OHSHIMA Kousei 大島弘世

Researcher Number	10598626
Affiliation (based on the past Project Information) *help	2015: 愛媛大学, 医学部附属病院, 医員 2015: 愛媛大学, 大学院医学系研究科, 医員
Review Section/Research Field	Except Principal Investigator Neurosurgery
Keywords	Except Principal Investigator 認知機能 / 受容体機能調節タンク / 脳卒中 / 認知症 / 受容体機能調節タンパク / クロストーク / 受容体 / アンジオテンシン / AT2受容体 / レニン・アンジオテンシン系 / 血液脳関門 / 糖尿病

Elucidation of a preventive strategy against diabetic dementia induced by blood-brain barrier disruption
- Principal Investigator
  
  MOGI MASAKI
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Ehime University
Systematic Approach for the Enhancement of Cognitive Function by the Activation of Angiotensin Type 2 receptor Associated Protein
- Principal Investigator
  
  Horiuchi Masatsugu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurosurgery
- Research Institution
  Ehime University

All 2016 2015 2014 2013 Other

All Journal Article Presentation

[Journal Article] Angiotensin II type 2 inhibits vascular intimal proliferation with activation of PPARγ.2016
- Author(s)
  Kukida M, Mogi M, Ohshima K, Nakaoka H, Iwanami J, Kanno H, Tsukuda K, Chisaka T, Min LJ, Wang XL, Bai HY, Shan BS, Higaki A, Yamauchi T, Okura T, Higaki J, Horiuchi M.
- Journal Title
  
  Am J Hypertens
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293310
[Journal Article] Angiotensin II type 2 receptor signaing affects dopamine levels in the brain and prevents binge eating disorder.2015
- Author(s)
  Nakaoka H, Mogi M, Kan-no H, Tsukuda K, Ohshima K, Wang XL, Chisaka T, Bai HY, Shan BS, Kukida M, Iwanami J, Horiuchi M.
- Journal Title
  
  J Renin Angiotensin Aldosterone Syst
  
  Volume: in press
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293310
[Journal Article] Possible synergistic effect of direct angiotensin II type 2 receptor stimulation by compound 21 with memantine on prevention of cognitive decline in type 2 diabetic mice.2014
- Author(s)
  Iwanami J, Mogi M, Tsukuda K, Jing F, Ohshima K, Wang XL, Nakaoka H, Kan-no H, Chisaka T, Bai HY, Min LJ, Horiuchi M.
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 724 Pages: 9-15
- DOI
  10.1016/j.ejphar.2013.12.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24791506, KAKENHI-PROJECT-25293310, KAKENHI-PROJECT-25462220
[Journal Article] Possible role of angiotensin-converting enzyme 2 and activation of angiotensin II type 2 receptor by angiotensin-(1-7) in improvement of vascular remodeling by angiotensin II type 1 receptor blockade2014
- Author(s)
  Ohshima K, Mogi M(31人中②), et al
- Journal Title
  
  Hypertension
  
  Volume: 63 Issue: 3
- DOI
  10.1161/hypertensionaha.113.02426
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23390188, KAKENHI-PROJECT-23591048, KAKENHI-PROJECT-25293310, KAKENHI-PROJECT-26461072
[Journal Article] Direct stimulation of angiotensin II type2 receptor initiated after stroke ameliorates ischemic brain damage.2014
- Author(s)
  Min LJ, Mogi M, Tsukuda K, Jing F, Ohshima K, Nakaoka H, Kanno H, Wang XL, Chisaka T, Bai HY, Iwanami J, Horiuchi M.
- Journal Title
  
  Am J Hypertens.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293310
[Journal Article] Role of angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis in the hypotensive effect of azilsartan.2014
- Author(s)
  Iwanami J, Mogi M, Tsukuda K, Wang XL, Nakaoka H, Jing F, Ohshima K, Chisaka T, Bai HY, Kanno H, Min LJ, Horiuchi M.
- Journal Title
  
  Hypertens Res.
  
