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Yoshimoto Nobuyasu  吉本 信保

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YOSHIMOTO Nobuyasu  吉本 信保

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Researcher Number 10551244
Other IDs
Affiliation (Current) 2025: 医療法人徳洲会札幌東徳洲会病院医学研究所, ゲノム診断研究部, 研究員
Affiliation (based on the past Project Information) *help 2019 – 2023: 名古屋市立大学, 医薬学総合研究院(医学), 研究員
2016 – 2018: 名古屋市立大学, 大学院医学研究科, 研究員
2015: 名古屋市立大学, 医学(系)研究科(研究院), 研究員
2014 – 2015: 名古屋市立大学, 大学院医学研究科, 助教
2012 – 2015: 名古屋市立大学, 医学(系)研究科(研究院), 助教
2012: 名古屋市立大学, 大学院・医学研究科, 助教
2011: 名古屋市立大学, 医学(系)研究科(研究院), 臨床研究医
Review Section/Research Field
Principal Investigator
General surgery / Basic Section 55010:General surgery and pediatric surgery-related
Except Principal Investigator
General surgery
Keywords
Principal Investigator
一塩基多型 / リスクモデル / エストロゲンレセプター陽性乳癌 / 血清バイオマーカー / 遺伝子多型 / 発症予防 / 罹患リスクモデル / SNP / ER陽性乳癌 / 発症リスクモデル … More / ホルモンレセプター陽性乳癌 / 化学予防 / 高リスク群 / 乳癌易罹患性 / エストロゲンレセプター陽性乳癌罹患モデル / エストロゲン依存性乳癌 / 血清ホルモン … More
Except Principal Investigator
乳癌 / エストロゲンレセプター / 乳腺外科学 / 薬剤抵抗性 / 体細胞変異 / 薬剤耐性 / 骨転移 / RAI2 / breast cancer / miR-1290 / ポリアミン / LMTK3 / 癌 / miR-210 / マイクロRNA Less
  • Research Projects

    (10 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (8 People)
  •  Establishment of ER positive breast cancer risk model that can be prevented by chemoprevention focusing on single nucleotide polymorphisms of metabolism enzymes genePrincipal Investigator

    • Principal Investigator
      YOSHIMOTO Nobuyasu
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Nagoya City University
  •  The elucidation of the metastasis in bone marrow mechanism in hormonal therapy-resistant breast cancer and development of the new molecular target drug

    • Principal Investigator
      KONDO NAOTO
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Nagoya City University
  •  Exome sequencing of human breast cancer tissues resistant to taxanes.

    • Principal Investigator
      Endo Yumi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Nagoya City University
  •  Diagnostic approach to breast cancer patients based on target metabolomics in saliva

    • Principal Investigator
      Toyama Tatsuya
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Nagoya City University
  •  Treatment strategy of breast cancer using micro RNA-1290

    • Principal Investigator
      Hato Yukari
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Nagoya City University
  •  Establishment of estrogen receptor positive breast cancer risk model consisting of genetic polymorphisms and serum biomarkersPrincipal Investigator

    • Principal Investigator
      YOSHIMOTO Nobuyasu
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Nagoya City University
  •  The target therapy for LMTK3 in hormone receptor-positive breast cancer

    • Principal Investigator
      Asano Tomoko
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Nagoya City University
  •  New treatment strategy for triple-negative breast cancer targeting micro RNA

    • Principal Investigator
      TOYAMA Tatsuya
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Nagoya City University
  •  Estrogen receptor positive breast cancer risk score constructed by genetic factors and endogenous hormonesPrincipal Investigator

    • Principal Investigator
      YOSHIMOTO Nobuyasu
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Nagoya City University
  •  Analysis of microRNAs and development of novel therapeutic strategies in breast cancer

    • Principal Investigator
      YAMASHITA Hiroko
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Hokkaido University
      Nagoya City University

All 2024 2022 2021 2020 2019 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation

  • [Journal Article] Axillary Lymph Node Swelling Mimicking Breast Cancer Metastasis After COVID-19 Vaccination: A Japanese Case Report and Literature Review2022

