OHTSUKI Takahiro 大槻貴博

Researcher Number	10593642
Other IDs	https://orcid.org/0000-0003-0598-2130
Affiliation (based on the past Project Information) *help	2016 – 2018: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員 2013 – 2014: 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 研究員
Review Section/Research Field	Principal Investigator Basic Section 49060:Virology-related / Tumor therapeutics / Experimental pathology
Keywords	Principal Investigator 治療ワクチン / HCV / C型肝炎 / 組換えワクシニアウイルス / 感染免疫 / 免疫抑制解除 / T細胞活性化 / 細胞性免疫賦活化 / 細胞性免疫再賦活化 / HCV治療ワクチン … More / C型慢性肝炎 / マクロファージ / ワクチン / 慢性肝炎 Less

HCV特異的な細胞性免疫の抑制を解除するC型肝炎治療ワクチンの作用機序解明Principal Investigator
- Principal Investigator
  
  大槻貴博
- Project Period (FY)
  2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49060:Virology-related
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Generation and analysis of therapeutic vaccine for HCVPrincipal Investigator
- Principal Investigator
  
  OHTSUKI Takahiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
The functional mechanism of a recombinant vaccinia virus that encodes nonstructural proteins of the hepatitis C virusPrincipal Investigator
- Principal Investigator
  
  OHTSUKI Takahiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  Tokyo Metropolitan Institute of Medical Science

All 2017 2016 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model2017
- Author(s)
  Yuko Tokunaga, Yosuke Osawa, Takahiro Ohtsuki, Yukiko Hayashi, Kenzaburo Yamaji, Daisuke Yamane, Mitsuko Hara, Keisuke Munekata, Kyoko Tsukiyama-Kohara, Tsunekazu Hishima, Soichi Kojima, Kiminori Kimura, and *Michinori Kohara
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 325-325
- DOI
  10.1038/s41598-017-00282-w
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01272, KAKENHI-PROJECT-15H04739, KAKENHI-PROJECT-26460965, KAKENHI-PROJECT-26860312, KAKENHI-PROJECT-16K18467, KAKENHI-PROJECT-17K15584, KAKENHI-PROJECT-15K15146
[Journal Article] CKR-L3, a deletion version CCR6-isoform shows coreceptor-activity for limited human and simian immunodeficiency viruses.2014
- Author(s)
  Islam S, Kanbe K, Shimizu N, Ohtsuki T, Jinno-Oue A, Tanaka A, Hoshino H.
- Journal Title
  
  BMC Infect Dis.
  
  Volume: 14 Issue: 1 Pages: 354-354
- DOI
  10.1186/1471-2334-14-354
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25860305
[Journal Article] In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus2014
- Author(s)
  Watanabe T, Hatakeyama H, Matsuda-Yasui C, Sato Y, Sudoh M, Takagi A, Hirata Y, Ohtsuki T, Arai M, Inoue K, Harashima H, Kohara M
- Journal Title
  
  Scientific Reports
  
  Volume: in press Issue: 1 Pages: 4750-4750
- DOI
  10.1038/srep04750
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-24107502, KAKENHI-PROJECT-24390117, KAKENHI-PROJECT-24590988, KAKENHI-PUBLICLY-25114712, KAKENHI-PROJECT-25860305, KAKENHI-PROJECT-26893001
[Journal Article] Kinetics of peripheral hepatitis B virus-specific CD8(+) T cells in patients with onset of viral reactivation.2012
- Author(s)
  Aoki J, Kowazaki Y, Ohtsuki T, Okamoto R, Ohashi K, Hayashi S, Sakamaki H, Kohara M, Kimura K
- Journal Title
  
