TAKAHAMA HIROYUKI 高濱博幸

… Alternative Names

Takahama Hiroyuki 高濱博幸

TAKAHAMA Hiroyuki 高濱博幸

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Researcher Number	10570301
Other IDs
Affiliation (Current)	2025: 東北大学, 大学病院, 講師 2025: 東北大学, 医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2023: 東北大学, 医学系研究科, 講師 2023: 東北大学, 大学病院, 講師 2022: 東北大学, 大学院, 講師 2021: 東北大学, 大学病院, 助教 2020: 国立研究開発法人国立循環器病研究センター, 病院, 医長 2015 – 2019: 国立研究開発法人国立循環器病研究センター, 病院, 医師 2010 – 2011: 独立行政法人国立循環器病研究センター, 心臓血管内科, 医師
Review Section/Research Field	Principal Investigator Basic Section 53020:Cardiology-related / Cardiovascular medicine / Circulatory organs internal medicine Except Principal Investigator Basic Section 53020:Cardiology-related
Keywords	Principal Investigator BNP / 心不全 / バイオマーカー / 早期発見 / 疫学研究 / 心不全発症 / 急性心不全 / リバースリモデリング / ナトリウム利尿ペプチド / 心不全モデル … More / 心筋生検 / 拡張期心不全 / スプライシン / 循環器・高血圧 / 分子イメージング / 循環器 … More Except Principal Investigator 心不全 / 分子型 / ARNI / N-terminal BNP / 心臓リモデリング / N-terminal proBNP / ANP / total BNP / proBNP / mature BNP / BNP / ドラッグリポジショニング / トランスレーショナル研究 / 薬物治療 Less

東北メディカル・メガバンクを活用した心不全に対する超早期疾患予測モデルの開発Principal Investigator
- Principal Investigator
  
  高濱博幸
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Tohoku University
Translational research using molecular form of B-type natriuretic peptide
- Principal Investigator
  
  Nishikimi Toshio
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Kyoto University
ProBNP processing in patients with acute heart failure and clinical applicationPrincipal Investigator
- Principal Investigator
  
  Takahama Hiroyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  National Cardiovascular Center Research Institute
Elucidation of the mechanism of heart failure improvement effect by SGLT2 inhibitor and development of new heart failure treatment
- Principal Investigator
  
  Hiroshi Asanuma
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53020:Cardiology-related
- Research Institution
  Meiji University of Integrative Medicine
Exploratory study for clinical pathophysiology of heart failure with preserved ejection (HFpEF) and development for experimental model of HFpEF.Principal Investigator
- Principal Investigator
  
  Takahama Hiroyuki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cardiovascular medicine
- Research Institution
  National Cardiovascular Center Research Institute
分子イメージングを利用した冠動脈硬化性病変の非侵襲的診断法の開発Principal Investigator
- Principal Investigator
  
  TAKAHAMA Hiroyuki
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  National Cardiovascular Center Research Institute

All 2023 2022 2021 2020 2019 2018 2017 2015 2012 2011 2010

All Journal Article Presentation

[Journal Article] Molecular ratio of mature B-type natriuretic peptide in acute heart failure: an indicator for ventricular contractile recovery2021
- Author(s)
  Kimura A, Takahama H, Nishikimi T, Takashio S, Hayashi T, Nagai-Okatani C, Nakagawa Y, Yasuda S, Anzai T, Minamino N, Izumi C.
- Journal Title
  
  ESC Heart Fail.
  
  Volume: 8 Issue: 6 Pages: 5617-5621
- DOI
  10.1002/ehf2.13684
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08126, KAKENHI-PROJECT-20K17136, KAKENHI-PROJECT-20K08414
[Journal Article] 急性心不全患者におけるBNP前駆体のプロセシング亢進による新しい心不全代償機構の検証2020
- Author(s)
  高濱博幸
- Journal Title
  
  Bio Clinica
  
  Volume: 36 Pages: 250-257
- Data Source
  KAKENHI-PROJECT-18K08057
[Journal Article] Difference in the prevalence of subclinical left ventricular impairment among left ventricular geometric pattern in a community-based population2020
- Author(s)
  Hasegawa T, Asakura M, Asanuma H, Amaki M, Takahama H, Sugano Y, Kanzaki H, Yasuda S, Anzai T, Izumi C, Kitakaze M.
- Journal Title
  
  J Cardiol.
  
