XU Jianjun 徐建軍

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Xu Jianjun 徐建軍

徐建軍ジョケングン

XU Jian-jun 徐建軍

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Researcher Number	10581689
Other IDs
Affiliation (Current)	2025: 鹿児島大学, 医歯学域医学系, 講師
Affiliation (based on the past Project Information) *help	2019 – 2022: 鹿児島大学, 医歯学域医学系, 講師 2017: 鹿児島大学, 医歯学域医学系, 講師 2016: 鹿児島大学, 医歯学域医学系, 助教 2015: 鹿児島大学, 医歯学域医学系, 講師 2011: 鹿児島大学, 大学院・医歯学総合研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 48020:Physiology-related Except Principal Investigator General physiology / Basic Section 48020:Physiology-related
Keywords	Principal Investigator Calcium channel / Pull-down assay / カルシムチャンネル / イオンチャネル / 自己調節 / パッチクランプ法 / pull-down assay / カルモジュリン / 心筋細胞 / カルシムチャネル … More Except Principal Investigator … More 心筋細胞 / 心筋 / カルモジュリン / Caチャネル / リン酸化 / 調節機構 / Pull-down法 / パッチクランプ法 / Cav1.2チャネル / 分子構造シミュレーション / Ca2+依存性不活性化 / Cav1.2 チャネル / 蛋白質構造シミュレーション / プルダウン法 / パッチクランプ / カルシウム依存性活性化 / カルシウム依存性不活性化 / カルシウムチャネル / イオンチャネル / Ca2+ チャネル / Ca2+依存性調節 / Aキナーゼ / 能動輸送 / トランスポーター / シグナル伝達 / チャネル / 生体膜 Less

Molecular mechanism of the regulation of Cav1.2 channels by calmodulin
- Principal Investigator
  
  Kameyama Masaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Kagoshima University
Molecular mechanism of self-regulation of Cav1.2 channel by channel cytoplasmic fragmentsPrincipal Investigator
- Principal Investigator
  
  Xu Jianjun
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48020:Physiology-related
- Research Institution
  Kagoshima University
Study on the regulatory mechanisms of L-type Ca2+ channels
- Principal Investigator
  
  KAMEYAMA Masaki
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Kagoshima University
An interrelation among regulatory mechanisms of cardiac Ca2+channels
- Principal Investigator
  
  KAMEYAMA Masaki
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Kagoshima University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2012 2011 2010 2009

All Journal Article Presentation

[Journal Article] Regulation of Cardiac Cav1.2 Channels by Calmodulin2023
- Author(s)
  Kameyama Masaki、Minobe Etsuko、Shao Dongxue、Xu Jianjun、Gao Qinghua、Hao Liying
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 24 Issue: 7 Pages: 6409-6409
- DOI
  10.3390/ijms24076409
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K06845, KAKENHI-PROJECT-20K07263
[Journal Article] Ca2C Dyshomeostasis Links Risk Factors to Neurodegeneration in Parkinson’s Disease2022
- Author(s)
  Jianjun Xu, Etsuko Minobe, Masaki Kameyama
- Journal Title
  
  Frontiers in Cellular Neuroscience
  
  Volume: 16 Pages: 1-15
- DOI
  10.3389/fncel.2022.867385
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07285, KAKENHI-PROJECT-20K07263, KAKENHI-PROJECT-22K06845
[Journal Article] Properties of Calmodulin Binding to NaV1.2 IQ Motif and Its Autism-Associated Mutation R1902C2021
- Author(s)
  Jia Wanying, Liu Junyan, Yu Zhiyi, Zhang Xiaohong, Xu Xiaoxue, Wang Yuting, Gao Qinghua, Feng Rui, Wan Yujun, Xu Jianjun, Minobe Etsuko, Kameyama Masaki, Wang Wuyang, Guo Feng
- Journal Title
  
  Neurochemical Research
  
  Volume: 46 Issue: 3 Pages: 523-534
- DOI
  10.1007/s11064-020-03189-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07303, KAKENHI-PROJECT-20K07263, KAKENHI-PROJECT-19K07285
[Journal Article] Purification of insoluble GST-fused and GST-cleaved Cav1.2 channel fragment by denaturation and renaturation2019
- Author(s)
  Gao QingHua, Minobe Etsuko, Kameyama Masaki, Xu Jianjun
- Journal Title
  
