HARAGUCHI TAKESHI 原口健

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Haraguchi Takeshi 原口健

HARAGUCHI Takeshi 原口健

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Researcher Number	10549455
Other IDs
Affiliation (Current)	2025: 千葉大学, 真菌医学研究センター, 特任准教授
Affiliation (based on the past Project Information) *help	2019 – 2022: 千葉大学, 真菌医学研究センター, 特任准教授 2016 – 2018: 千葉大学, 真菌医学研究センター, 特任助教 2014 – 2015: 東京大学, 医科学研究所, 助教 2009 – 2012: 東京大学, 医科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor biology / Biological Sciences / Tumor biology Except Principal Investigator Tumor biology / Carcinogenesis / Biological Sciences
Keywords	Principal Investigator miRNA / microRNA / 癌幹細胞 / EMT / miRNA inhibitor / CPP / 腫瘍 / アクティブターゲッティング / LNP / DDS … More / 核酸医薬 / トリプルネガティブ / 乳癌 / microRNA inhibitor / ライブラリー / 乳がん / 癌 / vimentin / E-cadherin / miR-200 / がん / inhibitor / RNA干渉 … More Except Principal Investigator Brm / SWI/SNF複合体 / miRNA / 上皮がん細胞 / SWI/SNF 複合体 / アクチン / 上皮細胞 / 核内アクチン / SWI/SNFクロマチン構造因子 / SRF / MKL1/2 / Egr1 / エピジェネティクス / CD44 / Cdx2 / がん細胞 / フィードバックループ / miR200c / 上皮-間充織変換 / miR-15/-16 / miR-199a / miR-200c / Cdx1 / 上皮‐間充織変換 / 発現制御 / siRNA / Brm遺伝子 / GFP遺伝子 / 遺伝子治療 / ウイルスベクター / レンチウイルス / NFI-B / miR-21 / shRNA / レトロウイルス / in situ hybridization / feedback 制御 / 大腸癌 / RNA干渉 / NF-I / プロモーター / microRNA / レンチウイルスベクター / Decoy RNA / Requiem / AP-1 / NFkB / SNF複合体 / SNFクロマチン構造変換因子 / SWI / NFkappaB / 足場非依存的な増殖 / requiem / RelB / レトロウイルスベクター Less

Development of peptide-ligand modified LNP for microRNA inhibition in tumor tissues.Principal Investigator
- Principal Investigator
  
  Haraguchi Takeshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Chiba University
Regulatory mechanisms involved in SRF-MKL1/2 complex in epithelial tumors
- Principal Investigator
  
  Iba Hideo
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Chiba University
Search for miRNAs that regulate stemness of breast cancer stem cell to find therapeutic targets of triple-negative breast cancer.Principal Investigator
- Principal Investigator
  
  Haraguchi Takeshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Chiba University
  The University of Tokyo
複数種類ｍｉＲＮＡの強制発現及び機能阻害による人工癌幹細胞作製法の開発Principal Investigator
- Principal Investigator
  
  原口健
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Significance and Molecular mechanisms of abnormal expression of miRNA in carcinogenesis.
- Principal Investigator
  
  IBA Hideo
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Carcinogenesis
- Research Institution
  The University of Tokyo
Screening for microRNA which is related to cancer progression by using novel microRNA inhibitory vectorsPrincipal Investigator
- Principal Investigator
  
  HARAGUCHI Takeshi
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
- Research Institution
  The University of Tokyo
Development of new types of retrovirus vectors that modulate epigenetical regulation.
- Principal Investigator
  
  IBA Hideo
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo

All 2017 2016 2015 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Other

[Book] 遺伝子医学MOOK2012
- Author(s)
  原口健、伊庭英夫
- Publisher
  メディカルドゥ(印刷中)
- Data Source
  KAKENHI-PROJECT-22700873
[Book] 遺伝子医学MOOK2012
- Author(s)
  原口健、伊庭英夫
- Publisher
  メディカルドウ(印刷中)
- Data Source
  KAKENHI-PROJECT-22300318
[Book] 遺伝子医学MOOK、2'-OME RNAオリゴを基盤とした独特の二次構造を持つ新規microRNA阻害剤、S-TuD2012
- Author(s)
  原口健、伊庭英夫
- Publisher
  メディカルドゥ(印刷中)
- Data Source
  KAKENHI-PROJECT-22700873
[Book] 遺伝子医学MOOK23号　「臨床・創薬利用が見えてきたmicroRNA」2012
- Author(s)
  原口　健
- Total Pages
  236
- Publisher
  メディカルドゥ社
- Data Source
  KAKENHI-PUBLICLY-23130504
[Book] 遺伝子医学MOOK2012
- Author(s)
  原口健、伊庭英夫
- Publisher
  メディカルドゥ(印刷中)
- Data Source
  KAKENHI-PUBLICLY-23130504
[Book] 実験医学2010
- Author(s)
  原口健
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22700873
[Book] 生体の科学2010
- Author(s)
  原口健
- Total Pages
  6
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-22700873
[Book] 生体の科学、TuD RNA発現ベクターを用いたmiRNAの活性阻害による機能解析2010
- Author(s)
  原口健、桜井浩平、伊庭英夫
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-22700873
[Book] 実験医学、TuD RNA発現ベクターによる特定のmicroRNAの高効率阻害法2010
- Author(s)
  原口健、伊庭英夫
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22700873
[Journal Article] Tumor suppression via inhibition of SWI/SNF complex-dependent NF-κB activation.2017
- Author(s)
  1.Kobayashi, K*., Hiramatsu, H*., Nakamura, S., Kobayashi, K., Haraguchi, T. and Iba, H. (* equally contributed)
- Journal Title
  
