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OHSHIMA Kousei  大島 弘世

ORCIDConnect your ORCID iD *help
Researcher Number 10598626
Affiliation (based on the past Project Information) *help 2015: 愛媛大学, 医学部附属病院, 医員
2015: 愛媛大学, 大学院医学系研究科, 医員
Review Section/Research Field
Except Principal Investigator
Neurosurgery
Keywords
Except Principal Investigator
認知機能 / 受容体機能調節タンク / 脳卒中 / 認知症 / 受容体機能調節タンパク / クロストーク / 受容体 / アンジオテンシン / AT2受容体 / レニン・アンジオテンシン系 / 血液脳関門 / 糖尿病
  • Research Projects

    (2 results)
  • Research Products

    (20 results)
  • Co-Researchers

    (4 People)
  •  Elucidation of a preventive strategy against diabetic dementia induced by blood-brain barrier disruption

    • Principal Investigator
      MOGI MASAKI
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Ehime University
  •  Systematic Approach for the Enhancement of Cognitive Function by the Activation of Angiotensin Type 2 receptor Associated Protein

    • Principal Investigator
      Horiuchi Masatsugu
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurosurgery
    • Research Institution
      Ehime University

All 2016 2015 2014 2013 Other

All Journal Article Presentation

  • [Journal Article] Angiotensin II type 2 inhibits vascular intimal proliferation with activation of PPARγ.2016

    • Author(s)
      Kukida M, Mogi M, Ohshima K, Nakaoka H, Iwanami J, Kanno H, Tsukuda K, Chisaka T, Min LJ, Wang XL, Bai HY, Shan BS, Higaki A, Yamauchi T, Okura T, Higaki J, Horiuchi M.
    • Journal Title

      Am J Hypertens

      Volume: in press

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293310
  • [Journal Article] Angiotensin II type 2 receptor signaing affects dopamine levels in the brain and prevents binge eating disorder.2015

    • Author(s)
      Nakaoka H, Mogi M, Kan-no H, Tsukuda K, Ohshima K, Wang XL, Chisaka T, Bai HY, Shan BS, Kukida M, Iwanami J, Horiuchi M.
    • Journal Title

      J Renin Angiotensin Aldosterone Syst

      Volume: in press

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293310
  • [Journal Article] Possible synergistic effect of direct angiotensin II type 2 receptor stimulation by compound 21 with memantine on prevention of cognitive decline in type 2 diabetic mice.2014

    • Author(s)
      Iwanami J, Mogi M, Tsukuda K, Jing F, Ohshima K, Wang XL, Nakaoka H, Kan-no H, Chisaka T, Bai HY, Min LJ, Horiuchi M.
    • Journal Title

      Eur J Pharmacol

      Volume: 724 Pages: 9-15

    • DOI

      10.1016/j.ejphar.2013.12.015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791506, KAKENHI-PROJECT-25293310, KAKENHI-PROJECT-25462220
  • [Journal Article] Possible role of angiotensin-converting enzyme 2 and activation of angiotensin II type 2 receptor by angiotensin-(1-7) in improvement of vascular remodeling by angiotensin II type 1 receptor blockade2014

    • Author(s)
      Ohshima K, Mogi M(31人中②), et al
    • Journal Title

      Hypertension

      Volume: 63 Issue: 3

    • DOI

      10.1161/hypertensionaha.113.02426

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23390188, KAKENHI-PROJECT-23591048, KAKENHI-PROJECT-25293310, KAKENHI-PROJECT-26461072
  • [Journal Article] Direct stimulation of angiotensin II type2 receptor initiated after stroke ameliorates ischemic brain damage.2014

    • Author(s)
      Min LJ, Mogi M, Tsukuda K, Jing F, Ohshima K, Nakaoka H, Kanno H, Wang XL, Chisaka T, Bai HY, Iwanami J, Horiuchi M.
    • Journal Title

      Am J Hypertens.

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293310
  • [Journal Article] Role of angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis in the hypotensive effect of azilsartan.2014

    • Author(s)
      Iwanami J, Mogi M, Tsukuda K, Wang XL, Nakaoka H, Jing F, Ohshima K, Chisaka T, Bai HY, Kanno H, Min LJ, Horiuchi M.
    • Journal Title

      Hypertens Res.

