Kinoshita Makoto 木下允

… Alternative Names

Makoto Kinoshita 木下允

KINOSHITA Makoto 木下允

木下允キノシタマコト

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Researcher Number	10573222
Other IDs
Affiliation (Current)	2025: 大阪大学, 大学院医学系研究科, 特任教授(常勤)
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院医学系研究科, 特任講師(常勤) 2020 – 2021: 大阪大学, 医学系研究科, 特任講師(常勤) 2018 – 2019: 大阪大学, 医学系研究科, 特任助教(常勤) 2013: 大阪大学, 医学(系)研究科(研究院), 助教 2012: 大阪大学, 医学部付属病院, 医員 2010: 大阪大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 52020:Neurology-related / Gastroenterology Except Principal Investigator Basic Section 52020:Neurology-related / Neurology
Keywords	Principal Investigator 多発性硬化症 / 自己抗体介在性神経免疫疾患 / 温度感受性 / 中枢神経免疫疾患 / EAE / 温度感受性受容体 / Leaky gut syndrome / 臨床データベース / 糞便菌叢メタゲノム / Leaky Gut Syndrome … More / Leaky Gut / 制御性T細胞 / 免疫細胞 / アミノ酸 … More Except Principal Investigator 胸腺腫 / B細胞 / 重症筋無力症 / NMO / 多発性硬化症 / PET / 酢酸 / アストロサイト Less

自己抗体介在性神経免疫疾患におけるimmune flare signatureの同定Principal Investigator
- Principal Investigator
  
  木下允
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
B cell maturation in thymi of myasthenia gravis patients
- Principal Investigator
  
  Kazushiro Takata
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
温度感受性受容体を標的とした多発性硬化症環境因子の解明Principal Investigator
- Principal Investigator
  
  木下允
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
Leaky Gut Syndrome and Multiple SclerosisPrincipal Investigator
- Principal Investigator
  
  Makoto Kinoshita
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Osaka University
食餌由来必須アミノ酸による腸管炎症制御機構の解明Principal Investigator
- Principal Investigator
  
  木下允
- Project Period (FY)
  2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Osaka University
11C-Acetate PET imaging for the evaluation of astrocytes in Multiple Sclerosis
- Principal Investigator
  
  NAKATSUJI Yuji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Osaka University

All 2013 2012 2011 2010

All Journal Article Presentation Book

[Book] アクチュアル脳・神経疾患の臨床最新アプローチ多発性硬化症と視神経脊髄炎実験モデルからみた病態辻省次、吉良潤一編2012
- Author(s)
  中辻裕司、木下允、望月秀樹
- Publisher
  中山書店
- Data Source
  KAKENHI-PROJECT-22590931
[Book] NMO の実験的研究の進歩と今後の展望多発性硬化症(MS)と視神経脊髄炎(NMO)の基礎と臨床2012
- Author(s)
  木下允、中辻裕司
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-22590931
[Book] NMOの実験的研究の進歩と今後の展望　多発性硬化症（MS）と視神経脊髄炎（NMO）の基礎と臨床2012
- Author(s)
  木下允
- Total Pages
  8
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-22590931
[Book] NMOの実験的研究最前線2010
- Author(s)
  木下允、中辻裕司
- Publisher
  Brain Medical
- Data Source
  KAKENHI-PROJECT-22590931
[Book] NMO の実験的研究最前線 Brain Medical2010
- Author(s)
  木下允、中辻裕司
- Publisher
  メディカルレビュー社
- Data Source
  KAKENHI-PROJECT-22590931
[Journal Article] Disease-Association Analysis of an Inflammation-Related Feedback Loop2013
- Author(s)
  Murakami M, Nakatsuji Y, Kinoshita M
- Journal Title
  
  Cell Reports
  
  Volume: 3 Pages: 1-14
- Data Source
  KAKENHI-PROJECT-22590931
[Journal Article] Where do AQP4 Antibodies Fit in the Pathogenesis of NMO?2012
- Author(s)
  Kinoshita M, Nakatsuji Y
- Journal Title
  
  Multiple Sclerosis International
- Data Source
  KAKENHI-PROJECT-22590931
[Journal Article] Elevation of Sema4A implicates Th cell skewing and the efficacy of interferon-β therapy in multiple sclerosis2012
- Author(s)
  Nakatsuji Y, Okuno T, Moriya M, SugimotoT, Kinoshita M
- Journal Title
  
  J Immunology
  
  Volume: 188 Pages: 4858-4865
- Data Source
  KAKENHI-PROJECT-22590931
[Journal Article] Where Do AQP4 Antibodies Fit in the Pathogenesis of NMO?2012
- Author(s)
  Kinoshita M, Nakatsuji Y
- Journal Title
  
  Multiple Sclerosis International
  
  Volume: (in press) Pages: 1-6
- DOI
  10.1155/2012/862169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590931
[Journal Article] Review of animal models of neuromyelitis optica (review article)2012
- Author(s)
  Jones MV, Kinoshita M,Nakatsuji Y, Levy M
- Journal Title
  
