INOUE Masafumi 井上雅文

Researcher Number	10586655
Other IDs	https://orcid.org/0000-0002-2553-053X
Affiliation (based on the past Project Information) *help	2016: 徳島大学, 先端酵素学研究所, 助教 2015: 徳島大学, 疾患プロテオゲノム研究センター, 特任助教 2013: 公益財団法人先端医療振興財団, 研究員 2012: 公益財団法人先端医療振興財団, その他部局等, 研究員 2011: 公益財団法人先端医療振興財団, 医薬品開発・支援部門, 研究員
Review Section/Research Field	Principal Investigator Medical genome science Except Principal Investigator Pathological medical chemistry
Keywords	Principal Investigator メチル化基質代謝 / DNAメチル化 / エピジェネティクス / 慢性炎症 / オメガ６系脂質 / 食事誘導性肥満 Except Principal Investigator シナプス / アミロイド / タウ / ミトコンドリア … More / カルシウム / 構造異常 / 神経細胞死 / 認知症 Less

食事誘導性肥満マウス視床下部におけるメチル化基質代謝変化に起因するエピゲノム解析Principal Investigator
- Principal Investigator
  
  井上雅文
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical genome science
- Research Institution
  The University of Tokushima
A study on the molecular mechanisms of neurodegeneration induced by high-mass amyloid-beta assembly, amylospheroids (ASPD)
- Principal Investigator
  
  HOSHI Minako
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Foundation for Biomedical Research and Innovation

All 2016 2015 2013 2012 2011 Other

All Journal Article Presentation

[Journal Article] Structural insight into an Alzheimer’s brain-derived spherical assembly of amyloid beta by solid-state NMR2015
- Author(s)
  Parthasarathy, S. Inoue, M. Xiao, Y.Matsumura, Y. Nabeshima, Y. L. Hoshi, M. Ishii, Y.
- Journal Title
  
  J. Am. Chem. Soc
  
  Volume: 137 Issue: 20 Pages: 6480-6483
- DOI
  10.1021/jacs.5b03373
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21099, KAKENHI-PLANNED-26115004
[Journal Article] Na,K-ATPaseα3 is a death target of alzheimer patient amyloid-β assembly.2015
- Author(s)
  Ohnishi T, ..., Matsui K, ..., Hoshi M （計35名, 記載欄不足）
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 112 Issue: 32 Pages: 4465-4474
- DOI
  10.1073/pnas.1421182112
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K12765, KAKENHI-PROJECT-15K21099, KAKENHI-PROJECT-221S0003, KAKENHI-PLANNED-26115004, KAKENHI-PUBLICLY-26117501, KAKENHI-PROJECT-25430048, KAKENHI-PROJECT-26750365, KAKENHI-PROJECT-25290077, KAKENHI-PROJECT-26293213, KAKENHI-PROJECT-25702054
[Journal Article] Involvement of the γ-secretase-mediated EphA4 signaling pathway in synaptic pathogenesis of Alzheimer's disease2012
- Author(s)
  Matsui C, Inoue E, Kakita A, Arita K, Deguchi-Tawarada M, Togawa A, Yamada A, Takai Y, Takahashi H
- Journal Title
  