  Protein Expression and Purification
  
  Volume: 160 Pages: 7-10
- DOI
  10.1016/j.pep.2019.03.013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07285, KAKENHI-PROJECT-19K07303
[Journal Article] A novel role of the antitumor agent tricyclodecan-9-yl-xanthogenate as an open channel blocker of KCNQ1/KCNE12018
- Author(s)
  Wu, MK, Takemoto M, Luo H, Xu JJ, Lu MH, Kameyama M, Takumi T, Song WJ
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 824 Pages: 99-107
- DOI
  10.1016/j.ejphar.2018.02.013
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08181, KAKENHI-PROJECT-16K10218, KAKENHI-PUBLICLY-17H05749, KAKENHI-PROJECT-16H06316, KAKENHI-PLANNED-16H06463
[Journal Article] A new interaction between proximal and distal C-terminus of Cav1.2 channels.2017
- Author(s)
  Lyu L, Gao Q, Xu JJ, Minobe E, Zhu T, Kameyama M
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 133 Pages: 240-246
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08181
[Journal Article] PKA and phosphatases attached to the Cav1.2 channel regulate channel activity in cell-free patches.2016
- Author(s)
  Xu JJ, Yu LF, Minobe E, Lu LT, Lei M, Kameyama M
- Journal Title
  
  Am J Physiol
  
  Volume: 310 Issue: 2 Pages: C136-C141
- DOI
  10.1152/ajpcell.00157.2015
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08181, KAKENHI-PROJECT-25460294
[Journal Article] Regulation of the Cav1.2 cardiac channel by redox via modulation of CaM interaction with the channel.2015
- Author(s)
  Sun Y, Xu JJ, Minobe E, Shimoara S, Hao LY, Kameyama M
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 128 Issue: 3 Pages: 137-143
- DOI
  10.1016/j.jphs.2015.06.003
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08181, KAKENHI-PROJECT-25460294
[Journal Article] Nucleotides maintain the activity of Cav1.2 channels in guinea-pig ventricular myocytes.2015
- Author(s)
  Liu SY, Xu JJ, Minobe E, Gao QH, Feng R, Zhao MM, Guo F, Yang L, Kameyama M, Hao LY
- Journal Title
  
  Biophys Biochem Res Comm
  
  Volume: 460 Issue: 3 Pages: 813-818
- DOI
  10.1016/j.bbrc.2015.03.111
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08181, KAKENHI-PROJECT-25460294
[Journal Article] Calmodulin-and Ca^<2+>-dependent facilitation and inactivation of the CaV1. 2 Ca^<2+> channels in guinea-pig ventricular myocytes2010
- Author(s)
  Han DY, Minobe E, Wang WY, Guo F, Xu JJ, Hao LY, Kameyama M.
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 112(3) Pages: 310-319
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390059
[Journal Article] The distinct roles of calmodulin and calmodulin kinase II in the reversal of run-down of L-type Ca^<2+> channels in guinea-pig ventricular myocytes2009
- Author(s)
  Hao LY, Wang WY, Minobe M, Han DY, Xu JJ, Kameyama A, Kameyama M.
- Journal Title
  