  Volume: 75 Issue: 4 Pages: 439-446
- DOI
  10.1016/j.jjcc.2019.09.007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08052
[Journal Article] HFpEFとHFrEFの病態生理と治療法の違いはバイオマーカーで説明可能か？2020
- Author(s)
  高濱博幸
- Journal Title
  
  Heart View
  
  Volume: 10 Pages: 84-87
- Data Source
  KAKENHI-PROJECT-18K08057
[Journal Article] Endogenously released adenosine causes pulmonary vasodilation during the acute phase of pulmonary embolization in dogs.2019
- Author(s)
  Takahama H, Asanuma H, Tsukamoto O, Ito S, Kitakaze M.
- Journal Title
  
  Int J Cardiol Heart Vasc.
  
  Volume: 24 Pages: 100396-100396
- DOI
  10.1016/j.ijcha.2019.100396
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08052, KAKENHI-PROJECT-17K09578
[Journal Article] AST-120, an Adsorbent of Uremic Toxins, Improves the Pathophysiology of Heart Failure in Conscious Dogs.2019
- Author(s)
  Asanuma H, Chung H, Ito S, Min KD, Ihara M, Takahama H, Funayama M, Imazu M, Fukuda H, Ogai A, Asano Y, Minamino T, Takashima S, Morita T, Sugimachi M, Asakura M, Kitakaze M.
- Journal Title
  
  Cardiovasc Drugs Ther.
  
  Volume: 33 Issue: 3 Pages: 277-286
- DOI
  10.1007/s10557-019-06875-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08052, KAKENHI-PROJECT-18K19547, KAKENHI-PROJECT-19H03652
[Journal Article] Superiority of proatrial natriuretic peptide in the prognostic power in patients with acute decompensated heart failure on hospital admission: comparison with B-type natriuretic peptide and other natriuretic peptide forms2019
- Author(s)
  Takashio Seiji、Takahama Hiroyuki、et al.
- Journal Title
  
  Open Heart
  
  Volume: 6 Issue: 2 Pages: e001072-e001072
- DOI
  10.1136/openhrt-2019-001072
- NAID
  120006878492
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08057, KAKENHI-PROJECT-18K08103, KAKENHI-PROJECT-19K08580, KAKENHI-PROJECT-17K18414
[Journal Article] Change in the NT‐proBNP/Mature BNP Molar Ratio Precedes Worsening Renal Function in Patients With Acute Heart Failure: A Novel Predictor Candidate for Cardiorenal Syndrome2019
- Author(s)
  Takahama Hiroyuki、Nishikimi Toshio、et al
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 8 Issue: 17
- DOI
  10.1161/jaha.118.011468
- NAID
  120006878493
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08057, KAKENHI-PROJECT-18K08103, KAKENHI-PROJECT-19K08580, KAKENHI-PROJECT-17K18414
[Journal Article] Ratio of pro-B-type natriuretic peptide (BNP) to total BNP is decreased in mild, but not severe, acute decompensated heart failure patients: A novel compensatory mechanism for acute heart failure2018
- Author(s)
  Takahama Hiroyuki、Takashio Seiji、Nishikimi Toshio、Hayashi Tomohiro、Nagai-Okatani Chiaki、Nakagawa Yasuaki、Amaki Makoto、Ohara Takahiro、Hasegawa Takuya、Sugano Yasuo、Kanzaki Hideaki、Yasuda Satoshi、Kangawa Kenji、Minamino Naoto、Anzai Toshihisa
- Journal Title
  
  International Journal of Cardiology
  
  Volume: 258 Pages: 165-171
- DOI
  10.1016/j.ijcard.2017.12.047
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K18414, KAKENHI-PROJECT-15K09109, KAKENHI-PROJECT-15K09138, KAKENHI-PROJECT-18K08057, KAKENHI-PROJECT-18K08103, KAKENHI-PROJECT-16K09498
[Journal Article] Plasma soluble neprilysin levels are unchanged during recovery after decompensation of heart failure: a matter of the magnitude of the changes in systemic haemodynamics?2018
- Author(s)
  Takahama H, et al.
- Journal Title
  
  European Heart Journal
  
  Volume: 39 Issue: 37 Pages: 3472-3473
- DOI
  10.1093/eurheartj/ehy454
- Data Source
  KAKENHI-PROJECT-18K08057
[Journal Article] Use of serum fibroblast growth factor 23 vs. plasma B-type natriuretic peptide levels in assessing the pathophysiology of patients with heart failure.2017
- Author(s)
  Imazu M, Takahama H, Amaki M, Sugano Y, Ohara T, Hasegawa T, Kanzaki H, Anzai T, Mochizuki N, Asanuma H, Asakura M, Kitakaze M.
- Journal Title
  
  Hypertens Res.
  
