Yoshimura Hidekane 吉村豪兼

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YOSHIMURA Hidekane 吉村豪兼

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Researcher Number	10612997
Other IDs	https://orcid.org/0000-0001-9601-7496
Affiliation (Current)	2024: 信州大学, 学術研究院医学系(医学部附属病院), 講師
Affiliation (based on the past Project Information) *help	2024: 信州大学, 学術研究院医学系(医学部附属病院), 講師 2021 – 2022: 信州大学, 学術研究院医学系(医学部附属病院), 講師 2019 – 2020: 信州大学, 学術研究院医学系, 助教 2014 – 2016: 信州大学, 医学部, 助教(特定雇用) 2013: 信州大学, 医学部附属病院, 医員
Review Section/Research Field	Principal Investigator Basic Section 56050:Otorhinolaryngology-related / Otorhinolaryngology
Keywords	Principal Investigator 遺伝子治療 / 遺伝性難聴 / 難聴 / モデルマウス / アデノ随伴ウイルスベクター / マイクロアレイ / 遺伝子 / 聴覚 / 耳科学 / 遺伝子発現 / 内耳

遺伝性難聴に対する遺伝子治療と人工内耳のハイブリッド治療への展開Principal Investigator
- Principal Investigator
  
  吉村豪兼
- Project Period (FY)
  2024 – 2028
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Shinshu University
Tropism of AAV vectors in adult mammalian inner ear subtypesPrincipal Investigator
- Principal Investigator
  
  Yoshimura Hidekane
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56050:Otorhinolaryngology-related
- Research Institution
  Shinshu University
Usher症候群に関する遺伝的背景に関する研究Principal Investigator
- Principal Investigator
  
  吉村豪兼
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shinshu University
Comprehensive analysis of alternative splicing variants identified from tonotopical differences in the mouse cochleaPrincipal Investigator
- Principal Investigator
  
  YOSHIMURA Hidekane
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Otorhinolaryngology
- Research Institution
  Shinshu University

All 2022 2021 2020 2019 2016 2015 2014

All Journal Article Presentation

[Journal Article] Audiological Features in 63 Patients With Cochlear Nerve Deficiency2022
- Author(s)
  Matsuura Kazuki、Yoshimura Hidekane、Shinagawa Jun、Kurozumi Masahiro、Takumi Yutaka
- Journal Title
  
  Otology & Neurotology
  
  Volume: 43 Issue: 1 Pages: 23-28
- DOI
  10.1097/mao.0000000000003365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18727
[Journal Article] Clinical and molecular features of patients with <scp> <i>COL1</i> </scp> ‐related disorders: Implications for the wider spectrum and the risk of vascular complications2022
- Author(s)
  Takeda Ryojun、Yamaguchi Tomomi、Hayashi Shujiro、Sano Shinichirou、Kawame Hiroshi、Kanki Sachiko、Taketani Takeshi、Yoshimura Hidekane、Nakamura Yukio、Kosho Tomoki
- Journal Title
  
  American Journal of Medical Genetics Part A
  
  Volume: 188 Issue: 9 Pages: 2560-2575
- DOI
  10.1002/ajmg.a.62887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18727
[Journal Article] Mutation-agnostic RNA interference with engineered replacement rescues<i>Tmc1</i>-related hearing loss2022
- Author(s)
  Iwasa Yoichiro、Klimara Miles J、Yoshimura Hidekane、Walls William D、Omichi Ryotaro、West Cody A、Shibata Seiji B、Ranum Paul T、Smith Richard JH
- Journal Title
  
  Life Science Alliance
  
  Volume: 6 Issue: 3 Pages: e202201592-e202201592
- DOI
  10.26508/lsa.202201592
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18727
[Journal Article] Frequency and natural course of congenital cytomegalovirus-associated hearing loss in children2021
- Author(s)
  Kasuga Mariko、Yoshimura Hidekane、Shinagawa Jun、Nishio Shin-ya、Takumi Yutaka、Usami Shin-ichi
- Journal Title
  
  Acta Oto-Laryngologica
  
  Volume: 141 Issue: 12 Pages: 1038-1043
- DOI
  10.1080/00016489.2021.2000638
- Data Source
  KAKENHI-PROJECT-19K18727
[Journal Article] Correction to: Detailed clinical features and genotype?phenotype correlation in an OTOF-related hearing loss cohort in Japan2021
- Author(s)
  Iwasa Yoh-ichiro、Nishio Shin-ya、Yoshimura Hidekane、Sugaya Akiko et al.
- Journal Title
  
