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KATO Hiroki  加藤 博己

ORCIDConnect your ORCID iD *help
Researcher Number 10597173
Other IDs
Affiliation (based on the past Project Information) *help 2018: 京都大学, ウイルス・再生医科学研究所, 准教授
2017: 京都大学, ウイルス研究所, 准教授
2016: 京都大学, ウイルス・再生医科学研究所, 准教授
2013: 京都大学, ウイルス研究所, 准教授
Review Section/Research Field
Principal Investigator
Medium-sized Section 42:Veterinary medical science, animal science, and related fields
Except Principal Investigator
Pediatrics / Biological Sciences / Virology
Keywords
Except Principal Investigator
自然免疫 / インターフェロン / ウイルス / 免疫学 / 感染症 / MAFB / 遺伝子改変マウス / 遺伝子異常 / NLRP3 / 遺伝性炎症性疾患 … More / NLRC4 / CAPS / 遺伝子探索 / 炎症 / IFIH1 / deep intron変異 / PCYT1A / 自己炎症性疾患 / 原発性免疫不全症 / 炎症性疾患 / Aicardi-Goutieres症候群 / メバロン酸キナーゼ欠損症 / 全エクソーム解析 / iPS細胞 / FLNA異常症 / NLRC4異常症 / APOBEC / 遺伝子 / ゲノム / 複製複合体 / イメージング / ストレス顆粒 / RIG-I / ストレス Less
  • Research Projects

    (4 results)
  • Research Products

    (34 results)
  • Co-Researchers

    (19 People)
  •  植物由来二本鎖RNAを用いた犬のメラノーマに対する新規治療法の確立Principal Investigator

    • Principal Investigator
      加藤 博己
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 42:Veterinary medical science, animal science, and related fields
    • Research Institution
      Kyoto University
  •  Exploration of the causative genes and elucidation of the pathophysiology on immune dysregulatory diseases with intractable inflammation

    • Principal Investigator
      Ryuta Nishikomori
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Kyoto University
  •  Competition between viruses and intracellular antiviral immunity

    • Principal Investigator
      Fujita Takashi
    • Project Period (FY)
      2012 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Viral RNA factory formation and activation of antiviral innate immunity

    • Principal Investigator
      FUJITA Takashi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Virology
    • Research Institution
      Kyoto University

All 2017 2016 2015 2014 2013 2012 2011 Other

All Journal Article Presentation Book

  • [Book] Intracellular Viral RNA Sensors: RIG.I Like Receptors in Nucleic Acid Sensors and Antiviral Immunity2011

    • Author(s)
      Seiji P. Yamamoto, Ryo Narita, Seigyoku Go, Kiyohiro Takahasi, Hiroki Kato and Takashi Fujita(Ed. Suryaprakash Sambhara and Takashi Fujita)
    • Data Source
      KAKENHI-PROJECT-23249023
  • [Journal Article] Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules.2016

    • Author(s)
      Oh SW, Onomoto K, Wakimoto M, Onoguchi K, Ishidate F, Fujiwara T, Yoneyama M, Kato H, Fujita T.
    • Journal Title

      PLoS Pathogens

      Volume: 12 Issue: 2 Pages: 1-22

    • DOI

      10.1371/journal.ppat.1005444

    • NAID

      120005763384

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K19103, KAKENHI-PUBLICLY-15H01252, KAKENHI-PROJECT-26293101, KAKENHI-PLANNED-24115004
  • [Journal Article] RIG-I-like receptors and autoimmune diseases.2015

    • Author(s)
      Kato H, Fujita T
    • Journal Title

      Curr Opin Immunol

      Volume: 37 Pages: 40-45

    • DOI

      10.1016/j.coi.2015.10.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-24115004
  • [Journal Article] The ASK family kinases differentially mediate induction of type I interferon and apoptosis during the antiviral response.2015

    • Author(s)
      Okazaki T., Higuchi M., Takeda K., Iwatsuki-Horimoto K., Kiso M., Miyagishi M., Yanai H., Kato A., Yoneyama M., Fujita T., Taniguchi T., Kawaoka Y., Ichijo H. and Gotoh Y.
    • Journal Title

      Science Signaling

      Volume: 8 Issue: 388 Pages: 1-12

    • DOI

      10.1126/scisignal.aab1883

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K06990, KAKENHI-PROJECT-24590786, KAKENHI-PLANNED-22123003, KAKENHI-PLANNED-26114009, KAKENHI-PLANNED-24115004, KAKENHI-PROJECT-25221302, KAKENHI-PROJECT-15H02357, KAKENHI-PROJECT-15H02514, KAKENHI-PROJECT-26293016, KAKENHI-PROJECT-15H05773, KAKENHI-PROJECT-15H05787
  • [Journal Article] Sensing viral invasion by RIG-I like receptors2014

    • Author(s)
      Yoo JS, Kato H, Fujita T
    • Journal Title

      Current Opinion in Microbiology

      Volume: 20 Pages: 131-138

    • DOI

      10.1016/j.mib.2014.05.012

    • NAID

      120005458276

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-24115004
  • [Journal Article] A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection.2014

    • Author(s)
      Narita R, Takahasi K, Murakami E, Hirano E, Yamamoto SP, Yoneyama M, Kato H, Fujita T.
    • Journal Title

      PLoS Pathog.