    • Author(s)
      YOSHIMOTO NOBUYASU、TAKURA KOHEI、YANAGI AKEMI、TAKAYAMA SATORU、SAKAMOTO MASAKI、ISHIKAWA KEN、KATADA TAKEYASU、KAWATE AKIFUMI、TAKAYAMA SHORYU、YAMASHITA MASAKATSU、YAMAMOTO SHINYA、YOKOYAMA KIOTO、KANI HISANORI
    • Journal Title

      In Vivo

      Volume: 36 Issue: 2 Pages: 1041-1046

    • DOI

      10.21873/invivo.12800

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K18036
  • [Journal Article] Axillary Lymph Node Swelling After COVID-19 Booster Vaccination: Japanese Case Report and Literature Review2022

    • Author(s)
      Yoshimoto N, Yanagi A, Takayama S, Sakamoto M, Tomoda K, Ishikawa K, Kawate A, Takayama S, Yamashita M, Yamamoto S, Yokoyama K, Suzuki H, Kani H
    • Journal Title

      In Vivo

      Volume: 36 Issue: 4 Pages: 1977-1981

    • DOI

      10.21873/invivo.12921

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K18036
  • [Journal Article] Timing and Duration of Axillary Lymph Node Swelling After COVID-19 Vaccination: Japanese Case Report and Literature Review2022

    • Author(s)
      Yoshimoto N, Yanagi A, Takayama S, Sakamoto M, Tomoda K, Ishikawa K, Takura K, Kawate A, Takayama S, Yamashita M, Yamamoto S, Yokoyama K, Kani H
    • Journal Title

      In Vivo

      Volume: 36 Issue: 3 Pages: 1333-1336

    • DOI

      10.21873/invivo.12834

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K18036
  • [Journal Article] COVID-19 Screening of Breast Cancer Patients During Treatment: A Single Center Experience in Japan2021

    • Author(s)
      YOSHIMOTO NOBUYASU、TAKAYAMA SATORU、SAKAMOTO MASAKI、ISHIKAWA KEN、KATADA TAKEYASU、KAWATE AKIFUMI、TAKURA KOHEI、TAKAYAMA SHORYU、YAMASHITA MASAKATSU、YAMAMOTO SHINYA、YOKOYAMA KIOTO、KANI HISANORI
    • Journal Title

      Cancer Diagnosis & Prognosis

      Volume: 1 Issue: 5 Pages: 423-425

    • DOI

      10.21873/cdp.10056

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K18036
  • [Journal Article] Diagnostic approach to breast cancer patients based on target metabolomics in saliva by liquid chromatography with tandem mass spectrometry.2016

    • Author(s)
      Takayama T, Tsutsui H, Shimizu I, Toyama T, Yoshimoto N, Endo Y, Inoue K, Todoroki K, Min JZ, Mizuno H, Toyo'oka T.
    • Journal Title

      Clin Chim Acta.

      Volume: 452 Pages: 18-26

    • DOI

      10.1016/j.cca.2015.10.032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K10060, KAKENHI-PROJECT-15K07895, KAKENHI-PROJECT-16K08200
  • [Journal Article] High expression of LMTK3 is an independent factor indicating a poor prognosis in estrogen receptor α-positive breast cancer patients.2014

    • Author(s)
      Asano T, Sato S, Yoshimoto N, Endo Y, Hato Y, Dong Yu, Takahashi S, Fujii Y, Toyama T
    • Journal Title

      Jpn J Clin Oncol

      Volume: 44 Issue: 10 Pages: 889-897

    • DOI

      10.1093/jjco/hyu113

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25461990
  • [Journal Article] MiR-1290 and its potential targets are associated with characteristics of estrogen receptor α-positive breast cancer2013

    • Author(s)
      Endo Y
    • Journal Title

      Endocr-Relat Cancer

      Volume: 20 Issue: 1 Pages: 91-102

    • DOI

      10.1530/erc-12-0207

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591902, KAKENHI-PROJECT-24791387
  • [Journal Article] エストロゲンレセプター陽性乳癌におけるmicroRNAの役割に関する研究2012