  Human Genetics
  
  Volume: 141 Issue: 3-4 Pages: 993-995
- DOI
  10.1007/s00439-021-02392-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K16890, KAKENHI-PROJECT-19K18727
[Journal Article] Vibrant soundbridge implantation prior to auricular reconstruction with unilateral microtia‐atresia2021
- Author(s)
  Yoshimura Hidekane、Takahashi Masahiro、Iwasaki Satoshi、Shinagawa Jun、Takashimizu Ikkei、Nagai Fumio、Yotsuyanagi Takatoshi、Usami Shin‐ichi
- Journal Title
  
  Clinical Case Reports
  
  Volume: 9 Issue: 8
- DOI
  10.1002/ccr3.4408
- Data Source
  KAKENHI-PROJECT-19K18727
[Journal Article] A nationwide epidemiologic, clinical, genetic study of Usher syndrome in Japan2021
- Author(s)
  Yoshimura Hidekane、Nishio Shin-ya、Isaka Yuichi、Kurokawa Toru、Usami Shin-ichi、The Interactable Hearing Disorder Consortium
- Journal Title
  
  Acta Oto-Laryngologica
  
  Volume: 141 Issue: 9 Pages: 841-846
- DOI
  10.1080/00016489.2021.1966500
- Data Source
  KAKENHI-PROJECT-19K18727
[Journal Article] Milestones toward cochlear gene therapy for patients with hereditary hearing loss2021
- Author(s)
  Yoshimura Hidekane、Nishio Shin‐Ya、Usami Shin‐Ichi
- Journal Title
  
  Laryngoscope Investigative Otolaryngology
  
  Volume: 6 Issue: 5 Pages: 958-967
- DOI
  10.1002/lio2.633
- Data Source
  KAKENHI-PROJECT-19K18727
[Journal Article] Cochlear Implantation From the Perspective of Genetic Background.2020
- Author(s)
  Usami SI, Nishio SY, Moteki H, Miyagawa M, Yoshimura H.
- Journal Title
  
  Anat Rec.
  
  Volume: 303 Issue: 3 Pages: 563-593
- DOI
  10.1002/ar.24360
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09885, KAKENHI-PROJECT-19K18727, KAKENHI-PROJECT-17K11322
[Journal Article] Hair Cell Transduction Efficiency of Single- and Dual-AAV Serotypes in Adult Murine Cochleae2020
- Author(s)
  Omichi Ryotaro、Yoshimura Hidekane、Shibata Seiji B.、Vandenberghe Luk H.、Smith Richard J.H.
- Journal Title
  
  Molecular Therapy - Methods & Clinical Development
  
  Volume: 17 Pages: 1167-1177
- DOI
  10.1016/j.omtm.2020.05.007
- NAID
  120006869551
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18727
[Journal Article] A comparative analysis of genetic hearing loss phenotypes in European/American and Japanese populations.2020
- Author(s)
  Walls WD, Moteki H, Thomas TR, Nishio SY, Yoshimura H, Iwasa Y, et al
- Journal Title
  
  Hum Genet
  
  Volume: NA Issue: 10 Pages: 1315-1323
- DOI
  10.1007/s00439-020-02174-y
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16900, KAKENHI-PROJECT-19K18727
[Journal Article] Genetic testing has the potential to impact hearing preservation following cochlear implantation2020
- Author(s)
  Yoshimura Hidekane、Moteki Hideaki、Nishio Shin-ya、Miyajima Hiroki、Miyagawa Maiko、Usami Shin-ichi
- Journal Title
  
  Acta Oto-Laryngologica
  
  Volume: 5 Issue: 6 Pages: 1-7
- DOI
  10.1080/00016489.2020.1730439
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K18727, KAKENHI-PROJECT-19K09885
[Journal Article] Electric-acoustic stimulation with longer electrodes for potential deterioration in low-frequency hearing2020
- Author(s)
  Yoshimura Hidekane、Moteki Hideaki、Nishio Shin-ya、Usami Shin-ichi
- Journal Title
  
  Acta Oto-Laryngologica
  
  Volume: 140 Issue: 8 Pages: 624-630
- DOI
  10.1080/00016489.2020.1760351
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18727
[Journal Article] USH2 Caused by GPR98 Mutation Diagnosed by Massively Parallel Sequencing in Advance of the Occurrence of Visual Symptoms.2015
- Author(s)
  Moteki H, Yoshimura H, Azaiez H, Booth KT, Shearer AE, Sloan CM, Kolbe DL, Murata T, Smith RJ, Usami SI.
- Journal Title
  
  Ann Otol Rhinol Laryngol
  
  Volume: 124
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670715
[Journal Article] Identification of a Novel CLRN1 Gene Mutation in Usher Syndrome Type 3: Two Case Reports.2015
- Author(s)
  Yoshimura H, Oshikawa C, Nakayama J, Moteki H, Usami SI.
- Journal Title
  
