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SAKAKIBARA Shuhei  榊原 修平

Researcher Number 10618838
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-3157-5870
Affiliation (Current) 2023: 滋慶医療科学大学, 医療管理学研究科, 准教授
Affiliation (based on the past Project Information) *help 2019 – 2021: 大阪大学, 免疫学フロンティア研究センター, 寄附研究部門准教授
2016 – 2018: 大阪大学, 免疫学フロンティア研究センター, 寄附研究部門助教
2012 – 2015: 大阪大学, 微生物病研究所, 助教
Review Section/Research Field
Principal Investigator
Virology / Immunology / Basic Section 49070:Immunology-related
Except Principal Investigator
Immunology / Basic Section 43060:System genome science-related
Keywords
Principal Investigator
自己抗体産生 / 自己免疫疾患 / 自己抗体 / 全身性エリテマトーデス / 免疫寛容 / B細胞 / 自己反応性免疫応答 / ウイルス / ウイルス感染 / polyreactive抗体 … More / 自己反応性B細胞 / 持続性ウイルス感染 / 液性免疫応答 / 獲得免疫 / 多分子反応性抗体 / B細胞 / 免疫学 / 抗dsDNA抗体 / アナジー / 抗DNA抗体 … More
Except Principal Investigator
セマフォリン / プレキシン / アレルギー疾患 / T細胞 / B細胞 / 樹状細胞 / Sema4D / plexin B2 / Akt / PKN1 / B細胞抗原受容体 / EBウイルス / Sema4A / Tim-2 / Th2 / IL-4 / リンパ球 / 免疫制御 / Plexin / セマフォリンファミリー / 分子標的 / 気道アレルギー / T細胞受容体 / エピトープ / 機械学習 / 1細胞シークエンシング / レパトアシークエンシング / クラスタリング / 深層学習 / 検証実験 / エピトープ予測 / タンパク質立体構造予測 Less
  • Research Projects

    (6 results)
  • Research Products

    (32 results)
  • Co-Researchers

    (13 People)
  •  Development, validation and application of machine learning system for TCR epitope prediction

    • Principal Investigator
      寺口 俊介
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 43060:System genome science-related
    • Research Institution
      Shiga University
      Osaka University
  •  Affinity maturation of anti-DNA B cells in systemic lupus erythematosusPrincipal Investigator

    • Principal Investigator
      Sakakibara Shuhei
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      Osaka University
  •  The emergence of self-reactive B cells through somatic mutation and dysfunctional immune tolerance of peripheral B cells in a BCR-knock in mouse modelPrincipal Investigator

    • Principal Investigator
      Sakakibara Shuhei
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Osaka University
  •  Generation of polyreactive B cells in murine herpesvirus infectionPrincipal Investigator

    • Principal Investigator
      Sakakibara Shuhei
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Virology
    • Research Institution
      Osaka University
  •  Autoantibody production during gamma-herpesvirus infectionPrincipal Investigator

    • Principal Investigator
      SAKAKIBARA Shuhei
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Virology
    • Research Institution
      Osaka University
  •  Roles of guidance factors in immune regulation

    • Principal Investigator
      KIKUTANI Hitoshi
    • Project Period (FY)
      2008 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Immunology
    • Research Institution
      Osaka University

All 2021 2020 2019 2018 2016 2015 2014 2013 2012

All Journal Article Presentation

  • [Journal Article] Multiple tolerance checkpoints restrain affinity maturation of B cells expressing the germline precursor of a lupus patient-derived anti-dsDNA antibody in knock-in mice2021

    • Author(s)
      El Hussien Marwa Ali、Tsai Chao-Yuan、Satouh Yuhkoh、Motooka Daisuke、Okuzaki Daisuke、Ikawa Masahito、Kikutani Hitoshi、Sakakibara Shuhei
    • Journal Title

      International Immunology

      Volume: 34 Pages: 207-223

    • DOI

      10.1093/intimm/dxab111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07622
  • [Journal Article] Self-reactive and polyreactive B cells are generated and selected in the germinal center during γ-herpesvirus infection.2020

    • Author(s)
      3.Sakakibara S, Yasui T, Jinzai H, O’Donnell K, Tsai C-Y, Mintamitani T, Takeda K, Belz GT, Tarlinton DM, and Kikutani H.
    • Journal Title

      Int Immunol.

