yamashita masahiro 山下雅大

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YAMASHITA MASAHIRO 山下雅大

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Researcher Number	10606685
Other IDs	https://orcid.org/0000-0002-4459-0642
Affiliation (Current)	2024: 岩手医科大学, 医学部, 助教
Affiliation (based on the past Project Information) *help	2023: 岩手医科大学, 医学部, 助教 2016 – 2021: 岩手医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Basic Section 52010:General internal medicine-related / Laboratory medicine
Keywords	Principal Investigator 肺線維症 / マクロファージ / 関節リウマチ / VEGFR-3 / 肺傷害 / 診断マーカー / 単球マーカー / CD206 / 表面マーカー / 単球 / 慢性閉塞性肺疾患 / 間質性肺炎

関節リウマチ合併肺線維症の病態形成に関する基盤研究Principal Investigator
- Principal Investigator
  
  山下雅大
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Iwate Medical University
A novel maker for pulmonary fibrosis using VEGFR-3-positive monocyte-lineage cells.Principal Investigator
- Principal Investigator
  
  YAMASHITA MASAHIRO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Iwate Medical University
Development of diagnostic methods in interstitial pneumonia via surface markers of macophagesPrincipal Investigator
- Principal Investigator
  
  YAMASHITA MASAHIRO
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  Iwate Medical University

All 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Patent

[Journal Article] VEGF-C/VEGFR-3 signalling in macrophages ameliorates acute lung injury.2021
- Author(s)
  Yamashita M, Niisato M, Kawasaki Y, Karaman S, Robciuc MR, Shibata Y, Ishida Y, Nishio R, Masuda T, Sugai T, Ono M, Tuder RM, Alitalo K, Yamauchi K.
- Journal Title
  
  Eur Respir J.
  
  Volume: 59 Issue: 4 Pages: 2100880-2100880
- DOI
  10.1183/13993003.00880-2021
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07894, KAKENHI-PROJECT-20K07412
[Journal Article] S100A9/CD163 expression profiles in classical monocytes as biomarkers to discriminate idiopathic pulmonary fibrosis from idiopathic nonspecific interstitial pneumonia.2021
- Author(s)
  Yamashita M, Utsumi Y, Nagashima H, Nitanai H, Yamauchi K.
- Journal Title
  
  Sci Rep.
  
  Volume: 11 Issue: 1 Pages: 12135-12135
- DOI
  10.1038/s41598-021-91407-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07894
[Journal Article] Distinct S100A9/CD163 expression profiles in classical monocytes as biomarkers to discriminate IPF from iNSIP2021
- Author(s)
  Masahiro Yamashita, Yuh Utsumi, Hiromi Nagashima, Hiroo Nitanai, Kohei Yamauchi
- Journal Title
  
  Scientific Reports
  
  Volume: in press
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07894
[Journal Article] S100A9/CD163 Expression in Circulating Classical Monocytes in Chronic Obstructive Pulmonary Disease2020
- Author(s)
  Masahiro Yamashita, Yuh Utsumi, Kohei Yamashita
- Journal Title
  
  Journal of Chronic Obstructuve Pulmonary Disease
  
  Volume: 17 Issue: 5 Pages: 587-594
- DOI
  10.1080/15412555.2020.1793925
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07894
[Journal Article] Deficiency of protein-L-isoaspartate (D-aspartate) <i>O</i>-methyl-transferase expression under endoplasmic reticulum stress promotes epithelial mesenchymal transition in lung adenocarcinoma2018
- Author(s)
  Yamashita Masahiro、Ogasawara Masahito、Kawasaki Yasushi、Niisato Miyuki、Saito Heisuke、Kasai Shuya、Maesawa Chihaya、Maemondo Makoto、Yamauchi Kohei
- Journal Title
  
  Oncotarget
  
  Volume: 9 Issue: 17 Pages: 13287-13300
- DOI
  10.18632/oncotarget.24324
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08726, KAKENHI-PROJECT-15K09237, KAKENHI-PROJECT-16K08940, KAKENHI-PROJECT-17K09658
[Journal Article] Distinct Profiles of CD163-Positive Macrophages in Idiopathic Interstitial Pneumonias2018
- Author(s)
  Yamashita M, Saito R, Yasuhira S, Fukuda Y, Sasamo H, Sugai T, Yamauchi K, Maemondo M
- Journal Title
  
  J Immunol Res
  
  Volume: 2018 Pages: 1436236-1436236
- DOI
  10.1155/2018/1436236
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08940, KAKENHI-PROJECT-15K09237, KAKENHI-PROJECT-17K08700
[Journal Article] Fractional exhaled nitric oxide levels as a predictor of long-term prognoses in patients with mild asthma.2016
- Author(s)
  Yamashita M, Shibanai M, Sekimura K, Nitanai H, Ogasawara M, Kobayashi H, Yamauchi K.
- Journal Title
  
  Respir Investig
  
  Volume: 54 Issue: 3 Pages: 139-147
- DOI
  10.1016/j.resinv.2015.11.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461164, KAKENHI-PROJECT-16K08940
[Journal Article] The protective role of protein L-isoaspartyl (D-aspartate) O-methyltransferase for maintenance of mitochondrial morphology in A549 cell.2016
- Author(s)
  Ogasawara M, Otani M, Takano M, Shudou M, Inaba Y, Nirasawa S, Takahashi S, Kiyoi T, Tanaka Y, Kameda K, Kunugita N, Maeyama K, Sano K, Yamashita M, Yamauchi K.
- Journal Title
  
  Exp Lung Res.
  