  Ann Otol Rhinol Laryngol
  
  Volume: 124
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670715
[Journal Article] Novel ABHD12 Mutations in PHARC Patients: The Differential Diagnosis of Deaf-Blindness.2015
- Author(s)
  Yoshimura H, Hashimoto T, Murata T, Fukushima K, Sugaya A, Nishio SY, Usami SI.
- Journal Title
  
  Ann Otol Rhinol Laryngol
  
  Volume: 124
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670715
[Journal Article] Massively parallel DNA sequencing facilitates diagnosis of patients with Usher syndrome type 12014
- Author(s)
  Yoshimura H, Iwasaki S, Nishio SY, Kumakawa K, Tono T, Kobayashi Y, Sato H, Nagai K, Ishikawa K, Ikezono T, Naito Y, Fukushima K, Oshikawa C, Kimitsuki T, Nakanishi H, Usami S.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 3 Pages: e90688-e90688
- DOI
  10.1371/journal.pone.0090688
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25670715
[Journal Article] Deafness gene expression patterns in the mouse cochlea found by microarray analysis.2014
- Author(s)
  Yoshimura H, Takumi Y, Nishio SY, Suzuki N, Iwasa Y, Usami S.
- Journal Title
  
  PLoS One.
  
  Volume: 9 Issue: 3 Pages: e92547-e92547
- DOI
  10.1371/journal.pone.0092547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25670715
[Presentation] EAS with longer electrodes2022
- Author(s)
  Hidekane Yoshimura, Yutaka Takumi, Shin-ichi Usami
- Organizer
  18th Japan-Korea Joint Meeting of Otorhinolaryngology - Head and Neck Surgery
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] Milestone toward cochlear gene therapy for patients with hereditary hearing loss2022
- Author(s)
  Hidekane Yoshimura, Yutaka Takumi, Shin-ichi Usami
- Organizer
  7th East Asian Symposium on Otology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] 遺伝性難聴モデルとしてのC57BL/6マウスの検証2022
- Author(s)
  吉村豪兼, 西尾信哉, 宇佐美真一, 工穣
- Organizer
  第31回　日本耳科学会学術講演会
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] マウス内耳へのサイズの大きい遺伝子導入を可能にするTriple AAV approach2022
- Author(s)
  吉村豪兼, 工穣
- Organizer
  第32回　日本耳科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] Enhanced cochlear transgene delivery in adult mice - toward the investigation of gene therapy for hearing loss2022
- Author(s)
  Hidekane Yoshimura, Ryotaro Omichi, Seiji B. Shibata, Richard JH Smith, Yutaka Takumi
- Organizer
  The 4th World Congress on Endoscopic Ear
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] 成体マウスを用いた内耳研究のための解剖・手技2022
- Author(s)
  吉村豪兼
- Organizer
  第31回　日本耳科学会学術講演会
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] EAS 手術時の術中蝸電図モニタリングの有用性と限界2022
- Author(s)
  吉村豪兼、品川潤、權田綾子、工穣、宇佐美真一
- Organizer
  第67回　日本聴覚医学会総会・学術研究会
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] How do we select the proper array length for patients with high-frequency hearing loss?2022
- Author(s)
  Hidekane Yoshimura, Yutaka Takumi, Shin-ichi Usami
- Organizer
  7th East Asian Symposium on Otology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] 原因遺伝子解析に基づいた若年発症型両側性感音難聴の診断意義2022
- Author(s)
  吉村豪兼, 品川潤, 西尾信哉, 宇佐美真一, 工穣
- Organizer
  第66回　日本聴覚医学会
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] 遺伝子治療実験のためのマウス内耳解剖とホールマウント作製2022
- Author(s)
  吉村豪兼、大道亮太郎、岩佐陽一郎、工穣、宇佐美真一
- Organizer
  第122回　日本耳鼻咽喉科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] 新生児120,823人を対象とした先天性難聴児の疫学調査2022
- Author(s)
  吉村豪兼、大久保卓哉、品川潤、工穣、宇佐美真一
- Organizer
  第123回　日本耳鼻咽喉科頭頸部外科学会
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] 成体マウスにおける前庭解剖と免疫染色のためのホールマウント標本作製2022
- Author(s)
  吉村豪兼, 工穣
- Organizer
  第81回日本めまい平衡医学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] Pendred症候群に対する遺伝子治療の可能性2020
- Author(s)
  吉村豪兼
- Organizer
  第30回　日本耳科学会学術講演会
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] EASに学ぶ低侵襲人工内耳手術と周術期管理2020
- Author(s)
  吉村豪兼
- Organizer
  第30回　日本耳科学会学術講演会
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] 後ろ向きコホート研究に基づく症候群性難聴の原因遺伝子解析2020
- Author(s)
  吉村豪兼、宇佐美真一
- Organizer
  第81回　耳鼻咽喉科臨床学会
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] Genetic testing has the potential to impact hearing preservation following cochlear implantation2020
- Author(s)
  Hidekane Yoshimura
- Organizer
  第30回　日本耳科学会学術講演会
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] 側頭頭頂筋膜弁による外耳道後壁再建を併用した人工内耳植込術例2019
- Author(s)
  吉村豪兼、茂木英明、宮嶋宏樹、宇佐美真一
- Organizer
  第81回　耳鼻臨床学会
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] RNA干渉を用いた成体難聴モデルマウスに対する遺伝子治療2019
- Author(s)
  吉村豪兼, 柴田清児ブルース, 茂木英明, 宇佐美真一
- Organizer
  第120回　日本耳鼻咽喉科学会総会・学術講演会
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] Assessment of Factors Influencing Residual Hearing Preservation in Cochlear Implantation2019
- Author(s)
  Hidekane Yoshimura, Hideaki Moteki, Shin-ya Nishio, Maiko Miyagawa, Shin-ichi Usami
- Organizer
  APSCI2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] 遅発性難聴患者の原因遺伝子解析2019
- Author(s)
  吉村豪兼、森健太郎、北野友裕、岡晋一郎、品川潤、横田陽、宮嶋宏樹、井坂友一、西尾信哉、茂木英明、宇佐美真一
- Organizer
  第29回　日本耳科学会
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] Simultaneous vs. Sequential Bilateral Cochlear Implantation in Children2019
- Author(s)
  Hidekane Yoshimura, Hideaki Moteki, Shin-ya Nishio, Maiko Miyagawa, Shin-ichi Usami
- Organizer
  APSCI2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] EAS using longer electrodes2019
- Author(s)
  Hidekane Yoshimura, Hideaki Moteki, Shin-ya Nishio, Shin-ichi Usami
- Organizer
  XVIII HSP workshop
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] EAS 手術時の蝸牛マイクロホン電位測定による術中モニタリング2019
- Author(s)
  吉村豪兼、茂木英明、安川梨香、横田修、宇佐美真一
- Organizer
  第64回　日本聴覚医学会
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] Combined Cochlear Implantation and Mastoid Obliteration using Temporoparietal Fascial Flap: A case report2019
- Author(s)
  Hidekane Yoshimura, Hideaki Moteki, Hiroki Miyajima, Shin-ichi Usami
- Organizer
  HEARING IMPLANT WORKSHOP
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] Combined Cochlear Implantation and Mastoid Obliteration using Temporoparietal Fascial Flap: A case report2019
- Author(s)
  Hidekane Yoshimura, Hideaki Moteki, Hiroki Miyajima, Shin-ichi Usami
- Organizer
  1st International Joint Conference on Otology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18727
[Presentation] Laser-capture micro dissection combined with next-generation sequencing analysis of cell type-specific deafness gene expression in the mouse cochlea.2016
- Author(s)
  Nishio S, Takumi Y, Yoshimura H, Usami S.
- Organizer
  ARO 39th MidWinter Metting
- Place of Presentation
  San Diego, California, USA
- Year and Date
  2016-02-22
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25670715