      Volume: 32 Pages: 27-38

    • DOI

      10.1093/intimm/dxz057

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07622
  • [Journal Article] Allergic conversion of protective mucosal immunity against nasal bacteria in patients with chronic rhinosinusitis with nasal polyposis2019

    • Author(s)
      Takeda K, Sakakibara S, Yamashita K, Motooka D, Nakamura S, El Hussien MA, Katayama J, Maeda Y, Nakata M, Hamada S, Standley DM, Hayama M, Shikina T, Inohara H, Kikutani H.
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 143 Pages: 1163-1175

    • DOI

      10.1016/j.jaci.2018.07.006

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K11610, KAKENHI-PROJECT-17K11958, KAKENHI-PROJECT-18K19643, KAKENHI-PROJECT-15KK0306, KAKENHI-PROJECT-16H05847, KAKENHI-PROJECT-17H04369, KAKENHI-PROJECT-18H02430, KAKENHI-PROJECT-16K08837, KAKENHI-PROJECT-17K19751, KAKENHI-PROJECT-19H03825
  • [Journal Article] Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus2018

    • Author(s)
      Sakakibara S., Arimori T., Yamashita K., et al
    • Journal Title

      Ann Rheum Dis.

      Volume: 7 Pages: 1507-1515

    • DOI

      10.1038/s41598-017-16681-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08837, KAKENHI-PROJECT-17H01420, KAKENHI-PROJECT-17K10002
  • [Journal Article] Bystander inhibition of humoral immune responses by Epstein-Barr virus LMP12018

    • Author(s)
      Tsai C.-Y., Sakakibara S., Yasui T., Minamitani T., Okuzaki D., and Kikutani H.
    • Journal Title

      International Immunology

      Volume: 30(12) Pages: 579-590

    • DOI

      10.1093/intimm/dxy053

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08837, KAKENHI-PROJECT-16K14650
  • [Journal Article] Evasion of affinity-based selection in germinal centers by Epstein-Barr virus LMP2A2015

    • Author(s)
      Minamitani T, Yasui T, Ma Y, Zhou H, Okuzaki D, Tsai CY, Sakakibara S, Gewurz BE, Kieff E, Kikutani H.
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 112 Pages: 11612-116127

    • DOI

      10.1073/pnas.1514484112

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860303
  • [Journal Article] Contribution of viral mimics of cellular genes to KSHV infection and disease.2014

    • Author(s)
      Shuhei Sakakibara and Giovanna Tosato
    • Journal Title

      Viruses

      Volume: 6(9) Pages: 3472-3472

    • DOI

      10.3390/v6093472

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26860303
  • [Journal Article] ウイルス感染による自己抗体産生誘導2014

    • Author(s)
      榊原 修平・ 菊谷 仁
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 61 Pages: 74-80

    • NAID

      40019955503

    • Data Source
      KAKENHI-PROJECT-24790440
  • [Journal Article] ウイルス感染による自己抗体先生誘導2014

    • Author(s)
      榊原修平、菊谷仁
    • Journal Title

      臨床免疫・アレルギー科

      Volume: vol.61, No.1

    • Data Source
      KAKENHI-PROJECT-24790440
  • [Journal Article] A20/TNFAIP3 inhibits NF-κB activation induced by the Kaposi's sarcoma-associated herpesvirus vFLIP oncoprotein2013

    • Author(s)
      Sakakibara, S., Espigol-Frigole G., Gasperini P., Uldrick T.S., Yarchoan R., and Tosato G.
    • Journal Title

      Oncogene

      Volume: 32 Pages: 1223-1232

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790440
  • [Journal Article] Protein kinase N1, a cell inhibitor of Akt kinase, has a central role in quality control of germinal center formation.2012

    • Author(s)
      Yasui T, Sakakibara-Yada K, Nishimura T, Morita K, Tada S, Mosialos G, Kieff E, Kikutani H
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 109(51) Pages: 21022-21027

