Nishida Yuya 西田友哉

… Alternative Names

西田友哉ニシダユウヤ

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Researcher Number	10581449
Other IDs	https://orcid.org/0000-0002-8396-423X
Affiliation (Current)	2025: 順天堂大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2017 – 2024: 順天堂大学, 医学部, 准教授 2011: Tokyo Medical and Dental University, 難治疾患研究所, その他
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 54040:Metabolism and endocrinology-related / Pathological medical chemistry / Cell biology Except Principal Investigator Basic Section 54040:Metabolism and endocrinology-related / Medium-sized Section 54:Internal medicine of the bio-information integration and related fields / Metabolomics
Keywords	Principal Investigator 膵β細胞 / オートファジー / インスリン / 糖尿病 / クリノファジー / リソソーム / ゲノムワイドスクリーニング / インスリン分泌顆粒 / CRISPR/Cas9 / 蛍光レポーター … More / 超解像顕微鏡 / ミクロオートファジー / CRISPR / ユビキチン・プロテアソーム / 糖代謝異常 / 細胞内Ca / トランスクリプトーム / オートファジーフラックス / レポーターマウス / インスリン抵抗性 / ヒストンアシル化 / βハイドロキシ酪酸 / ケトン食 / βヒドロキシ酪酸化 / ケトジェニック食 / βヒドロキシブチル化 / アセチル化 / ヒストン修飾 / ケトン体 / アシル化 … More Except Principal Investigator オートファジー / 膵β細胞 / ２型糖尿病 / 周産期 / 妊娠糖尿病 / 耐糖能異常 / 妊娠 / 膵α細胞 / マイトファジー / グルカゴン / インスリン / 糖尿病 Less

インスリン分泌顆粒のリソソーム依存的分解を介した膵β細胞恒常性維持機構の解明Principal Investigator
- Principal Investigator
  
  西田友哉
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Juntendo University
Mechanisms of autophagy regulation and its disruption in pancreatic beta cells
- Principal Investigator
  
  綿田裕孝
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Juntendo University
Pathophysiology of pancreatic beta cell insufficiency using a novel in vivo gene screening method
- Principal Investigator
  
  綿田裕孝
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Juntendo University
妊娠期膵β細胞量増大および妊娠糖尿病発症におけるオートファジーの意義の解明
- Principal Investigator
  
  池田富貴
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Juntendo University
インスリン分泌顆粒分解の空間的・時間的評価と分子機構および病態生理学的意義の検討Principal Investigator
- Principal Investigator
  
  西田友哉
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
Discovery of new anti-diabetic drugs activating autophagy in beta cells
- Principal Investigator
  
  Watada Hirotaka
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 54:Internal medicine of the bio-information integration and related fields
- Research Institution
  Juntendo University
Significance of pathophysiological roles of autophagy in the organs regulating glucose metabolismPrincipal Investigator
- Principal Investigator
  
  Nishida Yuya
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Juntendo University
インスリン分泌顆粒分解の空間的・時間的評価と分子機構および病態生理学的意義の検討Principal Investigator
- Principal Investigator
  
  西田友哉
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Juntendo University
Molecular Mechanism of beta cell failure due to autophagic failure
- Principal Investigator
  
  Hirotaka Watada
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54040:Metabolism and endocrinology-related
- Research Institution
  Juntendo University
Analysis of the novel protein acylations focused on histone modificationsPrincipal Investigator
- Principal Investigator
  
  Nishida Yuya
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Juntendo University
Autophagic failure in islets
- Principal Investigator
  
  WATADA HIROTAKA
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Juntendo University
オルタナティブオートファジーの分子機構および生理的意義の解明Principal Investigator
- Principal Investigator
  
  西田友哉
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Medical and Dental University

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article Presentation

[Journal Article] 膵β細胞におけるオートファジーの多様性とその理解2023
- Author(s)
  西田友哉、青山周平、金井晶子、岩本達也、伊藤南、植木響政、小池正人、綿田裕孝
- Journal Title
  
  日本体質医学会雑誌
  
  Volume: 85
- Data Source
  KAKENHI-PUBLICLY-22H04655
[Journal Article] Monitoring autophagic flux in vivo revealed its physiological response and significance of heterogeneity in pancreatic beta cells2023
- Author(s)
  Aoyama Shuhei、Nishida Yuya、Uzawa Hirotsugu、Himuro Miwa、Kanai Akiko、Ueki Kyosei、Ito Minami、Iida Hitoshi、Tanida Isei、Miyatsuka Takeshi、Fujitani Yoshio、Matsumoto Masaki、Watada Hirotaka
- Journal Title
  