  J Gastroenterol
  
  Volume: 47 Issue: 6 Pages: 22-22
- DOI
  10.1007/s00535-012-0676-y
- NAID
  10031184063
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591004, KAKENHI-PROJECT-24390117, KAKENHI-PUBLICLY-25114712, KAKENHI-PROJECT-25860305
[Presentation] Heterologous prime-boost接種法によるC型肝炎ウイルス治療ワクチン効果の解析.2017
- Author(s)
  大槻貴博、塩釜ゆみ子、徳永優子、山地賢三郎、保富康宏、小原道法.
- Organizer
  第21回日本ワクチン学会学術集会
- Data Source
  KAKENHI-PROJECT-16K18467
[Presentation] C型肝炎ウイルスに対する治療ワクチンの作製と作用機序の解明2016
- Author(s)
  大槻貴博
- Organizer
  第39回分子生物学会年会
- Place of Presentation
  神奈川県横浜市パシフィコ横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16K18467
[Presentation] Tissue macrophages are responsible for inflammatory liver disease in the HCV transgenic mice.2013
- Author(s)
  Kiminori Kimura, Takahiro Ohtsuki, Yuko Tokunaga, Satoshi Sekiguchi, Michinori Kohara.
- Organizer
  The 64th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
- Place of Presentation
  Washington, USA.
- Data Source
  KAKENHI-PROJECT-25860305
[Presentation] C型肝炎トランスジェニックマウスにおいて肝臓内組織炎症性M2マクロファージが慢性肝炎を引き起こす.2013
- Author(s)
  大槻貴博, 木村公則, 徳永優子, 林幸子, 小原道法.
- Organizer
  第61回日本ウイルス学会学術集会.
- Place of Presentation
  神戸国際会議場. 兵庫
- Data Source
  KAKENHI-PROJECT-25860305
[Presentation] Tissue macrophages are responsible for inflammatory liver disease in the hepatitis C virus transgenic mice.2013
- Author(s)
  Takahiro Ohtsuki. Kiminori Kimura, Yuko Tokunaga, Hayashi Yukiko, Michinori Kohara.
- Organizer
  20th International Symposium on Hepatitis C Virus and Related Viruses.
- Place of Presentation
  Melbourne Convention and Exhibition Centre. Melbourne, Australia.
- Data Source
  KAKENHI-PROJECT-25860305
[Presentation] Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis
- Author(s)
  Yuko Tokunaga, Kiminori Kimura, Takahiro Ohtsuki, Yukiko Hayashi, Mitsuko Hara, Keisuke Munekata, Tsunekazu Hishima, Hiroyuki Kouji, Soichi Kojima, Michinori Kohara
- Organizer
  21th International symposium on Hepatitis C Virus and Related viruses
- Place of Presentation
  Banff, Canada
- Year and Date
  2014-09-07 – 2014-09-11
- Data Source
  KAKENHI-PROJECT-25860305
[Presentation] 選択的Wnt/β-catenin/CBPシグナル阻害剤による肝線維症改善作用
- Author(s)
  徳永優子、木村公則、大槻貴博、林幸子、原詳子、宗片圭祐、比島恒和、小嶋聡一、小原道法
- Organizer
  第62回日本ウイルス学会
- Place of Presentation
  パシフィコ横浜, 神奈川
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-25860305

1. KIMURA Kiminori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
2. 畠山浩人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 小原道法

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHTSUKI Takahiro 大槻 貴博

Research Projects

Research Products

Co-Researchers

HCV特異的な細胞性免疫の抑制を解除するC型肝炎治療ワクチンの作用機序解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Generation and analysis of therapeutic vaccine for HCVPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The functional mechanism of a recombinant vaccinia virus that encodes nonstructural proteins of the hepatitis C virusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis in mouse model2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] CKR-L3, a deletion version CCR6-isoform shows coreceptor-activity for limited human and simian immunodeficiency viruses.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vivo therapeutic potential of Dicer-hunting siRNAs targeting infectious hepatitis C virus2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Kinetics of peripheral hepatitis B virus-specific CD8(+) T cells in patients with onset of viral reactivation.2012

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] Heterologous prime-boost接種法によるC型肝炎ウイルス治療ワクチン効果の解析.2017

Author(s)

Organizer

Data Source

[Presentation] C型肝炎ウイルスに対する治療ワクチンの作製と作用機序の解明2016

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] Tissue macrophages are responsible for inflammatory liver disease in the HCV transgenic mice.2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] C型肝炎トランスジェニックマウスにおいて肝臓内組織炎症性M2マクロファージが慢性肝炎を引き起こす.2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Tissue macrophages are responsible for inflammatory liver disease in the hepatitis C virus transgenic mice.2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Selective inhibitor of Wnt/β-catenin/CBP signaling ameliorates hepatitis C virus-induced liver fibrosis

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] 選択的Wnt/β-catenin/CBPシグナル阻害剤による肝線維症改善作用

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

OHTSUKI Takahiro 大槻貴博