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Yamamoto Yumi  山本 由美

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… Alternative Names

山本 由美  ヤマモト ユミ

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Researcher Number 10614927
Affiliation (Current) 2025: 国立研究開発法人国立循環器病研究センター, 病院, 室長
Affiliation (based on the past Project Information) *help 2023 – 2024: 国立研究開発法人国立循環器病研究センター, 病院, 上級研究員
2021: 国立研究開発法人国立循環器病研究センター, 病院, 上級研究員
2019 – 2020: 国立研究開発法人国立循環器病研究センター, 研究所, 非常勤研究員
2018: 国立研究開発法人国立循環器病研究センター, 研究所, 研修生
2015 – 2017: 国立研究開発法人国立循環器病研究センター, 研究所, 流動研究員 … More
2015: 国立研究開発法人国立循環器病研究センター, 研究所, 派遣研究員
2014: 独立行政法人国立循環器病研究センター, 研究所, 流動研究員
2012: 山口大学, 医学(系)研究科(研究院), 研究員
2011: 山口大学, 大学院・医学系研究科, 学術研究員 Less
Review Section/Research Field
Principal Investigator
Basic Section 49030:Experimental pathology-related / Nerve anatomy/Neuropathology / General surgery
Except Principal Investigator
Medium-sized Section 57:Oral science and related fields
Keywords
Principal Investigator
CADASIL / 遺伝性脳小血管病 / 脳小血管病 / 血管性認知症 / NOTCH3 / 壁細胞 / 脳梗塞 / Notch3 / 治療法開発 / iPS細胞 … More / small vessel disease / 血管平滑筋細胞 / アクチン / 血管平滑筋 / 病態メカニズム / 認知症 / 脳血管障害 / CADASIL / 血管新生 … More
Except Principal Investigator
歯科医科連携 / マトリソーム / 口腔内細菌 / 脳内出血 Less
  • Research Projects

    (7 results)
  • Research Products

    (9 results)
  • Co-Researchers

    (5 People)
  •  遺伝性脳小血管病の新規治療薬:iPS細胞とマウスモデルを用いた非臨床POC取得Principal Investigator

    • Principal Investigator
      山本 由美
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Collaborative dental-medical research on the mechanism of intracerebral hemorrhage via cerebrovascular matrisome injury by oral bacteria

    • Principal Investigator
      猪原 匡史
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 57:Oral science and related fields
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Development of novel treatment of hereditary small vessel disease using iPSCsPrincipal Investigator

    • Principal Investigator
      Yamamoto Yumi
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Development of novel treatment for CADASIL using induced pluripotent stem cellsPrincipal Investigator

    • Principal Investigator
      Yamamoto Yumi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49030:Experimental pathology-related
    • Research Institution
      National Cardiovascular Center Research Institute
  •  The mechanism of actin metabolism abnormality in a hereditary small vessel disease and development of novel treatmentPrincipal Investigator

    • Principal Investigator
      Yamamoto Yumi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      National Cardiovascular Center Research Institute
  •  Pathogenic roles of actin metabolism in cerebral small vessel diseasePrincipal Investigator

    • Principal Investigator
      Yamamoto Yumi
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      National Cardiovascular Center Research Institute
  •  虚血組織での壁細胞特異的Notch3を介した血管新生メカニズムの解明Principal Investigator

    • Principal Investigator
      山本 由美
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      General surgery
    • Research Institution
      Yamaguchi University

All 2020 2019 2017 2016 2015

All Journal Article Presentation Patent

  • [Journal Article] Human iPS cell-derived mural cells as an in vitro model of hereditary cerebral small vessel disease2020

    • Author(s)
      Yamamoto Yumi、Kojima Katsutoshi、Taura Daisuke、Sone Masakatsu、Washida Kazuo、Egawa Naohiro、Kondo Takayuki、Minakawa Eiko N.、Tsukita Kayoko、Enami Takako、Tomimoto Hidekazu、Mizuno Toshiki、Kalaria Raj N.、Inagaki Nobuya、Takahashi Ryosuke、Harada-Shiba Mariko、Ihara Masafumi、Inoue Haruhisa
    • Journal Title