  Scientific Reports,
  
  Volume: 7 Issue: 1 Pages: 11772-11772
- DOI
  10.1038/s41598-017-11806-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07154
[Journal Article] Dynamics and plasticity of the epithelial to mesenchymal transition induced by miR-200 family inhibition2016
- Author(s)
  Haraguchi, T, Kondo, M, Uchikawa, R, Kobayashi, K, Hiramatsu, H, Kobayashi, K , Chit, UW, Shimizu, T, Iba, H.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 1-12
- DOI
  10.1038/srep21117
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26430109, KAKENHI-PROJECT-15K19108, KAKENHI-PLANNED-24115007
[Journal Article] The miR-199a/Brm/EGR1 axis is a determinant of anchorage-independent growth in epithelial tumor cell lines.2015
- Author(s)
  Kobayashi, K., Sakurai, K., Hiramatsu, H., Inada, K., Shiogama, K.,　Nakamura, S., 　Suemasa, F., Kobayashi, K., Imoto, S., Haraguchi, T., Ito, H., Ishizaka, A., Tsutsumi, Y., & Iba H.
- Journal Title
  
  Scientific Reports,
  
  Volume: 5:8428 Issue: 1 Pages: 8428-8428
- DOI
  10.1038/srep08428
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24115007, KAKENHI-PROJECT-25430143, KAKENHI-PROJECT-26430109
[Journal Article] Multiple microRNAs induced by Cdx1 suppress Cdx2 in human colorectal tumor cells.2012
- Author(s)
  Tagawa, T., Haraguchi, T., Hiramatsu, H., Kobayashi, K., Sakurai, K., Inada, K., and Iba, H.
- Journal Title
  
  Biochem. J.
  
  Volume: 447 Pages: 449-455
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300318
[Journal Article] 2’-OME RNAオリゴを基盤とした独特の二次構造を持つ新規microRNA阻害剤、S-TuD.2012
- Author(s)
  原口　健
- Journal Title
  
  遺伝子医学MOOK
  
  Volume: 23 Pages: 169-175
- Data Source
  KAKENHI-PROJECT-22300318
[Journal Article] Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors2012
- Author(s)
  Y. Kurashima, T. Amiya, T. Nochi, K. Fujisawa, T. Haraguchi, H. Iba, H. Tsutsui, S. Sato, S. Nakajima, H. Iijima, M. Kubo, J. Kunisawa, H. Kiyono
- Journal Title
  
  Nat Commun.
  
  Volume: 3-1034 Issue: 1 Pages: 1034-1034
- DOI
  10.1038/ncomms2023
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04859, KAKENHI-PROJECT-12J07362, KAKENHI-PROJECT-22300318, KAKENHI-PROJECT-23229004, KAKENHI-PROJECT-23659199, KAKENHI-PROJECT-24659217, KAKENHI-PUBLICLY-23116506, KAKENHI-PUBLICLY-23130504, KAKENHI-PLANNED-24115007, KAKENHI-PUBLICLY-24117704
[Journal Article] A potent2'-O-methylated RNA-based microRNAinhibitor with unique secondary structures.2012
- Author(s)
  Haraguchi, T., Nakano, H., Tagawa, T., Ohki, T., Ueno, Y., Yoshida, T., and Iba, H.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300318
[Journal Article] A potent 2'-O-methylated RNA-based microRNA inhibitor with unique secondary structures2012
- Author(s)
  Haraguchi,T., Nakano, H., Tagawa, T., Ohki, T., Ueno, Y., Yoshida, T., Iba, H.
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: (in press) Issue: 8 Pages: 1-13
- DOI
  10.1093/nar/gkr1317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300318, KAKENHI-PROJECT-22700873, KAKENHI-PUBLICLY-23130504, KAKENHI-PROJECT-23580141, KAKENHI-PLANNED-24115007, KAKENHI-PUBLICLY-24117704
[Journal Article] Micro RNAs miR-199a-5p and-3p target the Brm subunit of SWI/SNF to generate a double-negative feedback loop in a variety of human cancers2011
- Author(s)
  Sakurai, K, Furukawa C, Haraguchi T, Inada K, Shiogama K, Tagawa T, Fujita S, Ueno Y, Ogata A, Ito M, Tsutsumi Y, Iba H
- Journal Title
  
