Minegaki Tetsuya 峯垣哲也

Researcher Number	10549306
Other IDs
Affiliation (based on the past Project Information) *help	2015 – 2020: 京都薬科大学, 薬学部, 助教 2013 – 2015: 京都薬科大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy Except Principal Investigator Medical pharmacy / Applied pharmacology
Keywords	Principal Investigator 抗がん剤耐性 / がん微小環境 / セカンドライン / DNA損傷修復 / 相乗効果 / PARP阻害剤 / 食道癌 Except Principal Investigator 食道癌 / 微小環境 / ビスホスホネート系薬物 … More / 食道がん / 治療標的 / コレステロール合成 / ビスホスホネート / 低酸素 / がん微小環境 / 医薬品相互作用 / 末期腎不全患者 / SN-38 / 尿毒症物質 / 有機アニオン輸送ポリペプチド / 末期腎不全 / 薬物相互作用 / 有害事象 / 薬物有害事象 / 薬物トランスポーター / 薬物代謝酵素 / 慢性腎臓病 / 抗癌剤耐性 / 癌 / エピジェネティクス / 癌細胞 / ビスホスホネート系薬剤 / 細胞増殖抑制作用 / ホスホネート系薬剤 / 細胞周期 / アポトーシス / がん細胞 Less

がん微小環境による抗がん剤耐性メカニズムの変化とその克服法の解明Principal Investigator
- Principal Investigator
  
  峯垣哲也
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kyoto Pharmaceutical University
Enhancement mechanisms of cell growth suppression by bisphosphonates in cancer microenvironment
- Principal Investigator
  
  NISHIGUCHI KOHSHI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Establishment of the second line chemotherapy for esophageal cancer using poly (ADP-ribose) polymerase inhibitorsPrincipal Investigator
- Principal Investigator
  
  Minegaki Tetsuya
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto Pharmaceutical University
Mechanism for unpredictable drug interaction in patients with chronic kidney disease
- Principal Investigator
  
  Tsujimoto Masayuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kyoto Pharmaceutical University
Establishment of an novel reversal of anticancer drug resistance based on the epigenetic information
- Principal Investigator
  
  Takara Kohji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Himeji Dokkyo University
Anticancer effects of bisphosphonates in human esophageal squamous cell
- Principal Investigator
  
  NISHIGUCHI KOHSHI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kyoto Pharmaceutical University

All 2020 2019 2018 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] Synergistic Effects of Olaparib and DNA-damaging Agents in Oesophageal Squamous Cell Carcinoma Cell Lines.2019
- Author(s)
  Keisuke Miyamoto, Tetsuya Minegaki, Mami Tanahashi, Ayaka Yamamoto, Yumi Moriyama, Akari Wada, Ayaka Matsumoto, Keisuke Ota, Mai Tanaka, Utako Masuda, Masayuki Tsujimoto, Kohshi Nishiguchi
- Journal Title
  
  Anticancer Research
  
  Volume: 39 Issue: 4 Pages: 1813-1820
- DOI
  10.21873/anticanres.13288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K18964
[Journal Article] Acceleration of carboxylesterase-mediated activation of irinotecan to SN-38 by serum from patients with end-stage kidney disease2018
- Author(s)
  Koide Hiroyoshi、Tsujimoto Masayuki、Katsube Yurie、Ochiai Megumi、Hojo Ayako、Furukubo Taku、Izumi Satoshi、Yamakawa Tomoyuki、Shima Daisuke、Minegaki Tetsuya、Nishiguchi Kohshi
- Journal Title
  
  Cancer Chemotherapy and Pharmacology
  
  Volume: in press Issue: 6 Pages: 1121-1128
- DOI
  10.1007/s00280-018-3583-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08601
[Journal Article] Substrate-dependent effects of molecular-targeted anticancer agents on activity of organic anion transporting polypeptide 1B12018
- Author(s)
  Koide Hiroyoshi、Tsujimoto Masayuki、Takeuchi Ai、Tanaka Miyu、Ikegami Yoko、Tagami Mayu、Abe Syoko、Hashimoto Miki、Minegaki Tetsuya、Nishiguchi Kohshi
- Journal Title
  
