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Yahagi Ayano  矢作 綾野

ORCIDConnect your ORCID iD *help
Researcher Number 10584873
Other IDs
Affiliation (Current) 2025: 東京女子医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help 2023 – 2025: 東京女子医科大学, 医学部, 助教
2014 – 2021: 川崎医科大学, 医学部, 助教
Review Section/Research Field
Principal Investigator
Basic Section 54010:Hematology and medical oncology-related / Collagenous pathology/Allergology
Except Principal Investigator
Experimental pathology / Basic Section 54010:Hematology and medical oncology-related / Basic Section 54030:Infectious disease medicine-related / Basic Section 59010:Rehabilitation science-related
Keywords
Principal Investigator
マイコプラズマ / ノックインモデル / Col1a1-ECFP / 線維芽細胞様滑膜細胞 (FLS) / Mycoplasma fermentans / 関節炎動物モデル / 関節滑膜組織 / 獲得免疫 / 自然免疫 / Mycoplasma fermentans感染 / gp130F759 / 関節リウマチ … More
Except Principal Investigator
… More マクロファージ / BST-1/CD157 / ADPリボシルシクラーゼ / とトンボポエチン / ライソソーム / 血小板分化 / ミトコンドリア / オルガネラ / 血小板 / 巨核球 / 造血幹細胞 / TLR / B細胞 / 細胞膜外酵素 / 自然免疫 / 抗体産生 / IL-6 / 辺縁帯B細胞 / 滑膜 / 関節リウマチモデル / CD38 / CD157レポーターマウス / CX3CR1 / 単球・マクロファージ亜集団 / マクロファージ様滑膜細胞 / gp130F759 / CD157 / BST-1 / 骨髄系細胞特異的BST-1欠損 / gp130 / Bst1-flox / TLR2 / ROS産生 / 可溶性BST-1 / 血管新生 / IL-6/gp130 / 末梢血単球亜集団 / 滑膜炎 / preclinical phase / 線維化 / 滑膜細胞 / IL-6/gp130/STAT3 / 関節リウマチ / 活性酸素 / Toll様受容体2 / 単球・マクロファージ / 結核 / ノックアウトマウス / 腸内常在細菌叢 / 無菌化(germ free) / 1型胸腺非依存性抗原 / メタボローム解析 / 腸管内常在細菌叢 / 無菌マウス / 腸内細菌叢 Less
  • Research Projects

    (7 results)
  • Research Products

    (35 results)
  • Co-Researchers

    (14 People)
  •  トロンボポエチンによる急性期炎症時の骨髄および末梢血のリンパ球免疫応答の解析Principal Investigator

    • Principal Investigator
      矢作 綾野
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Tokyo Women's Medical University
  •  Analysis of organelle functions for the homeostasis of hematopoietic stem cells and platelet production

    • Principal Investigator
      石津 綾子
    • Project Period (FY)
      2022 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      Tokyo Women's Medical University
  •  脳梗塞後リハビリテーションによる大脳基底核経路ネットワーク改変メカニズムの解明

    • Principal Investigator
      岡部 直彦
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59010:Rehabilitation science-related
    • Research Institution
      Kawasaki Medical School
  •  A novel regulatory mechanism for innate immune signals by ectoenzymes BST-1 and CD38

    • Principal Investigator
      Iseki Masanori
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54030:Infectious disease medicine-related
    • Research Institution
      Kawasaki Medical School
  •  Roles for CD157 in functions of macrophage lineage cells and early pathophysiology of a rheumatoid arthritis model

    • Principal Investigator
      Ishihara Katsuhiko
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Kawasaki Medical School
  •  Histological changes of the synovial tissues and involvement of acquired immunity in a murine model for rheumatoid arthritis induced by infection with Mycoplasma fermentans.Principal Investigator

    • Principal Investigator
      Yahagi Ayano
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Kawasaki Medical School
  •  Function of extracellular ADP-ribosyl cyclase BST-1/CD157 in the intestine

    • Principal Investigator
      Katsuhiko Ishihara
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      Kawasaki Medical School

All 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] Imatinib has minimal effects on inflammatory and osteopenic phenotypes in a murine cherubism model2021

    • Author(s)
      Mukai Tomoyuki、Akagi Takahiko、Hiramatsu Asano Sumie、Tosa Ikue、Ono Mitsuaki、Kittaka Mizuho、Ueki Yasuyoshi、Yahagi Ayano、Iseki Masanori、Oohashi Toshitaka、Ishihara Katsuhiko、Morita Yoshitaka
    • Journal Title