  Cancer Research
  
  Volume: 71 Pages: 1680-1689
- Data Source
  KAKENHI-PROJECT-22700873
[Journal Article] MicroRNA regulation of glycoprotein B5R in oncolytic vaccinia virus reduces viral pathogenicity without impairing its antitumor efficacy2011
- Author(s)
  Hikichi, M., Kidokoro, M., Haraguchi, T., Iba, H., Shida, H., Tahara, H., Nakamura, T.
- Journal Title
  
  Molecular Therapy
  
  Volume: 19 Pages: 1107-1115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300318
[Journal Article] MicroRNA regulation of vaccinia virus for enhanced oncolytic activity and reduced pathogenicity in oncolytic virotherapy2011
- Author(s)
  Hikichi M, Kidokoro M, Haraguchi T, Iba H, Shida H, Tahara H & Nakamura T.
- Journal Title
  
  Molecular Therapy
  
  Volume: 19巻 Issue: 6 Pages: 1107-15
- DOI
  10.1038/mt.2011.36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249069, KAKENHI-PROJECT-22659227, KAKENHI-PROJECT-22680065, KAKENHI-PROJECT-22700873, KAKENHI-PUBLICLY-23130504
[Journal Article] Micro RNA regulation of glycoprotein B5R in oncolytic vaccinia virus reduces viral pathogeni city without impairing itsantitumor efficacy2011
- Author(s)
  Hikichi M, Kidokoro M, Haraguchi T, Iba H, Shida H, Tahara H, Nakamura T
- Journal Title
  
  Mol Ther
  
  Volume: 19(6) Pages: 1107-15
- Data Source
  KAKENHI-PROJECT-22700873
[Journal Article] MicroRNA regulation of glycoprotein B5R in oncolytic vaccinia virus reduces viral pathogenicity without impairing its antitumor efficacy.2011
- Author(s)
  Hikichi, M., Kidokoro, M., Haraguchi,T., Iba, H., Shida, H., Tahara, H., and Nakamura, T.
- Journal Title
  
  Molecular Therapy
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300318
[Journal Article] MicroRNA regulation of glycoprotein B5R in oncolytic vaccinia virus reduces viral pathogenicity without impairing its antitumor efficacy.2011
- Author(s)
  Hikichi, M., Kidokoro, M., Haraguchi, T., Iba, H., Shida, H., Tahara, H., Nakamura, T.
- Journal Title
  
  Molecular Therapy
  
  Volume: (Published online)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300318
[Journal Article] MicroRNAs miR-199a-5p and -3p target the Brm subunit of SWI/SNF to generate a double-negative feedback loop in a variety of human cancers.2011
- Author(s)
  Sakurai, K, Furukawa C, Haraguchi T, Inada K, Shiogama K, Tagawa T, Fujita S, Ueno Y, Ogata A, Ito M, Tsutsumi Y, Iba H.
- Journal Title
  
  Cancer Research
  
  Volume: 71 Pages: 1680-1689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700873
[Journal Article] MicroRNA Regulation of Glycoprotein B5R in Oncolytic Vaccinia Virus Reduces Viral Pathogenicity Without Impairing Its Antitumor Efficacy2011
- Author(s)
  Hikichi M, Kidokoro M, Haraguchi T, Iba H, Shida H, Tahara H, Nakamura T.
- Journal Title
  
  Molecular Therapy
  
  Volume: (Published online)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700873
[Journal Article] microRNAs miR-199a-5p and -3p target the Brm subunit of SWI/SNFto generate a double-negative feedback loop ina variety of human cancers.2011
- Author(s)
  Sakurai, K., Furukawa, C., Haraguchi, T., Inada, K.,Shiogama, K., Tagawa, T., Fujita, S., Ueno, Y., Ogata, A., Ito,M., Tsutsumi, Y., and Iba, H.
- Journal Title
  
  Cancer Research
  
  Volume: 71 Pages: 1680-1689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300318
[Journal Article] Requiem Protein Links RelB/p52 and the Brm-type SWI/SNF Complex in a Noncanonical NF-kappa B Pathway.2010
- Author(s)
  Tando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T, Mizutani T, Izumi T, Isobe T, Akiyama T, Inoue J, Iba H.
- Journal Title
  