  Xenobiotica
  
  Volume: in press Issue: 10 Pages: 1059-1071
- DOI
  10.1080/00498254.2017.1393582
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08601
[Journal Article] Evaluation of Trace Elements in Augmentation of Statin-Induced Cytotoxicity in Uremic Serum-Exposed Human Rhabdomyosarcoma Cells2018
- Author(s)
  Uchiyama Hitoshi、Tsujimoto Masayuki、Shimada Naomi、Tsutsui Koji、Nitta Ayaka、Yoshida Takuya、Furukubo Taku、Izumi Satoshi、Yamakawa Tomoyuki、Tachiki Hidehisa、Minegaki Tetsuya、Nishiguchi Kohshi
- Journal Title
  
  Toxins
  
  Volume: 10 Issue: 2 Pages: 53-53
- DOI
  10.3390/toxins10020053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K08601
[Journal Article] Augmentation of the cytotoxic effects of nitrogen-containing bisphosphonates in hypoxia2018
- Author(s)
  Tetsuya Minegaki, Saya Koiki, Yutaro Douke, Chihiro Yamane, Ai Suzuki, Misato Mori, Masayuki Tsujimoto, and Kohshi Nishiguchi
- Journal Title
  
  Journal of Pharmacy and Pharmacology
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08423
[Journal Article] Cooperative inhibitory effects of uremic toxins and other serum components on OATP1B1-mediated transport of SN-382017
- Author(s)
  Yurie Katsube, Masayuki Tsujimoto, Hiroyoshi Koide, Megumi Ochiai, Ayako Hojyo, Kaori Ogawa, Kengo Kambara, Nao Torii, Daisuke Shima, Taku Furukubo, Satoshi Izumi, Tomoyuki Yamakawa, Tetsuya Minegaki, Kohshi Nishiguchi
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 79 Issue: 4 Pages: 783-789
- DOI
  10.1007/s00280-017-3276-y
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15K08601
[Journal Article] Effects of bisphosphonates on human esophageal squamous cell carcinoma cell survival2015
- Author(s)
  Tetsuya Minegaki, Saori Fukushima, Chihiro Morioka, Hitomi Takanashi, Junki Uno, Shiori Tsuji, Satoshi Yamamoto, Airi Watanabe, Masayuki Tsujimoto, and Kohshi Nishiguchi
- Journal Title
  