  Cell Chemical Biology
  
  Volume: - Issue: 6 Pages: 658-671.e4
- DOI
  10.1016/j.chembiol.2023.03.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19288, KAKENHI-PROJECT-21K16373, KAKENHI-PROJECT-22K16402, KAKENHI-PROJECT-20H03735, KAKENHI-PROJECT-20K08917, KAKENHI-PROJECT-20K21386, KAKENHI-PUBLICLY-22H04655, KAKENHI-PUBLICLY-22H04652, KAKENHI-PLANNED-20H05930, KAKENHI-PROJECT-23K23870
[Journal Article] 膵β細胞におけるオートファジーの多様性とその理解2023
- Author(s)
  西田友哉、青山周平、金井晶子、岩本達也、伊藤南、植木響政、小池正人、綿田裕孝
- Journal Title
  
  日本体質医学会雑誌
  
  Volume: 85
- Data Source
  KAKENHI-PROJECT-20K08917
[Journal Article] Genome-wide screening for regulators of degradation of insulin secretory granules with a fluorescent reporter.2023
- Author(s)
  Kanai A, Nishida Y, Iwamoto T, Yokota M, Aoyama S, Ueki K, Ito M, Uzawa H, Iida H, Koike M, Watada H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 676 Pages: 132-140
- DOI
  10.1016/j.bbrc.2023.07.040
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K07523, KAKENHI-PROJECT-23K06323, KAKENHI-PUBLICLY-22H04655, KAKENHI-PROJECT-22H04926
[Journal Article] Genetic ablation of p62/SQSTM1 demonstrates little effect on pancreatic β-cell function under autophagy deficiency2022
- Author(s)
  Fukae Toshinaru、Miyatsuka Takeshi、Himuro Miwa、Wakabayashi Yuka、Iida Hitoshi、Aoyama Shuhei、Mita Tomoya、Ikeda Fuki、Haruna Hidenori、Takubo Noriyuki、Nishida Yuya、Shimizu Toshiaki、Watada Hirotaka
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 612 Pages: 99-104
- DOI
  10.1016/j.bbrc.2022.04.092
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03735
[Journal Article] Cumulative autophagy insufficiency in mice leads to progression of β-cell failure2022
- Author(s)
  Suzuki L, Miyatsuka T, Himuro M, Wakabayashi Y, Osonoi S, Miura M, Katahira T, Fujitani Y, Iida H, Mizukami H, Nishida Y, Watada H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 611 Pages: 38-45
- DOI
  10.1016/j.bbrc.2022.04.040
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19421, KAKENHI-PROJECT-20H03463, KAKENHI-PROJECT-20H03735
[Journal Article] Defective autophagy in vascular smooth muscle cells enhances the healing of abdominal aortic aneurysm2021
- Author(s)
  Mochida Akihiro、Mita Tomoya、Azuma Kosuke、Osonoi Yusuke、Masuyama Atsushi、Nakajima Kenichi、Goto Hiromasa、Nishida Yuya、Miyatsuka Takeshi、Mitsumata Masako、Watada Hirotaka
- Journal Title
  
  Physiological Reports
  
  Volume: 9 Issue: 17
- DOI
  10.14814/phy2.15000
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-20H05343, KAKENHI-PROJECT-20K08917
[Journal Article] Rubicon is dispensable for maintaining homeostasis in pancreatic beta cells following increased insulin resistance.2020
- Author(s)
  Aoyama S, Nishida Y, Fujitani Y, Fukunaka A, Miyatsuka T, Suzuki L, Himuro M, Yoshimori T, Watada H.
- Journal Title
  
  Endocr J.
  
  Volume: 67(11) Issue: 11 Pages: 1119-1126
- DOI
  10.1507/endocrj.ej20-0326
- NAID
  130007945802
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08971, KAKENHI-PROJECT-20K08917, KAKENHI-PUBLICLY-20H05343, KAKENHI-PROJECT-20H03463
[Journal Article] Cellular autophagy in α cells plays a role in the maintenance of islet architecture2019
- Author(s)
  Himuro Miwa、Miyatsuka Takeshi、Suzuki Luka、Miura Masaki、Katahira Takehiro、Goto Hiromasa、Nishida Yuya、Sasaki Shugo、Koike Masato、Shiota Chiyo、Gittes George K、Fujitani Yoshio、Watada Hirotaka
- Journal Title
  
