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JIANG Shi Wen  大高 時文

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… Alternative Names

JIANG Shiwen  蒋 時文

ODAKA Tokifumi  大高 時文

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Researcher Number 10548746
Other IDs
Affiliation (Current) 2025: 関西医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2024: 関西医科大学, 医学部, 助教
2017: 関西医科大学, 医学部, 助教
2014: 立命館大学, 総合科学技術研究機構, 補助研究員
Review Section/Research Field
Principal Investigator
Basic Section 42040:Laboratory animal science-related
Except Principal Investigator
System genome science / System genome science
Keywords
Principal Investigator
宿主免疫 / 腸内細菌叢(ビフィズス菌・乳酸桿菌) / 成人T細胞白血病(ATL) / ヒトT細胞白血病ウイルスI型 (HTLV-1) / ヒト化マウス
Except Principal Investigator
Natural antisense RNA / 制御性RNA / natural antisense RNA / IFN-alpha1 antisense RNA / RISC … More / ヒトAgo2抗体 / RNA-seq法 / ceRNA ネットワーク / ヒトインフルエンザウイルス感染 / 抗ヒトHuR抗体 / 抗ヒトAgo2抗体 / RIP-RT PCR / RIP-RNAseq / RNAseq / EphA2 / ceRNA network / competing endogenous RNA / microRNA / POC実験 / インフルエンザウイルス感染 / Proof-of-Concept実験 / 遺伝子発現制御 / アンチセンスRNA / タンパク質非コード性RNA / ceRNA / NAT / lncRNA / Competing endogenous RNA / 非コードRNA / nucleic acid medicine / long non-coding RNA / 機能性RNA Less
  • Research Projects

    (3 results)
  • Research Products

    (17 results)
  • Co-Researchers

    (7 People)
  •  HTLV-1 感染モデルマウスを用いた腸内細菌投与によるATL発症予防法の開発Principal Investigator

    • Principal Investigator
      大高 時文
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 42040:Laboratory animal science-related
    • Research Institution
      Kansai Medical University
  •  Development of next-generation nucleic acid medicines based on the anti-influenza viral regulatory antisense RNA

    • Principal Investigator
      Kimura Tomonori
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      System genome science
    • Research Institution
      Ritsumeikan University
  •  A modulator of human innate immunity that affects antiviral type 1 interferon response

    • Principal Investigator
      KIMURA Tominori
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      System genome science
    • Research Institution
      Ritsumeikan University

All 2018 2017 2016 2015 2013 2012 Other

All Journal Article Presentation

  • [Journal Article] Interferon-alpha competing endogenous RNA network antagonizes microRNA-12702015

    • Author(s)
      Kimura, T., Jiang, S., Yoshida, N., Sakamoto, R., Nishizawa, M.
    • Journal Title

      Cellular and Molecular Life Sciences

      Volume: 印刷中 Issue: 14 Pages: 2749-2761

    • DOI

      10.1007/s00018-015-1875-5

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24510283, KAKENHI-PROJECT-15K06885, KAKENHI-PROJECT-15K06926
  • [Journal Article] Stabilization of human interferon-α1 mRNA by its antisense RNA2013

    • Author(s)
      Tominori Kimura, Shiwen Jiang, Mikio Nishizawa, Emi Yoshigai, Iwao, Hashimoto, Masao Nishikawa, Tadayoshi Okumura, Hisao Yamada
    • Journal Title

      Cellular and Molecular Life Sciences

      Volume: 70 Issue: 8 Pages: 1451-1467

    • DOI

      10.1007/s00018-012-1216-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24510283
  • [Presentation] Interferon-α1 antisense RNA modulates levels of Interferon-α1 mRNA expression and antagonizes proliferation of human Influenza A virus in a guinea pig model system2018

    • Author(s)
      Ryo Sakamoto, Shiwen Jiang, Yusuke Tsukada, Hiroyuki Tsujimoto and Tominori Kimura
    • Organizer
      RNA Therapeutics Conference 2018: from base pairs to bedsides (accepted for presentation)
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K06926
  • [Presentation] Interferon-α ceRNA network antagonizes miR-1270 with various accessibilities2017

    • Author(s)
      Noriyuki Yoshida, Shiwen Jiang, Ryo Sakamoto, Aya Ogawara, Mei Kondo, Masashi Michibuchi, Tominori Kimura
    • Organizer
      ConBio2017
    • Data Source
      KAKENHI-PROJECT-15K06926
  • [Presentation] Effect of AHCC on metastatic mammary carcinoma-derived MDA-MB-231 cell proliferation, and EphA2 gene expression that affects the tumor cell growth2016

    • Author(s)
      Tokifumi Odaka, Ryo Sakamoto, Noriyuki Yoshida, Tominori Kimura
    • Organizer
      The 24th International Congress on Nutrition and Integrative Medicine
    • Place of Presentation
      Hotel Royton Sapporo, Sapporo, Japan
    • Year and Date
      2016-07-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K06926
  • [Presentation] ヒト乳がん細胞増殖とEphA2遺伝子発現に及ぼすActive Hexose Correlated Compoundの効果2016