  Dis. Esophagus
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460230
[Presentation] 5-FU耐性ヒト乳癌細胞株は抗がん剤感受性細胞に5-FU耐性を伝達する2020
- Author(s)
  北山純花、峯垣哲也、原祢幸汰、葛本貴大、米田朋美、辻本雅之、西口工司
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-19K16459
[Presentation] 53BP1の発現抑制は食道癌細胞株におけるPARP阻害剤と抗癌剤との相乗的な細胞毒性を減弱させる2019
- Author(s)
  平野沙耶香、峯垣哲也、宮本恵輔、林逸佳、青山淑美、西野翔太、辻本雅之、西口工司
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K18964
[Presentation] ヒト食道癌細胞株の低酸素環境下におけるビスホスホネートに対する感受性増強機序の解明2019
- Author(s)
  楠斐未、峯垣哲也、池上歩花、奥田博允、藤井啓子、眞弓万里奈、北山純花、原祢幸汰、葛本貴大、米田朋美、辻本雅之、西口工司
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16K08423
[Presentation] Effects of uremic serum on statin-induced cytotoxicity and its mechanism2017
- Author(s)
  Hitoshi Uchiyama, Masayuki Tsujimoto, Tadakazu Shinmoto, Hitomi Ogino, Tomoko Oda, Ayaka Nitta, Koji Tsutsui, Naomi Shimada, Takuya Yoshida, Taku Furukubo, Satoshi Izumi, Tomoyuki Yamakawa, Hidehisa Tachiki, Tetsuya Minegaki, Kohshi Nishiguchi
- Organizer
  2017AAPS Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08601
[Presentation] OATP1B1を介した基質の取り込みに及ぼす分子標的薬の影響2017
- Author(s)
  田中美優、辻本雅之、小出博義、竹内あい、池上葉子、田上真優、阿部祥子、橋本実季、峯垣哲也、西口工司
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-15K08601
[Presentation] 低酸素下におけるビスホスホネート系薬物の細胞毒性増強とそのメカニズムの解明2017
- Author(s)
  峯垣哲也、戀木沙耶、道家雄太郎、山根千尋、鈴木　藍、森　美里、辻本雅之、西口工司
- Organizer
  日本薬学会　第137年会
- Place of Presentation
  仙台
- Year and Date
  2017-03-24
- Data Source
  KAKENHI-PROJECT-16K08423
[Presentation] 末期腎不全患者においてコルヒチン及びクラリスロマイシンの相互作用が重篤化するメカニズムの解明2017
- Author(s)
  下野香帆、辻本雅之、内山仁、板谷あゆみ、古久保拓、和泉　智、立木秀尚、山川智之、峯垣哲也、西口工司
- Organizer
  第38回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-15K08601
[Presentation] ヒト食道癌細胞株の抗癌剤感受性に及ぼすポリ(ADPリボース) ポリメラーゼ阻害剤オラパリブの影響2017
- Author(s)
  宮本恵輔、峯垣哲也、森山由美、和田明莉、松本彩夏、太田圭祐、田中麻衣、増田詩子、棚橋真実、山本彩佳、荒木悠、稲垣恵未、林絵里、辻本雅之、西口工司
- Organizer
  第67回　日本薬学会近畿支部総会・大会
- Data Source
  KAKENHI-PROJECT-16K18964
[Presentation] 低酸素環境下における食道癌細胞株に対するビスホスホネートによる細胞増殖抑制作用の増強2016
- Author(s)
  山根千尋、峯垣哲也、戀木沙耶、道家雄太郎、鈴木藍、森美里、辻本雅之、西口工司
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-25460230
[Presentation] Hypoxia Potentiates the Cytotoxic Effects of Nitrogen-Containing Bisphosphonates in Human Esophageal Cancer Cell Line.2016
- Author(s)
  Kohshi Nishiguchi, Tetsuya Minegaki, Saya Koiki, Yutaro Doke, Chihiro Yamane, Ai Suzuki, Misato Mori, Masayuki Tsujimoto
- Organizer
  2016 AAPS Annual Meeting and Exposition
- Place of Presentation
  Denver, Colorado, USA
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08423
[Presentation] The Poly (ADP-ribose) Polymerase Inhibitor, Olaparib, Potentiates the Cytotoxic Effects of Anti-Cancer Drugs in Human Esophageal Squamous Cell Carcinoma Cell Lines2016
- Author(s)
  Tetsuya Minegaki, Keisuke Miyamoto, Mami Tanahashi, Ayaka Yamamoto, Yu Araki, Megumi Inagaki, Eri Hayashi, Masayuki Tsujimoto, Kohshi Nishiguchi
- Organizer
  2016 AAPS Annual Meeting and Exposition
- Place of Presentation
  Denver, Colorado, USA
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K18964
[Presentation] The Identification of the Mechanism of Elevated Plasma Concentration of SN-38 in Patients with Endstage Kidney Disease:Focus on Metabolic Enzymes and Transporter in the Liver.2016
- Author(s)
  Yurie Katsube, Masayuki Tsujimoto, Hiroyoshi Koide, Megumi Ochiai, Ayako Hojyo, Daisuke Shima,Taku Furukubo, Satoshi Izumi, Tomoyuki Yamakawa, Tetsuya Minegaki, Kohshi Nishiguchi
