Miki Daiki 三木大樹

… Alternative Names

MIKI Daiki 三木大樹

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Researcher Number	10584592
Other IDs
Affiliation (Current)	2025: 広島大学, 医系科学研究科(医), 准教授
Affiliation (based on the past Project Information) *help	2019 – 2023: 広島大学, 医系科学研究科(医), 講師 2018: 広島大学, 医歯薬保健学研究科(医), 講師 2015 – 2017: 国立研究開発法人理化学研究所, 統合生命医科学研究センター, 副チームリーダー 2014: 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Medium-sized Section 52:General internal medicine and related fields / General internal medicine and related fields
Keywords	Principal Investigator ゲノム / ヒトゲノム / 非ウイルス性肝癌 / NAFLD / NASH / 肝癌 / SNP / 非肥満 / 高度肥満 / 脂肪性肝疾患 … More / 肥満 / 脂肪肝 / オミックス / 遺伝子多型 / 機械学習 / 腸内細菌 / 肝臓学 / HCV / SVR … More Except Principal Investigator 肥満 / モデル動物 / NASH / ヒト肝細胞キメラマウス / 脂肪肝 / 治療 / 線維化 / 成長ホルモン / ヒト肝細胞 / 脂肪化 / ゲノム編集 / cas9 / lentivirus / cancer therapy / dsDNA / exosome / genome editing Less

ゲノム・オミックス解析による非肥満および高度肥満合併脂肪性肝疾患の病態解析Principal Investigator
- Principal Investigator
  
  三木大樹
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hiroshima University
Study of NASH using human hepatocyte chimeric mouse and biopsy specimen
- Principal Investigator
  
  Chayama Kazuaki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  Hiroshima University
Prediction of the risk of non-viral hepatocarcinogenesis by machine learning using genomic information of host and intestinal commensal bacteriaPrincipal Investigator
- Principal Investigator
  
  Miki Daiki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Hiroshima University
Identification of novel genetic factors and genetic risk assessment models for non-viral HCCPrincipal Investigator
- Principal Investigator
  
  Daiki Miki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Hiroshima University
  Institute of Physical and Chemical Research
Establishment of highly safe gene therapy without usage of double stranded DNA
- Principal Investigator
  
  Chayama Kazuaki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Research Field
  
  General internal medicine and related fields
- Research Institution
  Hiroshima University
The investigation of genetic polymorphisms in viral-sensing pathway affecting development of diseases caused by hepatitis viruses.Principal Investigator
- Principal Investigator
  
  MIKI Daiki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Institute of Physical and Chemical Research

All 2024 2023 2021 2020 2019 2018 2017 2016 2015 2014 2013

All Journal Article Presentation Book

[Book] 消化器・肝臓内科　第10巻第6号「SVR後肝発癌と遺伝子多型」2021
- Author(s)
  三木大樹、茶山一彰
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-20K08288
[Journal Article] Multi-omics analysis of a fatty liver model using human hepatocyte chimeric mice.2024
- Author(s)
  Ichikawa A, Miki D, Hayes CN, Teraoka Y, Nakahara H, Tateno C, Ishida Y, Chayama K, Oka S.
- Journal Title
  
  Sci Rep.
  
  Volume: 14(1) Issue: 1 Pages: 3362-3362
- DOI
  10.1038/s41598-024-53890-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K07416, KAKENHI-PROJECT-21H04817
[Journal Article] Sodium-glucose cotransporter-2 inhibitors improve FibroScan-aspartate aminotransferase scores in patients with nonalcoholic fatty liver disease complicated by type 2 diabetes.2023
- Author(s)
  Ogawa Y, Nakahara T, Ando Y, Yamaoka K, Fujii Y, Uchikawa S, Fujino H, Ono A, Murakami E, Kawaoka T, Miki D, Yamauchi M, Tsuge M, Imamura M, Oka S.
- Journal Title
  
  Eur J Gastroenterol Hepatol.
  
  Volume: 35(9) Issue: 9 Pages: 989-996
- DOI
  10.1097/meg.0000000000002588
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23K07416
[Journal Article] Increasing incidence of non-HBV- and non-HCV-related hepatocellular carcinoma: single-institution 20-year study.2021
- Author(s)
  Nagaoki Y, Hyogo H, Ando Y, Kosaka Y, Uchikawa S, Nishida Y, Teraoka Y, Morio K, Fujino H, Ono A, Nakahara T, Murakami E, Yamauchi M, Okamoto W, Kawaoka T, Tsuge M, Hiramatsu A, Miki D, Imamura M, Takahashi S, Chayama K, Aikata H.
- Journal Title
  
  BMC Gastroenterol.
  
  Volume: 21(1) Issue: 1 Pages: 306-306
- DOI
  10.1186/s12876-021-01884-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08288, KAKENHI-PROJECT-21K07896, KAKENHI-PROJECT-21K08006
[Journal Article] 肝炎ウイルス排除後の肝発がん2021
- Author(s)
  三木大樹、相方浩、茶山一彰
- Journal Title
  
  月刊薬事
  
  Volume: 63(4) Pages: 77-82
- Data Source
  KAKENHI-PROJECT-20K08288
[Journal Article] In vitro analysis of hepatic stellate cell activation influenced by transmembrane 6 superfamily 2 polymorphism.2021
- Author(s)
  Liu S, Murakami E, Nakahara T, Ohya K, Teraoka Y, Makokha GN, Uchida T, Morio K, Fujino H, Ono A, Yamauchi M, Kawaoka T, Miki D, Tsuge M, Hiramatsu A, Abe-Chayama H, Hayes NC, Imamura M, Aikata H, Chayama K.
- Journal Title
  
  Mol Med Rep.
  
  Volume: 23(16) Issue: 1 Pages: 1-7
- DOI
  10.3892/mmr.2020.11654
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08288, KAKENHI-PROJECT-18K15814
[Journal Article] Comparison of liver disease state progression in patients with eradication of versus persistent infection with hepatitis C virus: Markov chain analysis.2021
- Author(s)
  Tada T, Toyoda H, Kumada T, Kurisu A, Sugiyama A, Akita T, Ohisa M, Aikata H, Miki D, Chayama K, Tanaka J.
- Journal Title
  
  J Viral Hepat.
  