      Volume: 10 Issue: 10 Pages: 1-11

    • DOI

      10.1371/journal.ppat.1004417

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23390108, KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115004, KAKENHI-PUBLICLY-25115503, KAKENHI-PROJECT-26293101
  • [Journal Article] Autoimmunity caused by constitutive activation of cytoplasmic viral RNA sensors2014

    • Author(s)
      Kato H, Fujita T
    • Journal Title

      Cytokine & Growth Factor Reviews

      Volume: 25 Issue: 6 Pages: 739-747

    • DOI

      10.1016/j.cytogfr.2014.08.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-24115004
  • [Journal Article] Autoimmune Disorders Associated with Gain of Function of the Intracellular Sensor MDA52014

    • Author(s)
      Funabiki M, Kato H, Miyachi M, Toki H, Motegi H, Inoue M, Minowa O, Yoshida A, Deguchi K, Sato H, Ito S, Shiroishi T, Takeyasu K, Noda T and Fujita T
    • Journal Title

      Immunity

      Volume: 40 Pages: 199-212

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-24115004
  • [Journal Article] Autoimmune Disorders Associated with Gain of Function of the Intracellular Sensor MDA52014

    • Author(s)
      Funabiki M, Kato H, Miyachi M, Toki H, Motegi H, Inoue M, Minowa O, Yoshida A, Deguchi K, Sato H, Ito S, Shiroishi T, Takeyasu K, Noda T and Fujita T
    • Journal Title

      Immunity

      Volume: 40 Pages: 199-212

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249023
  • [Journal Article] Antiviral innate immunity and stress granule responses.2014

    • Author(s)
      Onomoto K, Yoneyama M, Fung G, Kato H, Fujita T.
    • Journal Title

      Trends Immunol.

      Volume: 35 Issue: 9 Pages: 420-428

    • DOI

      10.1016/j.it.2014.07.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390108, KAKENHI-PLANNED-24115004, KAKENHI-PUBLICLY-25115503, KAKENHI-PROJECT-26293101
  • [Journal Article] Aicardi-Goutières syndrome is caused by IFIH1 mutations.2014

    • Author(s)
      Oda, H., Nakagawa, K., Abe, J., Awaya, T., Funabiki, M., Hijikata, A., Nishikomori, R., Funatsuka, M., Ohshima, Y., Sugawara, Y., Yasumi, T., Kato, H., Shirai, T., Ohara, O., Fujita, T., Heike, T.
    • Journal Title

      America Journal of Human Genetics

      Volume: 95 Issue: 1 Pages: 121-125

    • DOI

      10.1016/j.ajhg.2014.06.007

    • NAID

      120005460706

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-24115004, KAKENHI-PROJECT-24370046, KAKENHI-PROJECT-24390263, KAKENHI-PROJECT-25280109, KAKENHI-PROJECT-25670474
  • [Journal Article] DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation2014

    • Author(s)
      Yoo, J-S., Takahasi, K., Ng, CS., Ouda, R., Onomoto, K., Yoneyama, M., Lai, J-C., Lattmann, S., Nagamine, Y., Matsui, T., Iwabuchi, K., Kato, H. Fujita, T.
    • Journal Title

      PLoS Pathog

      Volume: 10(3) Issue: 3 Pages: 1-18

    • DOI

      10.1371/journal.ppat.1004012

    • NAID

      120005466661

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23249023, KAKENHI-PROJECT-23310041, KAKENHI-PROJECT-23390108, KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115004, KAKENHI-PROJECT-24651056, KAKENHI-PUBLICLY-25115503, KAKENHI-PROJECT-26293101
  • [Journal Article] Virus-induced expression of retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 in the cochlear sensory epithelium2013

    • Author(s)
      Hayashi Y, Onomoto K, Narita R, Yoneyama, M, Kato H, Nakagawa T, Ito J, Taura A, Fujita T
    • Journal Title

      Microbes and Infection

      Volume: 15 Pages: 592-598

    • NAID

      120005312147

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-24115004
  • [Journal Article] Functional characterization of domains of IPS-1 using an inducible oligomerization system2013