1. NISHIO Shin-ya (70467166)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
2. USAMI Shin-ichi (10184996)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
3. MIYAGAWA Maiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 菅谷明子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. 岩佐陽一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Yoshimura Hidekane 吉村 豪兼

YOSHIMURA Hidekane 吉村 豪兼

Research Projects

Research Products

Co-Researchers

遺伝性難聴に対する遺伝子治療と人工内耳のハイブリッド治療への展開Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Tropism of AAV vectors in adult mammalian inner ear subtypesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Usher症候群に関する遺伝的背景に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Comprehensive analysis of alternative splicing variants identified from tonotopical differences in the mouse cochleaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Audiological Features in 63 Patients With Cochlear Nerve Deficiency2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical and molecular features of patients with <scp> <i>COL1</i> </scp> ‐related disorders: Implications for the wider spectrum and the risk of vascular complications2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutation-agnostic RNA interference with engineered replacement rescues<i>Tmc1</i>-related hearing loss2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Frequency and natural course of congenital cytomegalovirus-associated hearing loss in children2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Correction to: Detailed clinical features and genotype?phenotype correlation in an OTOF-related hearing loss cohort in Japan2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Vibrant soundbridge implantation prior to auricular reconstruction with unilateral microtia‐atresia2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A nationwide epidemiologic, clinical, genetic study of Usher syndrome in Japan2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Milestones toward cochlear gene therapy for patients with hereditary hearing loss2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Cochlear Implantation From the Perspective of Genetic Background.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hair Cell Transduction Efficiency of Single- and Dual-AAV Serotypes in Adult Murine Cochleae2020

Author(s)

Journal Title

DOI

NAID

Data Source

Yoshimura Hidekane 吉村豪兼

YOSHIMURA Hidekane 吉村豪兼