  Volume: 28(3) Issue: 3 Pages: 538-547
- DOI
  10.1111/jvh.13444
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08288
[Journal Article] Risk factors for histological progression of non-alcoholic steatohepatitis analyzed from repeated biopsy cases.2020
- Author(s)
  Daijo K, Nakahara T, Inagaki Y, Nanba M, Nishida Y, Uchikawa S, Kodama K, Oya K, Morio K, Fujino H, Ono A, Murakami E, Yamauchi M, Kawaoka T, Miki D, Tsuge M, Hiramatsu A, Hayes CN, Imamura M, Aikata H, Ochi H, Chayama K.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: - Issue: 8 Pages: 1412-1419
- DOI
  10.1111/jgh.14968
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446, KAKENHI-PROJECT-20K08288, KAKENHI-PROJECT-18K15814
[Journal Article] C型肝炎による発癌のリスク因子2020
- Author(s)
  三木大樹、茶山一彰
- Journal Title
  
  消化器内科
  
  Volume: 2(5) Pages: 76-82
- Data Source
  KAKENHI-PROJECT-20K08288
[Journal Article] PNPLA3 and HLA-DQB1 polymorphisms are associated with hepatocellular carcinoma after hepatitis C virus eradication.2020
- Author(s)
  Miki D, Akita T, Kurisu A, Kawaoka T, Nakajima T, Hige S, Karino Y, Toyoda H, Kumada T, Tsuge M, Hiramatsu A, Imamura M, Aikata H, Hayes CN, Honda K, Seike M, Akuta N, Kobayashi M, Kumada H, Tanaka J, Chayama K.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 55(12) Issue: 12 Pages: 1162-1170
- DOI
  10.1007/s00535-020-01731-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08288
[Journal Article] Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases2020
- Author(s)
  Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Yamaji T, et al
- Journal Title
  
  Nature Genetics
  
  Volume: 52 Issue: 7 Pages: 669-679
- DOI
  10.1038/s41588-020-0640-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10655, KAKENHI-PROJECT-20K07709, KAKENHI-PROJECT-20K08288, KAKENHI-PROJECT-16H02468, KAKENHI-PROJECT-18H02894, KAKENHI-PLANNED-17H06419, KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-18H04053, KAKENHI-PROJECT-20H00543, KAKENHI-PROJECT-18H02688, KAKENHI-PROJECT-18H02931, KAKENHI-PROJECT-18H02932, KAKENHI-PROJECT-19H03559, KAKENHI-PROJECT-19H03881, KAKENHI-PROJECT-19K22525, KAKENHI-PROJECT-19K17962, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-20H03695, KAKENHI-PROJECT-20H03943, KAKENHI-PROJECT-18H02940
[Journal Article] Impact of viral eradication by direct-acting antivirals on the risk of hepatocellular carcinoma development, prognosis, and portal hypertension in hepatitis C virus-related compensated cirrhosis patients.2020
- Author(s)
  Nagaoki Y, Imamura M, Teraoka Y, Morio K, Fujino H, Ono A, Nakahara T, Murakami E, Yamauchi M, Kawaoka T, Miki D, Tsuge M, Hiramatsu A, Hayes CN, Chayama K, Aikata H.
- Journal Title
  
  Hepatol Res.
  
  Volume: 50(11) Issue: 11 Pages: 1222-1233
- DOI
  10.1111/hepr.13554
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08288
[Journal Article] PD1 gene polymorphism is associated with a poor prognosis in hepatocellular carcinoma following liver resection, cohort study.2020
- Author(s)
  Yamamoto M, Kobayashi T, Mashima H, Miki D, Kuroda S, Hamaoka M, Aikata H, Chayama K, Ohdan H.
- Journal Title
  
  Int J Surg.
  
  Volume: 80 Pages: 84-90
- DOI
  10.1016/j.ijsu.2020.05.007
- NAID
  120007168956
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08288, KAKENHI-PROJECT-18K08706
[Journal Article] Comparative study on the replication of HCV1b genome between wild-type and cell culture-adaptive mutant in regard to sensitivities against anti-HCV drugs.2019
- Author(s)
  Miyayama Y, Lee H, Song H, Abe-Chayama H, Miki D, Imamura M, Chayama K, Hijikata M.
- Journal Title
  
  Microbiol Immunol.
  
  Volume: - Issue: 4 Pages: 296-303
- DOI
  10.1111/1348-0421.12768
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446
[Journal Article] Pruritus in patients with chronic liver disease and serum autotaxin levels in patients with primary biliary cholangitis.2019
- Author(s)
  Fujino H, Tanaka M, Imamura M, Morio K, Ono A, Nakahara T, Murakami E, Kawaoka T, Takahashi S, Miki D, Tsuge M, Hiramatsu A, Aikata H, Hayes CN, Chayama K.
- Journal Title
  
  BMC Gastroenterol.
  
  Volume: 19 Issue: 1 Pages: 169-169
- DOI
  10.1186/s12876-019-1092-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446
[Journal Article] Levocarnitine Use Is Associated With Improvement in Sarcopenia in Patients With Liver Cirrhosis.2019
- Author(s)
  Hiramatsu A, Aikata H, Uchikawa S, Ohya K, Kodama K, Nishida Y, Daijo K, Osawa M, Teraoka Y, Honda F, Inagaki Y, Morio K, Morio R, Fujino H, Nakahara T, Murakami E, Yamauchi M, Kawaoka T, Miki D, Tsuge M, Imamura M, Tanaka J, Chayama K.
- Journal Title
  
  Hepatol Commun.
  
  Volume: 22 Issue: 3 Pages: 348-355
- DOI
  10.1002/hep4.1309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09446, KAKENHI-PROJECT-17H03589
[Journal Article] Comparison of intracellular responses between HBV genotype A and C infection in human hepatocyte chimeric mice2019
- Author(s)
  Tsushima K, Tsuge M, Hiraga N, Uchida T, Murakami E, Makokha GN, Kurihara M, Nomura Motonobu, Hiyama Y, Fujino H, Ono A, Nakahara T, Yamauchi M, Abe-Chayama H, Kawaoka T, Miki D, Imamura M, Aikata H, Hayes CN, Chayama K
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 印刷中 Issue: 7 Pages: 650-659
- DOI
  10.1007/s00535-019-01558-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07973, KAKENHI-PROJECT-17KK0194, KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446
[Journal Article] The impact of interferon-free direct-acting antivirals on clinical outcome after curative treatment for hepatitis C virus-associated hepatocellular carcinoma: Comparison with interferon-based therapy.2019
- Author(s)
  Nagaoki Y, Imamura M, Nishida Y, Daijo K, Teraoka Y, Honda F, Nakamura Y, Morio K, Fujino H, Nakahara T, Kawaoka T, Tsuge M, Hiramatsu A, Kawakami Y, Miki D, Hiyama Y, Ochi H, Chayama K, Aikata H.
- Journal Title
  
  J Med Virol.
  