  J. Pharmacol. Sci
  
  Volume: 111(4) Pages: 416-425
- NAID
  10026154787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390059
[Presentation] Two molecules of calmodulin also contribute to Ca2+-dependent inactivation and its responsible binding site in Cav1.2 channel. 第100回日本生理学会大会 2023.3.14-16 京都2023
- Author(s)
  蓑部悦子、徐建軍、亀山正樹
- Organizer
  第100回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-20K07263
[Presentation] カルモジュリンを介したCav1.2チャネルの２つの不活性化機構.2022
- Author(s)
  蓑部悦子、徐　健軍、亀山正樹
- Organizer
  第73回西日本生理学会
- Data Source
  KAKENHI-PROJECT-20K07263
[Presentation] ２分子のカルモジュリンによるCav1.2チャネルのカルシウム依存性不活性化2020
- Author(s)
  蓑部悦子、徐建軍、森　誠之、亀山正樹
- Organizer
  第９７回日本生理学会大会、大分
- Data Source
  KAKENHI-PROJECT-19K07285
[Presentation] 心筋の電位依存性Ca2+チャネル(Cav1.2) のCa2+依存性不活性化の構造シミュレーション2019
- Author(s)
  亀山正樹、蓑部悦子、徐建軍、高青華
- Organizer
  第７０回西生理学会、宮崎
- Data Source
  KAKENHI-PROJECT-19K07285
[Presentation] Cav1.2型チャネルC末端の自己調節を基にしたPKAリン酸化のチャネル調節機序2018
- Author(s)
  高青華、雷明、徐建軍、蓑部悦子、朱曜南、ハオ麗英、亀山正樹
- Organizer
  第95回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-15K08181
[Presentation] The mechanism for PKA-mediated facilitation of Cav1.2 channel: A new model2017
- Author(s)
  呂力ティン, 高青華, 雷明, 徐建軍, 蓑部悦子, 亀山正樹.
- Organizer
  第94回日本生理学会大会
- Data Source
  KAKENHI-PROJECT-15K08181
[Presentation] Cav1.2 型Ca2+チャネルC 末端部におけるPKAリン酸化のチャネル活性調節機序2017
- Author(s)
  高青華、雷明、徐建軍、蓑部悦子、朱曜南、ハオ麗英、亀山正樹
- Organizer
  第68回西日本生理学会
- Data Source
  KAKENHI-PROJECT-15K08181
[Presentation] Cav1.2型Ca2+チャネルC末端部のチャネル活性調節作用2016
- Author(s)
  高青華、徐建軍、呂力Ting、蓑部悦子、Hao麗英、亀山正樹
- Organizer
  第67回西日本生理学会
- Place of Presentation
  レインボー桜島（鹿児島県鹿児島市）
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-15K08181
[Presentation] Mechanism underlying PKA-mediated facilitation of cardiac Cav1.2 channels.2015
- Author(s)
  呂力Ｔｉｎｇ、雷　明、徐建軍、蓑部悦子、矢沢和人、亀山正樹
- Organizer
  第66回西日本生理学会
- Place of Presentation
  久留米大学（福岡県久留米市）
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-15K08181
[Presentation] Cav1. 2 Ca^<2+>チャネルC末端部には、複数の機能的Aキナーゼリン酸化部位がある2012
- Author(s)
  蓑部悦子、前田佐知子、徐建軍、はお麗英、封瑞、矢沢和人、亀山亜砂子、亀山正樹
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-21390059
[Presentation] モルモット心室筋細胞におけるL型Ca^<2+>チャネルの過酸化水素による活性調節機構2012
- Author(s)
  楊磊、徐建軍、蓑部悦子、封瑞、亀山亜砂子、矢沢和人、亀山正樹
- Organizer
  第89回日本生理学会大会
- Place of Presentation
  松本
- Data Source
  KAKENHI-PROJECT-21390059
[Presentation] CaMKII-dependent and independent facilitation of L-type Ca^<2+> channels by hydrogen peroxide in guinea-pig ventricular myocytes2011
- Author(s)
  Yang L, Xu J-J, Minobe E, Feng R, Kameyama A, Yazawa K, Kameyama M.
- Organizer
  The 62th meeting of the Physiological Society of West Japan
- Place of Presentation
  Saga
- Data Source
  KAKENHI-PROJECT-21390059
[Presentation] Facilitation of L-type Ca^<2+> channels by hydrogen peroxide in guinea-pig ventricular myocytes2011
- Author(s)
  Yang L, Xu J-J, Minobe E, Feng R, Kameyama A, Yazawa K, Kameyama M.
- Organizer
  The 5th Biennial Meeting of Society for Free Radical Research(SFRR)-Asia and The 8th Conference of Asian Society for Mitochondrial Research and Medicine(ASMRM)
- Place of Presentation
  Kagoshima
- Data Source
  KAKENHI-PROJECT-21390059
[Presentation] Both PKA-mediated phosphorylation and calmodulin interaction are required for basal activity of cardiac L-type Ca^<2+> channel2011
- Author(s)
  Xu J-J, Saud ZA, Liu Y, Yang L, Minobe E, Kameyama A, Yazawa K, Hao L-Y, Kameyama M.
- Organizer
  The 88th Annual Meeting of the Physiological Society of Japan
- Data Source
  KAKENHI-PROJECT-21390059
[Presentation] Ca^<2+>-dependent modulation in calmodulin-linked Cav1. 2 channels2010
- Author(s)
  Minobe E, Mori MX, Xu J-J, Kameyama M.
- Organizer
  The 9th Japan-Korea Joint Symposium on Brain Sciences, and Cardiac and Smooth Muscles
- Place of Presentation
  Kagoshima
- Data Source
  KAKENHI-PROJECT-21390059
[Presentation] PKA-mediated phosphorylation modulates the interaction of calmodulin with cardiac Cav1.2 channels.2010
- Author(s)
  Xu J-J
- Organizer
  The 9th Japan-Korea Joint Symposium on Brain Sciences, and Cardiac and Smooth Muscles.
- Place of Presentation
  Kagoshima
- Data Source
  KAKENHI-PROJECT-21390059
[Presentation] PKA-mediated phosphorylation modulates the interaction of calmod ulin with cardiac Cav1. 2 channels2010
- Author(s)
  Xu J-J, Saud ZA, Liu Y, Yang L, Minobe E, Kameyama A, Yazawa K, Hao L-Y, Kameyama M.
- Organizer
  The 9th Japan-Korea Joint Symposium on Brain Sciences, and Cardiac and Smooth Muscles
- Place of Presentation
  Kagoshima
- Data Source
  KAKENHI-PROJECT-21390059
[Presentation] Ca^<2+> channels and cardiac functions2009
- Author(s)
  Kameyama M, Hao L-Y, Minobe E, Xu J-J, Han D-Y, Nie H-G, Saud ZA, Wang W-Y, Asmara H.
- Organizer
  The 36th International Congress of Physiological Sciences(IUPS2009)
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-21390059
[Presentation] Facilitatory and inhibitory effects of calmodulin on activity of Cav1. 2 Ca^<2+> channel2009
- Author(s)
  Han D-Y, Hao L-Y, Minobe E, Wang W-Y, Xu J-J, Kamey ama M.
- Organizer
  The 36th International Congress of Physiological Sciences(IUPS2009)
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-21390059
[Presentation] Regulation of Cav1. 2 Ca^<2+> channels by Ca^<2+>, calmodulin and CaMKII2009
- Author(s)
  Kameyama M, Hao L-Y, Minobe E, Xu J-J, Han D-Y, Nie H-G, Saud ZA, Wang W-Y, Asmara H, Yazawa K.
- Organizer
  IUPS Satellite Symposium on Ion channels : function, structure and physiology
- Place of Presentation
  Hiei/Kyoto
- Data Source
  KAKENHI-PROJECT-21390059