    • Author(s)
      山下啓子、遠山竜也、吉本信保、遠藤友美
    • Journal Title

      日本内分泌・甲状腺外科学会雑誌

      Volume: 29 Pages: 289-292

    • NAID

      130004600581

    • Data Source
      KAKENHI-PROJECT-23591902
  • [Journal Article] Distinct expressions of microRNAs that directly target estrogen receptor α in human breast cancer2011

    • Author(s)
      Yoshimoto N, Toyama T, Takahashi S, Sugiura H, Endo Y, Iwasa M, Fujii Y, Yamashita H
    • Journal Title

      Breast cancer Res Treat

      Volume: 130 Pages: 331-339

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591902
  • [Journal Article] Genetic and environmental predictors, endogenous hormones and growth factors, and risk of estrogen receptor-positive breast cancer in Japanese women2011

    • Author(s)
      Yoshimoto N, Nishiyama T, Toyama T, Takahashi S, Shiraki N, Sugiura H, Endo Y, Iwasa M, Fujii Y, Yamashita H
    • Journal Title

      Cancer Science

      Volume: 102 Issue: 11 Pages: 2065-72

    • DOI

      10.1111/j.1349-7006.2011.02047.x

    • NAID

      10030245302

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591901
  • [Presentation] デジタルPCRを用いた乳癌患者の血漿遊離核酸モニタリングの有用性2024

    • Author(s)
      吉本信保、河井伸午、野島萌、南盛一、高山悟、横山希生人
    • Organizer
      第32回日本乳癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K18036
  • [Presentation] 乳癌患者における血液中遊離核酸の遺伝子解析2022

    • Author(s)
      吉本信保、河井伸午、南盛一、高山悟、川手章史、高山昇龍、山本真也、横山希生人
    • Organizer
      第30回日本乳癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K18036
  • [Presentation] COVID-19 流行下における当院での乳癌診療の取り組み2021

    • Author(s)
      吉本信保、川手章史、山本真也、高山悟
    • Organizer
      第29回日本乳癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-19K18036
  • [Presentation] フルベストラント単剤治療後に逐次的にパルボシクリブを追加投与し治療が奏功した再発乳癌の1例2020

    • Author(s)
      吉本信保、内藤明広
    • Organizer
      第32回日本内分泌外科学会総会
    • Data Source
      KAKENHI-PROJECT-19K18036
  • [Presentation] CYP2C19 rs4917623の一塩基多型は、エストロゲンレセプター陽性乳癌でのタモキシフェンの効果を予測しうる2019

    • Author(s)
      吉本信保、内藤 明広、川口 暢子、加藤 美和、近藤 直人、 鰐淵 友美、遠山 竜也
    • Organizer
      第27回日本乳癌学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K18036
  • [Presentation] The CYP2C19 rs4917623 single nucleotide polymorphism to predict tamoxifen efficacy in estrogen receptor-positive breast cancer patients.2019

    • Author(s)
      Nobuyasu Yoshimoto, Akihiro Naito, Nobuko Kawaguchi, Miwa Kato, Naoto Kondo, Yumi Wanifuchi-Endo, Tatsuya Toyama
    • Organizer
      2019 ASCO annual meeting
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K18036
  • [Presentation] 再発乳癌患者における唾液中ポリアミン発現に意義について2016

    • Author(s)
      近藤直人、吉本信保、遠藤友美、波戸ゆかり、西本真弓、遠山竜也
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2016-04-14
    • Data Source
      KAKENHI-PROJECT-15K10060
  • [Presentation] 遺伝因子を考慮したエストロゲンレセプター陽性乳癌罹患高リスク群同定への個別化アプローチ2016

    • Author(s)
      吉本信保
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-04-14
    • Data Source
      KAKENHI-PROJECT-26461955
  • [Presentation] 疫学因子・血清因子からなるマンモグラフィ濃度予測モデルの改良~統 計学的手法を用いた重要因子の同定~2016

    • Author(s)
      吉本信保
    • Organizer
      第24回日本乳癌学会学術集会
    • Place of Presentation
      東京ビックサイト(東京都江東区)
    • Year and Date
      2016-06-16
    • Data Source
      KAKENHI-PROJECT-26461955
  • [Presentation] TNRC9 rs3803662がマンモグラフィ濃度とエストロゲンレセプター陽性乳癌罹患リスクに与える影響2015