  Volume: 91 Issue: 4 Pages: 650-658
- DOI
  10.1002/jmv.25352
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09446, KAKENHI-PROJECT-17H06269
[Journal Article] Ribavirin induces hepatitis C virus genome mutations in chronic hepatitis patients who failed to respond to prior daclatasvir plus asunaprevir therapy.2019
- Author(s)
  Saito Y, Imamura M, Uchida T, Osawa M, Teraoka Y, Fujino H, Nakahara T, Ono A, Murakami E, Kawaoka T, Miki D, Tsuge M, Serikawa M, Aikata H, Abe-Chayama H, Hayes CN, Chayama K.
- Journal Title
  
  J Med Virol.
  
  Volume: 92 Issue: 2 Pages: 210-218
- DOI
  10.1002/jmv.25602
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446
[Journal Article] Efficacy of glecaprevir and pibrentasvir treatment for genotype 1b hepatitis C virus drug resistance-associated variants in humanized mice.2019
- Author(s)
  Osawa M, Uchida T, Imamura M, Teraoka Y, Fujino H, Nakahara T, Ono A, Murakami E, Kawaoka T, Miki D, Tsuge M, Hiramatsu A, Abe-Chayama H, Hayes CN, Makokha GN, Aikata H, Ishida Y, Tateno C, Miyayama Y, Hijikata M, Chayama K.
- Journal Title
  
  J Gen Virol.
  
  Volume: 100 Issue: 7 Pages: 1123-1131
- DOI
  10.1099/jgv.0.001268
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269, KAKENHI-PROJECT-17K09446
[Journal Article] Real-world efficacy of glecaprevir plus pibrentasvir for chronic hepatitis C patient with previous direct-acting antiviral therapy failures.2019
- Author(s)
  Osawa M, Imamura M, Teraoka Y, Uchida T, Morio K, Fujino H, Nakahara T, Ono A, Murakami E, Kawaoka T, Miki D, Tsuge M, Hiramatsu A, Aikata H, Hayes CN, Chayama K; Hiroshima Liver Study Group.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 54 Issue: 3 Pages: 291-296
- DOI
  10.1007/s00535-018-1520-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09446
[Journal Article] Serum HMGB1 concentrations at 4 weeks is a useful predictor of extreme poor prognosis for advanced hepatocellular carcinoma treated with sorafenib and hepatic arterial infusion chemotherapy.2018
- Author(s)
  Masuda K, Ono A, Aikata H, Kawaoka T, Nelson Hayes C, Teraoka Y, Daijo K, Nakamura-Inagaki Y, Morio K, Fujino H, Kan H, Uchida T, Masaki K, Kobayashi T, Nakahara T, Makokha GN, Zhang Y, Nagaoki Y, Miki D, Tsuge M, Hiramatsu A, Imamura M, Abe-Chayama H, Kawakami Y, Ochi H, Chayama K.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 53 Issue: 1 Pages: 107-118
- DOI
  10.1007/s00535-017-1348-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09446, KAKENHI-PROJECT-16K19346
[Journal Article] Prevalence of NS5A resistance associated variants in NS5A inhibitor treatment failures and an effective treatment for NS5A-P32 deleted hepatitis C virus in humanized mice.2018
- Author(s)
  Teraoka Y, Uchida T, Imamura M, Osawa M, Tsuge M, Abe-Chayama H, Hayes CN, Makokha GN, Aikata H, Miki D, Ochi H, Ishida Y, Tateno C, Chayama K; Hiroshima Liver Study Group.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 500 Issue: 2 Pages: 152-157
- DOI
  10.1016/j.bbrc.2018.04.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09446
[Journal Article] Involvement of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease.2018
- Author(s)
  Nakahara T, Hyogo H, Ono A, Nagaoki Y, Kawaoka T, Miki D, Tsuge M, Hiraga N, Hayes CN, Hiramatsu A, Imamura M, Kawakami Y, Aikata H, Ochi H, Abe-Chayama H, Furusho H, Shintani T, Kurihara H, Miyauchi M, Takata T, Arihiro K, Chayama K.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 53 Issue: 2 Pages: 269-280
- DOI
  10.1007/s00535-017-1368-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09446
[Journal Article] Serial profiling of circulating tumor DNA for optimization of anti-VEGF chemotherapy in metastatic colorectal cancer patients.2018
- Author(s)
  Yamauchi M, Urabe Y, Ono A, Miki D, Ochi H, Chayama K.
- Journal Title
  
  Int J Cancer.
  
  Volume: 142 Issue: 7 Pages: 1418-1426
- DOI
  10.1002/ijc.31154
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H06269
[Journal Article] Advanced liver fibrosis effects on the response to sofosbuvir-based antiviral therapies for chronic hepatitis C.2018
- Author(s)
  Morio K, Imamura M, Kawakami Y, Nakamura Y, Hatooka M, Morio R, Fujino H, Nakahara T, Murakami E, Kawaoka T, Tsuge M, Hiramatsu A, Aikata H, Hayes CN, Miki D, Ochi H, Katamura Y, Arataki K, Moriya T, Ito H, Tsuji K, Kohno H, Waki K, Tamura T, Nakamura T, Chayama K; Hiroshima Liver Study Group.
- Journal Title
  
  J Med Virol.
  
  Volume: 90 Issue: 12 Pages: 1834-1840
- DOI
  10.1002/jmv.25267
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09446
[Journal Article] Limitations of daclatasvir/asunaprevir plus beclabuvir treatment in cases of NS5A inhibitor treatment failure.2018
- Author(s)
  Teraoka Y, Uchida T, Imamura M, Hiraga N, Osawa M, Kan H, Saito Y, Tsuge M, Abe-Chayama H, Hayes CN, Makokha GN, Aikata H, Miki D, Ochi H, Ishida Y, Tateno C, Chayama K.
- Journal Title
  
  J Gen Virol.
  