    • DOI

      10.1073/pnas.1218925110

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20229007, KAKENHI-PROJECT-24590550, KAKENHI-PROJECT-24790883
  • [Presentation] Multiple tolerance checkpoints suppress generation and activationof B cells producing low-affinity germline precursors of SLEpatient-derived high- affinity anti-dsDNA antibody in BCR knock-inmice2019

    • Author(s)
      Ali El Hussien, S Sakakibara et al
    • Organizer
      日本免疫学会
    • Data Source
      KAKENHI-PROJECT-19K07622
  • [Presentation] Development and activation of B cells expressing germline precursor of SLE-derived highaffinity anti-DNA antibody in knock-in mice2018

    • Author(s)
      Ali El Hussien Marwa., Sakakibara S., Kikutani H
    • Organizer
      第47回日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08837
  • [Presentation] 全身性エリテマトーデス由来抗DNA抗体の構造学的解析から見た自己反応性B細胞の親和性成熟2016

    • Author(s)
      榊原 修平
    • Organizer
      自己免疫研究会
    • Place of Presentation
      東京 京王プラザホテル
    • Data Source
      KAKENHI-PROJECT-16K08837
  • [Presentation] Structural Basis of Antigen Recognition by Anti-dsDNA Antibodies Isolated from Systemic Lupus Erythematosus Patients2016

    • Author(s)
      榊原 修平
    • Organizer
      第45回 日本免疫学会
    • Place of Presentation
      沖縄 沖縄コンベンションセンター
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-16K08837
  • [Presentation] Antigen-specific maturation of autoantibodies in systemic lupus erythematosus2016

    • Author(s)
      榊原 修平
    • Organizer
      International Congress of Immunology 2016
    • Place of Presentation
      オーストラリア メルボルン メルボルンコンベンション&エキシビジョンセンター
    • Year and Date
      2016-08-12
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08837
  • [Presentation] Antigen-specific maturation of anti-nuclear antibodies in systemic lupus erythematosus2015

    • Author(s)
      Shuhei Sakakibara, Kazuya Takeda, Teruhito Yasui, Masashi Narazaki, Toshio Tanaka, Hitoshi Kikutani
    • Organizer
      第44回日本免疫学会 学術集会
    • Place of Presentation
      札幌市
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-26860303
  • [Presentation] Generation of polyreactive B cells during murine herpesvirus infection.2013

    • Author(s)
      ○Shuhei Sakakibara, Teruhito Yasui, Takeharu Minamitani, and Hitoshi Kikutani
    • Organizer
      Annual Meeting of Japanese Society of Immunology (第42回日本免疫学会学術集会)
    • Place of Presentation
      千葉・幕張
    • Data Source
      KAKENHI-PROJECT-24790440
  • [Presentation] Direct and indirect inhibition of germinal cnter formation and humoral immune responses by Epstein-Barr virus LMP1.2013

    • Author(s)
      ○Tsai, C.-Y., T. Yasui, T. Minamitani, S. Sakakibara, and H. Kikutani
    • Organizer
      Annual Meeting of Japanese Society of Immunology (第42回日本免疫学会学術集会)
    • Place of Presentation
      千葉・幕張
    • Data Source
      KAKENHI-PROJECT-24790440
  • [Presentation] Signal-cell biology技術を用いたヒト抗HSV1抗体の単離‐持続感染ウイルスに対するヒト液性免疫応答の推移。2013

    • Author(s)
      ○安居輝人、渡部明子、榊原修平、義江修、菊谷仁
    • Organizer
      第61回日本ウイルス学会
    • Place of Presentation
      兵庫・神戸
    • Data Source
      KAKENHI-PROJECT-24790440
  • [Presentation] Generation and selection of virus- and self-reactive B cells during herpesvirus infection2013

    • Author(s)
      Sakakibara, S., T. Yasui, T. Minamitani, and H. Kikutani
    • Organizer
      第41回日本免疫学会
    • Place of Presentation
      神戸市(口頭)
    • Data Source
      KAKENHI-PROJECT-24790440
  • [Presentation] Generation of autoreactive and poly-reactive antibody producing cells during gamma-herpevirus infection2013

    • Author(s)
      Sakakibara, S., T. Yasui, T. Minamitani, H. Jinzai, and H. Kikutani
    • Organizer
      The 15 th International Congress of Immunology
    • Place of Presentation
      イタリアミラノ(ポスター)
    • Data Source
      KAKENHI-PROJECT-24790440
  • [Presentation] Generation of polyreactive B cells during murine herpesvirus infection2013