  Volume: 42 Pages: 245-62
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08940
[Journal Article] Chaperone protein l-isoaspartate (d-aspartyl) O-methyltransferase as a novel predictor of poor prognosis in lung adenocarcinoma.2016
- Author(s)
  Saito H, Yamashita M, Ogasawara M, Yamada N, Niisato M, Tomoyasu M, Deguchi H, Tanita T, Ishida K, Sugai T, Yamauchi K.
- Journal Title
  
  Hum Pathol
  
  Volume: 50 Pages: 1-10
- DOI
  10.1016/j.humpath.2015.11.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460420, KAKENHI-PROJECT-26461194, KAKENHI-PROJECT-16K08940
[Journal Article] Development of Lymphatic Capillary Network Along the Alveolar Walls of Autopsied Human Lungs with Pneumonia.2016
- Author(s)
  Yamashita M, Niisato M, Hanasaka T, Iwama N, Takahashi T, Sugai T, Ono M, Yamauchi K.
- Journal Title
  
  Lymphat Res Biol.
  
  Volume: 14 Pages: 210-219
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08940
[Patent] 特発性間質性肺炎の亜型診断における新規診断法の開発2016
- Inventor(s)
  山下雅大
- Industrial Property Rights Holder
  山下雅大
- Industrial Property Rights Type
  特許
- Filing Date
  2016
- Data Source
  KAKENHI-PROJECT-16K08940
[Patent] 特発性間質性肺炎の病型の鑑別方法2016
- Inventor(s)
  山下雅大
- Industrial Property Rights Holder
  山下雅大
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-097519
- Filing Date
  2016-05-15
- Data Source
  KAKENHI-PROJECT-16K08940
[Presentation] ARDSにおけるマクロファージVEGFR-3機能の低下2022
- Author(s)
  山下雅大　山内広平
- Organizer
  第62回日本呼吸器学会総会
- Data Source
  KAKENHI-PROJECT-19K07894
[Presentation] COPD診断マーカーとしての末梢血単球S100A9/CD1632021
- Author(s)
  山下雅大　内海裕　山内広平
- Organizer
  第61回日本呼吸器学会総会
- Data Source
  KAKENHI-PROJECT-19K07894
[Presentation] COPD診断マーカーとしての末梢血単球S100A9/CD1632021
- Author(s)
  山下雅大内海裕　山内広平
- Organizer
  第61回日本呼吸器学会総会
- Data Source
  KAKENHI-PROJECT-19K07894
[Presentation] マクロファージIGF-1シグナルの急性肺傷害修復機能2020
- Author(s)
  山下雅大　前門戸任
- Organizer
  第60回日本呼吸器学会学術講演会
- Data Source
  KAKENHI-PROJECT-19K07894
[Presentation] Distinctive polarization of circulating classical monocytes between idiopathic pulmonary fibrosis and idiopathic nonspecific interstitial pneumonia.2020
- Author(s)
  Yamashita M
- Organizer
  European Respiratory Society2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07894
[Presentation] マクロファージIGF-1シグナルの急性肺傷害修復機能2020
- Author(s)
  山下雅大、前門戸任
- Organizer
  第60回日本呼吸器学会総会
- Data Source
  KAKENHI-PROJECT-16K08940
[Presentation] 単球表面マーカーのreprogramingを指標とした間質性肺炎の新規バイオマーカー2019
- Author(s)
  山下雅大、内海裕、前門戸任
- Organizer
  第59回日本呼吸器学会総会
- Data Source
  KAKENHI-PROJECT-16K08940
[Presentation] パラコート誘発肺傷害モデルにおけるマンノース受容体の役割2019
- Author(s)
  山下雅大、山内広平、前門戸任
- Organizer
  第59回日本呼吸器学会総会
- Data Source
  KAKENHI-PROJECT-16K08940
[Presentation] 急性呼吸窮迫症候群におけるVEGF-C/-Dレベル2018
- Author(s)
  山下雅大、前門戸任
- Organizer
  第58回日本呼吸器学会総会
- Data Source
  KAKENHI-PROJECT-16K08940
[Presentation] Protective roles of mannose receptor in an experimental pulmonary fibrosis model2018
- Author(s)
  M. Yamashita, M. Niisato, Y. Kawasaki, M. Maemondo
- Organizer
  European Respiratory Society2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08940
[Presentation] Reparable roles of VEGFR-3/VEGF-C signaling on macrophages in acute lung inflammation2018
- Author(s)
  Masahiro Yamashita, Miyuki Niisato, Yasushi Kawasaki, Masao Ono, Kohei Yamauchi, Makoto Maemondo
- Organizer
  American Thoracic Society2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08940
[Presentation] 急性呼吸窮迫症候群におけるVEGF-C/-Dレベル2018
- Author(s)
  山下雅大　前門戸任
- Organizer
  第58回日本呼吸器学会
- Data Source
  KAKENHI-PROJECT-16K08940
[Presentation] 急性肺傷害の修復におけるVEGFR-3陽性マクロファージの関与2017
- Author(s)
  山下雅大、山内広平
- Organizer
  日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2017-04-21
- Data Source
  KAKENHI-PROJECT-16K08940
[Presentation] 小胞体ストレスに対するProtein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT)2017
- Author(s)
  山下雅大　小笠原正人齋藤平佐山内広平　前門戸任
- Organizer
  第57回日本呼吸器学会
- Data Source
  KAKENHI-PROJECT-16K08940
[Presentation] 小胞体ストレスに対するProtein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT)2017
- Author(s)
  山下雅大　小笠原正人齋藤平佐山内広平　前門戸任
- Organizer
  第76回日本癌学会
- Data Source
  KAKENHI-PROJECT-16K08940
[Presentation] 急性肺傷害の修復におけるVEGFR-3陽性マクロファージの関与2017
- Author(s)
  山下雅大　山内広平
- Organizer
  第57回日本呼吸器学会
- Data Source
  KAKENHI-PROJECT-16K08940
[Presentation] 小胞体ストレスに対するProtein-L-isoaspartate (D-aspartate) O-methyltransferase代償発現の不足は肺腺癌浸潤を促す2017
- Author(s)
  山下雅大、小笠原正人、斉藤平佐、山内広平
- Organizer
  日本呼吸器学会学術講演会
- Place of Presentation
  東京
- Year and Date
  2017-04-21
- Data Source
  KAKENHI-PROJECT-16K08940
[Presentation] Distinct profiles of M2 macrophage markers among idiopathic interstitial pneumonias2016
- Author(s)
  M. Yamashita, R. Saito, M. Ogasawara, Y. Fukuda, H. Sasano, T. Sugai, K. Yamauchi
- Organizer
  American Thoracic Society
- Place of Presentation
  San Francisco
- Year and Date
  2016-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08940

