SAKAKIBARA Shuhei 榊原修平

Researcher Number	10618838
Other IDs	https://orcid.org/0000-0003-3157-5870
Affiliation (Current)	2023: 滋慶医療科学大学, 医療管理学研究科, 准教授
Affiliation (based on the past Project Information) *help	2019 – 2021: 大阪大学, 免疫学フロンティア研究センター, 寄附研究部門准教授 2016 – 2018: 大阪大学, 免疫学フロンティア研究センター, 寄附研究部門助教 2012 – 2015: 大阪大学, 微生物病研究所, 助教
Review Section/Research Field	Principal Investigator Virology / Basic Section 49070:Immunology-related / Immunology Except Principal Investigator Basic Section 43060:System genome science-related / Immunology
Keywords	Principal Investigator Ｂ細胞 / 免疫寛容 / 全身性エリテマトーデス / 自己抗体 / 自己免疫疾患 / 自己抗体産生 / 抗DNA抗体 / アナジー / 抗dsDNA抗体 / 免疫学 … More / B細胞 / 多分子反応性抗体 / 獲得免疫 / 液性免疫応答 / 持続性ウイルス感染 / 自己反応性B細胞 / polyreactive抗体 / ウイルス感染 / ウイルス / 自己反応性免疫応答 … More Except Principal Investigator タンパク質立体構造予測 / エピトープ予測 / 検証実験 / 深層学習 / クラスタリング / レパトアシークエンシング / 1細胞シークエンシング / 機械学習 / エピトープ / T細胞受容体 / 気道アレルギー / 分子標的 / セマフォリンファミリー / Plexin / 免疫制御 / リンパ球 / IL-4 / Th2 / Tim-2 / Sema4A / EBウイルス / B細胞抗原受容体 / PKN1 / Akt / plexin B2 / Sema4D / 樹状細胞 / B細胞 / T細胞 / アレルギー疾患 / プレキシン / セマフォリン Less

Development, validation and application of machine learning system for TCR epitope prediction
- Principal Investigator
  
  寺口俊介
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  Shiga University
  Osaka University
Affinity maturation of anti-DNA B cells in systemic lupus erythematosusPrincipal Investigator
- Principal Investigator
  
  Sakakibara Shuhei
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49070:Immunology-related
- Research Institution
  Osaka University
The emergence of self-reactive B cells through somatic mutation and dysfunctional immune tolerance of peripheral B cells in a BCR-knock in mouse modelPrincipal Investigator
- Principal Investigator
  
  Sakakibara Shuhei
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Osaka University
Generation of polyreactive B cells in murine herpesvirus infectionPrincipal Investigator
- Principal Investigator
  
  Sakakibara Shuhei
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Osaka University
Autoantibody production during gamma-herpesvirus infectionPrincipal Investigator
- Principal Investigator
  
  SAKAKIBARA Shuhei
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Osaka University
Roles of guidance factors in immune regulation
- Principal Investigator
  
  KIKUTANI Hitoshi
- Project Period (FY)
  2008 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Immunology
- Research Institution
  Osaka University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012

All Journal Article Presentation

[Journal Article] Multiple tolerance checkpoints restrain affinity maturation of B cells expressing the germline precursor of a lupus patient-derived anti-dsDNA antibody in knock-in mice2021
- Author(s)
  El Hussien Marwa Ali、Tsai Chao-Yuan、Satouh Yuhkoh、Motooka Daisuke、Okuzaki Daisuke、Ikawa Masahito、Kikutani Hitoshi、Sakakibara Shuhei
- Journal Title
  
  International Immunology
  
  Volume: 34 Issue: 4 Pages: 207-223
- DOI
  10.1093/intimm/dxab111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07622
[Journal Article] Self-reactive and polyreactive B cells are generated and selected in the germinal center during γ-herpesvirus infection.2020
- Author(s)
  3.Sakakibara S, Yasui T, Jinzai H, O’Donnell K, Tsai C-Y, Mintamitani T, Takeda K, Belz GT, Tarlinton DM, and Kikutani H.
- Journal Title
  
  Int Immunol.
  