  JOURNAL OF BIOLOGICAL CHEMISTRY
  
  Volume: 285 Pages: 21951-21960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700873
[Journal Article] microRNAs miR-199a-5p and -3p target the Brm subunit of SWI/SNF to generate a double-negative feedback loop in a variety of human cancers.2010
- Author(s)
  Sakurai, K., Furukawa, C., Haraguchi, T., Inada, K., Shiogama, K., Tagawa, T., Fujita, S., Ueno, Y., Ogata, A., Ito, M., Tsutsumi, Y., Iba, H.
- Journal Title
  
  Cancer Research
  
  Volume: 71 Pages: 1680-1689
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300318
[Journal Article] Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a non-canonical NF_KB pathway.2010
- Author(s)
  Tando, T., Ishizaka, A., Watanabe, H., Ito, T., Iids, S., Haraguchi, T., Mizutani, T., Izumi, T., Isobe, T., Akiyama, T., Inoue, J., Iba, H.
- Journal Title
  
  J.Biol.Chem.
  
  Volume: 285 Pages: 21951-21960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300318
[Journal Article] Requiem protein links RelB/p52 and theBrm-type SWI/SNF complex in a non-canonical NFκB pathway.2010
- Author(s)
  Tando, T., Ishizaka, A., Watanabe, H., Ito, T., Iida, S., Haraguchi, T., Mizutani, T., Izumi, T., Isobe, T., Akiyama, T., Inoue, J., and Iba, H.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 285 Pages: 21951-21960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300318
[Journal Article] miR-21の発現亢進と発癌-亢進は癌の原因か、結果か? またいかに亢進抑制するのか?2009
- Author(s)
  原口健、伊庭英夫
- Journal Title
  
  実験医学 27
  
  Pages: 1201-1207
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] miRNAの活性抑制法とその利用によるヒトがん治療「miRNAが変える創薬・がん・発生研究-次世代高感度アレイによる統合解析が明らかにするmiRNAの生命機能」2009
- Author(s)
  櫻井浩平、古川千尋、原口健、伊庭英夫
- Journal Title
  
  分子細胞治療 8
  
  Pages: 350-357
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells.2009
- Author(s)
  Haraguchi T, Ozaki Y, Iba H.
- Journal Title
  
  Nucleic Acids Res. 37
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] LNA in situ hybridization analysis of miR-21 expression during colorectal cancer development.2009
- Author(s)
  Yamamichi N, Shimomura R, Inada K, Sakurai K, Haraguchi T, Ozaki Y, Fujita S, Mizutani T, Furukawa C, Fujishiro M, Ichinose M, Shiogama K, Tsutsumi Y, Omata M, Iba H.
- Journal Title
  
  Clin. Cancer Res. 15
  
  Pages: 4009-4016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells2009
- Author(s)
  Yamamichi, N., Inada, K., Furukawa, C., Sakurai, K., Tando, T., Ishizaka, A., Haraguchi, T., Mizutani, T., Fujishiro, M., Shimomura, R., Oka, M., Ichinose, M., Tsutsumi, Y., Omata, M., Iab, H.
- Journal Title
  
  Experimental Cell Research 315
  
  Pages: 1779-1789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells.2009
- Author(s)
  Yamamichi N, Inada K, Furukawa C, Sakurai K, Tando T, Ishizaka A, Haraguchi T, Mizutani T, Fujishiro M, Shimomura R, Oka M, Ichinose M, Tsutsumi Y, Omata M, Iba H.
- Journal Title
  
  Exp. Cell Res. 315
  
  Pages: 1779-1789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] LNA in situ hybridization analysis of miR-21 expression during colorectal cancer development2009
- Author(s)
  Yamamichi, N., Shimomura, R., Inada, K., Sakurai, K., Haraguchi, T., Ozaki, Y., Fujita, S., Mizutani, T., Furukawa, C., Fujishiro, M., Ichinose, M., Shiogama, K., Tsutsumi, Y., Omata, M., Iba, H
- Journal Title
  
  Clinical Cancer Research 15
  
  Pages: 4009-4016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts inconcert with p54^<nrb>.2008
- Author(s)
  Ito, T., Watanabe, H., Yamamichi, N., Kondo, S., Tando, T., Haraguchi, T., Mizutani, T., Sakurai, K., Fujita, S., Izumi, T., Isobe, T., and Iba, H.
- Journal Title
  
  Biochemical J. 411
  
  Pages: 201-209
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Brm transactivates the telomerase reverse transcriptase (TERT) gene and modulates the splicing patterns of its transcripts in concert with p54nrb2008
- Author(s)
  Ito T, Watanabe H, Yamamichi N, Kondo S, Tando T, Haraguchi T, Mizutani T, Sakurai K, Fujita S, Izumi T, Isobe T, Iba H.
- Journal Title
  