  Mult Scler Relat Disord
  
  Volume: 1 Pages: 174-179
- Data Source
  KAKENHI-PROJECT-22590931
[Journal Article] The Lactic Acid Bacterimn Pediococcus acidilactici Suppresses Autoimmune Encephalomyelitis by Inducing IL-10-Producing Regulatory T Cells2011
- Author(s)
  Takata K, Kinoshita M, Okuno T, Moriya M, Kohda T, Honorat AJ, Sugimoto T Kumanogoh A, Kayama H, Takeda K, Sakoda S, Nakatsuji Y
- Journal Title
  
  PLoS ONE
  
  Volume: 6(11) Issue: 11 Pages: e27644-e27644
- DOI
  10.1371/journal.pone.0027644
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590931
[Journal Article] Anti-aquaporin-4 antibody induces astrocytic cytotoxicity in the absence of CNS antigen-specific T cells2010
- Author(s)
  Kinoshita M, Nakatsuji Y,Sakoda S
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 394 Pages: 205-210
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] 神経疾患、多発性硬化症の治療標的としての活性酸素種(ROS)2012
- Author(s)
  中辻裕司、JA Honorat、木下允、奥野龍禎、高田和城、甲田亨、多田智、佐古田三郎、望月秀樹
- Organizer
  第24回日本神経免疫学会
- Place of Presentation
  長野
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] 腸管免疫を利用した多発性硬化症のコントロール2012
- Author(s)
  高田和城, JA Honorat, 甲田亨, 木下允, 多田智, 奥野龍禎, 中辻裕司, 佐古田三郎, 望月秀樹
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] 血清Sema4A高値は多発性硬化症のTh17偏倚とインターフェロン治療抵抗性を示唆する2011
- Author(s)
  中辻裕司、奥野龍禎、森谷真之、杉本知之、木下允、高田和城、中野美佐、佐古田三郎、熊ノ郷淳
- Organizer
  第23回日本神経免疫学会
- Place of Presentation
  京王プラザホテル東京
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] Elevation of Sema4A implicates Th17 skewing and the efficacy of interferon-β therapy in multiple sclerosis. 2011.10. The 5th Joint Triennial Congress of the European and Americans Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS/ACTRIMS2011
- Author(s)
  Nakatsuji Y, Okuno T, Moriya M, Sugimoto T, Kinoshita M, Takata K, Nakano M, , Sakoda S and Kumanogoh A
- Organizer
  神経免疫学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] 腸管免疫を利用したEAEの制御2011
- Author(s)
  高田和城、木下允、森谷真之、奥野龍禎、中辻裕司、佐古田三郎
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] 食事抗原による腸管免疫活性が多発性硬化症のリスクファクターとなる2011
- Author(s)
  木下允、高田和城、奥野龍禎、香山尚子、竹田潔、熊ノ郷淳、佐古田三郎、中辻裕司
- Organizer
  第23回日本神経免疫学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] Sema3Eは実験的自己免疫性脳脊髄炎(EAE)においてTh17細胞の中枢神経系への移動に関与する2011
- Author(s)
  奥野龍禎、中辻裕司、高田和城、木下允、多田智、佐古田三郎、熊ノ郷淳
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋国際会議場(愛知県)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] Sema3EはEAEにおいてTh17細胞の中枢神経系への移動に関与する2011
- Author(s)
  奥野龍禎、中辻裕司、高田和城、木下允、多田智、佐古田三郎、熊ノ郷淳
- Organizer
  第23回日本神経免疫学会
- Place of Presentation
  京王プラザホテル東京
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] 腸管免疫を利用した乳酸菌による EAE の治療。2011
- Author(s)
  高田和城、木下允、奥野龍禎、佐古田三郎、中辻裕司
- Organizer
  第23回日本神経免疫学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] he lactic acid bacterium Pediococcus acidilactici suppresses autoimmune ence phalomyelitis by inducing IL-10-producing regulatory T cells2011
- Author(s)
  Takata K, Kinoshita M, Okuno T, Nakatsuji Y, Sakoda S
- Organizer
  The 5th Joint Triennial Congress of the European and Americans Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS/ACTRIMS)
- Place of Presentation
  Amsterdam, Netherlands
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] Elevation of Sema4A implicates Th17 skewing and the efficacy of interferon-β therapy in multiple sclerosis2011
- Author(s)
  Nakatsuji Y, Okuno T, Moriya M, Sugimoto T, Kinoshita M, Takata M, Nakano M, Sakoda S, Kumanogoh A
- Organizer
  The 5th Joint Triennial Congress of the European and Americans Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS/ACTRIMS)
- Place of Presentation
  Amsterdam, Netherlands
- Year and Date
  2011-10-20
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] 腸管免疫を利用した乳酸菌によるEAEの治療2011
- Author(s)
  高田和城、木下允、奥野龍禎、佐古田三郎、中辻裕司
- Organizer
  第23回日本神経免疫学会
- Place of Presentation
  京王プラザホテル東京
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] 食事抗原による腸管免疫活性が多発性硬化症のリスクファクターとなる2011
- Author(s)
  木下允、高田和城、奥野龍禎、香山尚子、竹田潔、熊ノ郷淳、佐古田三郎、中辻裕司
- Organizer
  第23回日本神経免疫学会
- Place of Presentation
  京王プラザホテル東京
- Year and Date
  2011-09-15
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] NMO 動物モデルにおける抗アクアポリン 4 抗体病原性の検討2010
- Author(s)
  木下允、中辻裕司、木村卓、森谷真之、高田和城、奥野龍禎、熊ノ郷淳、梶山孝司、芳川浩男、佐古田三郎
- Organizer
  第51回日本神経学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] Anti-aquaporin-4 antibody induces astrocytic cytotoxicity in the absence of CNS antigen-specific T cells2010
- Author(s)
  Kinoshita M
- Organizer
  The 10th International Congress of Neuroimmunology
- Place of Presentation
  Barcelona (Spain)
- Year and Date
  2010-10-29
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] Sema4A is a serum diagnostic marker of Multiple Sclerosis, which reflects the Th17 shift of PBMC.2010
- Author(s)
  Nakatsuji Y, Okuno T, Moriya M, SugimotoT, Kinoshita M, Nakano M, Kikutani H, Sakoda S, Kumanogoh A.
- Organizer
  The 10th International Congress of Neuroimmunology
- Place of Presentation
  Barcelona, Spain
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] NMO動物モデルにおける抗アクアポリン4抗体病原性の検討2010
- Author(s)
  木下允
- Organizer
  第51回日本神経学会
- Place of Presentation
  東京
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-22590931
[Presentation] Anti-aquaporin-4 antibody induces astrocytic cytotoxicity in the absence of CNS antigen-specific T cells.2010
- Author(s)
  Kinoshita M, Nakatsuji Y, Kimura T, Moriya M, Takata K, Okuno T, Kumanogoh A, Kajiyama K, Yoshikawa H, Sakoda S
- Organizer
  The 10th International Congress of Neuroimmunology
- Place of Presentation
  Barcelona, Spain.
- Data Source
  KAKENHI-PROJECT-22590931