      Oral Diseases

      Volume: - Issue: 3 Pages: 0-0

    • DOI

      10.1111/odi.14073

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08943, KAKENHI-PROJECT-19H03842, KAKENHI-PROJECT-21K08484, KAKENHI-PROJECT-20K21678
  • [Journal Article] CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production2019

    • Author(s)
      Yang Qianting、Liao Mingfeng、Wang Wenfei、Zhang Mingxia、Chen Qi、Guo Jiubiao、Peng Bin、Huang Jian、Liu Haiying、Yahagi Ayano、Xu Xingzhi、Ishihara Katsuhiko、Cooper Andrea、Chen Xinchun、Cai Yi
    • Journal Title

      mBio

      Volume: 10 Issue: 4

    • DOI

      10.1128/mbio.01949-19

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08798, KAKENHI-PROJECT-19K08943, KAKENHI-PROJECT-17K16217
  • [Journal Article] IL-6-PAD4 axis in the earliest phase of arthritis in knock-in gp130F759 mice, a model for rheumatoid arthritis2019

    • Author(s)
      Yahagi Ayano、Saika Taro、Hirano Hiroyasu、Takai-Imamura Miwa、Tsuji Fumio、Aono Hiroyuki、Iseki Masanori、Morita Yoshitaka、Igarashi Hideya、Saeki Yukihiko、Ishihara Katsuhiko
    • Journal Title

      RMD Open

      Volume: 5 Issue: 2 Pages: e000853-e000853

    • DOI

      10.1136/rmdopen-2018-000853

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08798, KAKENHI-PROJECT-19K08943, KAKENHI-PROJECT-17K16217
  • [Presentation] 関節リウマチモデルgp130F759の最初期滑膜細胞におけるシングルセルRNA-seq解析2021

    • Author(s)
      矢作 綾野、井関 將典、石原 克彦
    • Organizer
      第65回日本リウマチ学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-17K08798
  • [Presentation] Lack of bone marrow stromal cell antigen-1 (BST-1)/CD157 ameliorated colitis induced by dextran sodium sulfate (DSS)2021

    • Author(s)
      Katsuhiko Ishihara , Ayano Yahagi , Masanori Iseki , Ryo Katsumata , Akiko Shiotani
    • Organizer
      Virtual Immunology 2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08798
  • [Presentation] 関節リウマチモデルgp130F759の最初期滑膜細胞のシングルセルRNA-seq解析2021

    • Author(s)
      矢作 綾野、井関 將典、石原 克彦
    • Organizer
      第65回日本リウマチ学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-19K08943
  • [Presentation] The investigation of the pathogenesis of TNF Receptor-Associated Periodic Syndrome (TRAPS) using murine TRAPS models2021

    • Author(s)
      赤木貴彦, 向井知之, 浅野澄恵, 井関將典, 矢作綾野, 平野紘康, 中野和久, 石原克彦, 守田吉孝
    • Organizer
      The 50th Annual Meeting of the Japanese Society for Immunology(JSI2021)
    • Data Source
      KAKENHI-PROJECT-19K08943
  • [Presentation] Lack of bone marrow stromal cell antigen-1 (BST-1)/CD157 ameliorated colitis induced by dextran sodium sulfate (DSS)2021

    • Author(s)
      Katsuhiko Ishihara, Ayano Yahagi, Ryo Katsumata, Akiko Shiotani, Masanori Iseki
    • Organizer
      VIRTUAL IMMUNOLOGY2021
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08943
  • [Presentation] 関節リウマチモデルgp130F759の最初期病変におけるIL-6-PAD4連関2020

    • Author(s)
      矢作 綾野、井関 將典、石原 克彦
    • Organizer
      第64回日本リウマチ学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-19K08943
  • [Presentation] BST-1/CD157の欠損による滑膜線維芽細胞のIL-6産生低下により、GP130F759の関節炎における線維化が軽減した。2020

    • Author(s)
      石原 克彦, 矢作 綾野, 井関 將典
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K08798
  • [Presentation] BST-1/CD157の欠損による滑膜線維芽細胞のIL-6産生低下により、GP130F759の関節炎における線維化が軽減した。2020

    • Author(s)
      石原 克彦, 矢作 綾野, 井関 將典
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19K08943
  • [Presentation] BST-1/CD157はDSS誘発性大腸炎における腸上皮の傷害を促進させる2020