1. 川崎靖 (60385549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 山内広平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 前沢千早

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 菅井有

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

yamashita masahiro 山下 雅大

YAMASHITA MASAHIRO 山下 雅大

Research Projects

Research Products

Co-Researchers

関節リウマチ合併肺線維症の病態形成に関する基盤研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel maker for pulmonary fibrosis using VEGFR-3-positive monocyte-lineage cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of diagnostic methods in interstitial pneumonia via surface markers of macophagesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] VEGF-C/VEGFR-3 signalling in macrophages ameliorates acute lung injury.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] S100A9/CD163 expression profiles in classical monocytes as biomarkers to discriminate idiopathic pulmonary fibrosis from idiopathic nonspecific interstitial pneumonia.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct S100A9/CD163 expression profiles in classical monocytes as biomarkers to discriminate IPF from iNSIP2021

Author(s)

Journal Title

Data Source

[Journal Article] S100A9/CD163 Expression in Circulating Classical Monocytes in Chronic Obstructive Pulmonary Disease2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deficiency of protein-L-isoaspartate (D-aspartate) <i>O</i>-methyl-transferase expression under endoplasmic reticulum stress promotes epithelial mesenchymal transition in lung adenocarcinoma2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Distinct Profiles of CD163-Positive Macrophages in Idiopathic Interstitial Pneumonias2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Fractional exhaled nitric oxide levels as a predictor of long-term prognoses in patients with mild asthma.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The protective role of protein L-isoaspartyl (D-aspartate) O-methyltransferase for maintenance of mitochondrial morphology in A549 cell.2016

Author(s)

Journal Title

Data Source

[Journal Article] Chaperone protein l-isoaspartate (d-aspartyl) O-methyltransferase as a novel predictor of poor prognosis in lung adenocarcinoma.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Development of Lymphatic Capillary Network Along the Alveolar Walls of Autopsied Human Lungs with Pneumonia.2016

Author(s)

Journal Title

Data Source

[Patent] 特発性間質性肺炎の亜型診断における新規診断法の開発2016

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 特発性間質性肺炎の病型の鑑別方法2016

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

yamashita masahiro 山下雅大

YAMASHITA MASAHIRO 山下雅大