    • Author(s)
      Sakakibara, S., T. Yasui, T. Minamitani, and H. Kikutani
    • Organizer
      第42回日本免疫学会
    • Place of Presentation
      千葉市(口頭)
    • Data Source
      KAKENHI-PROJECT-24790440
  • [Presentation] Epstein-Barr virus LMP2a reduces the stringency of B cell selection in germinal center by augmenting BCR signal strength and enhancing plasma cell differentiation.2013

    • Author(s)
      ○Minamitani, T., T. Yasui, S. Sakakibara, C.-Y. Tsai, and H. Kikutani
    • Organizer
      Annual Meeting of Japanese Society of Immunology (第42回日本免疫学会学術集会)
    • Place of Presentation
      千葉・幕張
    • Data Source
      KAKENHI-PROJECT-24790440
  • [Presentation] Generation of self-reactive and poly-reactive antibody producing cells during g-herpesvirus infection2013

    • Author(s)
      ○Shuhei Sakakibara, Teruhito Yasui, Takeharu Minamitani, Hideyuki Jinzai and Hitoshi Kikutani
    • Organizer
      The 15 th International Congress of Immunology
    • Place of Presentation
      イタリア・ミラノ
    • Data Source
      KAKENHI-PROJECT-24790440
  • [Presentation] Generation of virus- and self-reactive B cells during herpesvirus infection2012

    • Author(s)
      Shuhei Sakakibara, Teruhito Yasui, Takeharu Minamitani, Hitoshi Kikutani
    • Organizer
      The 11th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      兵庫県淡路市
    • Data Source
      KAKENHI-PROJECT-24790440
  • [Presentation] ガンマヘルペスウイルス感染による自己抗原産生2012

    • Author(s)
      榊原修平
    • Organizer
      第60回日本ウイルス学会
    • Place of Presentation
      大阪市
    • Data Source
      KAKENHI-PROJECT-20229007
  • [Presentation] Generation of virus- and self-reactive B cells during herpesvirus infection2012

    • Author(s)
      Sakakibara, S. , T. Yasui, T. Minamitani, H. Kikutani
    • Organizer
      The 12th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      兵庫県淡路市(ポスター)
    • Data Source
      KAKENHI-PROJECT-24790440
  • [Presentation] ガンマヘルペスウイルス感染による自己抗体産生2012

    • Author(s)
      榊原修平、安居輝人、南谷武春、菊谷仁
    • Organizer
      第60回日本ウイルス学会学術集会
    • Place of Presentation
      大阪市(口頭
    • Data Source
      KAKENHI-PROJECT-24790440
  • [Presentation] Generation of virus-and self-reactive B cells during herpesvirus infection.2012

    • Author(s)
      Sakakibara, S.
    • Organizer
      The 11th Awaji International Forum on Infection and Immunity
    • Place of Presentation
      淡路市
    • Data Source
      KAKENHI-PROJECT-20229007
  • [Presentation] Generation and selection of virus- and self-reactive B cells during herpesvirus infection.2012

    • Author(s)
      Sakakibara, S.
    • Organizer
      第41回日本免疫学会
    • Place of Presentation
      神戸市
    • Data Source
      KAKENHI-PROJECT-20229007
  • [Presentation] ガンマヘルペスウイルス感染による免疫関連疾患発症機構の解明2012

    • Author(s)
      榊原修平
    • Organizer
      第27回ヘルペスウイルス研究会
    • Place of Presentation
      愛知県知多郡東浦町
    • Data Source
      KAKENHI-PROJECT-20229007
  • 1.  KIKUTANI Hitoshi (80161412)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 2.  YASUI Teruhito (60283074)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 3.  MIZUI Masayuki (30423106)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  寺口 俊介 (00467276)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  IKAWA Masato
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  SATO Yukoh
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  ALIEL-HUSSIEN Marwa
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  NARAZAKI Masashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 9.  NAKATA Masanobu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  高木 淳一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  多田 智
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 12.  奥崎 大介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 13.  STANDLEY Daron
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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