1. KAMEYAMA Masaki (60150059)

# of Collaborated Projects: 4 results

# of Collaborated Products: 27 results
2. MINOBE Etsuko (00448581)

# of Collaborated Projects: 3 results

# of Collaborated Products: 25 results
3. YAZAWA Kazuto (90212274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
4. GAO Qinghua (60813524)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
5. KAMEYAMA Asako

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
6. MORI Tomoyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HAO Liying

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
8. ZHU Tong

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
9. LYU Liting

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
10. LEI Ming

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results

XU Jianjun 徐 建軍

Xu Jianjun 徐 建軍

徐 建軍 ジョ ケングン

XU Jian-jun 徐 建軍

Research Projects

Research Products

Co-Researchers

Molecular mechanism of the regulation of Cav1.2 channels by calmodulin

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of self-regulation of Cav1.2 channel by channel cytoplasmic fragmentsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Study on the regulatory mechanisms of L-type Ca2+ channels

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

An interrelation among regulatory mechanisms of cardiac Ca2+channels

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Regulation of Cardiac Cav1.2 Channels by Calmodulin2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Ca2C Dyshomeostasis Links Risk Factors to Neurodegeneration in Parkinson’s Disease2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Properties of Calmodulin Binding to NaV1.2 IQ Motif and Its Autism-Associated Mutation R1902C2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Purification of insoluble GST-fused and GST-cleaved Cav1.2 channel fragment by denaturation and renaturation2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A novel role of the antitumor agent tricyclodecan-9-yl-xanthogenate as an open channel blocker of KCNQ1/KCNE12018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A new interaction between proximal and distal C-terminus of Cav1.2 channels.2017

Author(s)

Journal Title

Data Source

[Journal Article] PKA and phosphatases attached to the Cav1.2 channel regulate channel activity in cell-free patches.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Regulation of the Cav1.2 cardiac channel by redox via modulation of CaM interaction with the channel.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nucleotides maintain the activity of Cav1.2 channels in guinea-pig ventricular myocytes.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Calmodulin-and Ca^<2+>-dependent facilitation and inactivation of the CaV1. 2 Ca^<2+> channels in guinea-pig ventricular myocytes2010

Author(s)

Journal Title

Data Source

[Journal Article] The distinct roles of calmodulin and calmodulin kinase II in the reversal of run-down of L-type Ca^<2+> channels in guinea-pig ventricular myocytes2009

XU Jianjun 徐建軍

Xu Jianjun 徐建軍

徐建軍ジョケングン

XU Jian-jun 徐建軍