- Organizer
  2016 AAPS Annual Meeting and Exposition
- Place of Presentation
  Denver, Colorado, USA
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08601
[Presentation] アミノ酸トランスポーターの発現と抗癌剤耐性との関連性2016
- Author(s)
  中山優子、木下　淳、峯垣哲也、山本和宏、髙良恒史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26460246
[Presentation] ABCB5発現抑制によるシスプラチン耐性の誘導2016
- Author(s)
  中山優子、木下　淳、峯垣哲也、山本和宏、髙良恒史
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26460246
[Presentation] 低酸素下でのビスホスホネート系薬剤による細胞毒性の増強におけるメバロン酸経路の関与2016
- Author(s)
  戀木沙耶、峯垣哲也、道家雄太郎、山根千尋、鈴木　藍、森　美里、辻本雅之、西口工司
- Organizer
  医療薬学フォーラム2016　第24回クリニカルファーマシーシンポジウム
- Place of Presentation
  滋賀県大津市
- Year and Date
  2016-06-25
- Data Source
  KAKENHI-PROJECT-16K08423
[Presentation] 末期腎不全患者血清を曝露させた大腸がん由来細胞株におけるSN-38感受性の低下2016
- Author(s)
  小澤将一、辻本雅之、内山仁、伊藤なつこ、森下智恵、入江怜祐、坂下透子、山本瑞紀、古久保拓、和泉智、立木秀尚、山川智之、峯垣哲也、西口工司
- Organizer
  日本薬学会第136年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K08601
[Presentation] アリスキレンの肝消失過程に及ぼす有機アニオン輸送ポリポプチド1B1及び1B3の関与2016
- Author(s)
  入江裕子、辻本雅之、吉田拓弥、藤岡春乃、川上祥代、中谷沙紀、住本菜摘、須本真理子、中川智加、松本光司、峯垣哲也、西口工司
- Organizer
  日本薬学会第136年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K08601
[Presentation] 低酸素環境下におけるヒト食道癌細胞株の増殖に及ぼすビスホスホネート系薬物の影響2015
- Author(s)
  道家雄太郎、峯垣哲也、戀木沙耶、山根千尋、鈴木　藍、森　美里、辻本雅之、西口工司
- Organizer
  第25回日本医療薬学会年会
- Place of Presentation
  横浜
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-25460230
[Presentation] アミノ酸トランスポーターを標的としたシスプラチン耐性の克服2015
- Author(s)
  中山優子、深澤郁也、木下　淳、峯垣哲也、山本和宏、髙良恒史
- Organizer
  第25回日本医療薬学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2015-11-21
- Data Source
  KAKENHI-PROJECT-26460246
[Presentation] OATP1B1を介したプラバスタチン輸送に及ぼす末期腎不全患者血清の影響2015
- Author(s)
  木村朱李、辻本雅之、内山　仁、結城絵理子、佐伯　崇、吉田拓弥、古久保拓、和泉　智、山川智之、峯垣哲也、西口工司
- Organizer
  第9回日本腎臓病薬物療法学会学術集会・総会2015
- Place of Presentation
  宮城県仙台市
- Year and Date
  2015-10-24
- Data Source
  KAKENHI-PROJECT-15K08601
[Presentation] ヒト食道癌細胞株におけるビスホスホネート系薬物の増殖抑制作用とそのメカニズムの解明
- Author(s)
  高梨仁美、峯垣哲也、宇野順騎、福島沙織、森岡千尋、辻本雅之、西口工司
- Organizer
  第3回４大学連携研究フォーラム
- Place of Presentation
  京都府立医科大学
- Data Source
  KAKENHI-PROJECT-25460230
[Presentation] 食道癌細胞に対するビスホスホネート系薬物の細胞増殖抑制作用
- Author(s)
  森岡千尋、峯垣哲也、宇野順騎、高梨仁美、福島沙織、辻栞、山本知志、渡邊愛梨、辻本雅之、西口工司
- Organizer
  第63回　日本薬学会近畿支部総会・大会
- Place of Presentation
  同志社女子大学薬学部
- Data Source
  KAKENHI-PROJECT-25460230
[Presentation] ビスホスホネート系薬物のヒト食道癌細胞株に対する細胞毒性メカニズムの解明
- Author(s)
  峯垣哲也、森岡千尋、福島沙織、高梨仁美、宇野順騎、辻　栞、山本知志、渡邉愛梨、辻本雅之、西口工司
- Organizer
  第24回日本医療薬学会年会
- Place of Presentation
  名古屋
- Year and Date
  2014-09-27 – 2014-09-28
- Data Source
  KAKENHI-PROJECT-25460230
[Presentation] ヒト食道癌細胞株の増殖に及ぼすビスホスホネート系薬物の影響
- Author(s)
  福島沙織、峯垣哲也、宇野順騎、高梨仁美、森岡千尋、辻栞、山本知志、渡邊愛梨、辻本雅之、西口工司
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本市総合体育館
- Data Source
  KAKENHI-PROJECT-25460230
[Presentation] Poly (ADP-ribose) polymerase阻害剤Veliparib耐性ヒト乳癌細胞株の樹立とその特性
- Author(s)
  山本彩佳, 峯垣哲也, 棚橋真実, 宮本恵輔, 荒木悠, 稲垣恵未, 林絵里, 伊藤恵, 吉本咲貴, 中山優子, 高良恒史, 辻本雅之, 西口工司
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460246
[Presentation] アキシチニブで長期曝露したヒト腎臓癌由来Caki-2の細胞特性
- Author(s)
  中山優子、山本和宏、峯垣哲也、木下　淳、髙良恒史
- Organizer
  日本薬学会第135年会
- Place of Presentation
  デザイン・クリエイティブセンター神戸
- Year and Date
  2015-03-26 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26460246