  Volume: - Issue: 7 Pages: 00015-00017
- DOI
  10.1038/hr.2014.49
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293310
[Presentation] アンジオテンシンIIタイプ2受容体直接刺激はPPAR-gamma活性化を伴って血管リモデリングを抑制する2013
- Author(s)
  大島弘世、茂木正樹、中岡裕智、閔莉娟、菅野晴美、佃架奈、千坂俊行、Huiyu Bai、王小俐、岩波純、大木元明義、檜垣實男、堀内正嗣
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪国際会議場（大阪）
- Invited
- Data Source
  KAKENHI-PROJECT-25293310
[Presentation] ACE2/Angiotensin-(1-7)/ Mas axis plays an important role on cognitive function using ACE2-deficient mice.2013
- Author(s)
  王小俐、茂木正樹、岩波純、閔莉娟、佃架奈、中岡裕智、白薈鈺、菅野晴美、大島弘世、千阪俊行、堀内正嗣
- Organizer
  脳心血管抗加齢研究会2013　併催　アンチエイジングフェスタ2013
- Place of Presentation
  梅田スカイビル（大阪）
- Data Source
  KAKENHI-PROJECT-25293310
[Presentation] Possible Synergistic Effect of Direct Angiotensin II Type 2 Receptor Stimulation by Compound 21 with Memantine on Cognitive Impairment in Type 2 Diabetic Mouse2013
- Author(s)
  Mogi M, Iwanami J, Nakaoka H, Tsukuda K, Ohshima K, Fei J, Wang XL, Chisaka T, Min LJ and Horiuchi M.
- Organizer
  Alzheimer's Association International Conference 2013
- Place of Presentation
  Boston　Convention & Exhibition Center, USA
- Invited
- Data Source
  KAKENHI-PROJECT-25293310
[Presentation] Possible roles of crosstalk between angiotensin-converting enzyme 2/ Angiotensin (1-7)/ Mas Axis and Angiotensin (1-7) angiotensin II type 2 receptor axis in vascular remodeling2013
- Author(s)
  Ohshima K, Mogi M, Nakaoka H, Iwanai J, Min LJ, Tsukuda K, Kanno H, Chisaka T, Wang XL, Ogimoto A, Higaki J, Horiuchi M
- Organizer
  High Blood Pressure Research Scientific Sessions 2013
- Place of Presentation
  New Orileans Marriot, USA
- Invited
- Data Source
  KAKENHI-PROJECT-25293310
[Presentation] Direct Angiotensin II Type 2 Receptor Stimulation by Compound 21 Prevents Vascular Dementia; Involvement of NMDA Receptor Activation2013
- Author(s)
  Mogi M, Iwanami J, Min LJ Fei J, Tsukuda K, Ohshima K, Nakaoka H, Wang XL, Chisaka T, and Horiuchi M
- Organizer
  Alzheimer's Association International Conference 2013
- Place of Presentation
  Boston Convention & Exhibition Center, USA
- Invited
- Data Source
  KAKENHI-PROJECT-25293310
[Presentation] Gain of function approach by angiotensin-(1-7) to cognitive decline in ACE2 deficient mice.2013
- Author(s)
  Wang XL, Mogi M, Iwanami J, Tsukuda K, Min LJ, Nakaoka H, Bai H, Ohshima K, Chisaka T, Horiuchi M
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪国際会議場（大阪）
- Invited
- Data Source
  KAKENHI-PROJECT-25293310
[Presentation] 血管リモデリングにおけるACE2/アンジオテンシン（1-7）/ Mas系とアンジオテンシン（1-7）/ アンジオテンシンIIタイプ2受容体系のクロストーク2013
- Author(s)
  大島弘世、茂木正樹、中岡裕智、菅野晴美、佃架奈、千坂俊行、Huiyu Bai、王小俐、閔莉娟、岩波純、大木元明義、檜垣實男、堀内正嗣
- Organizer
  第36回日本高血圧学会総会
- Place of Presentation
  大阪国際会議場（大阪）
- Invited
- Data Source
  KAKENHI-PROJECT-25293310
[Presentation] Intrauterine growth restriction is a risk of vascular remodeling
- Author(s)
  Chisaka T, Mogi M, Nakaoka H, Ohshima K, Kan-no H, Tsukuda K, Wang XL, Bai H, Min LJ, Iwanami J, Horiuchi M
- Organizer
  Joint Meeting ESH-ISH HYPERTENSION ATHENS 2014
- Place of Presentation
  Megaron Athens Imternational Conference Centre
- Year and Date
  2014-06-13 – 2014-06-16
- Data Source
  KAKENHI-PROJECT-25293310
[Presentation] Angiotensin II type2 receptor interacting protein inhibits vascular remodeling with activation of perpxispme proliferator-activated receptor gamma
- Author(s)
  Ohshima K, Mogi M, Nakaoka H, Iwanami J, Min LJ, Kan-no H, Tsukuda K, Chisaka T, Bai H, Wang XL, Ogimoto A, Higaki J, Horiuchi M
- Organizer
  Joint Meeting ESH-ISH HYPERTENSION ATHENS 2014
- Place of Presentation
  Megaron Athens Imternational Conference Centre
- Year and Date
  2014-06-13 – 2014-06-16
- Data Source
  KAKENHI-PROJECT-25293310
[Presentation] Possible Synergistic Effect of Direct Angiotensin II Type 2 Receptor Stimulation by Compound 21 with Memantine on Cognitive Impairment in Type 2 Diabetic Mouse
- Author(s)
  Masaki Mogi, Jun Iwanami, Hirotomo Nakaoka, Kana Tsukuda, Kousei Ohshima, Jing Fei, Xiaoli Wang, Toshiyuki Chisaka, Li-Juan Min and Masatsugu Horiuchi
- Organizer
  The Alzheimer's Association International Conference
- Place of Presentation
  Boston, MA, USA
- Data Source
  KAKENHI-PROJECT-25462220
[Presentation] Hypotensive mechanism of telmisartan in high salt-loading human renin and angiotensinogen transgenic mice
- Author(s)
  Iwanami J, Mogi M, Tsukuda K, Wang XL, Ohshima K, Nakaoka H, Chisaka T, Bai H, Min LJ, Horiuchi M
- Organizer
  Joint Meeting ESH-ISH HYPERTENSION ATHENS 2014
- Place of Presentation
  Megaron Athens Imternational Conference Centre
- Year and Date
  2014-06-13 – 2014-06-16
- Data Source
  KAKENHI-PROJECT-25293310
[Presentation] Improved cognitive function by angiotensin-(1-7) in ace2ko mice
- Author(s)
  Wang XL, Iwanami J, Min LJ, Nakaoka H, Tsukuda K, Bai H, Ohshima K, Chisaka T, Mogi M, Horiuchi M
- Organizer
  Joint Meeting ESH-ISH HYPERTENSION ATHENS 2014
- Place of Presentation
  Megaron Athens Imternational Conference Centre
- Year and Date
  2014-06-13 – 2014-06-16
- Data Source
  KAKENHI-PROJECT-25293310
[Presentation] Gain-of-function of cognitive impairment by angiotensin-(1-7)in ACE deficient mice
- Author(s)
  Wang XL, Mogi M, Iwanami J, Tsukuda K, Min LJ, Nakaoka H, Bai HY, Ohshima K, Chisaka T, Horiuchi M
- Organizer
  第14回日本抗加齢医学会総会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2014-06-06 – 2014-06-08
- Data Source
  KAKENHI-PROJECT-25293310
[Presentation] Synergistic inhibitory effect of rosuvastatin and an AT2 receptor agonist on vascular remodeling
- Author(s)
  Bai H, Mogi M, Nakaoka H, Kan-no H, Tsukuda K, Ohshima K, Chisaka T, Wang XL, Min LJ, Iwanami J, Horiuchi M
- Organizer
  Joint Meeting ESH-ISH HYPERTENSION ATHENS 2014
- Place of Presentation
  Megaron Athens Imternational Conference Centre
- Year and Date
  2014-06-13 – 2014-06-16
- Data Source
  KAKENHI-PROJECT-25293310