    • Author(s)
      矢作 綾野、井関 將典、石原 克彦
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K08798
  • [Presentation] BST-1/CD157はDSS誘発性大腸炎における腸上皮の傷害を促進させる2020

    • Author(s)
      矢作 綾野、井関 將典、石原 克彦
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19K08943
  • [Presentation] 関節リウマチモデルgp130F759の最初期病変におけるIL-6-PAD4連関 -滑膜線維芽細胞と好中球の相互作用-2020

    • Author(s)
      矢作 綾野、井関 將典、石原 克彦
    • Organizer
      第64回日本リウマチ学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-17K08798
  • [Presentation] IL-6-PAD4 axis: IL-6 dependent PAD4 production in neutrophils at the earliest phase of arthritis in gp130F759.2019

    • Author(s)
      Ayano Yahagi, Taro Saika, Masanori Iseki, Katsuhiko Ishihara
    • Organizer
      The 48th Annual Meeting of the Japanese for Immunology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08798
  • [Presentation] Toll-like receptor-induced Ab production from marginal zone B cells is negatively regulated by ADP-ribosyl cyclase BST-1/CD1572019

    • Author(s)
      Masanori Iseki, Ayano Yahagi, Katsuhiko Ishihara
    • Organizer
      The 48th Annual Meeting of the Japanese Society for Immunology
    • Data Source
      KAKENHI-PROJECT-19K08943
  • [Presentation] CX3CR1-eGFP+macrophage-like synoviocytes in gp130F759, a mouse model for rheumatoid arthritis2019

    • Author(s)
      Ayano Yahagi, Yujiro Yokoyama, Noritaka Tsunematsu, Masanori Iseki, Katsuhiko Ishihara.
    • Organizer
      The 26th International Symposium on Molecular Cell Biology of Macrophages
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08798
  • [Presentation] IL-6-PAD4 axis: IL-6 dependent PAD4 production in neutrophils at the earliest phase of arthritis in gp130F7592019

    • Author(s)
      Ayano Yahagi, Taro Saika, Masanori Iseki, Katsuhiko Ishihara
    • Organizer
      The 48th Annual Meeting of the Japanese for Immunology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16217
  • [Presentation] 関節リウマチ(RA)モデルgp130F759の最初期変化とM.fermentansの影響2019

    • Author(s)
      矢作 綾野、井関 將典、石原 克彦
    • Organizer
      第34回自己免疫研究会
    • Data Source
      KAKENHI-PROJECT-17K16217
  • [Presentation] CX3CR1-eGFP+ macrophage-like synoviocytes in gp130F759, a mouse model for rheumatoid arthritis2019

    • Author(s)
      Ayano Yahagi, Yujiro Yokoyama, Noritaka Tsunematsu, Masanori Iseki, Katsuhiko Ishihara
    • Organizer
      The 26th International Symposium on Molecular Cell Biology of Macrophages
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16217
  • [Presentation] Toll-like receptor-induced Ab production from marginal zone B cells is negatively regulated by ADP-ribosyl cyclase BST-1/CD1572019

    • Author(s)
      Masanori Iseki, Ayano Yahagi, Katsuhiko Ishihara
    • Organizer
      The 48th Annual Meeting of the Japanese Society for Immunology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08798
  • [Presentation] Accelerated onset of arthritis by systemic infection of Mycoplasma fermentans in the knock-in mice gp130F7592018

    • Author(s)
      Ayano YAHAGI, Taro SAIKA, Hiroyasu HIRANO, Masanori ISEKI, Katsuhiko ISHIHARA
    • Organizer
      IMMUNOLOGY 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K16217
  • [Presentation] Deletion of padi4 exacerbated the arthritis in gp130F759.2018

    • Author(s)
      Ayano Yahagi, Masanori Iseki, Kazuhiko Yamamoto, Katsuhiko Ishihara
    • Organizer
      The 47th Annual Meeting of the Japanese Society for Immunology, Fukuoka
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08798
  • [Presentation] A novel function of ADP-ribosyl cyclases to regulate the length of the small intestine revealed in CD38/CD157 double knockout mice.2018

    • Author(s)
      Katsuhiko Ishihara, Ayano Yahagi, Masanori Iseki
    • Organizer
      IMMUNOLOGY 2018, 2018.5.4-8, Austin,Texas
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08798
  • [Presentation] BST-1/CD157 negatively regulates marginal zone B cell survival and Ab production induced with Toll-like receptor stimulation2018