  Brain Pathology
  
  Volume: 22 (6) Pages: 776-787
- Data Source
  KAKENHI-PROJECT-23390079
[Journal Article] Two distinct amyloid β-protein (Aβ) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology and toxicity analyses2011
- Author(s)
  Matsumura, S., Shinoda, K., Yamada, M., Yokojima, S., Inoue, M., Ohnishi, T., Shimada, T., Kikuchi, K., Masui, D., Hashimoto, S., Sato, M., Ito, A., Akioka, M., Takagi, S., Nakamura, Y., Nemoto, K., Hasegawa, Y., Takamoto, H., Inoue, H., Nakamura, S., Nabeshima, Y., Teplow, D.B., Kinjo, M., and Hoshi, M.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 286 Pages: 11555-11562
- Data Source
  KAKENHI-PROJECT-23390079
[Presentation] Dietary linoleic acid excess plays a key role in the development of obesity - a multiomics-based analysis2016
- Author(s)
  T Tanaka, M Inoue, T Sonoyama, Y Ogino, T Guo. H Koyama, K Nakao
- Organizer
  LIPID MAPS Annual Meeting
- Place of Presentation
  San Diego, CA（USA）
- Year and Date
  2016-05-17
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21099
[Presentation] Role of Dietary Linoleic Acid in the Development of Obesity--A Multiomics Analysis2016
- Author(s)
  T Tanaka, M Inoue, T Sonoyama, Y Ogino, T Guo, H Koyama, K Nakao
- Organizer
  34th Annual Scientific Meeting of The Obesity Society
- Place of Presentation
  New Orleans, LA（USA）
- Year and Date
  2016-11-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21099
[Presentation] Key role of dietary linoleic acid excess in obesity; a lipidomics-based analysis2016
- Author(s)
  T Tanaka, M Inoue, T Sonoyama, Y Ogino, T Guo, H Koyama, T Unzai, K Imaeda, K Nakao
- Organizer
  第37回日本肥満学会(The 37th Annual Meeting of Japan Siciety for the Study of Obesity)、Japan Korea Taiwan(JKT) Joint Symposium
- Place of Presentation
  東京ファッションタウンビル（東京都・江東区）
- Year and Date
  2016-10-08
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21099
[Presentation] 高脂肪食による視床下部リピドーム変化の病態生理的意義2016
- Author(s)
  田中智洋、井上雅文、園山拓洋、荻野陽平、Tingting Guo、小山博之、今枝憲郎、中尾一和
- Organizer
  第37回日本肥満学会
- Place of Presentation
  東京ファッションタウンビル（東京都・江東区）
- Year and Date
  2016-10-07
- Data Source
  KAKENHI-PROJECT-15K21099
[Presentation] Dynamism of the Hypothalamic Transcriptome Uncovers “Stages” during the Development of Diet-Induced Obesity in Mice2016
- Author(s)
  T Tanaka, T Sonoyama, H.Sawada, M.Inoue, Y Ogino, T Guo, K Nakao
- Organizer
  European Obesity Summit, Gothenburg
- Place of Presentation
  Gothenburg（Sweden）
- Year and Date
  2016-06-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21099
[Presentation] 食事誘導性肥満の発症におけるリノール酸の効果－代謝パラメータとリピドームの解析2015
- Author(s)
  井上雅文, 田中智洋, 園山拓洋, 里見佳典, 荻野陽平, Tingting Guo, 中尾一和
- Organizer
  第36回日本肥満学会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-02
- Data Source
  KAKENHI-PROJECT-15K21099
[Presentation] 食事誘導性肥満の発症におけるリノール酸の効果2015
- Author(s)
  井上雅文, 田中智洋, 園山拓洋, 里見佳典, 平山愛, 荻野陽平, Tingting Guo, 中尾一和
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K21099
[Presentation] Solid-state NMR study of pathologically relevant amyloid intermediate of 42-residue Alzheimer’s beta2013
- Author(s)
  S. Parthasarathy, M. Inoue, Y. Xiao, M. Hoshi, Y. Ishii
- Organizer
  57th annual meeting for biophysical society
- Place of Presentation
  Philadelphia
- Data Source
  KAKENHI-PROJECT-23390079
[Presentation] 14. SSNMR studies of amyloid fibril and pathologically relevant spherical amyloid amylospheroid (ASPD) for Aβ(1-42)2012
- Author(s)
  Y. Xiao, S. Parthasarathy, M. Inoue, M. Hoshi, Y. Ishii
- Organizer
  54th Experimental Nuclear Magnetic Resonance Conference
- Place of Presentation
  Pacific Grove
- Data Source
  KAKENHI-PROJECT-23390079
[Presentation] Molecular level structural studies of the Aβ(1-42) amylo-spheroids by solid-state NMR and resolution enhanced solid-state NMR by SAIL labeling and ultra fast MAS2012
- Author(s)
  S. Parthasarathy, M. Inoue, Y. Nishiyama, Y. Endo, Y. Xiao, T. Nemoto, M. Hoshi, M. Kainosho, Y. Ishii
- Organizer
  The 55th Annual Rocky Mountain Conference on Magnetic Resonance
- Place of Presentation
  Denver
- Data Source
  KAKENHI-PROJECT-23390079
[Presentation] Mechanism of mature neuron-specific toxicity induced by high-mass a myloid β-protein assembly with a unique toxic structure2011
- Author(s)
  Hoshi, M., Ohnishi, T., Inoue, M., Hiroaki, H., Nabeshima, Y., Kakita, A.
- Organizer
  The 10^<th> international conference on Alzheimer's diseases
- Place of Presentation
  Paris
- Data Source
  KAKENHI-PROJECT-23390079
[Presentation] A new toxic target for a high-mass amyloid ss-protein assembly with a unique toxic structure "International conference on Alzheimer's disease : Return to the Basics" at Annual meeting for Japanese Biochemical Societies, organized by Professors Iwata and Hoshi2011
- Author(s)
  Hoshi, M., Ohnishi, T., Inoue, M., Hiroaki, H., Nabeshima, Y., Kakita, A.
- Organizer
  Annual meeting for Japanese Biochemical Societies
- Place of Presentation
  Kyoto(オーガナイザー)(招待講演)
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-23390079
[Presentation] A new toxic target for a high-mass amyloid β-protein assembly with a unique toxic structure2011
- Author(s)
  Hoshi, M., Ohnishi, T., Inoue, M., Hiroaki, H., Nabeshima, Y., Kakita, A
- Organizer
  "International conference on Alzheimer's disease : Return to the Basics" at Annual meeting for Japanese Biochemical Societies, organized by Professors Iwata and Hoshi
- Place of Presentation
  Kyoto
- Year and Date
  2011-09-21
- Invited
- Data Source
  KAKENHI-PROJECT-23390079
[Presentation] Chemically essential substructure and solution conditions activate the amyloid-β protein as soluble and toxic spherical assembly
- Author(s)
  M. Inoue, T. Onishi, D. Masui, Y. Nabeshima, M. Hagiwara, H. Hiroaki, M. Hoshi
- Organizer
  Society for Neuroscience 2012
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-23390079
[Presentation] アミロイドβペプチドの毒性会合体形成経路の解明
- Author(s)
  井上雅文、大西隆之、廣明秀一、菊地和也、鍋島陽一、萩原正敏、金城政孝、星美奈子
- Organizer
  第7回日本ケミカルバイオロジー学会年会
- Place of Presentation
  京都
- Invited
- Data Source
  KAKENHI-PROJECT-23390079
[Presentation] Mechanism of mature neuron-specific toxicity induced by amylospheroids (ASPDs): analyses of the down-stream signal transduction pathways leading to the severe neurodegeneration.
- Author(s)
  T. Ohnishi T, M. Inoue, H. Komura, M. Tada, Y. Nabeshima, M. Hagiwara, A. Kakita and M. Hoshi M.
- Organizer
  Society for Neuroscience 2012
- Place of Presentation
  New Orleans
- Data Source
  KAKENHI-PROJECT-23390079