    • Author(s)
      Takamatsu S,Onoguchi K, Onomoto K, Narita R, Takahasi K, Ishidate F, Fujiwara TK, Yoneyama M, Kato H, Fujita T
    • Journal Title

      PLoS One

      Volume: 8 Issue: 1 Pages: 1-9

    • DOI

      10.1371/journal.pone.0053578

    • NAID

      120005241348

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20112009, KAKENHI-PROJECT-23249023, KAKENHI-PROJECT-23390108, KAKENHI-PROJECT-23890029, KAKENHI-ORGANIZER-24115001, KAKENHI-PLANNED-24115004
  • [Journal Article] Encephalomyocarditis Virus Disrupts Stress Granules, the Critical Platform for Triggering Antiviral Innate Immune Responses2013

    • Author(s)
      Ng C-S, Jogi M, Yoo J-S, Onomoto K, Koike S, Iwasaki T, Yoneyama M, Kato H, Fujita T
    • Journal Title

      Journal of Virology

      Volume: 87 Pages: 9511-9522

    • NAID

      120005327032

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-24115004
  • [Journal Article] Encephalomyocarditis Virus Disrupts Stress Granules, the Critical Platform for Triggering Antiviral Innate Immune Responses2013

    • Author(s)
      Ng C-S, Jogi M, Yoo J-S, Onomoto K, Koike S, Iwasaki T, Yoneyama M, Kato H, Fujita T
    • Journal Title

      Journal of Virology

      Volume: 87 Pages: 9511-9522

    • NAID

      120005327032

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249023
  • [Journal Article] Virus-induced expression of retinoic acid inducible gene-I and melanoma differentiation-associated gene 5 in the cochlear sensory epithelium2013

    • Author(s)
      Hayashi Y, Onomoto K, Narita R, Yoneyama, M, Kato H, Nakagawa T, Ito J, Taura A, Fujita T
    • Journal Title

      Microbes and Infection

      Volume: 15 Pages: 592-598

    • NAID

      120005312147

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249023
  • [Journal Article] Recognition of viruses in the cytoplasm by RLRs and other helicases-how conformational changes, mitochondrial dynamics and ubiquitination control innate immune responses2012

    • Author(s)
      Ng C-S., Kato H. and Fujita T.
    • Journal Title

      International Immunology

      Volume: 24 Pages: 739-749

    • NAID

      120005395231

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249023
  • [Journal Article] Retinoic Acid-inducible Gene I-inducible miR-23b Inhibits Infections by Minor Group Rhinoviruses through Downregulation of the Very Low Density Lipoprotein Receptor2011

    • Author(s)
      Ouda, R., Onomoto, K., Takahasi, K., Edwards, M.R., Kato, H., Yoneyama, M. and Fujita, T.
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Pages: 26210-219

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249023
  • [Journal Article] RIG-I-like receptors : cytoplasmic sensors for non-self RNA2011

    • Author(s)
      Kato, H., Takahasi, K. and Fujita, T.
    • Journal Title

      Immunological Reviews

      Volume: 243 Pages: 91-98

    • NAID

      120005587805

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249023
  • [Presentation] Leader-containing uncapped viral transcript activates RIG-I in antiviral stress granules2017

    • Author(s)
      Seong-Wook Oh, Hiroki Kato, Takashi Fujita
    • Organizer
      Keystone Symposia, Viral Immunity
    • Place of Presentation
      Santa Fe, NM, USA
    • Year and Date
      2017-02-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-24115004
  • [Presentation] The function of antiviral signal molecule IPS-1 via mitochondria2016

    • Author(s)
      Mai Wakimoto, Fumiyoshi Ishidate, Takahiro Fujiwara, Hiroki Kato, Takashi Fujita
    • Organizer
      The 15th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Year and Date
      2016-09-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-24115004
  • [Presentation] Analysis of innate immune responses in SFTSV infection2016

    • Author(s)
      Shintaro Yamada, Masayuki Shimojima, Ryo Narita, Hiroki Kato,Masayuki Saijo, Takashi Fujita
    • Organizer
      The 15th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Year and Date
      2016-09-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-24115004
  • [Presentation] Leader-Containing Uncapped Viral Transcript Activates RIG-I in Antiviral Stress Granules2016

    • Author(s)
      Seong-Wook Oh, Koji Onomoto, Mai Wakimoto, Kazuhide Onoguchi, Fumiyoshi Ishidate, Takahiro Fujiwara, Mitsutoshi Yoneyama, Hiroki Kato, Takashi Fujita
    • Organizer
      The 15th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji, Hyogo, Japan
    • Year and Date
      2016-09-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-24115004
  • [Presentation] Leader-containing uncapped viral transcript activates RIG-I in antiviral stress granules2015