1. MOGI MASAKI (20363236)

# of Collaborated Projects: 2 results

# of Collaborated Products: 19 results
2. HORIUCHI Masatsugu (40150338)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
3. IWANAMI Jun (90624792)

# of Collaborated Projects: 2 results

# of Collaborated Products: 18 results
4. TSUKUDA Kana (90647653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results

OHSHIMA Kousei 大島 弘世

Research Projects

Research Products

Co-Researchers

Elucidation of a preventive strategy against diabetic dementia induced by blood-brain barrier disruption

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Systematic Approach for the Enhancement of Cognitive Function by the Activation of Angiotensin Type 2 receptor Associated Protein

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Angiotensin II type 2 inhibits vascular intimal proliferation with activation of PPARγ.2016

Author(s)

Journal Title

Data Source

[Journal Article] Angiotensin II type 2 receptor signaing affects dopamine levels in the brain and prevents binge eating disorder.2015

Author(s)

Journal Title

Data Source

[Journal Article] Possible synergistic effect of direct angiotensin II type 2 receptor stimulation by compound 21 with memantine on prevention of cognitive decline in type 2 diabetic mice.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Possible role of angiotensin-converting enzyme 2 and activation of angiotensin II type 2 receptor by angiotensin-(1-7) in improvement of vascular remodeling by angiotensin II type 1 receptor blockade2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Direct stimulation of angiotensin II type2 receptor initiated after stroke ameliorates ischemic brain damage.2014

Author(s)

Journal Title

Data Source

[Journal Article] Role of angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis in the hypotensive effect of azilsartan.2014

Author(s)

Journal Title

DOI

Data Source

[Presentation] アンジオテンシンIIタイプ2受容体直接刺激はPPAR-gamma活性化を伴って血管リモデリングを抑制する2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] ACE2/Angiotensin-(1-7)/ Mas axis plays an important role on cognitive function using ACE2-deficient mice.2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Possible Synergistic Effect of Direct Angiotensin II Type 2 Receptor Stimulation by Compound 21 with Memantine on Cognitive Impairment in Type 2 Diabetic Mouse2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Possible roles of crosstalk between angiotensin-converting enzyme 2/ Angiotensin (1-7)/ Mas Axis and Angiotensin (1-7) angiotensin II type 2 receptor axis in vascular remodeling2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Direct Angiotensin II Type 2 Receptor Stimulation by Compound 21 Prevents Vascular Dementia; Involvement of NMDA Receptor Activation2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Gain of function approach by angiotensin-(1-7) to cognitive decline in ACE2 deficient mice.2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] 血管リモデリングにおけるACE2/アンジオテンシン（1-7）/ Mas系とアンジオテンシン（1-7）/ アンジオテンシンIIタイプ2受容体系のクロストーク2013

Author(s)

Organizer

Place of Presentation

Data Source

[Presentation] Intrauterine growth restriction is a risk of vascular remodeling

Author(s)

OHSHIMA Kousei 大島弘世