  Biochemical J. 411
  
  Pages: 201-209
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Frequent loss of Brm expression in gastric cancer correlates with histological features and differentiation state.2007
- Author(s)
  Yamamichi, N., Inada, K., Ichinose, M., Yamamichi-Nishina, M., Mizutani, T., Watanabe, H., Shiogama, K., Okazaki, T., Fujishiro, M., Yahagi, N., Haraguchi T., Fujita, S., Tsutsumi, Y., Omata, M. and Iba, H.
- Journal Title
  
  Cancer Research 22
  
  Pages: 10727-10735
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] SiRNAs do not induce RNA-dependent transcriptional silencing of retrovirus in human cells.2007
- Author(s)
  Haraguchi T, Mizutani T, Yamamichi N, Ito T, Minoguchi S, Iba, H.
- Journal Title
  
  FEBS Letter 581
  
  Pages: 4949-4954
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] RNA-dependent transcriptional silencing does not contribute to retroviral gene silencing in human cells.2007
- Author(s)
  Haraguchi, T., Mizutani, T., Yamamichi, N., Ito, T., Minoguchi, S., and Iba, H.
- Journal Title
  
  FEBS Letter 581
  
  Pages: 4949-4954
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Frequent loss of Brm expression in gastric cancer correlates with histological features and differentiation state.2007
- Author(s)
  Haraguchi T, Fujita S, Tsutsumi, Y, Omata M, Iba, H.
- Journal Title
  
  Cancer Research 67
  
  Pages: 10727-10735
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] SWI/SNF complex is essential for NRSF-mediated suppression of neuronal genes in human nonsmall cell lung carcinoma cell lines.2006
- Author(s)
  Watanabe H, Mizutani T, Haraguchi T, Yamamichi N, Minoguchi S, Yamamichi-Nishina M, Mori N, Kameda T, Sugiyama T, Iba H.
- Journal Title
  
  Oncogene 25
  
  Pages: 470-479
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells
- Author(s)
  Haraguchi, T., Ozaki, Y., and Iba, H.
- Journal Title
  
  Nucleic Acids Res. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a non-canonical NFκB pathway.
- Author(s)
  Tando T, Ishizaka A, Watanabe H, Ito T, Iida S, Haraguchi T, Mizutani T, Izumi T, Isobe T, Akiyama T, Inoue J, Iba H.
- Journal Title
  
  J Biol. Chem. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Journal Article] Ccbc2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells
- Author(s)
  Yamamichi, N., Inada, K., Furukawa, C., Sakurai, K., Tando, T. , Ishizaka , A., Haraguchi, T., Mizutani, T., Fujishiro, M., Shimomura, R., Oka, M., Ichinose, M., Tsutsumi, Y., Ornata, M., and Iba, H.
- Journal Title
  