  Volume: 99 Issue: 8 Pages: 1058-1065
- DOI
  10.1099/jgv.0.001091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09446
[Journal Article] Safety and efficacy of dual therapy with daclatasvir and asunaprevir for older patients with chronic hepatitis C.2017
- Author(s)
  Morio R, Imamura M, Kawakami Y, Morio K, Kobayashi T, Yokoyama S, Kimura Y, Nagaoki Y, Kawaoka T, Tsuge M, Hiramatsu A, Nelson Hayes C, Aikata H, Takahashi S, Miki D, Ochi H, Mori N, Takaki S, Tsuji K, Chayama K.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 52 Issue: 4 Pages: 504-511
- DOI
  10.1007/s00535-016-1255-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26860536, KAKENHI-PROJECT-15K09004
[Journal Article] Efficacy and safety of daclatasvir plus asunaprevir therapy for chronic hepatitis C patients with renal dysfunction.2017
- Author(s)
  Nakamura Y, Imamura M, Kawakami Y, Teraoka Y, Daijo K, Honda F, Morio K, Kobayashi T, Nakahara T, Nagaoki Y, Kawaoka T, Tsuge M, Hiramatsu A, Aikata H, Hayes CN, Miki D, Ochi H, Chayama K.
- Journal Title
  
  J Med Virol.
  
  Volume: 89 Issue: 4 Pages: 665-671
- DOI
  10.1002/jmv.24679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860536, KAKENHI-PROJECT-15K09004
[Journal Article] Real-world efficacy and safety of daclatasvir and asunaprevir therapy for hepatitis C virus-infected cirrhosis patients.2017
- Author(s)
  Morio K, Imamura M, Kawakami Y, Morio R, Kobayashi T, Yokoyama S, Nagaoki Y, Kawaoka T, Tsuge M, Hiramatsu A, Makokha GN, Hayes CN, Aikata H, Miki D, Ochi H, Honda Y, Mori N, Takaki S, Tsuji K, Chayama K.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 32 Issue: 3 Pages: 645-650
- DOI
  10.1111/jgh.13511
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860536, KAKENHI-PROJECT-15K09004
[Journal Article] IFNL4 polymorphism effects on outcome of simeprevir, peginterferon, and ribavirin therapy for older patients with genotype 1 chronic hepatitis C.2017
- Author(s)
  Mori N, Imamura M, Kawakami Y, Nagaoki Y, Kawaoka T, Tsuge M, Hiramatsu A, Hayes CN, Aikata H, Miki D, Ochi H, Honda Y, Takaki S, Tsuji K, Chayama K; Hiroshima Liver Study Group.
- Journal Title
  
  Hepatol Res.
  
  Volume: 47 Issue: 3
- DOI
  10.1111/hepr.12715
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860536
[Journal Article] The risks of hepatocellular carcinoma development after HCV eradication are similar between patients treated with peg-interferon plus ribavirin and direct-acting antiviral therapy.2017
- Author(s)
  Nagaoki Y, Imamura M, Aikata H, Daijo K, Teraoka Y, Honda F, Nakamura Y, Hatooka M, Morio R, Morio K, Kan H, Fujino H, Kobayashi T, Masaki K, Ono A, Nakahara T, Kawaoka T, Tsuge M, Hiramatsu A, Kawakami Y, Hayes CN, Miki D, Ochi H, Chayama K.
- Journal Title
  
  PLoS One.
  
  Volume: 12 Issue: 8 Pages: e0182710-e0182710
- DOI
  10.1371/journal.pone.0182710
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09446
[Journal Article] Rapid, Sensitive, and Accurate Evaluation of Drug Resistant Mutant (NS5A-Y93H) Strain Frequency in Genotype 1b HCV by Invader Assay2015
- Author(s)
  Satoshi Yoshimi, Hidenori Ochi, Eisuke Murakami, Takuro Uchida, Hiromi Kan, Sakura Akamatsu, C. Nelson Hayes, Hiromi Abe, Daiki Miki, Nobuhiko Hiraga, Michio Imamura, Hiroshi Aikata, Kazuaki Chayama.
- Journal Title
  
  PLOS ONE
  
  Volume: 10 Issue: 6 Pages: e0130022-e0130022
- DOI
  10.1371/journal.pone.0130022
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09004, KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26860536
[Journal Article] Association between variants in the interferon lambda 4 locus and substitutions in the hepatitis C virus non-structural protein 5A.2015
- Author(s)
  Akamatsu S, Hayes CN, Ochi H, Uchida T, Kan H, Murakami E, Abe H, Tsuge M, Miki D, Akiyama R, Hiraga N, Imamura M, Aikata H, Kawaoka T, Kawakami Y, Chayama K.
- Journal Title
  
  J Hepatol.
  
  Volume: 63 Issue: 3 Pages: 554-563
- DOI
  10.1016/j.jhep.2015.03.033
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26860536
[Journal Article] The effects of bisphosphonate zoledronic acid in hepatocellular carcinoma, depending on mevalonate pathway.2015
- Author(s)
  Honda Y, Takahashi S, Zhang Y, Ono A, Murakami E, Shi N, Kawaoka T, Miki D, Tsuge M, Hiraga N, Abe H, Ochi H, Imamura M, Aikata H, Chayama K.
- Journal Title
  
  J Gastroenterol Hepatol.
  
  Volume: 30 Issue: 3 Pages: 619-627
- DOI
  10.1111/jgh.12715
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536, KAKENHI-PROJECT-26860191
[Journal Article] Circulating tumor DNA analysis for liver cancers and its usefulness as a liquid biopsy.2015
- Author(s)
  Ono A, Fujimoto A, Yamamoto Y, Akamatsu S, Nobuhiko H, Imamura M, Kawaoka T, Tsuge M, Abe H, Hayes CN, Miki D, Furuta M, Tsunoda T, Miyano S, Kubo M, Aikata H, Ochi H, Kawakami Y, Arihiro K, Ohdan H, Nakagawa H, Chayama K
- Journal Title
  
  Cellular and Molecular Gastroenterology and Hepatology
  
  Volume: 1 Issue: 5 Pages: 516-534
- DOI
  10.1016/j.jcmgh.2015.06.009
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26430196, KAKENHI-PROJECT-26860536, KAKENHI-PUBLICLY-26114721, KAKENHI-PROJECT-15H04814
[Journal Article] Differences in serum microRNA profiles in hepatitis B and C virus infection.2015
- Author(s)
  Akamatsu S, Hayes CN, Tsuge M, Miki D, Akiyama R, Abe H, Ochi H, Hiraga N, Imamura M, Takahashi S, Aikata H, Kawaoka T, Kawakami Y, Ohishi W, Chayama K.
- Journal Title
  
  J Infect.
  