      Molecular Brain

      Volume: 13 Issue: 1 Pages: 38-38

    • DOI

      10.1186/s13041-020-00573-w

    • NAID

      120006818682

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K08514, KAKENHI-PROJECT-17H04670, KAKENHI-PROJECT-17K09880, KAKENHI-PROJECT-18K15347, KAKENHI-PROJECT-20K07883, KAKENHI-PROJECT-18K07058, KAKENHI-PROJECT-19J40007
  • [Journal Article] Disruption of transforming growth factor-beta superfamily signaling: A shared mechanism underlying hereditary cerebral small vessel disease2017

    • Author(s)
      Yamamoto Y and Ihara M
    • Journal Title

      Neurochem Int

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K18387
  • [Journal Article] Emerging evidence for pathogenesis of sporadic cerebral small vessel disease2016

    • Author(s)
      Ihara M, Yamamoto Y
    • Journal Title

      Stroke

      Volume: 47 Issue: 2 Pages: 554-560

    • DOI

      10.1161/strokeaha.115.009627

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H04271, KAKENHI-PROJECT-16K18387
  • [Patent] 特許権2016

    • Inventor(s)
      山本由美、猪原匡史、井上治久、月田香代子、江浪貴子
    • Industrial Property Rights Holder
      山本由美、猪原匡史、井上治久、月田香代子、江浪貴子
    • Industrial Property Rights Type
      特許
    • Filing Date
      2016-12-27
    • Data Source
      KAKENHI-PROJECT-16K18387
  • [Presentation] 患者由来iPS細胞を用いた遺伝性脳小血管病の病態研究2019

    • Author(s)
      山本 由美
    • Organizer
      第38回認知症学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07058
  • [Presentation] In vitro model of CADASIL: iPS cell-derived mural cells for unraveling the pathogenesis of a hereditary small vessel disease.2017

    • Author(s)
      6.Yumi Yamamoto, Katsutoshi Kojima, Daisuke Taura, Masakatsu Sone, Kazuo Washida, Naohiro Egawa, Takayuki Kondo, Eiko N Minakawa, Kayoko Tsukita, Takako Enami, Hidekazu Tomimoto, Toshiki Mizuno, Ryosuke Takahashi, Masafumi Ihara, Haruhisa Inoue.
    • Organizer
      ConBio2017
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K18387
  • [Presentation] An iPS cell model of CADASIL: insights into the pathogenesis of a hereditary small vessel disease2016

    • Author(s)
      Y. Yamamoto
    • Organizer
      第57回日本神経学会学術大会.
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-18
    • Data Source
      KAKENHI-PROJECT-16K18387
  • [Presentation] PATIENT-DERIVED IPS CELLS FOR UNRAVELING THE MOLECULAR PATHOGENESIS OF CADASIL2015

    • Author(s)
      Yumi Yamamoto, Katsutoshi Kojima, Daisuke Taura, Masakatsu Sone, Kazuo Washida, Naohiro Egawa, Takayuki Kondo, Eiko N Minakawa, Kayoko Tsukita, Takako Enami, Hidekazu Tomimoto, Toshiki Mizuno, Ryosuke Takahashi, Masafumi Ihara, Haruhisa Inoue
    • Organizer
      VASCOG world
    • Place of Presentation
      東京ファッションタウン
    • Year and Date
      2015-09-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26830039
  • [Presentation] 患者iPS細胞から壁細胞への分化誘導とCADASIL病態研究への応用2015

    • Author(s)
      山本由美、小嶋勝利、田浦大輔、曽根正勝、鷲田和夫、江川斉宏、近藤孝之、皆川栄子、月田香代子、江浪貴子、冨本秀和、水野敏樹、高橋良輔、猪原匡史、井上治久
    • Organizer
      VASCOG Japan
    • Place of Presentation
      東京ファッションタウン
    • Year and Date
      2015-09-19
    • Data Source
      KAKENHI-PROJECT-26830039
  • 1.  猪原 匡史 (00372590)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 2.  仲野 和彦 (00379083)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  殿村 修一 (10874290)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  SONE Masakatsu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  田浦 大輔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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