    • Author(s)
      Masanori Iseki, Ayano Yahagi, Katsuhiko Ishihara
    • Organizer
      The 47th Annual Meeting of the Japanese Society for Immunology, Fukuoka
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08798
  • [Presentation] Elongation of the small intestine and enlargement of the mesenteric lymph nodes in Bst1Cd38 double knockout mice.2018

    • Author(s)
      Katsuhiko Ishihara, Ayano Yahagi, Masanori Iseki
    • Organizer
      The 47th Annual Meeting of the Japanese Society for Immunology, Fukuoka
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08798
  • [Presentation] BST-1/CD157 on B cells negatively regulates Toll-like receptor signaling2017

    • Author(s)
      Masanori Iseki, Ayano Yahagi, Katsuhiko Ishihara
    • Organizer
      第46回日本免疫学会学術集会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08798
  • [Presentation] 関節リウマチモデルgp130F759の初期病態において関節のPadi4遺伝子が増強する2017

    • Author(s)
      矢作 綾野, 石原 克彦
    • Organizer
      第28回 日本生体防御学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08798
  • [Presentation] Padi4 expression by neutrophils in the synovium appears in the earliest phase of arthritis in gp130F7592016

    • Author(s)
      Ayano YAHAGI, Taro SAIKA, Katsuhiko ISHIHARA
    • Organizer
      日本免疫学会
    • Place of Presentation
      沖縄コンベンションセンター(宜野湾市)
    • Year and Date
      2016-12-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460499
  • [Presentation] Systemic infection with Mycoplasma fermentans facilitates development of arthritis in the knock-in mice gp130F759 through the action of neutrophils.2016

    • Author(s)
      Ayano YAHAGI, Hiroyasu HIRANO, Katsuhiko ISHIHARA
    • Organizer
      8th International forum on rheumatoid arthritis 2016
    • Place of Presentation
      品川プリンスホテル(東京)
    • Year and Date
      2016-10-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460499
  • [Presentation] Eosinophils are not essential for pathological reactions in experimental allergic rhinitis, but suppress IgE production.2016

    • Author(s)
      Taro Saika, Ayano Yahagi, Katsuhiko Ishihara, Yukiyoshi Hyo, Tamotsu Harada
    • Organizer
      日本免疫学会
    • Place of Presentation
      沖縄コンベンションセンター(宜野湾市)
    • Year and Date
      2016-12-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460499
  • [Presentation] Lack of microbiota revealed the role for BST-1/CD157 to maintain the homeostasis at mucosa-MLN interface2016

    • Author(s)
      Katsuhiko ISHIHARA, Ayano YAHAGI, Takaaki NISHIMOTO, Masanori ISEKI
    • Organizer
      日本免疫学会
    • Place of Presentation
      沖縄コンベンションセンター(宜野湾市)
    • Year and Date
      2016-12-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460499
  • [Presentation] Mycoplasma fermentans感染により早期化するgp130F759の関節炎発症は好中球依存性である2016

    • Author(s)
      矢作 綾野、石原 克彦
    • Organizer
      第27回日本生体防御学会
    • Place of Presentation
      九州大学病院キャンパスコラボステーションI(福岡市)
    • Year and Date
      2016-07-07
    • Data Source
      KAKENHI-PROJECT-26460499
  • [Presentation] Enhanced TI-1 antigen responses in BST-1/CD157 knock-out mice of C57BL/6J background.2015

    • Author(s)
      Katsuhiko Ishihara, Ayano Yahagi, Takaaki Nishimoto.
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-26460499
  • [Presentation] Critical roles of neutrophils for development of arthritis in the knock-in mouse gp130F759 induced by systemic infection of Mycoplasma fermentans2015

    • Author(s)
      Ayano YAHAGI, Hiroyasu HIRANO, Hideya IGARASHI, Katsuhiko ISHIHARA
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-26460499
  • 1.  Katsuhiko Ishihara (10263245)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 31 results
  • 2.  Iseki Masanori (30532353)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 22 results
  • 3.  五十嵐 英哉 (40291538)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 4.  岡部 直彦 (30614276)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  宮本 修 (00253287)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  佐々木 崇了 (10461253)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  西松 伸一郎 (20222185)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  丸山 恵美 (30792072)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  氷見 直之 (70412161)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  氏原 嘉洋 (80610021)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  石津 綾子 (10548548)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  菊田 幸子 (10367089)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  望月 牧子 (40751300)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  HIRANO Hiroyasu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results

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