    • Author(s)
      吉本信保
    • Organizer
      第23回日本乳癌学会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-07-02
    • Data Source
      KAKENHI-PROJECT-26461955
  • [Presentation] Genetic polymorphism of estrogen metabolizing enzyme CYP17A1 rs743572 impacts on serum testosterone level in Japanese premenopausal women2013

    • Author(s)
      Yoshimoto N, Nishiyama T, Yamashita H, Takahashi S, Shiraki N, Sugiura H, Endo Y, Iwasa M, Asano T, Hato Y, Fujii Y, Toyama T
    • Organizer
      36th Annual Breast Cancer Symposium
    • Place of Presentation
      San Antonio
    • Year and Date
      2013-12-13
    • Data Source
      KAKENHI-PROJECT-23591901
  • [Presentation] MicroRNAs and their potential targets associated with characteristics of estrogen receptor- positive breast cancer2013

    • Author(s)
      Endo Y, Toyama T, Takahashi S, Yoshimoto N, Iwasa M, Asano T, Fujii Y, Yamashita H
    • Organizer
      13th St. Gallen International Breast Cancer Conference 2013
    • Place of Presentation
      Olma-Messen St Gallen, Switzerland
    • Data Source
      KAKENHI-PROJECT-23591902
  • [Presentation] Genetic polymorphism of estrogen metabolizing enzyme CYP17A1 rs743572 impacts on serum testosterone level2013

    • Author(s)
      Yoshimoto N, Nishiyama T, Yamashita H, Takahashi S, Shiraki N, Sugiura H, Endo Y, Iwasa M, Asano T, Fujii Y, Toyama T
    • Organizer
      36th Annual San Antonio Breast Cancer Symposium
    • Place of Presentation
      San Antonio, TX, USA
    • Data Source
      KAKENHI-PROJECT-23591901
  • [Presentation] A mammographic density prediction model using environment factors, endogenous hormones and growth factors in Japanese women2012

    • Author(s)
      Yoshimoto N, Nishiyama T, Toyama T, Takahashi S, Shiraki N, Sugiura H, Endo Y, Iwasa M, Asano T, Fujii Y, Yamashita H
    • Organizer
      35th Annual San Antonio Breast Cancer Symposium
    • Place of Presentation
      San Antonio
    • Year and Date
      2012-12-06
    • Data Source
      KAKENHI-PROJECT-23591901
  • [Presentation] プレジデンシャルシンポジウムバイオロジーからみた乳癌の治療戦略エストロゲンレセプター陽性乳癌のバイオロジーに関する基礎的研究2012

    • Author(s)
      山下啓子、遠山竜也、吉本信保、遠藤友美、岩佐麻衣、浅野倫子、小林俊三
    • Organizer
      第20回日本乳癌学会総会
    • Place of Presentation
      ホテル日航熊本(熊本)
    • Data Source
      KAKENHI-PROJECT-23591902
  • [Presentation] Workshop: Molecular targeted cancer therapy and histochemistry Role of microRNAs in estrogen receptor α-positive breast cancer2012

    • Author(s)
      Yamashita H, Toyama T, Takahashi S, Yoshimoto N, Endo Y
    • Organizer
      14th International Congress of Histochemistry and Cytochemistry (ICHC2012)
    • Place of Presentation
      KyotoInternational Conference Center ,Kyoto
    • Data Source
      KAKENHI-PROJECT-23591902
  • [Presentation] シンポジウム乳癌診療の未来エストロゲンレセプター陽性乳癌におけるmicroRNAの役割に関する研究2012

    • Author(s)
      山下啓子、遠山竜也、吉本信保、遠藤友美、岩佐麻衣、浅野倫子、小林俊三
    • Organizer
      第24回日本内分泌外科学会総会
    • Place of Presentation
      名古屋国際会議場(名古屋)
    • Data Source
      KAKENHI-PROJECT-23591902
  • [Presentation] A mammographic density prediction model using enviornment factors, endogeneous hormones and growth factors in Japanese women2012