  Volume: 70 Issue: 3 Pages: 273-287
- DOI
  10.1016/j.jinf.2014.10.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536, KAKENHI-PROJECT-15K09002
[Journal Article] Human microRNA hsa-miR-1231 suppresses hepatitis B virus replication by targeting core mRNA.2014
- Author(s)
  Kohno T, Tsuge M, Murakami E, Hiraga N, Abe H, Miki D, Imamura M, Ochi H, Hayes CN, Chayama K.
- Journal Title
  
  J Viral Hepat
  
  Volume: 21(9) Issue: 9
- DOI
  10.1111/jvh.12240
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26860536
[Journal Article] Emergence of resistant variants detected by ultra-deep sequencing after asunaprevir and daclatasvir combination therapy in patients infected with hepatitis C virus genotype 1.2014
- Author(s)
  Kosaka K, Imamura M, Hayes CN, Abe H, Hiraga N, Yoshimi S, Murakami E, Kawaoka T, Tsuge M, Aikata H, Miki D, Ochi H, Matsui H, Kanai A, Inaba T, Chayama K.
- Journal Title
  
  J Viral Hepat.
  
  Volume: 22 Issue: 2 Pages: 158-165
- DOI
  10.1111/jvh.12271
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26461008, KAKENHI-PROJECT-26860536
[Journal Article] Quantitative effect of natural killer-cell licensing on hepatocellular carcinoma recurrence after curative hepatectomy2014
- Author(s)
  Tanimine N, Tanaka Y, Kobayashi T, Tashiro H, Miki D, Imamura M, Aikata H, Tanaka J, Chayama K, Ohdan H.
- Journal Title
  
  Cancer Immunol Res
  
  Volume: 2(12) Issue: 12 Pages: 1142-1147
- DOI
  10.1158/2326-6066.cir-14-0091
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670581, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536
[Journal Article] interferon lambda 4/interleukin-28B haplotype structure and its impact on susceptibility to hepatitis C virus and treatment response in the Japanese population2014
- Author(s)
  Ochi H, Miki D, Hayes CN, Abe H, Hayashida Y, Kubo M, Chayama K
- Journal Title
  
  Journal of General Virology
  
  Volume: 95巻 Issue: 6 Pages: 1297-306
- DOI
  10.1099/vir.0.060103-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790702, KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536, KAKENHI-PROJECT-221S0001
[Journal Article] Ribavirin dose reduction during telaprevir/ribavirin/peg-interferon therapy overcomes the effect of the ITPA gene polymorphism.2014
- Author(s)
  Akamatsu S, Hayes CN, Tsuge M, Murakami E, Hiraga N, Abe H, Miki D, Imamura M, Ochi H, Chayama K; Hiroshima Liver Study Group.
- Journal Title
  
  J Viral Hepat.
  
  Volume: 22 Issue: 2 Pages: 166-174
- DOI
  10.1111/jvh.12275
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26420796, KAKENHI-PROJECT-26860536
[Journal Article] Two patients treated with pegylated interferon/ribavirin/telaprevir triple therapy for recurrent hepatitis C after living donor liver transplantation.2014
- Author(s)
  Kawaoka T. Takahashi S. Tatsukawa Y. Hiramatsu A. Hiraga N. Miki D. Tsuge M. Imamura M. Kawakami Y. Aikata H. Ochi H. Ishiyama K. Ide K. Tashiro H. Ohdan H, and Chayama K
- Journal Title
  
  Hepatol Res
  
  Volume: 印刷中 Issue: 12 Pages: 1259-1264
- DOI
  10.1111/hepr.12296
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536
[Journal Article] Ultradeep sequencing study of chronic hepatitis C virus genotype 1 infection in patients treated with daclatasvir, peginterferon, and ribavirin2014
- Author(s)
  Murakami, E. Imamura, M. Hayes, C. N. Abe, H. Hiraga, N. Honda, Y. Ono, A. Kosaka, K. Kawaoka, T. Tsuge, M. Aikata, H. Takahashi, S. Miki, D. Ochi, H. Matsui, H. Kanai, A. Inaba, T. McPhee, F. Chayama, K.
- Journal Title
  
  Antimicrob Agents Chemother
  
  Volume: 58 Issue: 4 Pages: 2105-2112
- DOI
  10.1128/aac.02068-13
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591397, KAKENHI-PROJECT-24790701, KAKENHI-PROJECT-24790702, KAKENHI-PROJECT-26461008, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536
[Journal Article] Predictive value of the IFNL4 polymorphism on outcome of telaprevir, peginterferon, and ribavirin therapy for older patients with genotype 1b chronic hepatitis C2013
- Author(s)
  Fujino H. Imamura M. Nagaoki Y. Kawakami Y. Abe H. Hayes C N.et al
- Journal Title
  