      Volume: - Issue: 7 Pages: 00015-00017

    • DOI

      10.1038/hr.2014.49

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293310
  • [Presentation] アンジオテンシンIIタイプ2受容体直接刺激はPPAR-gamma活性化を伴って血管リモデリングを抑制する2013

    • Author(s)
      大島弘世、茂木正樹、中岡裕智、閔莉娟、菅野晴美、佃架奈、千坂俊行、Huiyu Bai、王小俐、岩波純、大木元明義、檜垣實男、堀内正嗣
    • Organizer
      第36回日本高血圧学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293310
  • [Presentation] ACE2/Angiotensin-(1-7)/ Mas axis plays an important role on cognitive function using ACE2-deficient mice.2013

    • Author(s)
      王小俐、茂木正樹、岩波純、閔莉娟、佃架奈、中岡裕智、白薈鈺、菅野晴美、大島弘世、千阪俊行、堀内正嗣
    • Organizer
      脳心血管抗加齢研究会2013 併催 アンチエイジングフェスタ2013
    • Place of Presentation
      梅田スカイビル(大阪)
    • Data Source
      KAKENHI-PROJECT-25293310
  • [Presentation] Possible Synergistic Effect of Direct Angiotensin II Type 2 Receptor Stimulation by Compound 21 with Memantine on Cognitive Impairment in Type 2 Diabetic Mouse2013

    • Author(s)
      Mogi M, Iwanami J, Nakaoka H, Tsukuda K, Ohshima K, Fei J, Wang XL, Chisaka T, Min LJ and Horiuchi M.
    • Organizer
      Alzheimer's Association International Conference 2013
    • Place of Presentation
      Boston Convention & Exhibition Center, USA
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293310
  • [Presentation] Possible roles of crosstalk between angiotensin-converting enzyme 2/ Angiotensin (1-7)/ Mas Axis and Angiotensin (1-7) angiotensin II type 2 receptor axis in vascular remodeling2013

    • Author(s)
      Ohshima K, Mogi M, Nakaoka H, Iwanai J, Min LJ, Tsukuda K, Kanno H, Chisaka T, Wang XL, Ogimoto A, Higaki J, Horiuchi M
    • Organizer
      High Blood Pressure Research Scientific Sessions 2013
    • Place of Presentation
      New Orileans Marriot, USA
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293310
  • [Presentation] Direct Angiotensin II Type 2 Receptor Stimulation by Compound 21 Prevents Vascular Dementia; Involvement of NMDA Receptor Activation2013

    • Author(s)
      Mogi M, Iwanami J, Min LJ Fei J, Tsukuda K, Ohshima K, Nakaoka H, Wang XL, Chisaka T, and Horiuchi M
    • Organizer
      Alzheimer's Association International Conference 2013
    • Place of Presentation
      Boston Convention & Exhibition Center, USA
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293310
  • [Presentation] Gain of function approach by angiotensin-(1-7) to cognitive decline in ACE2 deficient mice.2013

    • Author(s)
      Wang XL, Mogi M, Iwanami J, Tsukuda K, Min LJ, Nakaoka H, Bai H, Ohshima K, Chisaka T, Horiuchi M
    • Organizer
      第36回日本高血圧学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293310
  • [Presentation] 血管リモデリングにおけるACE2/アンジオテンシン(1-7)/ Mas系とアンジオテンシン(1-7)/ アンジオテンシンIIタイプ2受容体系のクロストーク2013

    • Author(s)
      大島弘世、茂木正樹、中岡裕智、菅野晴美、佃架奈、千坂俊行、Huiyu Bai、王小俐、閔莉娟、岩波純、大木元明義、檜垣實男、堀内正嗣
    • Organizer
      第36回日本高血圧学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25293310
  • [Presentation] Intrauterine growth restriction is a risk of vascular remodeling