    • Author(s)
      Yoshimoto N, Nishiyama T, Toyama T, Takahashi S, Shiraki N, Sugiura H, Endo Y, Iwasa M, Asano T, Fujii Y, Yamashita H
    • Organizer
      35th Annual San Antonio Breast Cancer Symposium
    • Place of Presentation
      Henry B. Gonzalez Convention Center (San Antonio, USA)
    • Data Source
      KAKENHI-PROJECT-23591901
  • [Presentation] 日本乳癌学会研究奨励賞受賞者講演 エストロゲンレセプター陽性乳癌の発症メカニズムと生物学的特性に関する研究2012

    • Author(s)
      吉本信保
    • Organizer
      第20回日本乳癌学会
    • Place of Presentation
      熊本市民会館(熊本)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23591901
  • [Presentation] Symposium: Breast cancer (Clinical research) Role of microRNAs in estrogen receptor-positive breast cancer2012

    • Author(s)
      Yamashita H, Toyama T, Yoshimoto N, EndoY, Takahashi S
    • Organizer
      15th International Congress on Hormonal Steroids and Hormones & Cancer (15th ICHSHC)
    • Place of Presentation
      ISHIKAWA ONGAKUDO,Kanazawa
    • Data Source
      KAKENHI-PROJECT-23591902
  • [Presentation] Genetic and environmental predictors, endogenous hormones and growth factors, and risk of estrogen receptor-positive breast cancer in Japanese women2011

    • Author(s)
      Yoshimoto N, Nishiyama T, Toyama T, Takahashi S, Shiraki N, Sugiura H, Endo Y, Iwasa M, Fujii Y, Yamashita H.
    • Organizer
      34th Anuual San Antonio Breast Cancer Symopsium
    • Place of Presentation
      San Antonio, Texas, USA
    • Data Source
      KAKENHI-PROJECT-23591901
  • [Presentation] Distinct expressions of microRNAs that directly target estrogen receptorαin human breast cancer2011

    • Author(s)
      Yamashita H, Yoshimoto N, Toyama T, Takahashi S, Sugiura H, Endo Y, Iwasa M, Fujii Y
    • Organizer
      Advances in Breast Cancer Research, American Association for Cancer Research
    • Place of Presentation
      San Francisco, U.S.A.
    • Data Source
      KAKENHI-PROJECT-23591902
  • [Presentation] Genetic and environmental predictors, endogenous hormones and growth factors, and risk of estrogen receptor-positive breast cancer in Japanese women2011

    • Author(s)
      Yoshimoto N, Nishiyama T, Toyama T, Takahashi S, Shiraki N, Sugiura H, Endo Y, Iwasa M, Fujii Y, Yamashita H
    • Organizer
      34th Annual San Antonio Breast Cancer Symposium
    • Place of Presentation
      San Antonio
    • Year and Date
      2011-12-09
    • Data Source
      KAKENHI-PROJECT-23591901
  • [Presentation] エストロゲンレセプター陽性乳癌の発症メカニズムと生物学的特性に関する研究2011

    • Author(s)
      吉本信保
    • Organizer
      第20回日本乳癌学会
    • Place of Presentation
      熊本(日本乳癌学会研究奨励賞受賞者講演)
    • Year and Date
      2011-06-28
    • Data Source
      KAKENHI-PROJECT-23591901
  • [Presentation] High expression of LMTK3 is an independent factor indicating a poor prognosis in Japanese estrogen receptor α-positive breast cancer patients.

    • Author(s)
      Toyama T, Asano T, Sato S, Yoshimoto N, Endo Y, Hato Y, Yu D, Takahashi S, Fujii Y.
    • Organizer
      2014 Annual San Antonio Breast Cancer Symposium
    • Place of Presentation
      San Antonio (U.S.A.)
    • Year and Date
      2014-12-09 – 2014-12-13
    • Data Source
      KAKENHI-PROJECT-25461990
  • 1.  TOYAMA Tastuya (30315882)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 19 results
  • 2.  Endo Yumi (20566228)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 2 results
  • 3.  YAMASHITA Hiroko (70332947)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 15 results
  • 4.  KONDO NAOTO (90529166)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 5.  Asano Tomoko (70624427)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 6.  Hato Yukari (20721864)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  豊岡 利正 (40183496)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 8.  Nishikawa Sayaka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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※ この処理は、研究者本人だけが実行できます。

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