  Exp. Cell Res. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] テトラサイクリン誘導型miRNA阻害ベクターを用いた、miR-200 ファミリー阻害により誘導されるEMTの動的解析2017
- Author(s)
  .原口　健
- Organizer
  日本核酸医薬学会第２回年会　札幌
- Data Source
  KAKENHI-PROJECT-17K07154
[Presentation] トリプルネガティブ乳癌の腫瘍形成能に関わるmicroRNAの同定2015
- Author(s)
  内川亮, 原口健, 近藤正幸, 小林和善, 伊庭英夫
- Organizer
  第38回日本分子生物学会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26430109
[Presentation] SWI/SNF クロマチン構造変換因子と miRNA の視点に立った上皮癌の遺伝子制御ネットワークの理解2015
- Author(s)
  伊庭英夫、小林和善、平松寛明、櫻井浩平、稲田健一、堤　寛、原口健
- Organizer
  第74回日本癌学会学術集会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26430109
[Presentation] 2 種の miRNA 阻害による乳癌幹細胞の造腫瘍能の抑制2015
- Author(s)
  原口健、近藤正幸、伊庭英夫
- Organizer
  第74回日本癌学会学術集会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26430109
[Presentation] グリオーマ幹細胞の幹細胞性の維持におけるSWI/SNFクロマチン構造変換複合体の役割2015
- Author(s)
  平松寛明、小林和善、小林郷介、原口健、稲生靖、藤堂具紀、伊庭英夫
- Organizer
  第38回日本分子生物学会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26430109
[Presentation] Brm型SWI/SNF複合体は転写因子SRFのMKL1依存的な活性を抑制することにより細胞の上皮性を維持している2015
- Author(s)
  小林和善, 平松寛明, 小林郷介, 原口健, 伊庭英夫
- Organizer
  第38回日本分子生物学会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26430109
[Presentation] miRNA発現及びmiRNA阻害レンチウイルスベクターライブラリーを用いた人工乳癌幹細胞作製法の開発2013
- Author(s)
  原口　健
- Organizer
  平成24年度　文部科学省新学術領域研究　がん研究分野の特性等を踏まえた支援活動　公開シンポジウム
- Place of Presentation
  東京
- Year and Date
  2013-01-30
- Data Source
  KAKENHI-PUBLICLY-23130504
[Presentation] Two methods for microRNA inhibition-TuD RNA expression vector 2’-O-methylated RNA-based microRNA inhibitor, S-TuD.2012
- Author(s)
  Haraguchi, T
- Organizer
  The 10th Stem Cell Research Symposium
- Place of Presentation
  淡路
- Year and Date
  2012-06-01
- Data Source
  KAKENHI-PUBLICLY-23130504
[Presentation] 独自の二次構造を持つ2’-OME RNAオリゴを基盤としたmicroRNA阻害剤「S-TuD」2012
- Author(s)
  原口　健
- Organizer
  第12回分子複合医薬研究会
- Place of Presentation
  大阪
- Year and Date
  2012-11-12
- Invited
- Data Source
  KAKENHI-PUBLICLY-23130504
[Presentation] Two methods for microRNA inhibition-TuD RNA expression vector & 2'-O-methylated RNA-based microRNA inhibitor, S-TuD.2012
- Author(s)
  Haraguchi, T., and Iba, H.
- Organizer
  The 10thStem Cell Research Symposium
- Place of Presentation
  淡路
- Year and Date
  2012-06-01
- Data Source
  KAKENHI-PROJECT-22300318
[Presentation] Identification of essential factors of SWI/SNF dependent-NF-kappaB activation and their roles in carcinogenesis.2012
- Author(s)
  Kobayashi, K., Sakurai, K., Haraguchi, T., Iba, H.
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Year and Date
  2012-09-20
- Data Source
  KAKENHI-PROJECT-22300318
[Presentation] 独自の二次構造を持つ2’-OME RNAオリゴ新規microRNA阻害剤「S-TuD」2012
- Author(s)
  原口　健
- Organizer
  第28回日本DDS学会学術集会
- Place of Presentation
  札幌
- Year and Date
  2012-07-05
- Invited
- Data Source
  KAKENHI-PUBLICLY-23130504
[Presentation] Development of S-TuD, a novel 2'-O-methylated RNA based microRNA inhibitor with unique secondary structures.2011
- Author(s)
  原口健、中野春男、吉田哲郎、伊庭英夫 :
- Organizer
  第34回日本分子生物学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22300318
[Presentation] A potent2'-O-Methylated RNA based microRNA inhibitor with unique secondary structures.2011
- Author(s)
  原口健、中野春男、吉田哲郎、伊庭英夫
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-22300318
[Presentation] Development of S-TuD, a novel 2'-O-methylated RNA based microRNA inhibitor with unique secondary structures2011
- Author(s)
  原口健、中野春男、吉田哲郎、伊庭英夫
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PUBLICLY-23130504
[Presentation] Development of S-TuD, a novel 2'-O-methylated RNA based microRNA inhibitor with unique secondary structures2011
- Author(s)
  原口健、中野春男、吉田哲郎、伊庭英夫
- Organizer
  第34回日本分子生物学会学術総会
- Place of Presentation
  横浜(招待講演)
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22300318
[Presentation] miRNA as an epigenetic switch2011
- Author(s)
  伊庭英夫、原口健、櫻井浩平、小林和善
- Organizer
  第18回東アジアシンポジウム
- Place of Presentation
  中国・上海(招待講演)
- Year and Date
  2011-12-07
- Data Source
  KAKENHI-PROJECT-22700873
[Presentation] miRNA as an epigenetic switch2011
- Author(s)
  伊庭英夫、原口健、櫻井浩平、小林和善
- Organizer
  第18回東アジアシンポジウム
- Place of Presentation
  中国・上海(招待講演)
- Year and Date
  2011-12-07
- Data Source
  KAKENHI-PUBLICLY-23130504
[Presentation] miRNA as an epigenetic switch2011
- Author(s)
  伊庭英夫、原口健、櫻井浩平、小林和善
- Organizer
  第18回東アジアシシポジウム
- Place of Presentation
  中国・上海(招待講演)
- Year and Date
  2011-12-07
- Data Source
  KAKENHI-PROJECT-22300318
[Presentation] A potent2'-0-Methylated RNA based microRNA inhibitor with unique secondary structures.2011
- Author(s)
  原口健、中野春男、吉田哲郎、伊庭英夫
- Organizer
  第70回日本癌学会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22700873
[Presentation] Development of S-TuD, a novel 2'-O-methylated RNA based microRNA inhibitor with unique secondary structures2011
- Author(s)
  原口健、中野春男、吉田哲郎、伊庭英夫
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22700873
[Presentation] A potent 2'-O-Methylated RNA based microRNA inhibitor with unique secondary structures2011