  J Gastroenterol
  
  Volume: 電子書籍 Issue: 12 Pages: 1548-1556
- DOI
  10.1007/s00535-013-0924-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670369, KAKENHI-PROJECT-26670383, KAKENHI-PROJECT-26860536
[Presentation] 大規模日本人データを用いた代謝異常と遺伝的要因の関連性についての検討2023
- Author(s)
  三木大樹, 中原隆志、岡志郎
- Organizer
  第109回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-23K07416
[Presentation] SVR後の肝発癌リスク予測に有用な血清AFP値に関する検討2021
- Author(s)
  三木大樹、相方浩、藤野初江、大野敦司、山内理海、柘植雅貴、茶山一彰
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08288
[Presentation] C型肝炎ウイルス排除後の新規肝発癌とPNPLA3遺伝子多型の検討2021
- Author(s)
  三木大樹、田中純子、茶山一彰
- Organizer
  第57回日本肝臓学会総会
- Data Source
  KAKENHI-PROJECT-20K08288
[Presentation] SVR後新規肝発癌リスク層別化における経時的AFP変化の意義2021
- Author(s)
  三木大樹，田中純子，茶山一彰
- Organizer
  第29回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-20K08288
[Presentation] PNPLA3遺伝子多型はHCV排除後の肝発癌に関連する2020
- Author(s)
  三木大樹, 相方浩、藤野初江、大野敦司、山内理海、柘植雅貴、茶山一彰
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K08288
[Presentation] 肝疾患における病因特異的な腸内細菌叢パターンの探索2020
- Author(s)
  三木大樹, 河岡友和、茶山一彰
- Organizer
  第106回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-20K08288
[Presentation] C型肝炎ウイルス排除後の新規肝発癌に関わるリスク因子の検討2020
- Author(s)
  三木大樹、田中純子、茶山一彰
- Organizer
  第28回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-20K08288
[Presentation] Multiple genetic factors affecting nonalcoholic fatty liver disease and nonalcoholic steatohepatitis-related hepatocellular carcinoma in the Japanese population2019
- Author(s)
  Daiki Miki, Yuichi Hiyama, Atsushi Ono, Masami Yamauchi, Masataka Tsuge, Hiroshi Aikata, Tatsuhiko Tsunoda, Kazuaki Chayama
- Organizer
  11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research: Biology to Precision Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09446
[Presentation] ASSOCIATION OF FNDC5, PNPLA3 AND TM6SF2 POLYMORPHISMS WITH HEPATIC STEATOSIS IN NAFLD PATIENTS2019
- Author(s)
  Daiki Miki, Takashi Nakahara, Eisuke Murakami, Hiromi Abe-Chayama, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Tomokazu Kawaoka, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Hiroshi Aikata, Nelson Hayes, Grace Naswa Makokha, Tatsuhiko Tsunoda, Kazuaki Chayama
- Organizer
  The Liver Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09446
[Presentation] DIFFERENTIAL EFFECTS OF HOST GENETIC FACTORS ON HCV PERSISTENCE ACCORDING TO HCV GENOTYPES2019
- Author(s)
  Daiki Miki, Tomokazu Kawaoka, Nelson Hayes, Hiromi Abe-Chayama, Hatsue Fujino, Grace Naswa Makokha, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Hiroshi Aikata, Tatsuhiko Tsunoda, Kazuaki Chayama
- Organizer
  The Liver Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09446
[Presentation] Prevalence of NS5A Resistance Associated Variants in NS5A Inhibitor Treatment Failures and an Effective Treatment for NS5A-P32 Deleted Hepatitis C Virus in Humanized Mice2018
- Author(s)
  Yuji Teraoka, Takuro Uchida, Michio Imamura, Mitutaka Osawa, Tomokazu Kawaoka, Masataka Tsuge, Hiromi Abe-Chayama, Nelson Hayes, Grace Naswa Makokha, Hiroshi Aikata, Daiki Miki, Hidenori Ochi, Yuji Ishida, Chise Tateno, Kazuaki Chayama
- Organizer
  The Liver Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09446
[Presentation] Association of TLL1 Polymorphism with Development of Hepatocellular Carcinoma after Hepatitis C Virus Eradication and Fibrosis Severity2018
- Author(s)
  Daiki Miki, Tomokazu Kawaoka, Yuko Nagaoki, Nelson Hayes, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Hiroshi Aikata, Hiromi Abe-Chayama, Hidenori Ochi, Tatsuhiko Tsunoda, Kazuaki Chayama
- Organizer
  The Liver Meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09446
[Presentation] 日本人における非アルコール性脂肪性肝疾患・非アルコール性脂肪肝炎関連肝細胞癌の発症に関連する宿主遺伝的要因2018
- Author(s)
  三木大樹、柘植雅貴、山内理海、相方浩、茶山一彰
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-17K09446
[Presentation] Japanese genetic study could not suggest the importance of the NTCP locus for HBV persistence.2016
- Author(s)
  Miki D, Ochi H, Hayes CN, Abe H, Akamatsu S, Ono A, Nakahara T, Zhang Y, Masaki K, Fujino H, Miyaki E, Kan H, Uchida T, Hiraga N, Tsuge M, Kawaoka T, Imamura M, Kawakami Y, Aikata H, Chayama K.
- Organizer
  The 25th Conference of the Asian Pacific Association for the Study of the Liver (APASL2016).
- Place of Presentation
  Tokyo, Japan.
- Year and Date
  2016-02-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] B型慢性肝炎病勢評価のための新規マーカーとしてのマイクロRNAの可能性2016
- Author(s)
  三木大樹、柘植雅貴、茶山一彰
- Organizer
  第52回日本肝臓学会総会
- Place of Presentation
  東京ベイ幕張ホール（千葉県千葉市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] Rapid, sensitive, and accurate evaluation system for drug resistant strain (NS5A-Y93H) frequency in genotype 1b HCV.2015
- Author(s)
  Ochi H, Yoshimi S, Murakami E, Uchida T, Kan H, Akamatsu S, Hayes CN, Abe H, Miki D, Hiraga N, Imamura M, Aikata H, Chayama K.
- Organizer
  The Liver Meeting 2015.
- Place of Presentation
  San Francisco, USA.
- Year and Date
  2015-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] Involvement of Endoplasmic Reticulum Stress Transducer BBF2H7 in Hepatocellular Carcinoma Promotion.2015
- Author(s)
  Zhang Y, Hayes CN, Tsuge M, Hiraga N, Uchida T, Miki D, Abe H, Chayama K.
- Organizer
  The Liver Meeting 2015.
- Place of Presentation
  San Francisco, USA.
- Year and Date
  2015-11-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] 肝癌で欠損がみられる遺伝子の生殖細胞系列多型は自身の発現量を調節することで発癌に寄与しうる．2015
- Author(s)
  三木大樹、相方浩、大野敦司、卜部祐司、柘植雅貴、川上由育、久保充明、中村祐輔、茶山一彰．
- Organizer
  第74回日本癌学会学術総会．
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] The impact of HLA-DQs and IFNL4 variant on hepatitis C virus-induced liver inflammation.2015
- Author(s)
  Miki D, Ochi H, Hayes CN, Abe H, Akamatsu S, Ono A, Nakahara T, Zhang Y, Masaki K, Fujino H, Miyaki E, Kan H, Uchida T, Hiraga N, Tsuge M, Kawaoka T, Imamura M, Kawakami Y, Aikata H, Chayama K.
- Organizer
  The Liver Meeting 2015.
- Place of Presentation
  San Francisco, USA.
- Year and Date
  2015-11-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] HCV持続感染におけるIFNL4とHLA-DQの遺伝子多型間相互作用．2015
- Author(s)
  三木大樹、越智秀典、阿部弘美、大野敦司、中原隆志、柾木慶一、村上英介、内田宅郎、菅宏美、河岡友和、柘植雅貴、平賀伸彦、今村道雄、川上由育、相方浩、茶山一彰．
- Organizer
  第101回日本消化器病学会総会．
- Place of Presentation
  仙台
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] HBV感染に伴うmicroRNA発現変化とmiRNAによるHBV複製制御．2015
- Author(s)
  柘植雅貴、平賀伸彦、村上英介、阿部弘美、三木大樹、河岡友和、平松憲、今村道雄、兵庫秀幸、川上由育、相方浩、越智秀典、茶山一彰．
- Organizer
  第51回日本肝臓学会総会．
- Place of Presentation
  熊本
- Year and Date
  2015-05-22
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] Difference of intracellular responses by HBV genotype A and C infection in humanized mouse model.2015
- Author(s)
  Tsuge M, Hiraga N, Abe H, Imamura M, Miki D, Ochi H, Hayes CN, Chayama K.
- Organizer
  The Liver Meeting 2015.
- Place of Presentation
  San Francisco, USA.
- Year and Date
  2015-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] Genetic association study failed to confirm an association between the NTCP S267F mutation and persistence of hepatitis B virus or development of hepatocellular carcinoma in the Japanese population.2015