1. TAKATA Kazushiro (20573223)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
2. NAKATSUJI Yuji (20332744)

# of Collaborated Projects: 1 results

# of Collaborated Products: 27 results
3. 清水幹人 (30817507)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kinoshita Makoto 木下 允

Makoto Kinoshita 木下 允

KINOSHITA Makoto 木下 允

木下 允 キノシタ マコト

Research Projects

Research Products

Co-Researchers

自己抗体介在性神経免疫疾患におけるimmune flare signatureの同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

B cell maturation in thymi of myasthenia gravis patients

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

温度感受性受容体を標的とした多発性硬化症環境因子の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Leaky Gut Syndrome and Multiple SclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

食餌由来必須アミノ酸による腸管炎症制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

11C-Acetate PET imaging for the evaluation of astrocytes in Multiple Sclerosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] アクチュアル 脳・神経疾患の臨床 最新アプローチ多発性硬化症と視神経脊髄炎 実験モデルからみた病態 辻省次、吉良潤一編2012

Author(s)

Publisher

Data Source

[Book] NMO の実験的研究の進歩と今後の展望 多発性硬化症(MS)と視神経脊髄炎(NMO)の基礎と臨床2012

Author(s)

Publisher

Data Source

[Book] NMOの実験的研究の進歩と今後の展望 多発性硬化症（MS）と視神経脊髄炎（NMO）の基礎と臨床2012

Author(s)

Total Pages

Publisher

Data Source

[Book] NMOの実験的研究最前線2010

Author(s)

Publisher

Data Source

[Book] NMO の実験的研究最前線 Brain Medical2010

Author(s)

Publisher

Data Source

[Journal Article] Disease-Association Analysis of an Inflammation-Related Feedback Loop2013

Author(s)

Journal Title

Data Source

[Journal Article] Where do AQP4 Antibodies Fit in the Pathogenesis of NMO?2012

Author(s)

Journal Title

Data Source

[Journal Article] Elevation of Sema4A implicates Th cell skewing and the efficacy of interferon-β therapy in multiple sclerosis2012

Author(s)

Journal Title

Data Source

[Journal Article] Where Do AQP4 Antibodies Fit in the Pathogenesis of NMO?2012

Author(s)

Journal Title

DOI

Kinoshita Makoto 木下允

Makoto Kinoshita 木下允

KINOSHITA Makoto 木下允

木下允キノシタマコト

[Book] アクチュアル脳・神経疾患の臨床最新アプローチ多発性硬化症と視神経脊髄炎実験モデルからみた病態辻省次、吉良潤一編2012

[Book] NMO の実験的研究の進歩と今後の展望多発性硬化症(MS)と視神経脊髄炎(NMO)の基礎と臨床2012

[Book] NMOの実験的研究の進歩と今後の展望　多発性硬化症（MS）と視神経脊髄炎（NMO）の基礎と臨床2012