- Author(s)
  原口健、中野春男、吉田哲郎、伊庭英夫
- Organizer
  第70回日本癌学会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-22700873
[Presentation] A potent 2'-O-Methylated RNA based microRNA inhibitor with unique secondary structures2011
- Author(s)
  原口健、中野春男、吉田哲郎、伊庭英夫
- Organizer
  第70回日本癌学会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PUBLICLY-23130504
[Presentation] Development of S-TuD, a novel2'-0-methylated RNA based microRNA inhibitor with unique secondary structures.2011
- Author(s)
  原口健、中野春男、吉田哲郎、伊庭英夫
- Organizer
  第34回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-13
- Data Source
  KAKENHI-PROJECT-22700873
[Presentation] A-potent2'-O-Methylated RNA based microRNA inhibitor with unique secondary structures2011
- Author(s)
  原口健、中野春男、吉田哲郎、伊庭英夫
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋(招待講演)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22300318
[Presentation] miRNA as an epigenetic switch.2011
- Author(s)
  伊庭英夫、原口健、櫻井浩平、小林和善
- Organizer
  第18回東アジアシンポジウム
- Place of Presentation
  上海
- Year and Date
  2011-12-07
- Data Source
  KAKENHI-PROJECT-22700873
[Presentation] マイクロRNAによって制御されるウイルスの開発とその応用2010
- Author(s)
  引地美奈、木所稔、原口健、伊庭英夫、志田壽利、田原秀晃、中村貴史
- Organizer
  第12回日本RNA学会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22700873
[Presentation] 特定のmicroRNAを長期間、高効率で阻害するDecoyRNA発現レンチウイルスベクターの確立2010
- Author(s)
  原口健、櫻井浩平、伊庭英夫
- Organizer
  第58回日本ウイルス学会
- Place of Presentation
  徳島
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-22700873
[Presentation] 特定のmicroRNAを長期間、高効率で阻害するDecoy RNA発現レンチウイルスベクターの確立2010
- Author(s)
  原口健
- Organizer
  第58回日本ウイルス学会
- Place of Presentation
  徳島あわぎんホール
- Year and Date
  2010-11-09
- Data Source
  KAKENHI-PROJECT-22700873
[Presentation] 特定のmicroRNAを長期間、高効率で阻害するDecoy RNA発現ベクター2009
- Author(s)
  原口健、伊庭英夫
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] 特定のmicroRNAを高効率で阻害する Decoy RNAの設計(Design of efficient RNA decoys that inhibit specific microRNA activity in mammalian cells)2009
- Author(s)
  原口健、伊庭英夫
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] Requiem functions in a non-canonical NFκB pathway as a linker protein between Rel/p52 and the SWI/SNF complex2009
- Author(s)
  丹藤利夫、石坂彩、原口健、水谷壮利、秋山泰身、井上純一郎、伊庭英夫
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] Requiem functions in anon-canonical NFκB pathway as a linker protein between Rel/p52 and the SWI/SNF complex2009
- Author(s)
  丹藤利夫、石坂彩、原口健、水谷壮利、秋山泰身、井上純一郎、伊庭英夫
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] 特定のmicroRNAを高効率で阻害するDecoy RNAの設計(Design of efficient RNA decoys that inhibit specific microRNA activity in mammalian cells. )2009
- Author(s)
  原口健、伊庭英夫
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] HIV-1のTat非依存的な発現を維持するSWI/SNF複合体の作用機序の解析2008
- Author(s)
  石坂彩、水谷壮利、山道信毅、原口健、富沢麻利子、岩本愛吉、伊庭英夫
- Organizer
  第5回日本ウイルス学会学術集会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] miR-21と標的遺伝子の発現制御ネットワーク解析(Analysis of regulatory network involving human miR-21 gene and its target genes. )2008
- Author(s)
  藤田修二、山道信毅、原口健、尾崎由佳、伊庭英夫
- Organizer
  第31回日本分子生物学会年会第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] ヒトvillin遺伝子の転写制御機構の解析2008
- Author(s)
  古川千尋、山道信毅、丹藤利夫、石坂彩、櫻井浩平、原口健、稲田健一、下村龍一、伊庭英夫
- Organizer
  第31回日本分子生物学会年会第81回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] HIV-1のTat非依存的な発現におけるSWI/SNF複合体の機能解析2007
- Author(s)
  水谷壮利、石坂彩、山道信毅、原口健、伊庭英夫
- Organizer
  第55回日本ウイルス学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] SWI/SNF複合体の触媒サブユニットBrmはTERT遺伝子の転写と選択的スプライシングに関与する2006
- Author(s)
  伊藤太二、渡部博貴、山道信毅、近藤俊輔、板垣千春、丹藤利夫、水谷壮利、原口健、櫻井浩平、藤田修二、泉友則、礒辺俊明、伊庭英夫
- Organizer
  日本分子生物学会2006フォーラム(分子生物学の未来)
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] レトロウイルスプロモーターサイレンシングにおけるRNAi機構の役割の検証2006
- Author(s)
  原口健、水谷壮利、伊庭英夫
- Organizer
  第54回日本ウイルス学会学術集会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] Unique expression mechanisms of Brm protein, a key regulatory host factor for continuous retroviral expression2005
- Author(s)
  Yamamichi N, Mizutani T, Yamamichi-Nishina M, Haraguchi T, Kameda T, Iba H.
- Organizer
  第5回あわじしま感染症・免疫フォーラム
- Place of Presentation
  兵庫
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] レトロウイルスの発現維持に必須な宿主因子Brmの特異な生合成過程2005
- Author(s)
  伊庭英夫、山道信毅、水谷壮利、原口健
- Organizer
  第53回日本ウイルス学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2005-11-22
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] p54nrbとSWI/SNF複合体の相互作用とその生化学的意義2005
- Author(s)
  伊藤太二、渡部博貴、山道信毅、近藤俊輔、板垣千春、丹藤利夫、水谷壮利、原口健、藤田修二、泉友則、礒辺俊明、伊庭英夫
- Organizer
  第28回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-17016015
[Presentation] Analysis on EMT using Tetracycline-inducible microRNA inhibitory vectors against miR-200c.
- Author(s)
  原口健、近藤正幸、伊庭英夫
- Organizer
  第73回日本癌学会学術
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26430109
[Presentation] 新規TuD RNA発現レンチウイルスベクターを用いたmiR-200cの発現制御によるEMTの分子機構の解析
- Author(s)
  近藤正幸、原口健、伊庭英夫
- Organizer
  第37回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26430109
[]
[]

