tomoko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Morphological basic dentistry
- Research Institution
  The Nippon Dental University

All 2023 2021 2020 2019 2018 2013 2011 Other

All Journal Article Presentation

[Journal Article] Radioprotective effects of edaravone on human umbilical vein endothelial cells2023
- Author(s)
  那須優則　安藤百花　小林朋子　三橋扶佐子　下浦優希　鈴木さつき　片柳亮太　戸円智幸　堀江哲郎
- Journal Title
  
  日本歯科大学紀要. 一般教育系
  
  Volume: 52 Pages: 21-27
- DOI
  10.14983/00001194
- URL
  https://ndu-rep.repo.nii.ac.jp/records/1240
- Year and Date
  2023-03-30
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-18K09824
[Journal Article] Characterization of dental pulp stem cells isolated from a patient diagnosed with Crouzon syndrome.2021
- Author(s)
  Torii D, Kobayashi T, Horie T, Tsutsui TW.
- Journal Title
  
  J Cell Physiol.
  
  Volume: 236 Issue: 7 Pages: 5317-5324
- DOI
  10.1002/jcp.30241
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K09626
[Journal Article] Characterization of proliferation, differentiation potential, and gene expression among clonal cultures of human dental pulp cells.2020
- Author(s)
  Kobayashi T, Torii D, Iwata T, Izumi Y, Nasu M, Tsutsui TW.
- Journal Title
  
  Human Cell
  
  Volume: － Issue: 3 Pages: 1-12
- DOI
  10.1007/s13577-020-00327-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11812, KAKENHI-PROJECT-18K09733, KAKENHI-PROJECT-18H02985
[Journal Article] ヒト歯髄幹細胞を用いた三次元培養におけるMineral Trioxide Aggregate (MTA)の効果2019
- Author(s)
  筒井健夫、小林朋子、鳥居大祐
- Journal Title
  
  日本臨床歯科医学会誌
  
  Volume: 5 Pages: 18-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11812
[Journal Article] ヒト歯髄幹細胞を用いた三次元培養におけるMineral Trioxide Aggregate (MTA)の効果2019
- Author(s)
  筒井健夫、小林朋子、鳥居大祐
- Journal Title
  
  日本臨床歯科医学会誌
  
  Volume: 5 Pages: 18-23
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K09626
[Journal Article] Expression status of mRNA for sex hormone receptors in human dental pulp cells and the response to sex hormones in the cells.2013
- Author(s)
  Inaba T, Kobayashi T, Tsutsui TW, Ogawa M, Uchida M, Tsutsui T
- Journal Title
  
  Archives of Oral Biology
  
  Volume: - Issue: 8 Pages: 943-950
- DOI
  10.1016/j.archoralbio.2013.02.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592903
[Journal Article] Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry2011
- Author(s)
  Kobayashi M, Tsutsui TW, Kobayashi T, Ohno M, Higo Y, Inaba T, Tsutsui T.
- Journal Title
  