  Volume: 32 Issue: 1 Pages: 27-38
- DOI
  10.1093/intimm/dxz057
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07622
[Journal Article] Allergic conversion of protective mucosal immunity against nasal bacteria in patients with chronic rhinosinusitis with nasal polyposis.2019
- Author(s)
  Takeda K, Sakakibara S, Yamashita K, Motooka D, Nakamura S, El Hussien MA, Katayama J, Maeda Y, Nakata M, Hamada S, Standley DM, Hayama M, Shikina T, Inohara H, Kikutani H.
- Journal Title
  
  J Allergy Clin Immunol
  
  Volume: 143 Issue: 3 Pages: 1163-1175
- DOI
  10.1016/j.jaci.2018.07.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K11610, KAKENHI-PROJECT-17K11958, KAKENHI-PROJECT-18K19643, KAKENHI-PROJECT-15KK0306, KAKENHI-PROJECT-16H05847, KAKENHI-PROJECT-17H04369, KAKENHI-PROJECT-18H02430, KAKENHI-PROJECT-16K08837, KAKENHI-PROJECT-17K19751, KAKENHI-PROJECT-19H03825
[Journal Article] Bystander inhibition of humoral immune responses by Epstein-Barr virus LMP1.2018
- Author(s)
  Tsai C.-Y., Sakakibara S., Yasui T., Minamitani T., Okuzaki D., and Kikutani H.
- Journal Title
  
  International Immunology
  
  Volume: 30(12) Pages: 579-90
- DOI
  10.1093/intimm/dxy053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08837, KAKENHI-PROJECT-16K14650
[Journal Article] Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus.2017
- Author(s)
  Sakakibara S., Arimori T., Yamashita K., et al
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 16428-16428
- DOI
  10.1038/s41598-017-16681-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08837, KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-17K10002
[Journal Article] Evasion of affinity-based selection in germinal centers by Epstein-Barr virus LMP2A2015
- Author(s)
  Minamitani T, Yasui T, Ma Y, Zhou H, Okuzaki D, Tsai CY, Sakakibara S, Gewurz BE, Kieff E, Kikutani H.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 112 Issue: 37 Pages: 11612-116127
- DOI
  10.1073/pnas.1514484112
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860303
[Journal Article] Contribution of viral mimics of cellular genes to KSHV infection and disease.2014
- Author(s)
  Shuhei Sakakibara and Giovanna Tosato
- Journal Title
  
  Viruses
  
  Volume: 6(9) Issue: 9 Pages: 3472-3472
- DOI
  10.3390/v6093472
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860303
[Journal Article] ウイルス感染による自己抗体産生誘導2014
- Author(s)
  榊原　修平･　菊谷　仁
- Journal Title
  
  臨床免疫･アレルギー科
  
  Volume: 61 Pages: 74-80
- NAID
  40019955503
- Data Source
  KAKENHI-PROJECT-24790440
[Journal Article] ウイルス感染による自己抗体先生誘導2014
- Author(s)
  榊原修平、菊谷仁
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: vol.61, No.1
- Data Source
  KAKENHI-PROJECT-24790440
[Journal Article] A20/TNFAIP3 inhibits NF-κB activation induced by the Kaposi's sarcoma-associated herpesvirus vFLIP oncoprotein2013
- Author(s)
  Sakakibara, S., Espigol-Frigole G., Gasperini P., Uldrick T.S., Yarchoan R., and Tosato G.
- Journal Title
  