  Journal of the Endocrine Society
  
  Volume: 3 Pages: 1979-92
- DOI
  10.1210/js.2019-00075
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04202, KAKENHI-PROJECT-16K09765, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-17K09848
[Journal Article] Establishment of a system for screening autophagic flux regulators using a modified fluorescent reporter and CRISPR/Cas92019
- Author(s)
  Yazawa Rieko、Nishida Yuya、Aoyama Shuhei、Tanida Isei、Miyatsuka Takeshi、Suzuki Luka、Himuro Miwa、Haruna Hidenori、Takubo Noriyuki、Shimizu Toshiaki、Watada Hirotaka
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 516 Issue: 3 Pages: 686-692
- DOI
  10.1016/j.bbrc.2019.06.129
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08669
[Journal Article] Heterogeneity of autophagic status in pancreatic β cells under metabolic stress.2018
- Author(s)
  Kamitani M, Miyatsuka T, Miura M, Azuma K, Suzuki L, Himuro M, Katahira T, Nishida Y, Fujitani Y, Watada H.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 496 Issue: 2 Pages: 328-334
- DOI
  10.1016/j.bbrc.2018.01.070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09765, KAKENHI-PROJECT-17H04202
[Presentation] Genome-wide Screening for Regulators of Degradation of Insulin Secretory Granules with a Fluorescent Reporter2023
- Author(s)
  Akiko Kanai, Yuya Nishida, Tatsuya Iwamoto, Mutsumi Yokota, Shuhei Aoyama, Kyosei Ueki, Minami Ito, Hirotsugu Uzawa, Hitoshi Iida, Masato Koike, Hirotaka Watada
- Organizer
  European Association for the Study of Diabetes
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04655
[Presentation] Analysis of the Role of Cathepsin D in Maintaining Pancreatic β cell Homeostasis2022
- Author(s)
  Kyosei Ueki、Yuya Nishida、Shuhei Aoyama、Hirotsugu Uzawa、Minami Ito、Akiko Kanai、Tatsuya Iwamoto、Hirotaka Watada
- Organizer
  The 10th International Symposium on Autophagy(ISA2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04655
[Presentation] Analysis of the Role of Cathepsin D in Maintaining Pancreatic β cell Homeostasis2022
- Author(s)
  Kyosei Ueki、Yuya Nishida、Shuhei Aoyama、Hirotsugu Uzawa、Minami Ito、Akiko Kanai、Tatsuya Iwamoto、Hirotaka Watada
- Organizer
  The 10th International Symposium on Autophagy(ISA2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08917
[Presentation] Identification of Novel Compounds That Regulate Autophagic Flux and Their Application to Drug Discovery2022
- Author(s)
  Minami Ito、Yuya Nishida、Shuhei Aoyama、Tatsuya Iwamoto、Akiko Kanai、Hirotatsu Kojima、Hirotaka Watada
- Organizer
  The 10th International Symposium on Autophagy(ISA2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08917
[Presentation] Identification of Molecular Mechanism of Degradation of Insulin Secretory Granules(ISG) by Genome-wide Screening2022
- Author(s)
  Akiko Kanai、Yuya Nishida、Shuhei Aoyama、Hirotsugu Uzawa、Tatsuya Iwamoto、Minami Ito、Kyosei Ueki、Masato Koike、Hirotaka Watada
- Organizer
  The 10th International Symposium on Autophagy(ISA2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-22H04655
[Presentation] 耐糖能異常における膵島オートファジー活性の変化とその意義の検討2022
- Author(s)
  青山周平、西田友哉
- Organizer
  第10回AAA
- Data Source
  KAKENHI-PROJECT-20K08917
[Presentation] 膵β細胞におけるオートファジーの多様性とその理解2022
- Author(s)
  西田友哉、青山周平、金井晶子、岩本達也、伊藤南、綿田裕孝
- Organizer
  第72回日本体質医学会　シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-20K08917
[Presentation] Identification of Molecular Mechanism of Degradation of Insulin Secretory Granules(ISG) by Genome-wide Screening2022
- Author(s)
  Akiko Kanai、Yuya Nishida、Shuhei Aoyama、Hirotsugu Uzawa、Tatsuya Iwamoto、Minami Ito、Kyosei Ueki、Masato Koike、Hirotaka Watada
- Organizer
  The 10th International Symposium on Autophagy(ISA2022)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08917
[Presentation] Identification of Novel Compounds That Regulate Autophagy Flux and Their Application to Drug Discovery2022
- Author(s)
  Minami Ito, Yuya Nishida, Shuhei Aoyama, Hirotsugu Uzawa, Tastuya Iwamoto, Akiko Kanai, Kyosei Ueki, Hirotatsu Kojima, Hirotaka Watada
- Organizer
  The 10th International Symposium on Autophagy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K19515
[Presentation] 膵β細胞におけるオートファジーの多様性とその理解2022
- Author(s)
  西田友哉、青山周平、金井晶子、岩本達也、伊藤南、植木響政、小池正人、綿田裕孝
- Organizer
  第72回　日本体質医学会　シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-22H04655
[Presentation] 蛍光レポーターによるインスリン分泌顆粒分解評価の確立とその分子機構の解明2021
- Author(s)
  西田友哉
- Organizer
  第14回オートファジー研究会
- Data Source
  KAKENHI-PUBLICLY-20H05343
[Presentation] 耐糖能異常における膵島オートファジー活性の変化とその意義の検討2021
- Author(s)
  青山周平、西田友哉
- Organizer
  第32回分子糖尿病シンポジウム
- Data Source
  KAKENHI-PROJECT-20K08917
[Presentation] 耐糖能異常における膵島オートファジー活性の変化とその意義の検討2021
- Author(s)
  青山周平、西田友哉
- Organizer
  第14回オートファジー研究会　若手の会
- Data Source
  KAKENHI-PROJECT-20K08917
[Presentation] ケトン体の抗老化作用2020
- Author(s)
  西田友哉
- Organizer
  第63回日本糖尿病学会年次学術集会　シンポジウム9
- Data Source
  KAKENHI-PROJECT-17K08669
[Presentation] Exploring the Role of Autophagy in Pancreatic Alpha Cells2019
- Author(s)
  Himuro, M., Miyatsuka, T., Suzuki, L., Miura, M., Katahira, T., Goto, H., Nishida, Y., Sasaki, S., Fujitani, Y.,Watada, H.
- Organizer
  79th American Diabetes Association, San Francisco(USA), 2019.6.7-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04202
[Presentation] Autophagy Deficiency Cumulatively Causes β-Cell Failure in Mice2019
- Author(s)
  Suzuki, L., Miyatsuka, T., Himuro, M., Miura, M., Katahira, T., Komiya, K., Fujitani, Y., Nishida, Y.,Watada, H.
- Organizer
  79th American Diabetes Association, San Francisco(USA), 2019.6.7-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04202
[Presentation] 膵β細胞における時間特異的Atg7欠損マウスの作製と機能解析2017
- Author(s)
  鈴木路可, 宮塚健, 氷室美和, 神谷麻衣, 三浦正樹, 小宮幸次, 藤谷与士夫, 西田友哉, 綿田裕孝
- Organizer
  第60回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-17H04202
[Presentation] Cumulative autophagy deficiency causes progressive β-cell failure.2017
- Author(s)
  Suzuki L., Miyatsuka T., Himuro M., Miura M., Fujitani Y., Nishida Y., Watada H.
- Organizer
  The 8th International Symposium on Autophagy
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04202