1. NISHIGUCHI KOHSHI (80379437)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
2. Tsujimoto Masayuki (90372739)

# of Collaborated Projects: 3 results

# of Collaborated Products: 23 results
3. Takara Kohji (00329939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 木下淳 (60454766)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. 中山優子 (50708419)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results

Minegaki Tetsuya 峯垣 哲也

Research Projects

Research Products

Co-Researchers

がん微小環境による抗がん剤耐性メカニズムの変化とその克服法の解明Principal Investigator

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Research Institution

Enhancement mechanisms of cell growth suppression by bisphosphonates in cancer microenvironment

Principal Investigator

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Research Institution

Establishment of the second line chemotherapy for esophageal cancer using poly (ADP-ribose) polymerase inhibitorsPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Mechanism for unpredictable drug interaction in patients with chronic kidney disease

Principal Investigator

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Establishment of an novel reversal of anticancer drug resistance based on the epigenetic information

Principal Investigator

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Anticancer effects of bisphosphonates in human esophageal squamous cell

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[Journal Article] Synergistic Effects of Olaparib and DNA-damaging Agents in Oesophageal Squamous Cell Carcinoma Cell Lines.2019

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[Journal Article] Acceleration of carboxylesterase-mediated activation of irinotecan to SN-38 by serum from patients with end-stage kidney disease2018

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[Journal Article] Substrate-dependent effects of molecular-targeted anticancer agents on activity of organic anion transporting polypeptide 1B12018

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[Journal Article] Evaluation of Trace Elements in Augmentation of Statin-Induced Cytotoxicity in Uremic Serum-Exposed Human Rhabdomyosarcoma Cells2018

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[Journal Article] Augmentation of the cytotoxic effects of nitrogen-containing bisphosphonates in hypoxia2018

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[Journal Article] Cooperative inhibitory effects of uremic toxins and other serum components on OATP1B1-mediated transport of SN-382017

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[Journal Article] Effects of bisphosphonates on human esophageal squamous cell carcinoma cell survival2015

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[Presentation] 5-FU耐性ヒト乳癌細胞株は抗がん剤感受性細胞に5-FU耐性を伝達する2020

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[Presentation] 53BP1の発現抑制は食道癌細胞株におけるPARP阻害剤と抗癌剤との相乗的な細胞毒性を減弱させる2019

Author(s)

Organizer

Minegaki Tetsuya 峯垣哲也