  Volume: 40 Issue: 2 Pages: 181-188
- DOI
  10.1038/hr.2016.130
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461134, KAKENHI-PROJECT-15K09109
[Journal Article] Pathophysiology of cardiorenal syndrome in patients with heart failure: potential therapeutic targets2017
- Author(s)
  Takahama Hiroyuki、Kitakaze Masafumi
- Journal Title
  
  American Journal of Physiology-Heart and Circulatory Physiology
  
  Volume: 313 Issue: 4 Pages: H715-H721
- DOI
  10.1152/ajpheart.00215.2017
- Data Source
  KAKENHI-PROJECT-15K09109
[Journal Article] A histamine H(2) receptor blocker ameliorates development of heart failure in dogs independently of β-adrenergic receptor blockade.2010
- Author(s)
  Takahama H, et al.
- Journal Title
  
  Basic Res Cardiol.
  
  Volume: 105 Pages: 787-794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790741
[Presentation] 心不全におけるBNP分子型の変化と病態生理学的意義2023
- Author(s)
  錦見俊雄、中川靖章、木下秀之、稲住英明、柳澤洋、金森敬彦、森内健史、高濱博幸、南野直人
- Organizer
  第２７回日本心不全学会
- Invited
- Data Source
  KAKENHI-PROJECT-21K08126
[Presentation] 心血管病におけるナトリウム利尿ペプチドの病態生理学的意義2022
- Author(s)
  中川靖章、錦見俊雄、桑原宏一郎、柳澤洋、木下秀之、森内健史、金森敬彦、植田洋平、八十田明宏、高濱博幸、南野直人、中尾一和
- Organizer
  第26回日本心不全学会学術集会
- Data Source
  KAKENHI-PROJECT-21K08126
[Presentation] Reduced effectiveness of natriuretic peptide in patients with severe heart failure: Is neurohormonal imbalance the key for therapy?2021
- Author(s)
  Takahama H
- Organizer
  日本循環器学会
- Data Source
  KAKENHI-PROJECT-18K08057
[Presentation] BNP分子型の新しい病態生理学的意義2021
- Author(s)
  錦見俊雄、中川靖章、高濱博幸、南野直人
- Organizer
  第20回日本心血管内分泌代謝学会
- Data Source
  KAKENHI-PROJECT-21K08126
[Presentation] Effects of endogenous adenosine on hemodynamics in experimental acute pulmonary embolization.2019
- Author(s)
  Takahama H, Asanuma H, Ito S, Kitakaze M.
- Organizer
  第36回国際心臓研究学会日本部会
- Data Source
  KAKENHI-PROJECT-18K08052
[Presentation] Management of serum phosphate level is an important novel therapeutic target in chronic heart failure.2019
- Author(s)
  Asanuma H, Fukuda H, Takahama H, Hitsumoto T, Imazu M, Nakajima Y, Ito S, Kitakaze M.
- Organizer
  第36回国際心臓研究学会日本部会
- Data Source
  KAKENHI-PROJECT-18K08052
[Presentation] Association of proBNP ratio to total BNP on admission with future cardiac reverse remodeling in acute decompensated heart failure patients with reduced ejection fraction2019
- Author(s)
  Kimura A, Takahama H et al.
- Organizer
  American Heart Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08057
[Presentation] roBNP ratio to total BNP predicts future cardiac reverse remodeling in acute heart failure patients with reduced ejection fraction.2018
- Author(s)
  Takahama H, et al.
- Organizer
  日本循環器学会
- Data Source
  KAKENHI-PROJECT-15K09109
[Presentation] Association of ratio of proBNP to total BNP with heart failure severity: A novel compensatory mechanism for acute heart failure2018
- Author(s)
  Takahama H, et al.
- Organizer
  日本循環器学会
- Data Source
  KAKENHI-PROJECT-15K09109
[Presentation] Impact of the superior predicting ability of pro-atrial natriuretic peptide level on admission for future clinical adverse events in patients with acute heart failure: Comparison with B-type natriuretic peptide level measured using conventional assay2018
- Author(s)
  Takahama H
- Organizer
  America Heart Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08057
[Presentation] Increased proBNP ratio to total BNP in heart failure patients after discharge: Is glycosylation of proBNP essential for cardiac homeostasis?2018
- Author(s)
  高濱博幸
- Organizer
  日本心不全学会
- Data Source
  KAKENHI-PROJECT-18K08057
[Presentation] Superior predictability of proANP level on admission for clinical outcomes in acute heart failure patients: Comparison with proBNP and BNP2018
- Author(s)
  高濱博幸
- Organizer
  日本循環器学会
- Data Source
  KAKENHI-PROJECT-18K08057
[Presentation] Impact of continuous reduction in B-type natriuretic peptide bioactivity during hospitalization in patients with advanced heart failure2017
- Author(s)
  Takahama H, et al.
- Organizer
  American Heart Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09109
[Presentation] Is there a relationship in a molar ratio of circulating BNP molecular forms with renal function in acute heart failure patients?2017
- Author(s)
  高濱博幸
- Organizer
  日本循環器学会総会
- Place of Presentation
  金沢市
- Year and Date
  2017-03-17
- Data Source
  KAKENHI-PROJECT-15K09109
[Presentation] Molar ratio of N-terminal fragment of pro-B-type natriuretic peptide (BNP) to proBNP predicts occurrence of acute kidney injury in patients with acute heart failure2017
- Author(s)
  Takahama H, et al.
- Organizer
  American Heart Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09109
[Presentation] Time course changes in plasma levels of B-type natriuretic peptide molecular forms in acute phases in hospitalized acute decompensated heart failure patients2015
- Author(s)
  高濱博幸
- Organizer
  American Heart Association
- Place of Presentation
  Orland
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09109
[Presentation] Molecular imaging using bubble immune-liposomes and echocardiography to detect thrombus in left atrial appendage in canine hearts2012
- Author(s)
  Takahama H, et al
- Organizer
  2012年アメリカ心臓病学会の学術集会に上記演題を投稿中である
- Data Source
  KAKENHI-PROJECT-22790741
[Presentation] Heart rate reduction during heart failure hospitalization is powerful predictor of cardiac events in patients with acute decompensated heart failure regardless heart rate at discharge2011
- Author(s)
  高濱博幸
- Organizer
  ヨーロッパ心臓病学会
- Place of Presentation
  パリ(フランス)
- Year and Date
  2011-08-31
- Data Source
  KAKENHI-PROJECT-22790741