- Author(s)
  Miki D, Ochi H, Hayes CN, Abe H, Akamatsu S, Ono A, Nakahara T, Zhang Y, Masaki K, Fujino H, Miyaki E, Kan H, Uchida T, Hiraga N, Tsuge M, Kawaoka T, Imamura M, Kawakami Y, Aikata H, Chayama K.
- Organizer
  The Liver Meeting 2015.
- Place of Presentation
  San Francisco, USA.
- Year and Date
  2015-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] HCV慢性感染肝組織内でのOAS1発現は自身近傍のSNPよりもIL28B近傍のSNPにより強く調節される．2015
- Author(s)
  三木大樹、阿部弘美、ヘイズ・ネルソン、越智秀典、河岡友和、大野敦司、中原隆志、村上英介、柾木慶一、内田宅郎、菅宏美、柘植雅貴、平賀伸彦、今村道雄、川上由育、相方浩、茶山一彰．
- Organizer
  第51回日本肝臓学会総会．
- Place of Presentation
  熊本
- Year and Date
  2015-05-21
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] Circulating tumor DNA analysis for liver cancers and its usefulness as a liquid biopsy.2015
- Author(s)
  Ono A, Hayes CN, Uchida T, Kan H, Masaki K, Nakahara T, Miki D, Kawaoka T, Tsuge M, Hiraga N, Imamura M, Kawakami Y, Aikata H, Ochi H, Abe H, Nakagawa H, Chayama K.
- Organizer
  The Liver Meeting 2015.
- Place of Presentation
  San Francisco, USA.
- Year and Date
  2015-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] The relationship between hepatocellular carcinoma development and reduced expression levels of the major germline genotype of PROSC, which is frequently deleted in hepatocellular carcinoma.2015
- Author(s)
  Miki D, Ochi H, Hayes CN, Abe H, Akamatsu S, Ono A, Nakahara T, Zhang Y, Masaki K, Fujino H, Miyaki E, Kan H, Uchida T, Hiraga N, Tsuge M, Kawaoka T, Imamura M, Kawakami Y, Aikata H, Chayama K.
- Organizer
  The Liver Meeting 2015.
- Place of Presentation
  San Francisco, USA.
- Year and Date
  2015-11-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] Genome-wide scan of miRNA polymorphisms revealed a suggestive association of miR-3143 with chronic hepatitis B virus infection.2015
- Author(s)
  Miki D, Ochi H, Hayes CN, Abe H, Akamatsu S, Ono A, Nakahara T, Zhang Y, Masaki K, Fujino H, Miyaki E, Kan H, Uchida T, Hiraga N, Tsuge M, Kawaoka T, Imamura M, Kawakami Y, Aikata H, Chayama K.
- Organizer
  The Liver Meeting 2015.
- Place of Presentation
  San Francisco, USA.
- Year and Date
  2015-11-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] A single amino acid substitution in HLA-DQB1 as well as an IFNL4 variant strongly affect susceptibility to chronic hepatitis C．2014
- Author(s)
  Miki D, Ochi H, Takahashi A, Hayes CN, Urabe Y, Abe H, et al．
- Organizer
  The Liver Meeting 2014.
- Place of Presentation
  Boston, USA.
- Year and Date
  2014-11-11
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] 当院におけるHBs抗原陰性化例の解析．2014
- Author(s)
  村上英介、柘植雅貴、藤野初枝、菅宏美、福原崇之、小林知樹、本田洋士、中原隆志、苗代典昭、大野敦司、宮木大輔、三木大樹、河岡友和、平賀伸彦、平松憲、今村道雄、兵庫秀幸、川上由育、相方浩、茶山一彰．
- Organizer
  第50回日本肝臓学会総会．
- Place of Presentation
  東京
- Year and Date
  2014-05-29
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] Two microRNA polymorphisms are associated with hepatitis B virus-related but not hepatitis C virus-related hepatocellular carcinoma in the Japanese population．2014
- Author(s)
  Miki D, Ochi H, Hayes CN, Abe H, Kawaoka T, Ono A, Akamatsu S, Nakahara T, Seki N, Murakami E, Zhang Y, Uchida T, Honda Y, Masaki K, Kan H, Tsuge M, Hiraga N, Imamura M, Kawakami Y, Aikata H, Kubo M, Chayama K．
- Organizer
  The Liver Meeting 2014.
- Place of Presentation
  Boston, USA.
- Year and Date
  2014-11-09
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] HCV感染におけるIFNL4の多型の違いによるIFN-λsの発現量とインターフェロン投与前後のインターフェロン誘導遺伝子の発現量の関係．2014
- Author(s)
  阿部弘美、三木大樹、平賀伸彦、今村道雄、柘植雅貴、小林知樹、河岡友和、川上由育、相方浩、越智秀典、茶山一彰．
- Organizer
  第50回日本肝臓学会総会．
- Place of Presentation
  東京
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] わが国におけるmiR-146aおよびmiR-196a2の遺伝子多型と肝炎ウイルス関連肝発癌リスク．2014
- Author(s)
  三木大樹、相方浩、大野敦司、卜部祐司、柘植雅貴、川上由育、久保充明、中村祐輔、茶山一彰．
- Organizer
  第73回日本癌学会学術総会．
- Place of Presentation
  横浜
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] HCV慢性化におけるHLA-DQB1の重要性：ゲノムワイド関連解析．2014
- Author(s)
  三木大樹、越智秀典、ヘイズ・ネルソン、阿部弘美、大野敦司、中原隆志、村上英介、河岡友和、柘植雅貴、平賀伸彦、今村道雄、川上由育、相方浩、高橋祥一、茶山一彰．
- Organizer
  第50回日本肝臓学会総会．
- Place of Presentation
  東京
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] HCV関連肝疾患におけるIFNL3(IL28B),IFNL4遺伝子型乖離例の頻度と抗ウイルス療法の効果の検討．2014
- Author(s)
  狩野吉康、山口将功、木村睦海、荒川智宏、中島知明、桑田靖昭、小関至、佐藤隆啓、大村卓味、髭修平、豊田成司、三木大樹、越智秀典、茶山一彰．
- Organizer
  第50回日本肝臓学会総会．
- Place of Presentation
  東京
- Year and Date
  2014-05-30
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] IFNL4/IL-28B haplotype structure and predictability of their variations for spontaneous and treatment-induced clearance of HCV infection in the Japanese population．2014
- Author(s)
  Ochi H, Miki D, Hayes CN, Abe H, Kubo M, Chayama K．
- Organizer
  The Liver Meeting 2014.
- Place of Presentation
  Boston, USA.
- Year and Date
  2014-11-09
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] Nucleotide analogue improves interferon responsiveness in HBV-infected human hepatocytes．2014
- Author(s)
  Tsuge M, Hiraga N, Murakami E, Imamura M, Abe H, Miki D, Ochi H, Hayes CN, Chayama K．
- Organizer
  The Liver Meeting 2014.
- Place of Presentation
  Boston, USA.
- Year and Date
  2014-11-11
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] Hepatitis B virus infection efficiency and immune response decreases with cell density in primary cultured hepatocytes．2014
- Author(s)
  Hayes CN, Abe H, Akamatsu S, Hiraga N, Imamura M, Tsuge M, Miki D, Aikata H, Ochi H, Ishida Y, Tateno C, Chayama K．
- Organizer
  The Liver Meeting 2014.
- Place of Presentation
  Boston, USA.
- Year and Date
  2014-11-11
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] Germline variants of highly point-mutated genes in hepatocellular carcinoma do not have strong effects on HCV-related hepatocarcinogenesis．2014
- Author(s)
  Miki D, Ochi H, Hayes CN, Ono A, Akamatsu S, Y. Urabe, Masaki K, Abe H, Kawaoka T, Nakahara T, Seki N, Murakami E, Zhang Y, Uchida T, Honda Y, Kan H, Tsuge M, Hiraga N, Imamura M, Kawakami Y, Aikata H, Kubo M, Chayama K．
- Organizer
  The Liver Meeting 2014.
- Place of Presentation
  Boston, USA.
- Year and Date
  2014-11-09
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] Pretreatment induction of ISGs in the presence of IFNL4 in hepatocytes but not in white blood cells is related with poor induction of ISGs following IFN-α therapy．2014
- Author(s)
  Abe H, Hayes CN, Hiraga N, Imamura M, Tsuge M, Miki D, Aikata H, Ochi H, Ishida Y, Tateno C, Yoshizato K, Chayama K．
- Organizer
  The Liver Meeting 2014.
- Place of Presentation
  Boston, USA.
- Year and Date
  2014-11-11
- Data Source
  KAKENHI-PROJECT-26860536
[Presentation] The IL28B SNP has a stronger regulatory effect on the expression of OAS1 than a nearby SNP located downstream of OAS1 in chronic HCV patients．2014
- Author(s)
  Miki D, Abe H, Hayes CN, Ochi H, Kawaoka T, Akamatsu S, Ono A, Nakahara T, Seki N, Murakami E, Zhang Y, Uchida T, Honda Y, Masaki K, Kan H, Tsuge M, Hiraga N, Imamura M, Kawakami Y, Aikata H, Kubo M, Chayama K．
- Organizer
  The Liver Meeting 2014.
- Place of Presentation
  Boston, USA.
- Year and Date
  2014-11-11
- Data Source
  KAKENHI-PROJECT-26860536