1. WATADA HIROTAKA (60343480)

# of Collaborated Projects: 6 results

# of Collaborated Products: 7 results
2. 宮塚健 (60622363)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. 池田富貴 (80445494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. FUKUNAKA Ayako

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 藤谷与士夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
6. 松本雅記

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 横田睦美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nishida Yuya 西田 友哉

西田 友哉 ニシダ ユウヤ

Research Projects

Research Products

Co-Researchers

インスリン分泌顆粒のリソソーム依存的分解を介した膵β細胞恒常性維持機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanisms of autophagy regulation and its disruption in pancreatic beta cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Pathophysiology of pancreatic beta cell insufficiency using a novel in vivo gene screening method

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

妊娠期膵β細胞量増大および妊娠糖尿病発症におけるオートファジーの意義の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

インスリン分泌顆粒分解の空間的・時間的評価と分子機構および病態生理学的意義の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Discovery of new anti-diabetic drugs activating autophagy in beta cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Significance of pathophysiological roles of autophagy in the organs regulating glucose metabolismPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

インスリン分泌顆粒分解の空間的・時間的評価と分子機構および病態生理学的意義の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular Mechanism of beta cell failure due to autophagic failure

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of the novel protein acylations focused on histone modificationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Autophagic failure in islets

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

オルタナティブオートファジーの分子機構および生理的意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] 膵β細胞におけるオートファジーの多様性とその理解2023

Author(s)

Journal Title

Nishida Yuya 西田友哉

西田友哉ニシダユウヤ