    • Author(s)
      Chisaka T, Mogi M, Nakaoka H, Ohshima K, Kan-no H, Tsukuda K, Wang XL, Bai H, Min LJ, Iwanami J, Horiuchi M
    • Organizer
      Joint Meeting ESH-ISH HYPERTENSION ATHENS 2014
    • Place of Presentation
      Megaron Athens Imternational Conference Centre
    • Year and Date
      2014-06-13 – 2014-06-16
    • Data Source
      KAKENHI-PROJECT-25293310
  • [Presentation] Angiotensin II type2 receptor interacting protein inhibits vascular remodeling with activation of perpxispme proliferator-activated receptor gamma

    • Author(s)
      Ohshima K, Mogi M, Nakaoka H, Iwanami J, Min LJ, Kan-no H, Tsukuda K, Chisaka T, Bai H, Wang XL, Ogimoto A, Higaki J, Horiuchi M
    • Organizer
      Joint Meeting ESH-ISH HYPERTENSION ATHENS 2014
    • Place of Presentation
      Megaron Athens Imternational Conference Centre
    • Year and Date
      2014-06-13 – 2014-06-16
    • Data Source
      KAKENHI-PROJECT-25293310
  • [Presentation] Possible Synergistic Effect of Direct Angiotensin II Type 2 Receptor Stimulation by Compound 21 with Memantine on Cognitive Impairment in Type 2 Diabetic Mouse

    • Author(s)
      Masaki Mogi, Jun Iwanami, Hirotomo Nakaoka, Kana Tsukuda, Kousei Ohshima, Jing Fei, Xiaoli Wang, Toshiyuki Chisaka, Li-Juan Min and Masatsugu Horiuchi
    • Organizer
      The Alzheimer's Association International Conference
    • Place of Presentation
      Boston, MA, USA
    • Data Source
      KAKENHI-PROJECT-25462220
  • [Presentation] Hypotensive mechanism of telmisartan in high salt-loading human renin and angiotensinogen transgenic mice

    • Author(s)
      Iwanami J, Mogi M, Tsukuda K, Wang XL, Ohshima K, Nakaoka H, Chisaka T, Bai H, Min LJ, Horiuchi M
    • Organizer
      Joint Meeting ESH-ISH HYPERTENSION ATHENS 2014
    • Place of Presentation
      Megaron Athens Imternational Conference Centre
    • Year and Date
      2014-06-13 – 2014-06-16
    • Data Source
      KAKENHI-PROJECT-25293310
  • [Presentation] Improved cognitive function by angiotensin-(1-7) in ace2ko mice

    • Author(s)
      Wang XL, Iwanami J, Min LJ, Nakaoka H, Tsukuda K, Bai H, Ohshima K, Chisaka T, Mogi M, Horiuchi M
    • Organizer
      Joint Meeting ESH-ISH HYPERTENSION ATHENS 2014
    • Place of Presentation
      Megaron Athens Imternational Conference Centre
    • Year and Date
      2014-06-13 – 2014-06-16
    • Data Source
      KAKENHI-PROJECT-25293310
  • [Presentation] Gain-of-function of cognitive impairment by angiotensin-(1-7)in ACE deficient mice

    • Author(s)
      Wang XL, Mogi M, Iwanami J, Tsukuda K, Min LJ, Nakaoka H, Bai HY, Ohshima K, Chisaka T, Horiuchi M
    • Organizer
      第14回日本抗加齢医学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-06-06 – 2014-06-08
    • Data Source
      KAKENHI-PROJECT-25293310
  • [Presentation] Synergistic inhibitory effect of rosuvastatin and an AT2 receptor agonist on vascular remodeling

    • Author(s)
      Bai H, Mogi M, Nakaoka H, Kan-no H, Tsukuda K, Ohshima K, Chisaka T, Wang XL, Min LJ, Iwanami J, Horiuchi M
    • Organizer
      Joint Meeting ESH-ISH HYPERTENSION ATHENS 2014
    • Place of Presentation
      Megaron Athens Imternational Conference Centre
    • Year and Date
      2014-06-13 – 2014-06-16
    • Data Source
      KAKENHI-PROJECT-25293310
  • 1.  MOGI MASAKI (20363236)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 19 results
  • 2.  HORIUCHI Masatsugu (40150338)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 18 results
  • 3.  IWANAMI Jun (90624792)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 18 results
  • 4.  TSUKUDA Kana (90647653)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results

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