1. Kitakaze Masafumi (20294069)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. Minamino Naoto (50124839)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
3. Anzai Toshihisa (60232089)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Ueda Hatsue (40522983)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Hiroshi Asanuma (20416217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
6. Nishikimi Toshio (80291946)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. 中川靖章 (70452357)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. ASAKURA Masanori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. NAGAI Chiaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 長谷川拓也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TAKAHAMA HIROYUKI 高濱 博幸

Takahama Hiroyuki 高濱 博幸

TAKAHAMA Hiroyuki 高濱 博幸

Research Projects

Research Products

Co-Researchers

東北メディカル・メガバンクを活用した心不全に対する超早期疾患予測モデルの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Translational research using molecular form of B-type natriuretic peptide

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ProBNP processing in patients with acute heart failure and clinical applicationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the mechanism of heart failure improvement effect by SGLT2 inhibitor and development of new heart failure treatment

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Exploratory study for clinical pathophysiology of heart failure with preserved ejection (HFpEF) and development for experimental model of HFpEF.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

分子イメージングを利用した冠動脈硬化性病変の非侵襲的診断法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Molecular ratio of mature B-type natriuretic peptide in acute heart failure: an indicator for ventricular contractile recovery2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 急性心不全患者におけるBNP前駆体のプロセシング亢進による新しい心不全代償機構の検証2020

Author(s)

Journal Title

Data Source

[Journal Article] Difference in the prevalence of subclinical left ventricular impairment among left ventricular geometric pattern in a community-based population2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] HFpEFとHFrEFの病態生理と治療法の違いはバイオマーカーで説明可能か？2020

Author(s)

Journal Title

Data Source

[Journal Article] Endogenously released adenosine causes pulmonary vasodilation during the acute phase of pulmonary embolization in dogs.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] AST-120, an Adsorbent of Uremic Toxins, Improves the Pathophysiology of Heart Failure in Conscious Dogs.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Superiority of proatrial natriuretic peptide in the prognostic power in patients with acute decompensated heart failure on hospital admission: comparison with B-type natriuretic peptide and other natriuretic peptide forms2019

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Change in the NT‐proBNP/Mature BNP Molar Ratio Precedes Worsening Renal Function in Patients With Acute Heart Failure: A Novel Predictor Candidate for Cardiorenal Syndrome2019

Author(s)

Journal Title

DOI

TAKAHAMA HIROYUKI 高濱博幸

Takahama Hiroyuki 高濱博幸

TAKAHAMA Hiroyuki 高濱博幸