    • Author(s)
      坂本 凌、大高 時文、吉田 徳之、木村 富紀
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県、横浜市)
    • Year and Date
      2016-12-01
    • Data Source
      KAKENHI-PROJECT-15K06926
  • [Presentation] 非コード性RNAに由来する核酸医薬シーズと生分解性DDSの一体開発による新規抗インフルエンザ薬の創出2015

    • Author(s)
      木村富紀,塚田雄亮,大高時文,辻元広行
    • Organizer
      日本核酸医薬学会第1回年会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-15K06926
  • [Presentation] インターフェロン-α1アンチセンスRNAはネットワークを形成し、microRNA-1270に拮抗するcompeting endogenous RNAとして機能する.2015

    • Author(s)
      坂本凌, 蒋時文, 吉田徳之, 木村富紀
    • Organizer
      第17回日本RNA学会年会
    • Place of Presentation
      ホテルライフォート札幌、札幌市、北海道
    • Year and Date
      2015-07-16
    • Data Source
      KAKENHI-PROJECT-15K06926
  • [Presentation] Effects of AHCC on regulatory roles of natural antisense RNA for human breast cancer2015

    • Author(s)
      Sakamoto, R., Yoshida, N., Jiang, S. and Kimura, T.
    • Organizer
      The 23rd International Congress on Nutrition and Integrative Medicine
    • Place of Presentation
      Hotel Royton Sapporo, Sapporo, Hokkaido,Japan
    • Year and Date
      2015-07-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K06926
  • [Presentation] Stabilisation of human interferon-α1 mRNA by its antisense RNA2012

    • Author(s)
      Tominori Kimura, Shiwen Jiang, Mikio Nishizawa, Emi Yoshigai, Tomoaki Nakano
    • Organizer
      The 22nd CDB Meeting on RNA Sciences in Cell and Developmental Biology II
    • Place of Presentation
      RIKEN Center for Developmental Biolgy,兵庫県
    • Data Source
      KAKENHI-PROJECT-24510283
  • [Presentation] Stabilisation of Human Interferon-α1 mRNA by Its Antisense RNA2012

    • Author(s)
      Tominori Kimura, Shiwen Jiang, Mikio Nisizawa, Emi Yoshigai
    • Organizer
      The Cold Spring Harbor Laboratory 2012 Meeting on Regulatory & Non-coding RNAs
    • Place of Presentation
      New York, USA
    • Data Source
      KAKENHI-PROJECT-24510283
  • [Presentation] センダイウイルスにより誘導される内因性アンチセンスRNAによるヒトインターフェロン-α1遺伝子の転写後性発現調節2012

    • Author(s)
      蒋 時文、吉開会美、西澤 幹雄、中村真一朗、木村 富紀
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      グランキューブ大阪、大阪府
    • Data Source
      KAKENHI-PROJECT-24510283
  • [Presentation] Effect of AHCC on IFN-α1 antisense RNA and mRNA expression levels in the respiratory tract of influenza virus A/PR/8/34-infected guinea pigs2012

    • Author(s)
      Shiwen Jiang, Tomoaki Nakano, Mikio Nishizawa, Tominori Kimura
    • Organizer
      The 20th International Congress on Nutrition and Integrative Medicine
    • Place of Presentation
      ホテルロイトン札幌、北海道
    • Invited
    • Data Source
      KAKENHI-PROJECT-24510283
  • [Presentation] センダイウイルスにより誘導される内因性アンチセンスRNAによるヒトインターフェロン-α1遺伝子の転写後性発現調節: 分子作用メカニズムの解析

    • Author(s)
      蒋 時文、吉田 徳之、西澤 幹雄、木村 富紀
    • Organizer
      第61回日本ウイルス学会学術集会・総会
    • Place of Presentation
      神戸国際会議場 (兵庫県)
    • Data Source
      KAKENHI-PROJECT-24510283
  • [Presentation] Effect of AHCC on IFN-α1 antisense RNA and mRNA expression levels: a molecular analysis of action.

    • Author(s)
      Nakano, T., Jiang, S. and Kimura, T.
    • Organizer
      The 21st International Congress on Nutrition and Integrative Medicine (ICNIM 2013)
    • Place of Presentation
      ホテルロイトン札幌 (北海道)
    • Data Source
      KAKENHI-PROJECT-24510283
  • [Presentation] 非コード性アンチセンスRNAはcompeting endogenous RNAとしてインターフェロン-α1 mRNAの安定性を制御する.

    • Author(s)
      蒋 時文、中野 智明、木村 富紀
    • Organizer
      第15回日本RNA学会年会
    • Place of Presentation
      愛媛県民文化会館・ひめぎんホール (愛媛県)
    • Data Source
      KAKENHI-PROJECT-24510283
  • [Presentation] A long noncoding antisense RNA regulates the stability of interferon-α1 mRNA by functioning as a competing endogenous RNA.

    • Author(s)
      Jiang, S., Yoshida, N., Nishizawa, M. and Kimura, T.
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド (兵庫県)
    • Data Source
      KAKENHI-PROJECT-24510283
  • 1.  KIMURA Tominori (40186325)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 17 results
  • 2.  INABA Muneo (70115947)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 3.  YOSHIDA Noriyuki (10363996)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 4.  西澤 幹雄 (40192687)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  松尾 禎之 (50447926)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  李 成一 (90361964)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  SAKAMOTO Ryou
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results

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