  Oncogene
  
  Volume: 32 Pages: 1223-1232
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790440
[Journal Article] Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation2012
- Author(s)
  Yasui T, Sakakibara-Yada K, Nishimura T, Morita K, Tada S, Mosialos G, Kieff E, Kikutani H
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 109(51) Issue: 51 Pages: 21022-7
- DOI
  10.1073/pnas.1218925110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20229007, KAKENHI-PROJECT-24590550, KAKENHI-PROJECT-24790883
[Presentation] Multiple tolerance checkpoints suppress generation and activationof B cells producing low-affinity germline precursors of SLEpatient-derived high- affinity anti-dsDNA antibody in BCR knock-inmice2019
- Author(s)
  Ali El Hussien, S Sakakibara et al
- Organizer
  日本免疫学会
- Data Source
  KAKENHI-PROJECT-19K07622
[Presentation] Development and activation of B cells expressing germline precursor of SLE-derived highaffinity anti-DNA antibody in knock-in mice2018
- Author(s)
  Ali El Hussien Marwa., Sakakibara S., Kikutani H
- Organizer
  第47回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-16K08837
[Presentation] 全身性エリテマトーデス由来抗DNA抗体の構造学的解析から見た自己反応性B細胞の親和性成熟2016
- Author(s)
  榊原　修平
- Organizer
  自己免疫研究会
- Place of Presentation
  東京　京王プラザホテル
- Data Source
  KAKENHI-PROJECT-16K08837
[Presentation] Structural Basis of Antigen Recognition by Anti-dsDNA Antibodies Isolated from Systemic Lupus Erythematosus Patients2016
- Author(s)
  榊原　修平
- Organizer
  第45回　日本免疫学会
- Place of Presentation
  沖縄　沖縄コンベンションセンター
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-16K08837
[Presentation] Antigen-specific maturation of autoantibodies in systemic lupus erythematosus2016
- Author(s)
  榊原　修平
- Organizer
  International Congress of Immunology 2016
- Place of Presentation
  オーストラリア　メルボルン　メルボルンコンベンション&エキシビジョンセンター
- Year and Date
  2016-08-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08837
[Presentation] Antigen-specific maturation of anti-nuclear antibodies in systemic lupus erythematosus2015
- Author(s)
  Shuhei Sakakibara, Kazuya Takeda, Teruhito Yasui, Masashi Narazaki, Toshio Tanaka, Hitoshi Kikutani
- Organizer
  第44回日本免疫学会　学術集会
- Place of Presentation
  札幌市
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26860303
[Presentation] Generation of polyreactive B cells during murine herpesvirus infection.2013
- Author(s)
  ○Shuhei Sakakibara, Teruhito Yasui, Takeharu Minamitani, and Hitoshi Kikutani
- Organizer
  Annual Meeting of Japanese Society of Immunology （第４２回日本免疫学会学術集会）
- Place of Presentation
  千葉･幕張
- Data Source
  KAKENHI-PROJECT-24790440
[Presentation] Direct and indirect inhibition of germinal cnter formation and humoral immune responses by Epstein-Barr virus LMP1.2013
- Author(s)
  ○Tsai, C.-Y., T. Yasui, T. Minamitani, S. Sakakibara, and H. Kikutani
- Organizer
  Annual Meeting of Japanese Society of Immunology （第４２回日本免疫学会学術集会）
- Place of Presentation
  千葉･幕張
- Data Source
  KAKENHI-PROJECT-24790440
[Presentation] Signal-cell biology技術を用いたヒト抗HSV1抗体の単離‐持続感染ウイルスに対するヒト液性免疫応答の推移。2013
- Author(s)
  ○安居輝人、渡部明子、榊原修平、義江修、菊谷仁
- Organizer
  第61回日本ウイルス学会
- Place of Presentation
  兵庫･神戸
- Data Source
  KAKENHI-PROJECT-24790440
[Presentation] Generation and selection of virus- and self-reactive B cells during herpesvirus infection2013
- Author(s)
  Sakakibara, S., T. Yasui, T. Minamitani, and H. Kikutani
- Organizer
  第41回日本免疫学会
- Place of Presentation
  神戸市(口頭)
- Data Source
  KAKENHI-PROJECT-24790440
[Presentation] Generation of autoreactive and poly-reactive antibody producing cells during gamma-herpevirus infection2013
- Author(s)
  Sakakibara, S., T. Yasui, T. Minamitani, H. Jinzai, and H. Kikutani
- Organizer
  The 15 th International Congress of Immunology
- Place of Presentation
  イタリアミラノ(ポスター)
- Data Source
  KAKENHI-PROJECT-24790440
[Presentation] Generation of polyreactive B cells during murine herpesvirus infection2013
- Author(s)
  Sakakibara, S., T. Yasui, T. Minamitani, and H. Kikutani
- Organizer
  第42回日本免疫学会
- Place of Presentation
  千葉市(口頭)
- Data Source
  KAKENHI-PROJECT-24790440
[Presentation] Epstein-Barr virus LMP2a reduces the stringency of B cell selection in germinal center by augmenting BCR signal strength and enhancing plasma cell differentiation.2013
- Author(s)
  ○Minamitani, T., T. Yasui, S. Sakakibara, C.-Y. Tsai, and H. Kikutani
- Organizer
  Annual Meeting of Japanese Society of Immunology　（第４２回日本免疫学会学術集会）
- Place of Presentation
  千葉･幕張
- Data Source
  KAKENHI-PROJECT-24790440
[Presentation] Generation of self-reactive and poly-reactive antibody producing cells during g-herpesvirus infection2013
- Author(s)
  ○Shuhei Sakakibara, Teruhito Yasui, Takeharu Minamitani, Hideyuki Jinzai and Hitoshi Kikutani
- Organizer
  The 15 th International Congress of Immunology
- Place of Presentation
  イタリア･ミラノ
- Data Source
  KAKENHI-PROJECT-24790440
[Presentation] Generation of virus- and self-reactive B cells during herpesvirus infection2012
- Author(s)
  Shuhei Sakakibara, Teruhito Yasui, Takeharu Minamitani, Hitoshi Kikutani
- Organizer
  The 11th Awaji International Forum on Infection and Immunity
- Place of Presentation
  兵庫県淡路市
- Data Source
  KAKENHI-PROJECT-24790440
[Presentation] ガンマヘルペスウイルス感染による自己抗原産生2012
- Author(s)
  榊原修平
- Organizer
  第60回日本ウイルス学会
- Place of Presentation
  大阪市
- Data Source
  KAKENHI-PROJECT-20229007
[Presentation] Generation of virus- and self-reactive B cells during herpesvirus infection2012
- Author(s)
  Sakakibara, S. , T. Yasui, T. Minamitani, H. Kikutani
- Organizer
  The 12th Awaji International Forum on Infection and Immunity
- Place of Presentation
  兵庫県淡路市(ポスター)
- Data Source
  KAKENHI-PROJECT-24790440
[Presentation] ガンマヘルペスウイルス感染による自己抗体産生2012
- Author(s)
  榊原修平、安居輝人、南谷武春、菊谷仁
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪市(口頭
- Data Source
  KAKENHI-PROJECT-24790440
[Presentation] Generation of virus-and self-reactive B cells during herpesvirus infection.2012
- Author(s)
  Sakakibara, S.
- Organizer
  The 11th Awaji International Forum on Infection and Immunity
- Place of Presentation
  淡路市
- Data Source
  KAKENHI-PROJECT-20229007
[Presentation] Generation and selection of virus- and self-reactive B cells during herpesvirus infection.2012
- Author(s)
  Sakakibara, S.
- Organizer
  第41回日本免疫学会
- Place of Presentation
  神戸市
- Data Source
  KAKENHI-PROJECT-20229007
[Presentation] ガンマヘルペスウイルス感染による免疫関連疾患発症機構の解明2012
- Author(s)
  榊原修平
- Organizer
  第27回ヘルペスウイルス研究会
- Place of Presentation
  愛知県知多郡東浦町
- Data Source
  KAKENHI-PROJECT-20229007