1. IBA Hideo (60111449)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. MIZUTANI Taketoshi (00376617)

# of Collaborated Projects: 2 results

# of Collaborated Products: 25 results
3. MINOGUCHI Shigeru (60322757)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. YAMAMICHI Nobutake (30463897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
5. ITO Taiji (60343109)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
6. KOHARA Michinori (10250218)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. INADA Kenichi (70246081)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. 伊庭英生

# of Collaborated Projects: 0 results

# of Collaborated Products: 58 results
9. 田原秀晃

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HARAGUCHI TAKESHI 原口 健

Haraguchi Takeshi 原口 健

HARAGUCHI Takeshi 原口 健

Research Projects

Research Products

Co-Researchers

Development of peptide-ligand modified LNP for microRNA inhibition in tumor tissues.Principal Investigator

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Review Section

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Regulatory mechanisms involved in SRF-MKL1/2 complex in epithelial tumors

Principal Investigator

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Research Institution

Search for miRNAs that regulate stemness of breast cancer stem cell to find therapeutic targets of triple-negative breast cancer.Principal Investigator

Principal Investigator

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Research Institution

複数種類ｍｉＲＮＡの強制発現及び機能阻害による人工癌幹細胞作製法の開発Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

Significance and Molecular mechanisms of abnormal expression of miRNA in carcinogenesis.

Principal Investigator

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Research Institution

Screening for microRNA which is related to cancer progression by using novel microRNA inhibitory vectorsPrincipal Investigator

Principal Investigator

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Research Institution

Development of new types of retrovirus vectors that modulate epigenetical regulation.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] 遺伝子医学MOOK2012

Author(s)

Publisher

Data Source

[Book] 遺伝子医学MOOK2012

Author(s)

Publisher

Data Source

[Book] 遺伝子医学MOOK、2'-OME RNAオリゴを基盤とした独特の二次構造を持つ新規microRNA阻害剤、S-TuD2012

Author(s)

Publisher

Data Source

[Book] 遺伝子医学MOOK23号 「臨床・創薬利用が見えてきたmicroRNA」2012

Author(s)

Total Pages

Publisher

Data Source

[Book] 遺伝子医学MOOK2012

Author(s)

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Data Source

[Book] 実験医学2010

Author(s)

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Data Source

[Book] 生体の科学2010

Author(s)

Total Pages

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Data Source

[Book] 生体の科学、TuD RNA発現ベクターを用いたmiRNAの活性阻害による機能解析2010

Author(s)

HARAGUCHI TAKESHI 原口健

Haraguchi Takeshi 原口健

HARAGUCHI Takeshi 原口健

[Book] 遺伝子医学MOOK23号　「臨床・創薬利用が見えてきたmicroRNA」2012