1. HOSHI Minako (30374010)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
2. OHNISHI Takayuki (30418959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. KAKITA Akiyoshi (80281012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
4. 松井広

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

INOUE Masafumi 井上 雅文

Research Projects

Research Products

Co-Researchers

食事誘導性肥満マウス視床下部におけるメチル化基質代謝変化に起因するエピゲノム解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A study on the molecular mechanisms of neurodegeneration induced by high-mass amyloid-beta assembly, amylospheroids (ASPD)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Structural insight into an Alzheimer’s brain-derived spherical assembly of amyloid beta by solid-state NMR2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Na,K-ATPaseα3 is a death target of alzheimer patient amyloid-β assembly.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Involvement of the γ-secretase-mediated EphA4 signaling pathway in synaptic pathogenesis of Alzheimer's disease2012

Author(s)

Journal Title

Data Source

[Journal Article] Two distinct amyloid β-protein (Aβ) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology and toxicity analyses2011

Author(s)

Journal Title

Data Source

[Presentation] Dietary linoleic acid excess plays a key role in the development of obesity - a multiomics-based analysis2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Role of Dietary Linoleic Acid in the Development of Obesity--A Multiomics Analysis2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Key role of dietary linoleic acid excess in obesity; a lipidomics-based analysis2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 高脂肪食による視床下部リピドーム変化の病態生理的意義2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Dynamism of the Hypothalamic Transcriptome Uncovers “Stages” during the Development of Diet-Induced Obesity in Mice2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 食事誘導性肥満の発症におけるリノール酸の効果－代謝パラメータとリピドームの解析2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 食事誘導性肥満の発症におけるリノール酸の効果2015

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Solid-state NMR study of pathologically relevant amyloid intermediate of 42-residue Alzheimer’s beta2013

Author(s)

Organizer

Place of Presentation

INOUE Masafumi 井上雅文