1. Chayama Kazuaki (00211376)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
2. 茶山弘美 (70572329)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 林亮平 (80772053)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. Hayes C.Nelson (50572327)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. ABE Hiromi

# of Collaborated Projects: 0 results

# of Collaborated Products: 11 results
6. YAMAJI Taiki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 越智秀典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 大段秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 田中友加

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 柘植雅貴

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 藤本明洋

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 松井啓隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 金井昭教

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Miki Daiki 三木 大樹

MIKI Daiki 三木 大樹

Research Projects

Research Products

Co-Researchers

ゲノム・オミックス解析による非肥満および高度肥満合併脂肪性肝疾患の病態解析Principal Investigator

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Study of NASH using human hepatocyte chimeric mouse and biopsy specimen

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Prediction of the risk of non-viral hepatocarcinogenesis by machine learning using genomic information of host and intestinal commensal bacteriaPrincipal Investigator

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Identification of novel genetic factors and genetic risk assessment models for non-viral HCCPrincipal Investigator

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Establishment of highly safe gene therapy without usage of double stranded DNA

Principal Investigator

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The investigation of genetic polymorphisms in viral-sensing pathway affecting development of diseases caused by hepatitis viruses.Principal Investigator

Principal Investigator

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[Book] 消化器・肝臓内科 第10巻第6号「SVR後肝発癌と遺伝子多型」2021

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[Journal Article] Multi-omics analysis of a fatty liver model using human hepatocyte chimeric mice.2024

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[Journal Article] Sodium-glucose cotransporter-2 inhibitors improve FibroScan-aspartate aminotransferase scores in patients with nonalcoholic fatty liver disease complicated by type 2 diabetes.2023

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[Journal Article] Increasing incidence of non-HBV- and non-HCV-related hepatocellular carcinoma: single-institution 20-year study.2021

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[Journal Article] 肝炎ウイルス排除後の肝発がん2021

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[Journal Article] In vitro analysis of hepatic stellate cell activation influenced by transmembrane 6 superfamily 2 polymorphism.2021

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[Journal Article] Comparison of liver disease state progression in patients with eradication of versus persistent infection with hepatitis C virus: Markov chain analysis.2021

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[Journal Article] Risk factors for histological progression of non-alcoholic steatohepatitis analyzed from repeated biopsy cases.2020

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Miki Daiki 三木大樹

MIKI Daiki 三木大樹

[Book] 消化器・肝臓内科　第10巻第6号「SVR後肝発癌と遺伝子多型」2021