1. KIKUTANI Hitoshi (80161412)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
2. YASUI Teruhito (60283074)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. MIZUI Masayuki (30423106)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 寺口俊介 (00467276)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. IKAWA Masato

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SATO Yukoh

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ALIEL-HUSSIEN Marwa

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NAKATA Masanobu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKAKIBARA Shuhei 榊原 修平

Research Projects

Research Products

Co-Researchers

Development, validation and application of machine learning system for TCR epitope prediction

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Affinity maturation of anti-DNA B cells in systemic lupus erythematosusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The emergence of self-reactive B cells through somatic mutation and dysfunctional immune tolerance of peripheral B cells in a BCR-knock in mouse modelPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Generation of polyreactive B cells in murine herpesvirus infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Autoantibody production during gamma-herpesvirus infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Roles of guidance factors in immune regulation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Multiple tolerance checkpoints restrain affinity maturation of B cells expressing the germline precursor of a lupus patient-derived anti-dsDNA antibody in knock-in mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Self-reactive and polyreactive B cells are generated and selected in the germinal center during γ-herpesvirus infection.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Allergic conversion of protective mucosal immunity against nasal bacteria in patients with chronic rhinosinusitis with nasal polyposis.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Bystander inhibition of humoral immune responses by Epstein-Barr virus LMP1.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evasion of affinity-based selection in germinal centers by Epstein-Barr virus LMP2A2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Contribution of viral mimics of cellular genes to KSHV infection and disease.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ウイルス感染による自己抗体産生誘導2014

Author(s)

Journal Title

NAID

Data Source

SAKAKIBARA Shuhei 榊原修平