    • Author(s)
      Oh, S-W., Onomoto, K., Wakimoto, M., Onoguchi, K., Yoneyama, M., Kato, H. and Fujita, T.
    • Organizer
      The 63rd Annual Meeting of the Japanese Society for Virology
    • Place of Presentation
      Fukuoka International Congress Center
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PLANNED-24115004
  • [Presentation] ウイルス NPによる顆粒形成の機構と生理的機能の解析2012

    • Author(s)
      呉成旭、尾野本浩司、高橋清大、石館文善、加藤博己、藤田尚志
    • Organizer
      第77回日本インターフェロン・サイトカイン学会学術集会
    • Year and Date
      2012-06-21
    • Data Source
      KAKENHI-PROJECT-23249023
  • [Presentation] 抗ウイルス自然免疫応答におけるアダプター分子 IPS-1のシグナル伝達機構の解析2012

    • Author(s)
      高松詩穂里、尾野本浩司、小野口和英、米山光俊、加藤博己、藤田尚志
    • Organizer
      第77回日本インターフェロン・サイトカイン学会学術集会
    • Year and Date
      2012-06-21
    • Data Source
      KAKENHI-PROJECT-23249023
  • [Presentation] The anti-tumor agent DMXAA induces IFN-β response via STING2012

    • Author(s)
      Vo DN, Kato H, Fujita T.
    • Organizer
      The 11th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji
    • Data Source
      KAKENHI-PROJECT-23249023
  • [Presentation] DHX36 regulates innate immunity by mediating of PKR-RIG-I axis signaling pathway2012

    • Author(s)
      Yoo J-S, Kato H, Nagamine Y, Fujita T.
    • Organizer
      第77回日本インターフェロン・サイトカイン学会学術集会
    • Year and Date
      2012-06-21
    • Data Source
      KAKENHI-PROJECT-23249023
  • [Presentation] Inhibition of virus-induced interferon gene activation through modulation of cytoplasmic stress granules by a viral protease2012

    • Author(s)
      Ng C-S, Kato H, FujitaT.
    • Organizer
      The 34th Naito Conference on Infection, Immunity and their Control for Health: Mucosal Barrier, Pathogen and Vaccine
    • Place of Presentation
      Sapporo
    • Data Source
      KAKENHI-PROJECT-23249023
  • [Presentation] Recognition of Green Pepper dsRNA by Viral RNA Sensor2012

    • Author(s)
      Watanabe T, Miyata N, Kato H, Fujita T.
    • Organizer
      10th NTU-KU Joint Symposium on Molecular and Cell Biology
    • Place of Presentation
      Taipei, Taiwan
    • Data Source
      KAKENHI-PROJECT-23249023
  • [Presentation] Mechanism and Physiological Role of Granules Formed by Viral Nucleocapsid Protein2012

    • Author(s)
      Go S, Onomoto K, Ishidate F, Kato H, Fujita T.
    • Organizer
      The 11th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji
    • Data Source
      KAKENHI-PROJECT-23249023
  • [Presentation] Innate immune responses against Hepatitis B Virus in ES2

    • Author(s)
      Wan-Ling Yao, Yuuki Kaname, Sotaro Ikeda, Hiroki Kato, Takashi Fujita
    • Organizer
      The 11th JSH Single Topic Conference
    • Place of Presentation
      Hiroshima
    • Year and Date
      2014-11-21 – 2014-11-22
    • Invited
    • Data Source
      KAKENHI-PLANNED-24115004
  • [Presentation] Innate Immune Responses Against Hepatitis B Virus in ES2

    • Author(s)
      Yao, W-L., Kaname, Y., Ikeda, S., Kato, H. and Fujita, T.
    • Organizer
      International Meeting on Molecular Mechanism of Hepatitis B Viruses
    • Place of Presentation
      UCLA
    • Year and Date
      2014-09-03 – 2014-09-06
    • Data Source
      KAKENHI-PLANNED-24115004
  • 1.  FUJITA Takashi (10156870)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 29 results
  • 2.  TAKAHASI Kiyohiro (90399965)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 3.  SHINDO Keisuke (10602344)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  Ryuta Nishikomori (70359800)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  OHARA Osamu (20370926)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  TOGUCHIDA Junya (40273502)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  高折 晃史 (20324626)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  八角 高裕 (00511891)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  平家 俊男 (90190173)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  斎藤 潤 (90535486)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  TANAKA Takayuki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  NAKAGAWA Kenji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  HONDA Yoshitaka
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  SHIMODERA Saeko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  OHTO Taisuke
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  ODA Hirotsugu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  ONOMOTO Koji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 18.  米山 光俊
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 19.  樋口 麻衣子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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