  Odontology
  
  Volume: 101 Issue: 1 Pages: 43-51
- DOI
  10.1007/s10266-011-0047-9
- NAID
  10031168902
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592903
[Presentation] 歯科再生医療に向けた細胞ソースとして臍帯由来細胞の可能性を検証する2023
- Author(s)
  小林朋子，望月真衣，中原　貴
- Organizer
  第31回硬組織再生生物学会学術大会・総会
- Data Source
  KAKENHI-PROJECT-23K18367
[Presentation] 歯科再生医療に向けた細胞ソースとして臍帯由来細胞の可能性を検証する2023
- Author(s)
  小林朋子，望月真衣，中原　貴
- Organizer
  第31回硬組織再生生物学会学術大会・総会
- Data Source
  KAKENHI-PROJECT-23K21496
[Presentation] 歯科再生医療に向けた細胞ソースとして臍帯由来細胞の可能性を検証する2023
- Author(s)
  小林朋子, 望月真衣, 中原　貴
- Organizer
  第31回硬組織再生生物学会学術大会
- Data Source
  KAKENHI-PROJECT-23K09365
[Presentation] ヒト歯髄細胞由来クローン間における多分化能の差異を指標とする網羅的遺伝子発現解析.2019
- Author(s)
  小林朋子, 鳥居大祐, 岩田隆紀, 和泉雄一, 那須優則, 筒井健夫
- Organizer
  日本組織培養学会第92回大会
- Data Source
  KAKENHI-PROJECT-17K11812
[Presentation] Crouzon 症候群患者由来の歯髄幹細胞における遺伝子発現とタンパク質発現の解析2019
- Author(s)
  鳥居大祐, 小林朋子, 堀江哲郎, 筒井健夫
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09626
[Presentation] Scleraxisノックアウトヒト歯根膜由来不死化細胞におけるTenomodulin遺伝子発現解析2018
- Author(s)
  鳥居大祐、小林朋子、堀江哲郎、筒井健夫
- Organizer
  第60回　歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18K09626
[Presentation] Isolation of clonal dental pulp cells with different differentiation potentials2013
- Author(s)
  Kobayashi T, Torii D, Tsutsui TW, Tsutsui T
- Organizer
  The 91st General Session & Exhibition of the International Association for Dental Research
- Place of Presentation
  Washington State Convention Center, Seattle, U.S.A..
- Year and Date
  2013-03-22
- Data Source
  KAKENHI-PROJECT-22791780
[Presentation] 歯髄細胞クローンの分化能の違いによる遺伝子発現の変動2013
- Author(s)
  小林朋子，鳥居大祐，筒井健夫，筒井健機
- Organizer
  歯科基礎医学会
- Place of Presentation
  岡山コンベンションセンター（岡山県）
- Data Source
  KAKENHI-PROJECT-23592903
[Presentation] 歯髄細胞クローンの分化能の違いによる遺伝子発現の変動2013
- Author(s)
  小林朋子, 鳥居大祐, 筒井健夫, 筒井健機
- Organizer
  第55回歯科基礎医学会学術大会
- Place of Presentation
  岡山コンベンションセンター(岡山県)
- Data Source
  KAKENHI-PROJECT-23592903
[Presentation] 培養ヒト歯髄細胞の多分化能の維持と細胞増殖-細胞クローン解析-2011
- Author(s)
  筒井健機, 小林朋子, 鳥居大祐, 肖黎, 筒井健夫
- Organizer
  第48回日本口腔組織培養学会学術大会
- Place of Presentation
  明海大学浦安キャンパス(千葉県)
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-23592903
[Presentation] 培養ヒト歯髄細胞クローン解析:多分化能と増殖能2011
- Author(s)
  小林朋子, 鳥居大祐, 筒井健夫, 肖黎, 筒井健機
- Organizer
  歯科基礎医学会
- Place of Presentation
  長良川国際会議場(岐阜県)
- Year and Date
  2011-10-02
- Data Source
  KAKENHI-PROJECT-22791780
[Presentation] 培養ヒト歯髄細胞クローン解析：多分化能と増殖能．2011
- Author(s)
  小林朋子，鳥居大祐，筒井健夫，肖　黎，筒井健機
- Organizer
  歯科基礎医学会
- Place of Presentation
  長良川国際会議場(岐阜県)
- Data Source
  KAKENHI-PROJECT-23592903
[Presentation] 無血清培地と血清培地におけるヒト歯髄細胞の細胞特性．2011
- Author(s)
  筒井健夫，鳥居大祐，小林朋子，筒井健機．
- Organizer
  歯科基礎医学会
- Place of Presentation
  長良川国際会議場(岐阜県)
- Data Source
  KAKENHI-PROJECT-23592903
[Presentation] 培養ヒト歯髄細胞の多分化能の維持と細胞増殖―細胞クローン解析―．2011
- Author(s)
  筒井健機，小林朋子，鳥居大祐，肖　黎，筒井健夫．
- Organizer
  日本口腔組織培養学会
- Place of Presentation
  明海大学浦安キャンパス(千葉県)
- Data Source
  KAKENHI-PROJECT-23592903
[Presentation] 培養ヒト歯髄細胞クローン解析:多分化能と増殖能2011
- Author(s)
  小林朋子、鳥居大祐、筒井健夫,肖黎、筒井健機
- Organizer
  第53回歯科基礎医学会学術開会
- Place of Presentation
  長良川国際会議場(岐阜県)
- Year and Date
  2011-10-02
- Data Source
  KAKENHI-PROJECT-22791780
[Presentation] 培養ヒト歯髄細胞の多分化能の維持と細胞増殖-細胞クローン解析-2011
- Author(s)
  筒井健機, 小林朋子, 鳥居大祐, 肖黎, 筒井健夫
- Organizer
  日本口腔組織培養学会
- Place of Presentation
  明海大学浦安キャンパス(千葉県)
- Year and Date
  2011-11-19
- Data Source
  KAKENHI-PROJECT-22791780
[Presentation] Isolation of clonal dental pulp cells with different differentiation potentials
- Author(s)
  Kobayashi T, Torii D, Tsutsui TW and Tsutsui T
- Organizer
  The 91st General Session & Exhibition of the International Association for Dental Research
- Place of Presentation
  Washington State Convention Center, Seattle, U. S. A.
- Data Source
  KAKENHI-PROJECT-22791780

1. 中原貴 (10366768)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
2. 望月真衣 (90821934)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. Tsutsui Takeo (70366764)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
4. Nasu Masanori (50130688)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 堀江哲郎 (10508675)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
6. TAKEKI Tsutsui (00097065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
7. TORII Daisuke (10548259)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. 三橋扶佐子 (60187896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 井出吉昭 (70409225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 田口光正 (60343943)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 大山智子 (90717646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 相良洋 (50145041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 中島慎太郎 (40817095)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kobayashi Tomoko 小林 朋子

KOBAYASHI Tomoko 小林 朋子

Research Projects

Research Products

Co-Researchers

自己多層化技術による粘膜組織シート（ＭＴＳ）の開発～口腔粘膜再生のフロンティア

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Human tooth regeneration using chimeric organoids of porcine enamel epithelial cells and human dental pulp stem cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

歯科再生医療に向けた臍帯ＭＳＣの歯硬組織形成ポテンシャルを検証するPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Engineering of test-tube dental implants using dental-derived medicinal regenerative cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Characterization of human dental pulp stem cells using radiation-crosslinked gelatin hydrogel.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the molecular mechanisms associated with pathogeny of Crouzon syndrome and drug discovery

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study of effects of radical scavenger edaravone and adipose stem cell exosome on X-Ray induced salivary gland damages

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of dental pulp regeneration focusing on the function of progenitor cells by novel marker analysisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The gene regulatory network relating to the differentiation of dental pulp stem cells into odontoblasts

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification and localization of new human pulpal stem cell markers for regenerative medicine studiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Radioprotective effects of edaravone on human umbilical vein endothelial cells2023

Author(s)

Journal Title

DOI

URL

Year and Date

Language

Data Source

[Journal Article] Characterization of dental pulp stem cells isolated from a patient diagnosed with Crouzon syndrome.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of proliferation, differentiation potential, and gene expression among clonal cultures of human dental pulp cells.2020

Author(s)

Kobayashi Tomoko 小林朋子

KOBAYASHI Tomoko 小林朋子